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Papers authored by Wetterau J

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Dapagliflozin, a Selective SGLT2 Inhibitor, Improves Glucose Homeostasis in Normal and Diabetic Rats.

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Han S, Hagan DL, Taylor JR, Xin L, Meng W, Biller SA, Wetterau JR, Washburn WN, and Whaley JM

Diabetes 57(6):1723-9, 2008 Jun - Who cited this? | PubMed ID: 18356408 | Fulltext

Discovery of Dapagliflozin: A Potent, Selective Renal Sodium-Dependent Glucose Cotransporter 2 (SGLT2) Inhibitor for the Treatment of Type 2 Diabetes.

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Meng W, Ellsworth BA, Nirschl AA, McCann PJ, Patel M, Girotra RN, Wu G, Sher PM, Morrison EP, Biller SA, Zahler R, Deshpande PP, Pullockaran A, Hagan DL, Morgan N, Taylor JR,

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Journal of medicinal chemistry 51(5):1145-9, 2008 Mar 13 - Who cited this? | PubMed ID: 18260618 | Fulltext

Muraglitazar, a novel dual (alpha/gamma) peroxisome proliferator-activated receptor activator, improves diabetes and other metabolic abnormalities and preserves beta-cell function in db/db mice.

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Harrity T, Farrelly D, Tieman A, Chu C, Kunselman L, Gu L, Ponticiello R, Cap M, Qu F, Shao C, Wang W, Zhang H, Fenderson W, Chen S, Devasthale P, Jeon Y,

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Diabetes 55(1):240-8, 2006 Jan - Who cited this? | PubMed ID: 16380499 | Fulltext

Design and synthesis of N-[(4-methoxyphenoxy)carbonyl]-N-[[4-[2-(5- methyl-2-phenyl-4-oxazolyl)ethoxy]phenyl]methyl]glycine [Muraglitazar/BMS-298585], a novel peroxisome proliferator-activated receptor alpha/gamma dual agonist with efficacious glucose and lipid-lowering activities.

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Devasthale PV, Chen S, Jeon Y, Qu F, Shao C, Wang W, Zhang H, Cap M, Farrelly D, Golla R, Grover G, Harrity T, Ma Z, Moore L, Ren J, Seethala R,

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Journal of medicinal chemistry 48(6):2248-50, 2005 Mar 24 - Who cited this? | PubMed ID: 15771468 | Fulltext

5-Carboxamido-1,3,2-dioxaphosphorinanes, potent inhibitors of MTP.

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Sulsky R, Robl JA, Biller SA, Harrity TW, Wetterau J, Connolly F, Jolibois K, and Kunselman L

Bioorganic & medicinal chemistry letters 14(20):5067-70, 2004 Oct 18 - Who cited this? | PubMed ID: 15380200 | Fulltext

Microsomal triglyceride transfer protein inhibitors: discovery and synthesis of alkyl phosphonates as potent MTP inhibitors and cholesterol lowering agents.

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Magnin DR, Biller SA, Wetterau J, Robl JA, Dickson JK, Taunk P, Harrity TW, Lawrence RM, Sun CQ, Wang T, Logan J, Fryszman O, Connolly F, Jolibois K, and Kunselman L

Bioorganic & medicinal chemistry letters 13(7):1337-40, 2003 Apr 7 - Who cited this? | PubMed ID: 12657277 | Fulltext

A novel series of highly potent benzimidazole-based microsomal triglyceride transfer protein inhibitors.

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Robl JA, Sulsky R, Sun CQ, Simpkins LM, Wang T, Dickson JK, Chen Y, Magnin DR, Taunk P, Slusarchyk WA, Biller SA, Lan SJ, Connolly F, Kunselman LK, Sabrah T, Jamil H,

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Journal of medicinal chemistry 44(6):851-6, 2001 Mar 15 - Who cited this? | PubMed ID: 11300866 | Fulltext

The role of the microsomal triglygeride transfer protein in abetalipoproteinemia.

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Berriot-Varoqueaux N, Aggerbeck LP, Samson-Bouma M, and Wetterau JR

Annual review of nutrition 20:663-97, 2000 - Who cited this? | PubMed ID: 10940349 | Fulltext

Anderson's disease: exclusion of apolipoprotein and intracellular lipid transport genes.

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Dannoura AH, Berriot-Varoqueaux N, Amati P, Abadie V, Verthier N, Schmitz J, Wetterau JR, Samson-Bouma ME, and Aggerbeck LP

Arteriosclerosis, thrombosis, and vascular biology 19(10):2494-508, 1999 Oct - Who cited this? | PubMed ID: 10521380 | Fulltext

An MTP inhibitor that normalizes atherogenic lipoprotein levels in WHHL rabbits.

