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Papers authored by Yarden Y

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Genomic amplicons target vesicle recycling in breast cancer.

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Mills GB, Jurisica I, Yarden Y, and Norman JC

The Journal of clinical investigation 119(8):2123-7, 2009 Aug - Who cited this? | PubMed ID: 19620778 | Fulltext

Monoubiquitinylation regulates endosomal localization of Lst2, a negative regulator of EGF receptor signaling.

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Mosesson Y, Chetrit D, Schley L, Berghoff J, Ziv T, Carvalho S, Milanezi F, Admon A, Schmitt F, Ehrlich M, and Yarden Y

Developmental cell 16(5):687-98, 2009 May - Who cited this? | PubMed ID: 19460345 | Fulltext

Systems biology of growth factor-induced receptor endocytosis.

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Zwang Y and Yarden Y

Traffic (Copenhagen, Denmark) 10(4):349-63, 2009 Apr - Who cited this? | PubMed ID: 19183301 | Fulltext

Persistent elimination of ErbB-2/HER2-overexpressing tumors using combinations of monoclonal antibodies: Relevance of receptor endocytosis.

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Ben-Kasus T, Schechter B, Lavi S, Yarden Y, and Sela M

Proceedings of the National Academy of Sciences of the United States of America 106(9):3294-9, 2009 Mar 3 - Who cited this? | PubMed ID: 19218427 | Fulltext

Cadherin endocytosis.

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Mosesson Y, Mills GB, and Yarden Y

Nature reviews. Cancer 9(2):143, 2009 Feb - Who cited this? | PubMed ID: 19148181 | Fulltext

Derailed endocytosis: an emerging feature of cancer.

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Mosesson Y, Mills GB, and Yarden Y

Nature reviews. Cancer 8(11):835-50, 2008 Nov - Who cited this? | PubMed ID: 18948996 | Fulltext

The histone H2B-specific ubiquitin ligase RNF20/hBRE1 acts as a putative tumor suppressor through selective regulation of gene expression.

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Shema E, Tirosh I, Aylon Y, Huang J, Ye C, Moskovits N, Raver-Shapira N, Minsky N, Pirngruber J, Tarcic G, Hublarova P, Moyal L, Gana-Weisz M, Shiloh Y, Yarden Y, Johnsen SA,

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Genes & development 22(19):2664-76, 2008 Oct 1 - Who cited this? | PubMed ID: 18832071 | Fulltext

Receptor tyrosine kinases: the emerging tip of systems control.

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Seger R, Rodeck U, and Yarden Y

IET systems biology 2(1):1, 2008 Jan - Who cited this? | PubMed ID: 18248079 | Fulltext

SnapShot: EGFR Signaling Pathway.

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Yarden Y and Shilo BZ

Cell 131(5):1018, 2007 Nov 30 - Who cited this? | PubMed ID: 18045542 | Fulltext

Defective ubiquitinylation of EGFR mutants of lung cancer confers prolonged signaling.

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Shtiegman K, Kochupurakkal BS, Zwang Y, Pines G, Starr A, Vexler A, Citri A, Katz M, Lavi S, Ben-Basat Y, Benjamin S, Corso S, Gan J, Yosef RB, Giordano S, and Yarden Y

Oncogene 26(49):6968-78, 2007 Oct 25 - Who cited this? | PubMed ID: 17486068 | Fulltext

Differential nuclear localization and kinase activity of alternative ErbB4 intracellular domains.

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Sundvall M, Peri L, Määttä JA, Tvorogov D, Paatero I, Savisalo M, Silvennoinen O, Yarden Y, and Elenius K

Oncogene 26(48):6905-14, 2007 Oct 18 - Who cited this? | PubMed ID: 17486069 | Fulltext

A reciprocal tensin-3-cten switch mediates EGF-driven mammary cell migration.

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Katz M, Amit I, Citri A, Shay T, Carvalho S, Lavi S, Milanezi F, Lyass L, Amariglio N, Jacob-Hirsch J, Ben-Chetrit N, Tarcic G, Lindzen M, Avraham R, Liao YC, Trusk P,

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Nature cell biology 9(8):961-9, 2007 Aug - Who cited this? | PubMed ID: 17643115 | Fulltext

Regulation of MAPKs by growth factors and receptor tyrosine kinases.

