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Papers authored by Wender PA

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Oligocarbonate molecular transporters: oligomerization-based syntheses and cell-penetrating studies.

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Cooley CB, Trantow BM, Nederberg F, Kiesewetter MK, Hedrick JL, Waymouth RM, and Wender PA

Journal of the American Chemical Society 131(45):16401-3, 2009 Nov 18 - Who cited this? | PubMed ID: 19860416 | Fulltext

Prolonging microtubule dysruption enhances the immunogenicity of chronic lymphocytic leukaemia cells.

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Shaha SP, Tomic J, Shi Y, Pham T, Mero P, White D, He L, Baryza JL, Wender PA, Booth JW, and Spaner DE

Clinical and experimental immunology 158(2):186-98, 2009 Nov - Who cited this? | PubMed ID: 19737143 | Fulltext

An approach to the site-selective diversification of apoptolidin a with Peptide-based catalysts.

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Lewis CA, Longcore KE, Miller SJ, and Wender PA

Journal of natural products 72(10):1864-9, 2009 Oct - Who cited this? | PubMed ID: 19769383 | Fulltext

Synthesis at the molecular frontier.

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Wender PA and Miller BL

Nature 460(7252):197-201, 2009 Jul 9 - Who cited this? | PubMed ID: 19587760 | Fulltext

Cyclocarboamination of alkynes with aziridines: synthesis of 2,3-dihydropyrroles by a catalyzed formal [3 + 2] cycloaddition.

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Wender PA and Strand D

Journal of the American Chemical Society 131(22):7528-9, 2009 Jun 10 - Who cited this? | PubMed ID: 19489638 | Fulltext

A cellular model of Alzheimer's disease therapeutic efficacy: PKC activation reverses Abeta-induced biomarker abnormality on cultured fibroblasts.

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Khan TK, Nelson TJ, Verma VA, Wender PA, and Alkon DL

Neurobiology of disease 34(2):332-9, 2009 May - Who cited this? | PubMed ID: 19233276 | Fulltext

A proapoptotic signaling pathway involving RasGRP, Erk, and Bim in B cells.

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Stang SL, Lopez-Campistrous A, Song X, Dower NA, Blumberg PM, Wender PA, and Stone JC

Experimental hematology 37(1):122-134, 2009 Jan - Who cited this? | PubMed ID: 19100522 | Fulltext

The synthesis of highly substituted cyclooctatetraene scaffolds by metal-catalyzed [2+2+2+2] cycloadditions: studies on regioselectivity, dynamic properties, and metal chelation.

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Wender PA, Christy JP, Lesser AB, and Gieseler MT

Angewandte Chemie (International ed. in English) 48(41):7687-90, 2009 - Who cited this? | PubMed ID: 19739178 | Fulltext

Overcoming multidrug resistance of small-molecule therapeutics through conjugation with releasable octaarginine transporters.

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Dubikovskaya EA, Thorne SH, Pillow TH, Contag CH, and Wender PA

Proceedings of the National Academy of Sciences of the United States of America 105(34):12128-33, 2008 Aug 26 - Who cited this? | PubMed ID: 18713866 | Fulltext

The Design, Synthesis, and Evaluation of C7 Diversified Bryostatin Analogs Reveals a Hot Spot for PKC Affinity.

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Wender PA and Verma VA

Organic letters 10(15):3331-4, 2008 Aug 7 - Who cited this? | PubMed ID: 18588309 | Fulltext

Function-Oriented Synthesis: Biological Evaluation of Laulimalide Analogues Derived from a Last Step Cross Metathesis Diversification Strategy.

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Mooberry SL, Hilinski MK, Clark EA, and Wender PA

Molecular pharmaceutics, 2008 Jul 29 - Who cited this? | PubMed ID: 18662015 | Fulltext

Single-Molecule Motions of Oligoarginine Transporter Conjugates on the Plasma Membrane of Chinese Hamster Ovary Cells.

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Lee HL, Dubikovskaya EA, Hwang H, Semyonov AN, Wang H, Jones LR, Twieg RJ, Moerner WE, and Wender PA

Journal of the American Chemical Society, 2008 Jun 26 - Who cited this? | PubMed ID: 18578528 | Fulltext

Efficient Synthetic Access to a New Family of Highly Potent Bryostatin Analogues via a Prins-Driven Macrocyclization Strategy.

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Wender PA, Dechristopher BA, and Schrier AJ

Journal of the American Chemical Society 130(21):6658-9, 2008 May 28 - Who cited this? | PubMed ID: 18452292 | Fulltext

Practical synthesis of prostratin, DPP, and their analogs, adjuvant leads against latent HIV.

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Wender PA, Kee JM, and Warrington JM

Science (New York, N.Y.) 320(5876):649, 2008 May 2 - Who cited this? | PubMed ID: 18451298 | Fulltext

The design of guanidinium-rich transporters and their internalization mechanisms.

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Wender PA, Galliher WC, Goun EA, Jones LR, and Pillow TH

Advanced drug delivery reviews 60(4-5):452-72, 2008 Mar 1 - Who cited this? | PubMed ID: 18164781 | Fulltext

Origins of differences in reactivities of alkenes, alkynes, and allenes in [Rh(CO)2Cl]2-catalyzed (5 + 2) cycloaddition reactions with vinylcyclopropanes.

