The Complete Peptide Reference Table - Labmeeting Health Reviews

A published AagingBase database identified 282 validated anti-ageing peptides — 144 natural and 136 synthetic. The clinically significant ones with human evidence are presented here across seven categories.

Table of Contents

Category 1 — Skin & Cosmetic Peptides

Peptide	Also Known As	What It Does
GHK-Cu	Copper peptide, Glycyl-L-histidyl-L-lysine-Cu	Stimulates collagen and elastin, activates 4,000+ genes, tightens skin, reduces wrinkles, promotes wound healing
Matrixyl 3000	Palmitoyl Tripeptide-1 + Palmitoyl Tetrapeptide-7	Signals fibroblasts to rebuild collagen matrix; reduces wrinkle depth by up to 45%
Matrixyl Synthe’6	Palmitoyl Tripeptide-38	Next-generation Matrixyl; targets all six components of the skin matrix simultaneously
Argireline	Acetyl Hexapeptide-3, Acetyl Hexapeptide-8	Partially inhibits muscle contraction (like topical Botox); reduces expression wrinkles up to 30%
SNAP-8	Acetyl Octapeptide-3	Extended version of Argireline; stronger SNARE complex inhibition; better for crow’s feet and forehead lines
Leuphasyl	Pentapeptide-18	Complements Argireline through a different receptor pathway; combined use achieves up to 47% wrinkle reduction
Syn-Ake	Dipeptide Diaminobutyroyl Benzylamide Diacetate	Synthetic snake venom-inspired peptide; relaxes facial muscles, reduces dynamic wrinkles
Palmitoyl Pentapeptide-4	Matrixyl (original), Pal-KTTKS	Original Matrixyl; collagen I, III, and IV stimulation; widely studied
Acetyl Tetrapeptide-9	—	Stimulates lumican production — a key proteoglycan that organises collagen fibres; improves skin firmness
Acetyl Dipeptide-31 Amide	AP31	Newest high-evidence peptide (2025 trials); nasolabial fold reduction, facial lifting, fastest onset of any cosmetic peptide — significant results from week 2
Hexapeptide-10	Serilisine	Promotes keratinocyte adhesion and laminin production; improves skin cohesion and reduces sagging
Tripeptide-10 Citrulline	—	Organises collagen fibre diameter for smoother skin texture
Oral collagen peptides	Hydrolysed collagen, collagen hydrolysate	Taken orally; improves skin hydration and wrinkle depth with strong meta-analysis evidence

Category 2 — Growth Hormone Secretagogues (GHS)

These peptides stimulate the pituitary gland to produce more growth hormone naturally — rather than injecting synthetic HGH directly, which carries greater risks.

Peptide	Also Known As	What It Does
Sermorelin	GRF 1-29, GHRH analogue	Stimulates pituitary GH release; anti-ageing, fat loss, muscle building, improved sleep and recovery
Ipamorelin	—	Selective GH secretagogue; minimal cortisol and prolactin side effects; often combined with CJC-1295
CJC-1295	DAC:GRF, Drug Affinity Complex-Growth Releasing Factor	Long-acting GHRH analogue; combined with Ipamorelin for sustained GH elevation
CJC-1295 without DAC	Mod GRF 1-29	Shorter-acting version; more physiological pulsatile GH release
Tesamorelin	Egrifta	FDA-approved GHRH analogue; reduces visceral fat; approved for HIV lipodystrophy
GHRP-2	Pralmorelin	Potent GH secretagogue; stimulates ghrelin receptor; increases appetite
GHRP-6	Growth Hormone Releasing Peptide-6	Similar to GHRP-2; stronger appetite stimulation; used for muscle building and recovery
Hexarelin	Examorelin	Most potent GHRP; also has direct cardiac protective effects
MK-677	Ibutamoren, Nutrobal	Oral GH secretagogue (non-peptide technically); daily oral dosing; raises IGF-1; improves sleep quality and muscle mass

