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Papers authored by Yoshimoto R

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Lox-1.

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Ogura S, Kakino A, Sato Y, Fujita Y, Iwamoto S, Otsui K, Yoshimoto R, and Sawamura T

Circulation journal : official journal of the Japanese Circulation Society 73(11):1993-9, 2009 Nov - Who cited this? | PubMed ID: 19801851 | Fulltext

Discovery and structure-activity relationships of a novel class of quinazoline glucokinase activators.

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Iino T, Sasaki Y, Bamba M, Mitsuya M, Ohno A, Kamata K, Hosaka H, Maruki H, Futamura M, Yoshimoto R, Ohyama S, Sasaki K, Chiba M, Ohtake N, Nagata Y, Eiki J,

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Bioorganic & medicinal chemistry letters 19(19):5531-8, 2009 Oct 1 - Who cited this? | PubMed ID: 19726182 | Fulltext

The design and optimization of a series of 2-(pyridin-2-yl)-1H-benzimidazole compounds as allosteric glucokinase activators.

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Takahashi K, Hashimoto N, Nakama C, Kamata K, Sasaki K, Yoshimoto R, Ohyama S, Hosaka H, Maruki H, Nagata Y, Eiki J, and Nishimura T

Bioorganic & medicinal chemistry 17(19):7042-51, 2009 Oct 1 - Who cited this? | PubMed ID: 19736020 | Fulltext

Synthesis, structure-activity relationships, and biological profiles of a dihydrobenzoxathiin class of histamine H(3) receptor inverse agonists.

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Sasaki T, Takahashi T, Nagase T, Mizutani T, Ito S, Mitobe Y, Miyamoto Y, Kanesaka M, Yoshimoto R, Tanaka T, Takenaga N, Tokita S, and Sato N

Bioorganic & medicinal chemistry letters 19(15):4232-6, 2009 Aug 1 - Who cited this? | PubMed ID: 19520574 | Fulltext

Discovery of novel 2-(pyridine-2-yl)-1H-benzimidazole derivatives as potent glucokinase activators.

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Ishikawa M, Nonoshita K, Ogino Y, Nagae Y, Tsukahara D, Hosaka H, Maruki H, Ohyama S, Yoshimoto R, Sasaki K, Nagata Y, Eiki J, and Nishimura T

Bioorganic & medicinal chemistry letters 19(15):4450-4, 2009 Aug 1 - Who cited this? | PubMed ID: 19540111 | Fulltext

Synthesis and evaluation of a novel 2-azabicyclo[2.2.2]octane class of long chain fatty acid elongase 6 (ELOVL6) inhibitors.

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Sasaki T, Nagase T, Takahashi T, Nagumo A, Shimamura K, Miyamoto Y, Kitazawa H, Kanesaka M, Yoshimoto R, Aragane K, Tokita S, and Sato N

Bioorganic & medicinal chemistry 17(15):5639-47, 2009 Aug 1 - Who cited this? | PubMed ID: 19596583 | Fulltext

Identification of a stable chemerin analog with potent activity toward ChemR23.

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Shimamura K, Matsuda M, Miyamoto Y, Yoshimoto R, Seo T, and Tokita S

Peptides 30(8):1529-38, 2009 Aug - Who cited this? | PubMed ID: 19540290 | Fulltext

Synthesis and biological evaluation of a novel 3-sulfonyl-8-azabicyclo[3.2.1]octane class of long chain fatty acid elongase 6 (ELOVL6) inhibitors.

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Nagase T, Takahashi T, Sasaki T, Nagumo A, Shimamura K, Miyamoto Y, Kitazawa H, Kanesaka M, Yoshimoto R, Aragane K, Tokita S, and Sato N

Journal of medicinal chemistry 52(14):4111-4, 2009 Jul 23 - Who cited this? | PubMed ID: 19522500 | Fulltext

5,5-Dimethyl-3-(5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-1-phenyl-3-(trifluoromethyl)-3,5,6,7-tetrahydro-1H-indole-2,4-dione, a Potent Inhibitor for Mammalian Elongase of Long-Chain Fatty Acids Family 6: Examination of Its Potential Utility as a Pharmacological Tool.

