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Papers authored by Winters KJ

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Pharmacokinetics and pharmacodynamics of prasugrel in subjects with moderate liver disease.

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Small DS, Farid NA, Li YG, Ernest CS, Winters KJ, Salazar DE, and Payne CD

Journal of clinical pharmacy and therapeutics 34(5):575-83, 2009 Oct - Who cited this? | PubMed ID: 19744013 | Fulltext

Prasugrel pharmacokinetics and pharmacodynamics in subjects with moderate renal impairment and end-stage renal disease.

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Small DS, Wrishko RE, Ernest CS, Ni L, Winters KJ, Farid NA, Li YG, Brandt JT, Salazar DE, Borel AG, Kles KA, and Payne CD

Journal of clinical pharmacy and therapeutics 34(5):585-94, 2009 Oct - Who cited this? | PubMed ID: 19744014 | Fulltext

Effect of rifampin on the pharmacokinetics and pharmacodynamics of prasugrel in healthy male subjects.

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Farid NA, Jakubowski JA, Payne CD, Li YG, Jin Y, Ernest II CS, Winters KJ, Brandt JT, Salazar DE, and Small DS

Current medical research and opinion 25(8):1821-9, 2009 Aug - Who cited this? | PubMed ID: 19530977 | Fulltext

Inhibition of platelet aggregation with prasugrel and clopidogrel: an integrated analysis in 846 subjects.

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Li YG, Ni L, Brandt JT, Small DS, Payne CD, Ernest CS, Rohatagi S, Farid NA, Jakubowski JA, and Winters KJ

Platelets 20(5):316-27, 2009 Aug - Who cited this? | PubMed ID: 19637095 | Fulltext

Genetic variation of CYP2C19 affects both pharmacokinetic and pharmacodynamic responses to clopidogrel but not prasugrel in aspirin-treated patients with coronary artery disease.

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Varenhorst C, James S, Erlinge D, Brandt JT, Braun OO, Man M, Siegbahn A, Walker J, Wallentin L, Winters KJ, and Close SL

European heart journal 30(14):1744-52, 2009 Jul - Who cited this? | PubMed ID: 19429918 | Fulltext

Assessment of P2Y(12) inhibition with the point-of-care device VerifyNow P2Y12 in patients treated with prasugrel or clopidogrel coadministered with aspirin.

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Varenhorst C, James S, Erlinge D, Braun OO, Brandt JT, Winters KJ, Jakubowski JA, Olofsson S, Wallentin L, and Siegbahn A

American heart journal 157(3):562.e1-9, 2009 Mar - Who cited this? | PubMed ID: 19249429 | Fulltext

Effect of Age on the Pharmacokinetics and Pharmacodynamics of Prasugrel during Multiple Dosing: An Open-Label, Single-Sequence, Clinical Trial.

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Small DS, Wrishko RE, Ernest CS, Ni L, Winters KJ, Farid NA, Li YG, Salazar DE, and Payne CD

Drugs & aging 26(9):781-90, 2009 - Who cited this? | PubMed ID: 19728751 | Fulltext

Patients with poor responsiveness to thienopyridine treatment or with diabetes have lower levels of circulating active metabolite, but their platelets respond normally to active metabolite added ex vivo.

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Erlinge D, Varenhorst C, Braun OO, James S, Winters KJ, Jakubowski JA, Brandt JT, Sugidachi A, Siegbahn A, and Wallentin L

Journal of the American College of Cardiology 52(24):1968-77, 2008 Dec 9 - Who cited this? | PubMed ID: 19055987 | Fulltext

Effect of atorvastatin on the pharmacokinetics and pharmacodynamics of prasugrel and clopidogrel in healthy subjects.

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Farid NA, Small DS, Payne CD, Jakubowski JA, Brandt JT, Li YG, Ernest CS, Salazar DE, Konkoy CS, and Winters KJ

Pharmacotherapy 28(12):1483-94, 2008 Dec - Who cited this? | PubMed ID: 19025429 | Fulltext

Population pharmacokinetics and pharmacodynamics of prasugrel and clopidogrel in aspirin-treated patients with stable coronary artery disease.

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Ernest CS, Small DS, Rohatagi S, Salazar DE, Wallentin L, Winters KJ, and Wrishko RE

Journal of pharmacokinetics and pharmacodynamics 35(6):593-618, 2008 Dec - Who cited this? | PubMed ID: 19023649 | Fulltext

Greater reduction of platelet activation markers and platelet-monocyte aggregates by prasugrel compared to clopidogrel in stable coronary artery disease.

