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Samuel's Colleagues

Adam E. Cohen
Harvard University

Alexander Fields
Harvard University

Bianxiao Cui
Stanford University

Christopher A Werley
Massachusetts Institute of Technology

Daniel Edward Rosenfeld
Stanford University

David Emil Moilanen
Stanford University

Feng Zhang
Stanford University

Jeffrey R Moffitt
Harvard University

Jeremy L. England
Princeton University

Jian Cui
Stanford University

John D Chodera
Stanford University

Julie Suzanne Biteen
Stanford University

Koenig Marcelle
Stanford University

Michael Anthony Thompson
Stanford University

Polly M. Fordyce
University of California-San Francisco

Steve Silverman
Stanford University

Yan Jiang
Stanford University

Yin Nah Teo
Stanford University

andrew t krueger
Stanford University

Add Samuel as a colleague

Samuel J Lord

Stanford University
PhD Student

Send Samuel J Lord a message

Research

Systems and Approaches
spectroscopy, microscopy, living cells

Interests
single-molecule spectroscopy, ultrasensitive detection, fluorophore design, cellular imaging, biophysics, chemical physics, physical chemistry

Summary
I help develop new organic fluorophores optimized for cellular imaging, especially single-molecule detection. The major class of fluorophores that I work with is called dicyanomethylenedihydrofuran (DCDHF), after the acceptor group present in all the derivatives. I am a physical chemist, and I work closely with our synthetic collaborators in the Twieg lab at Kent State University: We collaboratively design the fluorophores, the Tweig lab synthesizes them, and I characterize their photophysical properties. I am currently designing fluorophores with complex photochemistry: emitters that are photoactivatable, fluorogenic, or photoswitchable. Also, I am trying to take advantage of some interesting methods to specifically label biomolecules with the DCDHF fluorophores in living cells.

Published by Samuel J Lord

The influence of tetrahydroquinoline rings in dicyanomethylenedihydrofuran (DCDHF) single-molecule fluorophores

Tadpole Conformation of Gradient Polymer Brushes

Three-dimensional, single-molecule fluorescence imaging beyond the diffraction limit by using a double-helix point spread function.

Proceedings of the National Academy of Sciences of the United States of America 106(9):2995-9, 2009 Mar 3Who cited this? | PubMed ID: 19211795 | Fulltext
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DCDHF Fluorophores for Single-Molecule Imaging in Cells.

Chemphyschem : a European journal of chemical physics and physical chemistry, 2008 Nov 21Who cited this? | PubMed ID: 19025732 | Fulltext
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DCDHF Fluorophores for Single-Molecule Imaging in Cells.

Chemphyschem : a European journal of chemical physics and physical chemistry, 2008 Nov 21Who cited this? | PubMed ID: 19025732 | Fulltext
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Diffusion of lipid-like single-molecule fluorophores in the cell membrane.

The journal of physical chemistry. B 110(15):8151, 2006 Apr 20Who cited this? | PubMed ID: 16610918 | Fulltext
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Education