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Shimamura K, Kitazawa H, Miyamoto Y, Kanesaka M, Nagumo A, Yoshimoto R, Aragane K, Morita N, Ohe T, Takahashi T, Nagase T, Sato N, and Tokita S

The Journal of pharmacology and experimental therapeutics 330(1):249-56, 2009 Jul - Who cited this? | PubMed ID: 19359527 | Fulltext

Structure-activity relationships of 3,5-disubstituted benzamides as glucokinase activators with potent in vivo efficacy.

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Iino T, Hashimoto N, Sasaki K, Ohyama S, Yoshimoto R, Hosaka H, Hasegawa T, Chiba M, Nagata Y, Eiki J, and Nishimura T

Bioorganic & medicinal chemistry 17(11):3800-9, 2009 Jun 1 - Who cited this? | PubMed ID: 19427223 | Fulltext

Synthesis and evaluation of a novel indoledione class of long chain fatty acid elongase 6 (ELOVL6) inhibitors.

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Takahashi T, Nagase T, Sasaki T, Nagumo A, Shimamura K, Miyamoto Y, Kitazawa H, Kanesaka M, Yoshimoto R, Aragane K, Tokita S, and Sato N

Journal of medicinal chemistry 52(10):3142-5, 2009 May 28 - Who cited this? | PubMed ID: 19388647 | Fulltext

Isolation and characterization of post-splicing lariat-intron complexes.

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Yoshimoto R, Kataoka N, Okawa K, and Ohno M

Nucleic acids research 37(3):891-902, 2009 Feb - Who cited this? | PubMed ID: 19103666 | Fulltext

Synthesis and evaluation of structurally constrained quinazolinone derivatives as potent and selective histamine h3 receptor inverse agonists.

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Nagase T, Mizutani T, Sekino E, Ishikawa S, Ito S, Mitobe Y, Miyamoto Y, Yoshimoto R, Tanaka T, Ishihara A, Takenaga N, Tokita S, and Sato N

Journal of medicinal chemistry 51(21):6889-901, 2008 Nov 13 - Who cited this? | PubMed ID: 18841880 | Fulltext

Synthesis, structure-activity relationships, and biological profiles of a quinazolinone class of histamine h3 receptor inverse agonists.

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Nagase T, Mizutani T, Ishikawa S, Sekino E, Sasaki T, Fujimura T, Ito S, Mitobe Y, Miyamoto Y, Yoshimoto R, Tanaka T, Ishihara A, Takenaga N, Tokita S, Fukami T, and Sato N

Journal of medicinal chemistry 51(15):4780-9, 2008 Aug 14 - Who cited this? | PubMed ID: 18598020 | Fulltext

Determination of antihypertensive peptides from an izumi shrimp hydrolysate.

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Nii Y, Fukuta K, Yoshimoto R, Sakai K, and Ogawa T

Bioscience, biotechnology, and biochemistry 72(3):861-4, 2008 Mar - Who cited this? | PubMed ID: 18323650 | Fulltext

Distinctive role of central histamine H(3) receptor in various orexigenic pathways.

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Yoshimoto R, Kanatani A, and Tokita S

European journal of pharmacology 579(1-3):229-32, 2008 Jan 28 - Who cited this? | PubMed ID: 18037404 | Fulltext

Neural stem cells improve learning and memory in rats with Alzheimer's disease.

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Wu S, Sasaki A, Yoshimoto R, Kawahara Y, Manabe T, Kataoka K, Asashima M, and Yuge L

Pathobiology : journal of immunopathology, molecular and cellular biology 75(3):186-94, 2008 - Who cited this? | PubMed ID: 18550916 | Fulltext

Floating culture promotes the maintenance of hematopoietic stem cells.

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Kajiume T, Yuge L, Kawahara Y, Yoshimoto R, Sasaki A, Ide T, Asashima M, Kataoka K, and Kobayashi M

FEBS letters 581(24):4645-50, 2007 Oct 2 - Who cited this? | PubMed ID: 17825827 | Fulltext

Microgravity potentiates stem cell proliferation while sustaining the capability of differentiation.