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Wetterau JR, Gregg RE, Harrity TW, Arbeeny C, Cap M, Connolly F, Chu CH, George RJ, Gordon DA, Jamil H, Jolibois KG, Kunselman LK, Lan SJ, Maccagnan TJ, Ricci B, Yan M,

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Science (New York, N.Y.) 282(5389):751-4, 1998 Oct 23 - Who cited this? | PubMed ID: 9784135 | Fulltext

Evidence that microsomal triglyceride transfer protein is limiting in the production of apolipoprotein B-containing lipoproteins in hepatic cells.

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Jamil H, Chu CH, Dickson JK, Chen Y, Yan M, Biller SA, Gregg RE, Wetterau JR, and Gordon DA

Journal of lipid research 39(7):1448-54, 1998 Jul - Who cited this? | PubMed ID: 9684748 | Fulltext

Enhanced expression of hepatic acyl-coenzyme A synthetase and microsomal triglyceride transfer protein messenger RNAs in the obese and hypertriglyceridemic rat with visceral fat accumulation.

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Kuriyama H, Yamashita S, Shimomura I, Funahashi T, Ishigami M, Aragane K, Miyaoka K, Nakamura T, Takemura K, Man Z, Toide K, Nakayama N, Fukuda Y, Lin MC, Wetterau JR, and Matsuzawa Y

Hepatology (Baltimore, Md.) 27(2):557-62, 1998 Feb - Who cited this? | PubMed ID: 9462657 | Fulltext

Microsomal triglyceride transfer protein.

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Wetterau JR, Lin MC, and Jamil H

Biochimica et biophysica acta 1345(2):136-50, 1997 Apr 1 - Who cited this? | PubMed ID: 9106493 | Fulltext

A novel abetalipoproteinemia genotype. Identification of a missense mutation in the 97-kDa subunit of the microsomal triglyceride transfer protein that prevents complex formation with protein disulfide isomerase.

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Rehberg EF, Samson-Bouma ME, Kienzle B, Blinderman L, Jamil H, Wetterau JR, Aggerbeck LP, and Gordon DA

The Journal of biological chemistry 271(47):29945-52, 1996 Nov 22 - Who cited this? | PubMed ID: 8939939 | Fulltext

An inhibitor of the microsomal triglyceride transfer protein inhibits apoB secretion from HepG2 cells.

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Jamil H, Gordon DA, Eustice DC, Brooks CM, Dickson JK, Chen Y, Ricci B, Chu CH, Harrity TW, Ciosek CP, Biller SA, Gregg RE, and Wetterau JR

Proceedings of the National Academy of Sciences of the United States of America 93(21):11991-5, 1996 Oct 15 - Who cited this? | PubMed ID: 8876250 | Fulltext

Demonstration of a physical interaction between microsomal triglyceride transfer protein and apolipoprotein B during the assembly of ApoB-containing lipoproteins.

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Wu X, Zhou M, Huang LS, Wetterau J, and Ginsberg HN

The Journal of biological chemistry 271(17):10277-81, 1996 Apr 26 - Who cited this? | PubMed ID: 8626595 | Fulltext

The amino terminus of apolipoprotein B is necessary but not sufficient for microsomal triglyceride transfer protein responsiveness.

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Gretch DG, Sturley SL, Wang L, Lipton BA, Dunning A, Grunwald KA, Wetterau JR, Yao Z, Talmud P, and Attie AD

The Journal of biological chemistry 271(15):8682-91, 1996 Apr 12 - Who cited this? | PubMed ID: 8621500 | Fulltext

Crystallization of microsomal triglyceride transfer protein from bovine liver.

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Ohringer SL, Jamil H, Chu CH, Tabernero L, Einspahr HM, Wetterau JR, and Sack JS

Acta crystallographica. Section D, Biological crystallography 52(Pt 1):224-5, 1996 Jan 1 - Who cited this? | PubMed ID: 15299753 | Fulltext

Microsomal triglyceride transfer protein: a protein complex required for the assembly of lipoprotein particles.

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Gordon DA, Wetterau JR, and Gregg RE

Trends in cell biology 5(8):317-21, 1995 Aug - Who cited this? | PubMed ID: 14732096 | Fulltext

Microsomal triglyceride transfer protein (MTP) regulation in HepG2 cells: insulin negatively regulates MTP gene expression.