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Braun OO, Johnell M, Varenhorst C, James S, Brandt JT, Jakubowski JA, Winters KJ, Wallentin L, Erlinge D, and Siegbahn A

Thrombosis and haemostasis 100(4):626-33, 2008 Oct - Who cited this? | PubMed ID: 18841285 | Fulltext

Effect of ranitidine on the pharmacokinetics and pharmacodynamics of prasugrel and clopidogrel.

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Small DS, Farid NA, Li YG, Ernest CS, Payne CD, Salazar DE, and Winters KJ

Current medical research and opinion 24(8):2251-7, 2008 Aug - Who cited this? | PubMed ID: 18786302 | Fulltext

Switching directly to prasugrel from clopidogrel results in greater inhibition of platelet aggregation in aspirin-treated subjects.

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Payne CD, Li YG, Brandt JT, Jakubowski JA, Small DS, Farid NA, Salazar DE, and Winters KJ

Platelets 19(4):275-81, 2008 Jun - Who cited this? | PubMed ID: 18569863 | Fulltext

Effects of the proton pump inhibitor lansoprazole on the pharmacokinetics and pharmacodynamics of prasugrel and clopidogrel.

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Small DS, Farid NA, Payne CD, Weerakkody GJ, Li YG, Brandt JT, Salazar DE, and Winters KJ

Journal of clinical pharmacology 48(4):475-84, 2008 Apr - Who cited this? | PubMed ID: 18303127 | Fulltext

The active metabolite of prasugrel inhibits adenosine diphosphate- and collagen-stimulated platelet procoagulant activities.

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Frelinger AL, Jakubowski JA, Li Y, Barnard MR, Linden MD, Tarnow I, Fox ML, Sugidachi A, Winters KJ, Furman MI, and Michelson AD

Journal of thrombosis and haemostasis : JTH 6(2):359-65, 2008 Feb - Who cited this? | PubMed ID: 18021304 | Fulltext

The use of the VerifyNow P2Y12 point-of-care device to monitor platelet function across a range of P2Y(12) inhibition levels following prasugrel and clopidogrel administration.

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Jakubowski JA, Payne CD, Li YG, Brandt JT, Small DS, Farid NA, Salazar DE, and Winters KJ

Thrombosis and haemostasis 99(2):409-15, 2008 Feb - Who cited this? | PubMed ID: 18278193 | Fulltext

Prasugrel achieves greater and faster P2Y12receptor-mediated platelet inhibition than clopidogrel due to more efficient generation of its active metabolite in aspirin-treated patients with coronary artery disease.

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Wallentin L, Varenhorst C, James S, Erlinge D, Braun OO, Jakubowski JA, Sugidachi A, Winters KJ, and Siegbahn A

European heart journal 29(1):21, 2008 Jan - Who cited this? | PubMed ID: 18055486 | Fulltext

Prasugrel, a New Thienopyridine Antiplatelet Drug, Weakly Inhibits Cytochrome P450 2B6 in Humans.

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Farid NA, Payne CD, Ernest CS, Li YG, Winters KJ, Salazar DE, and Small DS

Journal of clinical pharmacology 48(1):53-9, 2008 Jan - Who cited this? | PubMed ID: 18094219 | Fulltext

A comparison of the antiplatelet effects of prasugrel and high-dose clopidogrel as assessed by VASP-phosphorylation and light transmission aggregometry.

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Jakubowski JA, Payne CD, Li YG, Farid NA, Brandt JT, Small DS, Salazar DE, and Winters KJ

Thrombosis and haemostasis 99(1):215-22, 2008 Jan - Who cited this? | PubMed ID: 18217157 | Fulltext

Common polymorphisms of CYP2C19 and CYP2C9 affect the pharmacokinetic and pharmacodynamic response to clopidogrel but not prasugrel.

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Brandt JT, Close SL, Iturria SJ, Payne CD, Farid NA, Ernest CS, Lachno DR, Salazar D, and Winters KJ

Journal of thrombosis and haemostasis : JTH 5(12):2429-36, 2007 Dec - Who cited this? | PubMed ID: 17900275 | Fulltext

Increased active metabolite formation explains the greater platelet inhibition with prasugrel compared to high-dose clopidogrel.

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Payne CD, Li YG, Small DS, Ernest CS, Farid NA, Jakubowski JA, Brandt JT, Salazar DE, and Winters KJ

Journal of cardiovascular pharmacology 50(5):555-62, 2007 Nov - Who cited this? | PubMed ID: 18030066 | Fulltext

Greater inhibition of platelet aggregation and reduced response variability with prasugrel versus clopidogrel: an integrated analysis.