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Katz M, Amit I, and Yarden Y

Biochimica et biophysica acta 1773(8):1161-76, 2007 Aug - Who cited this? | PubMed ID: 17306385 | Fulltext

Activation of AMP-activated protein kinase by human EGF receptor 2/EGF receptor tyrosine kinase inhibitor protects cardiac cells.

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Spector NL, Yarden Y, Smith B, Lyass L, Trusk P, Pry K, Hill JE, Xia W, Seger R, and Bacus SS

Proceedings of the National Academy of Sciences of the United States of America 104(25):10607-12, 2007 Jun 19 - Who cited this? | PubMed ID: 17556544 | Fulltext

ErbB-4 may control behavior of prostate cancer cells and serve as a target for molecular therapy.

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Ben-Yosef R, Starr A, Karaush V, Loew V, Lev-Ari S, Barnea I, Lidawi G, Shtabsky A, Greif Y, Yarden Y, and Vexler A

The Prostate 67(8):871-80, 2007 Jun 1 - Who cited this? | PubMed ID: 17440944 | Fulltext

Cancer therapeutic antibodies come of age: Targeting minimal residual disease.

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Ben-Kasus T, Schechter B, Sela M, and Yarden Y

Molecular oncology 1(1):42-54, 2007 Jun - Who cited this? | PubMed ID: 19383286 | Fulltext

A module of negative feedback regulators defines growth factor signaling.

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Amit I, Citri A, Shay T, Lu Y, Katz M, Zhang F, Tarcic G, Siwak D, Lahad J, Jacob-Hirsch J, Amariglio N, Vaisman N, Segal E, Rechavi G, Alon U, Mills GB,

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Nature genetics 39(4):503, 2007 Apr - Who cited this? | PubMed ID: 17322878 | Fulltext

The EGF receptor family: spearheading a merger of signaling and therapeutics.

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Bublil EM and Yarden Y

Current opinion in cell biology 19(2):124-34, 2007 Apr - Who cited this? | PubMed ID: 17314037 | Fulltext

Evolvable signaling networks of receptor tyrosine kinases: relevance of robustness to malignancy and to cancer therapy.

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Amit I, Wides R, and Yarden Y

Molecular systems biology 3:151, 2007 - Who cited this? | PubMed ID: 18059446 | Fulltext

p38 MAP kinase mediates stress-induced internalization of EGFR: implications for cancer chemotherapy.

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Zwang Y and Yarden Y

The EMBO journal 25(18):4195, 2006 Sep 20 - Who cited this? | PubMed ID: 16932740 | Fulltext

Conjugation to Nedd8 instigates ubiquitylation and down-regulation of activated receptor tyrosine kinases.

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Oved S, Mosesson Y, Zwang Y, Santonico E, Shtiegman K, Marmor MD, Kochupurakkal BS, Katz M, Lavi S, Cesareni G, and Yarden Y

The Journal of biological chemistry 281(31):21640-51, 2006 Aug 4 - Who cited this? | PubMed ID: 16735510 | Fulltext

Geldanamycins trigger a novel Ron degradative pathway, hampering oncogenic signaling.

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Germano S, Barberis D, Santoro MM, Penengo L, Citri A, Yarden Y, and Gaudino G

The Journal of biological chemistry 281(31):21710-9, 2006 Aug 4 - Who cited this? | PubMed ID: 16740632 | Fulltext

ErbB4 increases the proliferation potential of human lung cancer cells and its blockage can be used as a target for anti-cancer therapy.

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Starr A, Greif J, Vexler A, Ashkenazy-Voghera M, Gladesh V, Rubin C, Kerber G, Marmor S, Lev-Ari S, Inbar M, Yarden Y, and Ben-Yosef R

International journal of cancer. Journal international du cancer 119(2):269-74, 2006 Jul 15 - Who cited this? | PubMed ID: 16463386 | Fulltext

EGF-ERBB signalling: towards the systems level.

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Citri A and Yarden Y

Nature reviews. Molecular cell biology 7(7):505-16, 2006 Jul - Who cited this? | PubMed ID: 16829981 | Fulltext

Hsp90 increases LIM kinase activity by promoting its homo-dimerization.