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Yuge L, Kajiume T, Tahara H, Kawahara Y, Umeda C, Yoshimoto R, Wu SL, Yamaoka K, Asashima M, Kataoka K, and Ide T

Stem cells and development 15(6):921-9, 2006 Dec - Who cited this? | PubMed ID: 17253953 | Fulltext

Therapeutic potential of histamine H3 receptor agonist for the treatment of obesity and diabetes mellitus.

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Yoshimoto R, Miyamoto Y, Shimamura K, Ishihara A, Takahashi K, Kotani H, Chen AS, Chen HY, Macneil DJ, Kanatani A, and Tokita S

Proceedings of the National Academy of Sciences of the United States of America 103(37):13866-71, 2006 Sep 12 - Who cited this? | PubMed ID: 16954192 | Fulltext

Impaired drinking response in histamine H3 receptor knockout mice following dehydration or angiotensin-II challenge.

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Yoshimoto R, Miyamoto Y, Takahashi K, Kotani H, Kanatani A, and Tokita S

Pharmacology, biochemistry, and behavior 84(3):504-10, 2006 Jul - Who cited this? | PubMed ID: 16887177 | Fulltext

Detailed pharmacological characterization of GT-2331 for the rat histamine H3 receptor.

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Ito S, Yoshimoto R, Miyamoto Y, Mitobe Y, Nakamura T, Ishihara A, MacNeil DJ, Kanatani A, and Tokita S

European journal of pharmacology 529(1-3):40-6, 2006 Jan 4 - Who cited this? | PubMed ID: 16316645 | Fulltext

Simultaneous fluorometric measurement of histamine and tele-methylhistamine levels in rodent brain by high-performance liquid chromatography.

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Miyamoto Y, Yoshimoto R, Yumoto M, Ishihara A, Takahashi K, Kotani H, Kanatani A, and Tokita S

Analytical biochemistry 334(1):89-96, 2004 Nov 1 - Who cited this? | PubMed ID: 15464956 | Fulltext

Anisakis in a biopsy specimen from the edge of a gastric ulcer: report of a case.

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Shiomi M, Kamisako T, Yutani I, Yoshimoto R, Kudo M, and Fujii R

Gastrointestinal endoscopy 60(5):854-6, 2004 Nov - Who cited this? | PubMed ID: 15557978 | Fulltext

Energy-Dispersive XAFS Studies on the Spontaneous Dispersion of PdO and the Formation of Stable Pd Clusters in Zeolites.

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Okumura K, Yoshimoto R, Uruga T, Tanida H, Kato K, Yokota S, and Niwa M

The journal of physical chemistry. B 108(20):6250-5, 2004 May 20 - Who cited this? | PubMed ID: 18950108 | Fulltext

AT-1015, a novel serotonin2A receptor antagonist, improves resaturation of exercised ischemic muscle in hypercholesterolemic rabbits.

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Komiyama T, Kihara H, Hirose K, Yoshimoto R, and Shigematsu H

Journal of vascular surgery : official publication, the Society for Vascular Surgery [and] International Society for Cardiovascular Surgery, North American Chapter 39(3):661-7, 2004 Mar - Who cited this? | PubMed ID: 14981464 | Fulltext

Rational design, synthesis, and structure-activity relationships of novel factor Xa inhibitors: (2-substituted-4-amidinophenyl)pyruvic and -propionic acids.

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Sagi K, Nakagawa T, Yamanashi M, Makino S, Takahashi M, Takayanagi M, Takenaka K, Suzuki N, Oono S, Kataoka N, Ishikawa K, Shima S, Fukuda Y, Kayahara T, Takehana S, Shima Y,

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Journal of medicinal chemistry 46(10):1845-57, 2003 May 8 - Who cited this? | PubMed ID: 12723948 | Fulltext

Cardiac Ca(2+) channel-blocking effects of the cyproheptadine derivative AH-1058 in isolated guinea pig cardiomyocytes.

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Dohmoto H, Takahara A, Uneyama H, and Yoshimoto R

Journal of pharmacological sciences 91(2):163-6, 2003 Feb - Who cited this? | PubMed ID: 12686762 | Fulltext

Laser-perforated membranous biomaterials induced pore size-dependent bone induction when used as a new BMP carrier.