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Lin MC, Gordon D, and Wetterau JR

Journal of lipid research 36(5):1073-81, 1995 May - Who cited this? | PubMed ID: 7658155 | Fulltext

Microsomal triglyceride transfer protein. Specificity of lipid binding and transport.

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Jamil H, Dickson JK, Chu CH, Lago MW, Rinehart JK, Biller SA, Gregg RE, and Wetterau JR

The Journal of biological chemistry 270(12):6549-54, 1995 Mar 24 - Who cited this? | PubMed ID: 7896791 | Fulltext

Identification of two classes of lipid molecule binding sites on the microsomal triglyceride transfer protein.

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Atzel A and Wetterau JR

Biochemistry 33(51):15382-8, 1994 Dec 27 - Who cited this? | PubMed ID: 7803401 | Fulltext

Cloning and regulation of hamster microsomal triglyceride transfer protein. The regulation is independent from that of other hepatic and intestinal proteins which participate in the transport of fatty acids and triglycerides.

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Lin MC, Arbeeny C, Bergquist K, Kienzle B, Gordon DA, and Wetterau JR

The Journal of biological chemistry 269(46):29138-45, 1994 Nov 18 - Who cited this? | PubMed ID: 7961879 | Fulltext

Human microsomal triglyceride transfer protein large subunit gene structure.

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Sharp D, Ricci B, Kienzle B, Lin MC, and Wetterau JR

Biochemistry 33(31):9057-61, 1994 Aug 9 - Who cited this? | PubMed ID: 7545943 | Fulltext

Secretion of apolipoprotein B-containing lipoproteins from HeLa cells is dependent on expression of the microsomal triglyceride transfer protein and is regulated by lipid availability.

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Gordon DA, Jamil H, Sharp D, Mullaney D, Yao Z, Gregg RE, and Wetterau J

Proceedings of the National Academy of Sciences of the United States of America 91(16):7628-32, 1994 Aug 2 - Who cited this? | PubMed ID: 8052632 | Fulltext

The molecular basis of abetalipoproteinemia.

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Gregg RE and Wetterau JR

Current opinion in lipidology 5(2):81-6, 1994 Apr - Who cited this? | PubMed ID: 8044420 | Fulltext

Mechanism of microsomal triglyceride transfer protein catalyzed lipid transport.

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Atzel A and Wetterau JR

Biochemistry 32(39):10444-50, 1993 Oct 5 - Who cited this? | PubMed ID: 8399189 | Fulltext

Absence of microsomal triglyceride transfer protein in individuals with abetalipoproteinemia.

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Wetterau JR, Aggerbeck LP, Bouma ME, Eisenberg C, Munck A, Hermier M, Schmitz J, Gay G, Rader DJ, and Gregg RE

Science (New York, N.Y.) 258(5084):999-1001, 1992 Nov 6 - Who cited this? | PubMed ID: 1439810 | Fulltext

Effects of probucol on plasma lipids, lipoproteins and parameters of high density lipoprotein metabolism.

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Wetterau JR, Combs KA, Albers HW, Lamkin G, Stein EA, Barnhart RL, Chi EM, Jackson RL, and Harmony JA

Hormone and metabolic research. Hormon- und Stoffwechselforschung. Hormones et metabolisme 24(6):289-96, 1992 Jun - Who cited this? | PubMed ID: 1634195 | Fulltext

Protein disulfide isomerase appears necessary to maintain the catalytically active structure of the microsomal triglyceride transfer protein.

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Wetterau JR, Combs KA, McLean LR, Spinner SN, and Aggerbeck LP

Biochemistry 30(40):9728-35, 1991 Oct 8 - Who cited this? | PubMed ID: 1911761 | Fulltext

Characterization of plasma lipoproteins in patients heterozygous for human plasma cholesteryl ester transfer protein (CETP) deficiency: plasma CETP regulates high-density lipoprotein concentration and composition.

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Yamashita S, Hui DY, Wetterau JR, Sprecher DL, Harmony JA, Sakai N, Matsuzawa Y, and Tarui S

Metabolism: clinical and experimental 40(7):756-63, 1991 Jul - Who cited this? | PubMed ID: 1870431 | Fulltext

Structural properties of the microsomal triglyceride-transfer protein complex.

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Wetterau JR, Aggerbeck LP, Laplaud PM, and McLean LR

Biochemistry 30(18):4406-12, 1991 May 7 - Who cited this? | PubMed ID: 2021632 | Fulltext

A delayed-addition enzyme immunoassay for the relative cholesteryl ester transfer protein mass in patients with deficient plasma cholesteryl ester transfer activity.