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Yu ZX, Cheong PH, Liu P, Legault CY, Wender PA, and Houk KN

Journal of the American Chemical Society 130(8):2378-9, 2008 Feb 27 - Who cited this? | PubMed ID: 18251468 | Fulltext

Function-oriented synthesis, step economy, and drug design.

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Wender PA, Verma VA, Paxton TJ, and Pillow TH

Accounts of chemical research 41(1):40-9, 2008 Jan - Who cited this? | PubMed ID: 18159936 | Fulltext

Substituent effects, reactant preorganization, and ligand exchange control the reactivity in Rh(I)-catalyzed (5+2) cycloadditions between vinylcyclopropanes and alkynes.

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Liu P, Cheong PH, Yu ZX, Wender PA, and Houk KN

Angewandte Chemie (International ed. in English) 47(21):3939-41, 2008 - Who cited this? | PubMed ID: 18412215 | Fulltext

Nickel(0)-catalyzed [2 + 2 + 2 + 2] cycloadditions of terminal diynes for the synthesis of substituted cyclooctatetraenes.

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Wender PA and Christy JP

Journal of the American Chemical Society 129(44):13402-3, 2007 Nov 7 - Who cited this? | PubMed ID: 17929819 | Fulltext

A computationally designed Rh(I)-catalyzed two-component [5+2+1] cycloaddition of ene-vinylcyclopropanes and CO for the synthesis of cyclooctenones.

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Wang Y, Wang J, Su J, Huang F, Jiao L, Liang Y, Yang D, Zhang S, Wender PA, and Yu ZX

Journal of the American Chemical Society 129(33):10060-1, 2007 Aug 22 - Who cited this? | PubMed ID: 17655302 | Fulltext

Real-time analysis of uptake and bioactivatable cleavage of luciferin-transporter conjugates in transgenic reporter mice.

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Wender PA, Goun EA, Jones LR, Pillow TH, Rothbard JB, Shinde R, and Contag CH

Proceedings of the National Academy of Sciences of the United States of America 104(25):10340, 2007 Jun 19 - Who cited this? | PubMed ID: 17563383 | Fulltext

Function-oriented synthesis: studies aimed at the synthesis and mode of action of 1alpha-alkyldaphnane analogues.

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Wender PA, D'Angelo N, Elitzin VI, Ernst M, Jackson-Ugueto EE, Kowalski JA, McKendry S, Rehfeuter M, Sun R, and Voigtlaender D

Organic letters 9(9):1829-32, 2007 Apr 26 - Who cited this? | PubMed ID: 17408281 | Fulltext

Isolation, structure determination, and anti-cancer activity of apoptolidin D.

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Wender PA and Longcore KE

Organic letters 9(4):691-4, 2007 Feb 15 - Who cited this? | PubMed ID: 17286376 | Fulltext

Cyclopentadienone synthesis by rhodium(I)-catalyzed [3 + 2] cycloaddition reactions of cyclopropenones and alkynes.

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Wender PA, Paxton TJ, and Williams TJ

Journal of the American Chemical Society 128(46):14814-5, 2006 Nov 22 - Who cited this? | PubMed ID: 17105285 | Fulltext

Total synthesis and initial biological evaluation of new B-ring-modified bryostatin analogs.

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Wender PA, Horan JC, and Verma VA

Organic letters 8(23):5299-302, 2006 Nov 9 - Who cited this? | PubMed ID: 17078702 | Fulltext

Studies on oxidopyrylium [5+2] cycloadditions: toward a general synthetic route to the C12-hydroxydaphnetoxins.

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Wender PA, Bi FC, Buschmann N, Gosselin F, Kan C, Kee JM, and Ohmura H

Organic letters 8(23):5373-6, 2006 Nov 9 - Who cited this? | PubMed ID: 17078721 | Fulltext

Molecular transporters: synthesis of oligoguanidinium transporters and their application to drug delivery and real-time imaging.

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Goun EA, Pillow TH, Jones LR, Rothbard JB, and Wender PA

Chembiochem : a European journal of chemical biology 7(10):1497-515, 2006 Oct - Who cited this? | PubMed ID: 16972294 | Fulltext

Synthesis and PKC binding of a new class of a-ring diversifiable bryostatin analogues utilizing a double asymmetric hydrogenation and cross-coupling strategy.

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Wender PA and Horan JC

Organic letters 8(20):4581-4, 2006 Sep 28 - Who cited this? | PubMed ID: 16986955 | Fulltext

Pharmacophore mapping in the laulimalide series: total synthesis of a vinylogue for a late-stage metathesis diversification strategy.

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Wender PA, Hilinski MK, Skaanderup PR, Soldermann NG, and Mooberry SL

Organic letters 8(18):4105-8, 2006 Aug 31 - Who cited this? | PubMed ID: 16928085 | Fulltext

RhI-catalyzed C-C bond activation: seven-membered ring synthesis by a [6+1] carbonylative ring-expansion reaction of allenylcyclobutanes.