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Weerakkody GJ, Jakubowski JA, Brandt JT, Payne CD, Naganuma H, and Winters KJ

Journal of cardiovascular pharmacology and therapeutics 12(3):205-12, 2007 Sep - Who cited this? | PubMed ID: 17875947 | Fulltext

Clopidogrel poor responders: an objective definition based on Bayesian classification.

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Weerakkody GJ, Brandt JT, Payne CD, Jakubowski JA, Naganuma H, and Winters KJ

Platelets 18(6):428-35, 2007 Sep - Who cited this? | PubMed ID: 17763152 | Fulltext

Comparison of speed of onset of platelet inhibition after loading doses of clopidogrel versus prasugrel in healthy volunteers and correlation with responder status.

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Weerakkody GJ, Jakubowski JA, Brandt JT, Farid NA, Payne CD, Zhu J, Warner MR, Naganuma H, and Winters KJ

The American journal of cardiology 100(2):331-6, 2007 Jul 15 - Who cited this? | PubMed ID: 17631093 | Fulltext

The active metabolite of prasugrel inhibits ADP-stimulated thrombo-inflammatory markers of platelet activation: Influence of other blood cells, calcium, and aspirin.

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Frelinger AL, Jakubowski JA, Li Y, Barnard MR, Fox ML, Linden MD, Sugidachi A, Winters KJ, Furman MI, and Michelson AD

Thrombosis and haemostasis 98(1):192-200, 2007 Jul - Who cited this? | PubMed ID: 17598013 | Fulltext

Cytochrome P450 3A inhibition by ketoconazole affects prasugrel and clopidogrel pharmacokinetics and pharmacodynamics differently.

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Farid NA, Payne CD, Small DS, Winters KJ, Ernest CS, Brandt JT, Darstein C, Jakubowski JA, and Salazar DE

Clinical pharmacology and therapeutics 81(5):735-41, 2007 May - Who cited this? | PubMed ID: 17361128 | Fulltext

A multiple dose study of prasugrel (CS-747), a novel thienopyridine P2Y12 inhibitor, compared with clopidogrel in healthy humans.

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Jakubowski JA, Matsushima N, Asai F, Naganuma H, Brandt JT, Hirota T, Freestone S, and Winters KJ

British journal of clinical pharmacology 63(4):421-30, 2007 Apr - Who cited this? | PubMed ID: 17076696 | Fulltext

Dose-dependent inhibition of human platelet aggregation by prasugrel and its interaction with aspirin in healthy subjects.

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Jakubowski JA, Payne CD, Weerakkody GJ, Brandt JT, Farid NA, Li YG, Naganuma H, Lachno DR, and Winters KJ

Journal of cardiovascular pharmacology 49(3):167-73, 2007 Mar - Who cited this? | PubMed ID: 17414229 | Fulltext

A comparison of prasugrel and clopidogrel loading doses on platelet function: magnitude of platelet inhibition is related to active metabolite formation.

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Brandt JT, Payne CD, Wiviott SD, Weerakkody G, Farid NA, Small DS, Jakubowski JA, Naganuma H, and Winters KJ

American heart journal 153(1):66.e9-16, 2007 Jan - Who cited this? | PubMed ID: 17174640 | Fulltext

Prasugrel: a novel thienopyridine antiplatelet agent. A review of preclinical and clinical studies and the mechanistic basis for its distinct antiplatelet profile.

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Jakubowski JA, Winters KJ, Naganuma H, and Wallentin L

Cardiovascular drug reviews 25(4):357-74, 2007 - Who cited this? | PubMed ID: 18078435 | Fulltext

Evaluation of prasugrel compared with clopidogrel in patients with acute coronary syndromes: design and rationale for the TRial to assess Improvement in Therapeutic Outcomes by optimizing platelet InhibitioN with prasugrel Thrombolysis In Myocardial Infarction 38 (TRITON-TIMI 38).

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Wiviott SD, Antman EM, Gibson CM, Montalescot G, Riesmeyer J, Weerakkody G, Winters KJ, Warmke JW, McCabe CH, Braunwald E, and TRITON-TIMI 38 Investigators

American heart journal 152(4):627-35, 2006 Oct - Who cited this? | PubMed ID: 16996826 | Fulltext

Platelet inhibitory activity and pharmacokinetics of prasugrel (CS-747) a novel thienopyridine P2Y12 inhibitor: a single ascending dose study in healthy humans.

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Asai F, Jakubowski JA, Naganuma H, Brandt JT, Matsushima N, Hirota T, Freestone S, and Winters KJ

Platelets 17(4):209-17, 2006 Jun - Who cited this? | PubMed ID: 16769598 | Fulltext

Platelet inhibitory activity and pharmacokinetics of prasugrel (CS-747) a novel thienopyridine P2Y12 inhibitor: a multiple-dose study in healthy humans.

