Jonathan Michael Irish

Systems and Approaches
flow cytometry (incl. phospho-specific flow cytometry), computational biology, signaling profiles, primary human cells, immortalized cell lines, viral vectors, RNA interference, 2D PAGE / western blotting, collaboration

Interests
cancer (esp. leukemia and lymphoma), immunology, bioinformatics, clinical research, programming (computers and lymphocytes), signaling networks, cell aging and immortalization, data visualization and communication

Summary
I am a PhD research scientist who is passionate about clinical cancer research and the use of advanced technology to improve cancer therapy. My current goal is to combine bioinformatics techniques and immunology research in order to understand why cancer patients' cells resist existing therapies. By measuring signaling biology in every single cell in a patient's tumor sample we can build a map of altered biology called a signaling profile. Part of this goal is to be able to use signaling profiles to guide clinical decision making. I am especially interested in the critical choice of the first therapy for the patient. We are currently applying this approach to leukemia and lymphoma. If successful, I would like to see this approach generalized to many types of cancer. http://www.linkedin.com/in/jonathanirish