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Li R, Soosairajah J, Harari D, Citri A, Price J, Ng HL, Morton CJ, Parker MW, Yarden Y, and Bernard O

The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20(8):1218, 2006 Jun - Who cited this? | PubMed ID: 16641196 | Fulltext

Hsp90 recognizes a common surface on client kinases.

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Citri A, Harari D, Shohat G, Ramakrishnan P, Gan J, Lavi S, Eisenstein M, Kimchi A, Wallach D, Pietrokovski S, and Yarden Y

The Journal of biological chemistry 281(20):14361-9, 2006 May 19 - Who cited this? | PubMed ID: 16551624 | Fulltext

Hsp90 inhibitor 17-AAG reduces ErbB2 levels and inhibits proliferation of the trastuzumab resistant breast tumor cell line JIMT-1.

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Zsebik B, Citri A, Isola J, Yarden Y, Szöllosi J, and Vereb G

Immunology letters 104(1-2):146-55, 2006 Apr 15 - Who cited this? | PubMed ID: 16384610 | Fulltext

Monoubiquitylation: a recurrent theme in membrane protein transport.

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Mosesson Y and Yarden Y

The Israel Medical Association journal : IMAJ 8(4):233-7, 2006 Apr - Who cited this? | PubMed ID: 16671356 | Fulltext

In vitro and in vivo assays of monoubiquitination of receptor tyrosine kinases.

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Katz M, Mosesson Y, and Yarden Y

Methods in molecular biology (Clifton, N.J.) 327:115-29, 2006 - Who cited this? | PubMed ID: 16780216 | Fulltext

[Basic principles of signal transduction].

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Yarden Y

Onkologie 28 Suppl 4:14-7, 2005 Oct - Who cited this? | PubMed ID: 16205100 | Fulltext

The International Consortium on Systems Biology of Receptor Tyrosine Kinase Regulatory Networks.

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Sakaki Y, Kholodenko BN, Hatakeyama M, Kitano H, Kolch W, De Meyts P, Yarden Y, Westerhoff HV, and Wiley HS

Systems biology 152(2):53, 2005 Jun - Who cited this? | PubMed ID: 17044231 | Fulltext

Phosphorylation of carboxyl-terminal tyrosines modulates the specificity of Sprouty-2 inhibition of different signaling pathways.

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Rubin C, Zwang Y, Vaisman N, Ron D, and Yarden Y

The Journal of biological chemistry 280(10):9735-44, 2005 Mar 11 - Who cited this? | PubMed ID: 15637081 | Fulltext

Epigen, the last ligand of ErbB receptors, reveals intricate relationships between affinity and mitogenicity.

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Kochupurakkal BS, Harari D, Di-Segni A, Maik-Rachline G, Lyass L, Gur G, Kerber G, Citri A, Lavi S, Eilam R, Chalifa-Caspi V, Eshhar Z, Pikarsky E, Pinkas-Kramarski R, Bacus SS, and Yarden Y

The Journal of biological chemistry 280(9):8503, 2005 Mar 4 - Who cited this? | PubMed ID: 15611079 | Fulltext

Suppressors of cytokine signaling 4 and 5 regulate epidermal growth factor receptor signaling.

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Kario E, Marmor MD, Adamsky K, Citri A, Amit I, Amariglio N, Rechavi G, and Yarden Y

The Journal of biological chemistry 280(8):7038, 2005 Feb 25 - Who cited this? | PubMed ID: 15590694 | Fulltext

Synergistic down-regulation of receptor tyrosine kinases by combinations of mAbs: implications for cancer immunotherapy.

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Friedman LM, Rinon A, Schechter B, Lyass L, Lavi S, Bacus SS, Sela M, and Yarden Y

Proceedings of the National Academy of Sciences of the United States of America 102(6):1915-20, 2005 Feb 8 - Who cited this? | PubMed ID: 15684082 | Fulltext

Negative regulation of receptor tyrosine kinases: unexpected links to c-Cbl and receptor ubiquitylation.

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Rubin C, Gur G, and Yarden Y

Cell research 15(1):66, 2005 Jan - Who cited this? | PubMed ID: 15686631 | Fulltext

Hsp90 restrains ErbB-2/HER2 signalling by limiting heterodimer formation.