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Yamashita S, Sprecher DL, Matsuzawa Y, Sakai N, Tarui S, Harmony JA, and Wetterau JR

Clinica chimica acta; international journal of clinical chemistry 194(2-3):145-59, 1990 Dec 24 - Who cited this? | PubMed ID: 2093468 | Fulltext

Purification and characterization of apolipoprotein J.

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de Silva HV, Stuart WD, Park YB, Mao SJ, Gil CM, Wetterau JR, Busch SJ, and Harmony JA

The Journal of biological chemistry 265(24):14292-7, 1990 Aug 25 - Who cited this? | PubMed ID: 2387851 | Fulltext

Total deficiency of plasma cholesteryl ester transfer protein in subjects homozygous and heterozygous for the intron 14 splicing defect.

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Yamashita S, Hui DY, Sprecher DL, Matsuzawa Y, Sakai N, Tarui S, Kaplan D, Wetterau JR, and Harmony JA

Biochemical and biophysical research communications 170(3):1346-51, 1990 Aug 16 - Who cited this? | PubMed ID: 2390095 | Fulltext

A 70-kDa apolipoprotein designated ApoJ is a marker for subclasses of human plasma high density lipoproteins.

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de Silva HV, Stuart WD, Duvic CR, Wetterau JR, Ray MJ, Ferguson DG, Albers HW, Smith WR, and Harmony JA

The Journal of biological chemistry 265(22):13240-7, 1990 Aug 5 - Who cited this? | PubMed ID: 2376594 | Fulltext

Protein disulfide isomerase is a component of the microsomal triglyceride transfer protein complex.

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Wetterau JR, Combs KA, Spinner SN, and Joiner BJ

The Journal of biological chemistry 265(17):9800-7, 1990 Jun 15 - Who cited this? | PubMed ID: 2351674 | Fulltext

Crystallization and preliminary X-ray diffraction studies on the amino-terminal (receptor-binding) domain of human apolipoprotein E3 from serum very low density lipoproteins.

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Aggerbeck LP, Wetterau JR, Weisgraber KH, Mahley RW, and Agard DA

Journal of molecular biology 202(1):179-81, 1988 Jul 5 - Who cited this? | PubMed ID: 3172212 | Fulltext

Human apolipoprotein E3 in aqueous solution. I. Evidence for two structural domains.

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Wetterau JR, Aggerbeck LP, Rall SC, and Weisgraber KH

The Journal of biological chemistry 263(13):6240-8, 1988 May 5 - Who cited this? | PubMed ID: 3360781 | Fulltext

Human apolipoprotein E3 in aqueous solution. II. Properties of the amino- and carboxyl-terminal domains.

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Aggerbeck LP, Wetterau JR, Weisgraber KH, Wu CS, and Lindgren FT

The Journal of biological chemistry 263(13):6249-58, 1988 May 5 - Who cited this? | PubMed ID: 3360782 | Fulltext

Localization of intracellular triacylglycerol and cholesteryl ester transfer activity in rat tissues.

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Wetterau JR and Zilversmit DB

Biochimica et biophysica acta 875(3):610-7, 1986 Feb 28 - Who cited this? | PubMed ID: 3511967 | Fulltext

Purification and characterization of microsomal triglyceride and cholesteryl ester transfer protein from bovine liver microsomes.

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Wetterau JR and Zilversmit DB

Chemistry and physics of lipids 38(1-2):205-22, 1985 Aug 30 - Who cited this? | PubMed ID: 4064222 | Fulltext

A triglyceride and cholesteryl ester transfer protein associated with liver microsomes.

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Wetterau JR and Zilversmit DB

The Journal of biological chemistry 259(17):10863-6, 1984 Sep 10 - Who cited this? | PubMed ID: 6469986 | Fulltext

Quantitation of lipid transfer activity.

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Wetterau JR and Zilversmit DB

Methods of biochemical analysis 30:199-226, 1984 - Who cited this? | PubMed ID: 6330495 | Fulltext

Factors affecting the size of complexes of dipalmitoylphosphatidylcholine with human apolipoprotein A-I.

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Wetterau JR and Jonas A

The Journal of biological chemistry 258(4):2637-43, 1983 Feb 25 - Who cited this? | PubMed ID: 6401739 | Fulltext

Effect of dipalmitoylphosphatidylcholine vesicle curvature on the reaction with human apolipoprotein A-I.

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Wetterau JR and Jonas A

The Journal of biological chemistry 257(18):10961-6, 1982 Sep 25 - Who cited this? | PubMed ID: 6809761 | Fulltext

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