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Kuboki Y, Kikuchi M, Takita H, Yoshimoto R, Nakayama Y, Matsuda T, and Ikada Y

Connective tissue research 44 Suppl 1:318-25, 2003 - Who cited this? | PubMed ID: 12952216 | Fulltext

Increased locomotor activity, increased food and water intake and decreased PVN neurons in H1 calponin gene-deficient mice.

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Bannai M, Yoshimoto R, MiTSUI-SAITO M, Hori M, Nishihara M, Takahashi K, Yamamura H, Taniguchi S, Katsuki M, Ozaki H, and Karaki H

The Journal of veterinary medical science / the Japanese Society of Veterinary Science 65(1):153-5, 2003 Jan - Who cited this? | PubMed ID: 12576725 | Fulltext

Pharmacokinetics and pharmacodynamics of AJW200, a humanized monoclonal antibody to von Willebrand factor, in monkeys.

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Kageyama S, Yamamoto H, Nakazawa H, Matsushita J, Kouyama T, Gonsho A, Ikeda Y, and Yoshimoto R

Arteriosclerosis, thrombosis, and vascular biology 22(1):187-92, 2002 Jan - Who cited this? | PubMed ID: 11788481 | Fulltext

Antithrombotic activity of AT-1015, a potent 5-HT(2A) receptor antagonist, in rat arterial thrombosis model and its effect on bleeding time.

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Kihara H, Koganei H, Hirose K, Yamamoto H, and Yoshimoto R

European journal of pharmacology 433(2-3):157-62, 2001 Dec 21 - Who cited this? | PubMed ID: 11755147 | Fulltext

Chronic effect of doxorubicin on vascular endothelium assessed by organ culture study.

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Murata T, Yamawaki H, Yoshimoto R, Hori M, Sato K, Ozaki H, and Karaki H

Life sciences 69(22):2685-95, 2001 Oct 19 - Who cited this? | PubMed ID: 11712671 | Fulltext

In vivo antiarrhythmic profile of AP-792 assessed in different canine arrhythmia models.

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Takahara A, Hirasawa A, Dohmoto H, Shoji M, Yoshimoto R, Sugiyama A, and Hashimoto K

Japanese journal of pharmacology 87(1):21-6, 2001 Sep - Who cited this? | PubMed ID: 11676194 | Fulltext

Anti-human vWF monoclonal antibody, AJvW-2 Fab, inhibits repetitive coronary artery thrombosis without bleeding time prolongation in dogs.

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Kageyama S, Yamamoto H, Nakazawa H, and Yoshimoto R

Thrombosis research 101(5):395-404, 2001 Mar 1 - Who cited this? | PubMed ID: 11297756 | Fulltext

Utilization of telemetry system to assess the cardiovascular profile of AH-1058, a new cardioselective Ca2+ channel blocker, in conscious dogs.

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Takahara A, Dohmoto H, Yoshimoto R, Sugiyama A, and Hashimoto K

Japanese journal of pharmacology 85(3):331-4, 2001 Mar - Who cited this? | PubMed ID: 11325028 | Fulltext

Cardiovascular action of a cardioselective Ca(2+)channel blocker AH-1058 in conscious dogs assessed by telemetry.

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Takahara A, Dohmoto H, Yoshimoto R, Sugiyama A, and Hashimoto K

European journal of pharmacology 413(1):101-8, 2001 Feb 9 - Who cited this? | PubMed ID: 11173068 | Fulltext

Effects of a dual L/N-type Ca(2+) channel blocker cilnidipine on neurally mediated chronotropic response in anesthetized dogs.

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Konda T, Takahara A, Maeda K, Dohmoto H, and Yoshimoto R

European journal of pharmacology 413(1):117-20, 2001 Feb 9 - Who cited this? | PubMed ID: 11173070 | Fulltext

AH-1058: a novel cardioselective Ca2+ channel blocker.

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Takahara A, Sugiyama A, Yoshimoto R, and Hashimoto K

Cardiovascular drug reviews 19(4):279-96, 2001 - Who cited this? | PubMed ID: 11830748 | Fulltext

Regulation of shortening velocity by calponin in intact contracting smooth muscles.