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Citri A, Gan J, Mosesson Y, Vereb G, Szollosi J, and Yarden Y

EMBO reports 5(12):1165-70, 2004 Dec - Who cited this? | PubMed ID: 15568014 | Fulltext

Molecular approach to breast cancer treatment.

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Yarden Y, Baselga J, and Miles D

Seminars in oncology 31(5 Suppl 10):6-13, 2004 Oct - Who cited this? | PubMed ID: 15490369 | Fulltext

LRIG1 restricts growth factor signaling by enhancing receptor ubiquitylation and degradation.

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Gur G, Rubin C, Katz M, Amit I, Citri A, Nilsson J, Amariglio N, Henriksson R, Rechavi G, Hedman H, Wides R, and Yarden Y

The EMBO journal 23(16):3270-81, 2004 Aug 18 - Who cited this? | PubMed ID: 15282549 | Fulltext

Oncogenic growth factor receptors: implications for signal transduction therapy.

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Mosesson Y and Yarden Y

Seminars in cancer biology 14(4):262-70, 2004 Aug - Who cited this? | PubMed ID: 15219619 | Fulltext

Tal, a Tsg101-specific E3 ubiquitin ligase, regulates receptor endocytosis and retrovirus budding.

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Amit I, Yakir L, Katz M, Zwang Y, Marmor MD, Citri A, Shtiegman K, Alroy I, Tuvia S, Reiss Y, Roubini E, Cohen M, Wides R, Bacharach E, Schubert U, and Yarden Y

Genes & development 18(14):1737, 2004 Jul 15 - Who cited this? | PubMed ID: 15256501 | Fulltext

Role of protein ubiquitylation in regulating endocytosis of receptor tyrosine kinases.

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Marmor MD and Yarden Y

Oncogene 23(11):2057-70, 2004 Mar 15 - Who cited this? | PubMed ID: 15021893 | Fulltext

Signal transduction and oncogenesis by ErbB/HER receptors.

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Marmor MD, Skaria KB, and Yarden Y

International journal of radiation oncology, biology, physics 58(3):903-13, 2004 Mar 1 - Who cited this? | PubMed ID: 14967450 | Fulltext

Enlightened receptor dynamics.

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Gur G and Yarden Y

Nature biotechnology 22(2):169-70, 2004 Feb - Who cited this? | PubMed ID: 14755288 | Fulltext

The achilles heel of ErbB-2/HER2: regulation by the Hsp90 chaperone machine and potential for pharmacological intervention.

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Citri A, Kochupurakkal BS, and Yarden Y

Cell cycle (Georgetown, Tex.) 3(1):51-60, 2004 Jan - Who cited this? | PubMed ID: 14657666 | Fulltext

Signaling by growth factor receptors.

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Kochupurakkal BS and Yarden Y

Methods in molecular biology (Clifton, N.J.) 250:177-202, 2004 - Who cited this? | PubMed ID: 14755089 | Fulltext

Polar expression of ErbB-2/HER2 in epithelia. Bimodal regulation by Lin-7.

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Shelly M, Mosesson Y, Citri A, Lavi S, Zwang Y, Melamed-Book N, Aroeti B, and Yarden Y

Developmental cell 5(3):475-86, 2003 Sep - Who cited this? | PubMed ID: 12967566 | Fulltext

Endocytosis of receptor tyrosine kinases is driven by monoubiquitylation, not polyubiquitylation.

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Mosesson Y, Shtiegman K, Katz M, Zwang Y, Vereb G, Szollosi J, and Yarden Y

The Journal of biological chemistry 278(24):21323-6, 2003 Jun 13 - Who cited this? | PubMed ID: 12719435 | Fulltext

c-Cbl is a critical modulator of the Ron tyrosine kinase receptor.

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Penengo L, Rubin C, Yarden Y, and Gaudino G

Oncogene 22(24):3669-79, 2003 Jun 12 - Who cited this? | PubMed ID: 12802274 | Fulltext

The deaf and the dumb: the biology of ErbB-2 and ErbB-3.

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Citri A, Skaria KB, and Yarden Y

Experimental cell research 284(1):54-65, 2003 Mar 10 - Who cited this? | PubMed ID: 12648465 | Fulltext

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