Category 3 — Healing & Recovery Peptides

Peptide	Also Known As	What It Does
BPC-157	Body Protection Compound-157, Pentadecapeptide	Accelerates tendon, ligament, muscle, and gut healing; anti-inflammatory; promotes angiogenesis; one of the most researched healing peptides
TB-500	Thymosin Beta-4 fragment, Tβ4 frag	Promotes actin cell migration and tissue repair; systemic healing; reduces inflammation; often stacked with BPC-157
Thymosin Beta-4	Tβ4	Full-length version of TB-500; wound healing, anti-inflammatory, cardiac repair
KPV	Lysine-Proline-Valine	Anti-inflammatory tripeptide; gut healing; reduces IBD symptoms; derived from alpha-MSH
LL-37	Cathelicidin antimicrobial peptide	Antimicrobial and wound healing; promotes skin cell migration and angiogenesis

Category 4 — Immune & Longevity Peptides

Peptide	Also Known As	What It Does
Thymosin Alpha-1	Tα1, Thymalfasin, Zadaxin	Restores T-cell function, reverses thymic involution, reduces inflammaging, approved in 35+ countries for hepatitis and cancer support
Epitalon	Epithalamin, Tetrapeptide AEDG	Telomere lengthening peptide; regulates melatonin; strong animal longevity data; improves sleep and immune function
MOTS-c	Mitochondrial Open Reading Frame peptide	Mitochondria-derived; improves metabolic function, reduces inflammation, supports bone health and insulin sensitivity
SS-31	Elamipretide, Szeto-Schiller peptide	Mitochondrial protective peptide; reduces oxidative stress in mitochondria; cardiac and kidney protection
Humanin	—	Mitochondria-derived; neuroprotective; reduces Alzheimer’s risk markers; improves insulin sensitivity

Category 5 — Metabolic & Weight Management Peptides

Peptide	Also Known As	What It Does
Semaglutide	Ozempic, Wegovy	GLP-1 agonist; FDA-approved for type 2 diabetes and weight loss; reduces appetite and cardiovascular risk
Tirzepatide	Mounjaro, Zepbound	Dual GLP-1/GIP agonist; superior weight loss vs semaglutide in trials
Retatrutide	—	Triple agonist (GLP-1/GIP/glucagon); strongest weight loss peptide in clinical trials
AOD-9604	Advanced Obesity Drug, HGH frag 176-191	Fragment of HGH; stimulates fat breakdown without GH side effects; no effect on blood sugar
Liraglutide	Saxenda, Victoza	GLP-1 agonist; FDA-approved for weight management and type 2 diabetes

Category 6 — Neurological, Mood & Sleep Peptides

Peptide	Also Known As	What It Does

Peptide	Also Known As	What It Does
Selank	Tuftsin analogue, TP-7	Anxiolytic peptide; reduces anxiety without sedation; improves memory and cognitive function; no dependency
Semax	ACTH 4-7 analogue	Neuroprotective; improves BDNF; enhances focus, memory, and cognitive performance; used clinically in Russia
DSIP	Delta Sleep-Inducing Peptide	Directly promotes slow-wave sleep; reduces stress; antidepressant and neuroprotective properties
Pinealon	Epithalon brain peptide, EDR peptide	Neuroprotective; reduces oxidative stress in the brain; improves cognitive function and sleep
Dihexa	PNB-0408	Extremely potent cognitive enhancer; promotes synaptogenesis; 10 million times more potent than BDNF in animal studies
Cerebrolysin	FPE 1070	Neuropeptide mixture; promotes neurogenesis; used clinically for Alzheimer’s and brain injury
Oxytocin	“Love hormone”, Pitocin	Promotes bonding, reduces social anxiety, anti-inflammatory; injectable and nasal spray forms

Category 7 — Sexual Health & Hormonal Peptides

Peptide	Also Known As	What It Does
PT-141	Bremelanotide, Vyleesi	FDA-approved; activates melanocortin receptors in the brain to directly increase sexual desire in men and women; works regardless of testosterone levels
Kisspeptin	Metastin, KISS1	Stimulates GnRH release, which drives LH and FSH production — directly raising testosterone; reproductive health
Gonadorelin	GnRH, Lutrepulse	Stimulates LH and FSH; used to maintain testosterone and testicular function during TRT

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