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Papers authored by Zarrinkar PP

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Identification of N-(5-tert-Butyl-isoxazol-3-yl)-N'-{4-[7-(2-morpholin-4-yl-ethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea Dihydrochloride (AC220), a Uniquely Potent, Selective, and Efficacious FMS-Like Tyrosine Kinase-3 (FLT3) Inhibitor.

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Chao Q, Sprankle KG, Grotzfeld RM, Lai AG, Carter TA, Velasco AM, Gunawardane RN, Cramer MD, Gardner MF, James J, Zarrinkar PP, Patel HK, and Bhagwat SS

Journal of medicinal chemistry 52(23):7808-16, 2009 Dec 10 - Who cited this? | PubMed ID: 19754199 | Fulltext

AC220 is a uniquely potent and selective inhibitor of FLT3 for the treatment of acute myeloid leukemia (AML).

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Zarrinkar PP, Gunawardane RN, Cramer MD, Gardner MF, Brigham D, Belli B, Karaman MW, Pratz KW, Pallares G, Chao Q, Sprankle KG, Patel HK, Levis M, Armstrong RC, James J, and Bhagwat SS

Blood 114(14):2984-92, 2009 Oct 1 - Who cited this? | PubMed ID: 19654408 | Fulltext

Arylcarboxyamino-substituted diaryl ureas as potent and selective FLT3 inhibitors.

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Patel HK, Grotzfeld RM, Lai AG, Mehta SA, Milanov ZV, Chao Q, Sprankle KG, Carter TA, Velasco AM, Fabian MA, James J, Treiber DK, Lockhart DJ, Zarrinkar PP, and Bhagwat SS

Bioorganic & medicinal chemistry letters 19(17):5182-5, 2009 Sep 1 - Who cited this? | PubMed ID: 19646870 | Fulltext

Tuning a three-component reaction for trapping kinase substrate complexes.

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Statsuk AV, Maly DJ, Seeliger MA, Fabian MA, Biggs WH, Lockhart DJ, Zarrinkar PP, Kuriyan J, and Shokat KM

Journal of the American Chemical Society 130(51):17568-74, 2008 Dec 24 - Who cited this? | PubMed ID: 19053485 | Fulltext

High-throughput kinase profiling as a platform for drug discovery.

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Goldstein DM, Gray NS, and Zarrinkar PP

Nature reviews. Drug discovery 7(5):391-7, 2008 May - Who cited this? | PubMed ID: 18404149 | Fulltext

A quantitative analysis of kinase inhibitor selectivity.

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Karaman MW, Herrgard S, Treiber DK, Gallant P, Atteridge CE, Campbell BT, Chan KW, Ciceri P, Davis MI, Edeen PT, Faraoni R, Floyd M, Hunt JP, Lockhart DJ, Milanov ZV, Morrison MJ,

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Nature biotechnology 26(1):127, 2008 Jan - Who cited this? | PubMed ID: 18183025 | Fulltext

Structure of the kinase domain of an imatinib-resistant Abl mutant in complex with the Aurora kinase inhibitor VX-680.

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Young MA, Shah NP, Chao LH, Seeliger M, Milanov ZV, Biggs WH, Treiber DK, Patel HK, Zarrinkar PP, Lockhart DJ, Sawyers CL, and Kuriyan J

Cancer research 66(2):1007-14, 2006 Jan 15 - Who cited this? | PubMed ID: 16424036 | Fulltext

Inhibition of drug-resistant mutants of ABL, KIT, and EGF receptor kinases.

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Carter TA, Wodicka LM, Shah NP, Velasco AM, Fabian MA, Treiber DK, Milanov ZV, Atteridge CE, Biggs WH, Edeen PT, Floyd M, Ford JM, Grotzfeld RM, Herrgard S, Insko DE, Mehta SA,

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Proceedings of the National Academy of Sciences of the United States of America 102(31):11011-6, 2005 Aug 2 - Who cited this? | PubMed ID: 16046538 | Fulltext

A small molecule-kinase interaction map for clinical kinase inhibitors.

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Fabian MA, Biggs WH, Treiber DK, Atteridge CE, Azimioara MD, Benedetti MG, Carter TA, Ciceri P, Edeen PT, Floyd M, Ford JM, Galvin M, Gerlach JL, Grotzfeld RM, Herrgard S, Insko DE,

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Nature biotechnology 23(3):329-36, 2005 Mar - Who cited this? | PubMed ID: 15711537 | Fulltext

Arrays of arrays for high-throughput gene expression profiling.

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Zarrinkar PP, Mainquist JK, Zamora M, Stern D, Welsh JB, Sapinoso LM, Hampton GM, and Lockhart DJ

Genome research 11(7):1256-61, 2001 Jul - Who cited this? | PubMed ID: 11435408 | Fulltext

Analysis of gene expression profiles in normal and neoplastic ovarian tissue samples identifies candidate molecular markers of epithelial ovarian cancer.

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Welsh JB, Zarrinkar PP, Sapinoso LM, Kern SG, Behling CA, Monk BJ, Lockhart DJ, Burger RA, and Hampton GM

Proceedings of the National Academy of Sciences of the United States of America 98(3):1176, 2001 Jan 30 - Who cited this? | PubMed ID: 11158614 | Fulltext

Optimizing the substrate specificity of a group I intron ribozyme.

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Zarrinkar PP and Sullenger BA

Biochemistry 38(11):3426-32, 1999 Mar 16 - Who cited this? | PubMed ID: 10079089 | Fulltext

Probing the interplay between the two steps of group I intron splicing: competition of exogenous guanosine with omega G.

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Zarrinkar PP and Sullenger BA

Biochemistry 37(51):18056-63, 1998 Dec 22 - Who cited this? | PubMed ID: 9922174 | Fulltext

Kinetic intermediates trapped by native interactions in RNA folding.

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Treiber DK, Rook MS, Zarrinkar PP, and Williamson JR

Science (New York, N.Y.) 279(5358):1943-6, 1998 Mar 20 - Who cited this? | PubMed ID: 9506945 | Fulltext

Slow folding kinetics of RNase P RNA.

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Zarrinkar PP, Wang J, and Williamson JR

RNA (New York, N.Y.) 2(6):564-73, 1996 Jun - Who cited this? | PubMed ID: 8718685 | Fulltext

The kinetic folding pathway of the Tetrahymena ribozyme reveals possible similarities between RNA and protein folding.

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Zarrinkar PP and Williamson JR

Nature structural biology 3(5):432-8, 1996 May - Who cited this? | PubMed ID: 8612073 | Fulltext

The P9.1-P9.2 peripheral extension helps guide folding of the Tetrahymena ribozyme.

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Zarrinkar PP and Williamson JR

Nucleic acids research 24(5):854-8, 1996 Mar 1 - Who cited this? | PubMed ID: 8600452 | Fulltext

Kinetic intermediates in RNA folding.

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Zarrinkar PP and Williamson JR

Science (New York, N.Y.) 265(5174):918-24, 1994 Aug 12 - Who cited this? | PubMed ID: 8052848 | Fulltext

Unique fatty acid composition of normal cartilage: discovery of high levels of n-9 eicosatrienoic acid and low levels of n-6 polyunsaturated fatty acids.

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Adkisson HD, Risener FS, Zarrinkar PP, Walla MD, Christie WW, and Wuthier RE

The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 5(3):344-53, 1991 Mar 1 - Who cited this? | PubMed ID: 2001795 | Fulltext

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