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Takahashi K, Yoshimoto R, Fuchibe K, Fujishige A, Mitsui-Saito M, Hori M, Ozaki H, Yamamura H, Awata N, Taniguchi S, Katsuki M, Tsuchiya T, and Karaki H

Biochemical and biophysical research communications 279(1):150-7, 2000 Dec 9 - Who cited this? | PubMed ID: 11112431 | Fulltext

Proteolysis of acidic calponin by mu-calpain.

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Yoshimoto R, Hori M, Ozaki H, and Karaki H

Journal of biochemistry 128(6):1045-9, 2000 Dec - Who cited this? | PubMed ID: 11098148 | Fulltext

Ca2+-Sensitization of contraction in the h1 calponin-deficient smooth muscle.

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Yoshimoto R, Hori M, Takahashi K, Taniguchi SI, Katsuki M, Ozaki H, and Karaki H

Japanese journal of pharmacology 84(4):474-5, 2000 Dec - Who cited this? | PubMed ID: 11202623 | Fulltext

Anti-human von willebrand factor monoclonal antibody AJvW-2 prevents thrombus deposition and neointima formation after balloon injury in guinea pigs.

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Kageyama S, Yamamoto H, and Yoshimoto R

Arteriosclerosis, thrombosis, and vascular biology 20(10):2303, 2000 Oct - Who cited this? | PubMed ID: 11031219 | Fulltext

Inhibitory effects of a newly synthesized 5-HT2 receptor antagonist, AT-1015 (N-[2-[4-(5H-dibenzo[a,d]cyclohepten-5-ylidene)piperidino]-ethyl]-1-for myl-4-piperidinecarboxamide monohydrochloride monohydrate), on contraction and relaxation of pig coronary arteries induced by 5-HT and alpha-methylserotonin: comparison with ketanserin.

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Gong H, Rashid M, Nakamura T, Hattori K, Nakazawa M, Kihara H, Yoshimoto R, and Nagatomo T

Biological & pharmaceutical bulletin 23(9):1105-7, 2000 Sep - Who cited this? | PubMed ID: 10993215 | Fulltext

Antiarrhythmic and cardiohemodynamic effects of a novel Ca(2+) channel blocker, AH-1058, assessed in canine arrhythmia models.

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Takahara A, Sugiyama A, Dohmoto H, Yoshimoto R, and Hashimoto K

European journal of pharmacology 398(1):107-12, 2000 Jun 9 - Who cited this? | PubMed ID: 10856454 | Fulltext

Electrophysiological and cardiohemodynamic effects of AH-1058, a new type calcium channel blocker, assessed by the in vivo canine model.

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Takahara A, Sugiyama A, Dohmoto H, Yoshimoto R, and Hashimoto K

Japanese journal of pharmacology 83(2):107-12, 2000 Jun - Who cited this? | PubMed ID: 10928322 | Fulltext

Comparison of cardiovascular effects of a new calcium channel blocker AH-1058 with those of verapamil assessed in blood-perfused canine heart preparations.

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Takahara A, Sugiyama A, Dohmoto H, Yoshimoto R, and Hashimoto K

Journal of cardiovascular pharmacology 35(5):741-8, 2000 May - Who cited this? | PubMed ID: 10813376 | Fulltext

AT-1015, a novel serotonin (5-HT)2 receptor antagonist, blocks vascular and platelet 5-HT2A receptors and prevents the laurate-induced peripheral vascular lesion in rats.

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Kihara H, Hirose K, Koganei H, Sasaki N, Yamamoto H, Kimura A, Nishimori T, Shoji M, and Yoshimoto R

Journal of cardiovascular pharmacology 35(4):523-30, 2000 Apr - Who cited this? | PubMed ID: 10774780 | Fulltext

[Actin depolymerizing action by marine toxin, pectenotoxin-2].

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Hori M, Matsuura Y, Yoshimoto R, Ozaki H, Yasumoto T, and Karaki H

Nippon yakurigaku zasshi. Folia pharmacologica Japonica 114 Suppl 1:225P-229P, 1999 Oct - Who cited this? | PubMed ID: 10629885 | Fulltext

Selectivity of dihydropyridines for cardiac L-type and sympathetic N-type Ca2+ channels.

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Uneyama H, Uchida H, Konda T, Yoshimoto R, and Akaike N

European journal of pharmacology 373(1):93-100, 1999 May 28 - Who cited this? | PubMed ID: 10408255 | Fulltext

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