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Matsushima N, Jakubowski JA, Asai F, Naganuma H, Brandt JT, Hirota T, Freestone S, and Winters KJ

Platelets 17(4):218-26, 2006 Jun - Who cited this? | PubMed ID: 16769599 | Fulltext

Prasugrel achieves greater inhibition of platelet aggregation and a lower rate of non-responders compared with clopidogrel in aspirin-treated patients with stable coronary artery disease.

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Jernberg T, Payne CD, Winters KJ, Darstein C, Brandt JT, Jakubowski JA, Naganuma H, Siegbahn A, and Wallentin L

European heart journal 27(10):1166-73, 2006 May - Who cited this? | PubMed ID: 16621870 | Fulltext

The platelet inhibitory effects and pharmacokinetics of prasugrel after administration of loading and maintenance doses in healthy subjects.

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Jakubowski JA, Payne CD, Brandt JT, Weerakkody GJ, Farid NA, Small DS, Naganuma H, Li GY, and Winters KJ

Journal of cardiovascular pharmacology 47(3):377-84, 2006 Mar - Who cited this? | PubMed ID: 16633079 | Fulltext

Randomized comparison of prasugrel (CS-747, LY640315), a novel thienopyridine P2Y12 antagonist, with clopidogrel in percutaneous coronary intervention: results of the Joint Utilization of Medications to Block Platelets Optimally (JUMBO)-TIMI 26 trial.

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Wiviott SD, Antman EM, Winters KJ, Weerakkody G, Murphy SA, Behounek BD, Carney RJ, Lazzam C, McKay RG, McCabe CH, Braunwald E, and JUMBO-TIMI 26 Investigators

Circulation 111(25):3366-73, 2005 Jun 28 - Who cited this? | PubMed ID: 15967851 | Fulltext

Reduction in ischemic vascular complications with a hydrophilic-coated intra-aortic balloon catheter.

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Winters KJ, Smith SC, Cohen M, Kopistansky C, and McBride R

Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 46(3):357-62, 1999 Mar - Who cited this? | PubMed ID: 10348141 | Fulltext

Acute myocardial infarction during lung volume reduction surgery.

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Hogue CW, Stamos T, Winters KJ, Moulton M, Krucylak PE, and Cooper JD

Anesthesia and analgesia 88(2):332-4, 1999 Feb - Who cited this? | PubMed ID: 9972751 | Fulltext

Stent thrombosis in a patient receiving chemotherapy.

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Smith SC, Winters KJ, and Lasala JM

Catheterization and cardiovascular diagnosis 40(4):383-6, 1997 Apr - Who cited this? | PubMed ID: 9096941 | Fulltext

Modified heparin-bonded catheter for cannulation of the coronary sinus from the femoral vein.

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Winters KJ, Lasala JM, Eisenberg PR, Smith SC, Sewall DJ, and Shelton ME

Catheterization and cardiovascular diagnosis 39(4):433-7, 1996 Dec - Who cited this? | PubMed ID: 8958440 | Fulltext

Association of heparin-resistant thrombin activity with acute ischemic complications of coronary interventions.

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Oltrona L, Eisenberg PR, Lasala JM, Sewall DJ, Shelton ME, and Winters KJ

Circulation 94(9):2064-71, 1996 Nov 1 - Who cited this? | PubMed ID: 8901652 | Fulltext

Platelet interactions with fibronectin: divalent cation-independent platelet adhesion to the gelatin-binding domain of fibronectin.

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Winters KJ, Walsh JJ, Rubin BG, and Santoro SA

Blood 81(7):1778-86, 1993 Apr 1 - Who cited this? | PubMed ID: 8461464 | Fulltext

Relative importance of thrombin compared with plasmin-mediated platelet activation in response to plasminogen activation with streptokinase.

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Winters KJ, Santoro SA, Miletich JP, and Eisenberg PR

Circulation 84(4):1552-60, 1991 Oct - Who cited this? | PubMed ID: 1833087 | Fulltext

Dependence of plasmin-mediated degradation of platelet adhesive receptors on temperature and Ca2+.

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Winters KJ, Eisenberg PR, Jaffe AS, and Santoro SA

Blood 76(8):1546-57, 1990 Oct 15 - Who cited this? | PubMed ID: 2169924 | Fulltext

The nature of interactions between tissue-type plasminogen activator and platelets.

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Torr SR, Winters KJ, Santoro SA, and Sobel BE

Thrombosis research 59(2):279-93, 1990 Jul 15 - Who cited this? | PubMed ID: 2146766 | Fulltext

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