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Wender PA, Deschamps NM, and Sun R

Angewandte Chemie (International ed. in English) 45(24):3957-60, 2006 Jun 12 - Who cited this? | PubMed ID: 16683295 | Fulltext

Releasable luciferin-transporter conjugates: tools for the real-time analysis of cellular uptake and release.

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Jones LR, Goun EA, Shinde R, Rothbard JB, Contag CH, and Wender PA

Journal of the American Chemical Society 128(20):6526, 2006 May 24 - Who cited this? | PubMed ID: 16704230 | Fulltext

Intracellular cargo delivery by an octaarginine transporter adapted to target prostate cancer cells through cell surface protease activation.

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Goun EA, Shinde R, Dehnert KW, Adams-Bond A, Wender PA, Contag CH, and Franc BL

Bioconjugate chemistry 17(3):787 - Who cited this? | PubMed ID: 16704219 | Fulltext

Asymmetric catalysis of the [5 + 2] cycloaddition reaction of vinylcyclopropanes and pi-systems.

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Wender PA, Haustedt LO, Lim J, Love JA, Williams TJ, and Yoon JY

Journal of the American Chemical Society 128(19):6302-3, 2006 May 17 - Who cited this? | PubMed ID: 16683779 | Fulltext

Design, synthesis, and biological evaluation of a potent, PKC selective, B-ring analog of bryostatin.

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Wender PA and Verma VA

Organic letters 8(9):1893-6, 2006 Apr 27 - Who cited this? | PubMed ID: 16623578 | Fulltext

Rhodium(I)-catalyzed [4+2+2] cycloadditions of 1,3-dienes, alkenes, and alkynes for the synthesis of cyclooctadienes.

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Wender PA and Christy JP

Journal of the American Chemical Society 128(16):5354-5, 2006 Apr 26 - Who cited this? | PubMed ID: 16620102 | Fulltext

Metal-catalyzed [2+2+1] cycloadditions of 1,3-dienes, allenes, and CO.

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Wender PA, Croatt MP, and Deschamps NM

Angewandte Chemie (International ed. in English) 45(15):2459-62, 2006 Apr 3 - Who cited this? | PubMed ID: 16526073 | Fulltext

Total synthesis and biological evaluation of 11-desmethyllaulimalide, a highly potent simplified laulimalide analogue.

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Wender PA, Hilinski MK, Soldermann N, and Mooberry SL

Organic letters 8(7):1507-10, 2006 Mar 30 - Who cited this? | PubMed ID: 16562928 | Fulltext

Correlation of F0F1-ATPase inhibition and antiproliferative activity of apoptolidin analogues.

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Wender PA, Jankowski OD, Longcore K, Tabet EA, Seto H, and Tomikawa T

Organic letters 8(4):589-92, 2006 Feb 16 - Who cited this? | PubMed ID: 16468718 | Fulltext

Laulimalide and synthetic laulimalide analogues are synergistic with paclitaxel and 2-methoxyestradiol.

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Clark EA, Hills PM, Davidson BS, Wender PA, and Mooberry SL

Molecular pharmaceutics 3(4):457-67, 2006 - Who cited this? | PubMed ID: 16889440 | Fulltext

Actin is the primary cellular receptor of bistramide A.

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Statsuk AV, Bai R, Baryza JL, Verma VA, Hamel E, Wender PA, and Kozmin SA

Nature chemical biology 1(7):383-8, 2005 Dec - Who cited this? | PubMed ID: 16372404 | Fulltext

Dendrimeric molecular transporters: synthesis and evaluation of tunable polyguanidino dendrimers that facilitate cellular uptake.

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Wender PA, Kreider E, Pelkey ET, Rothbard J, and Vandeusen CL

Organic letters 7(22):4815, 2005 Oct 27 - Who cited this? | PubMed ID: 16235896 | Fulltext

Apoptolidins B and C: isolation, structure determination, and biological activity.

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Wender PA, Sukopp M, and Longcore K

Organic letters 7(14):3025-8, 2005 Jul 7 - Who cited this? | PubMed ID: 15987196 | Fulltext

Role of the A-ring of bryostatin analogues in PKC binding: synthesis and initial biological evaluation of new A-ring-modified bryologs.

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Wender PA, Clarke MO, and Horan JC

Organic letters 7(10):1995-8, 2005 May 12 - Who cited this? | PubMed ID: 15876038 | Fulltext

Transition metal-catalyzed intermolecular [5+2] and [5+2+1] cycloadditions of allenes and vinylcyclopropanes.

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Wegner HA, de Meijere A, and Wender PA

Journal of the American Chemical Society 127(18):6530-1, 2005 May 11 - Who cited this? | PubMed ID: 15869263 | Fulltext

Identification of a tunable site in bryostatin analogs: C20 Bryologs through late stage diversification.

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Wender PA and Baryza JL

Organic letters 7(6):1177-80, 2005 Mar 17 - Who cited this? | PubMed ID: 15760168 | Fulltext

Multicomponent cycloadditions: the four-component [5+1+2+1] cycloaddition of vinylcyclopropanes, alkynes, and CO.

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Wender PA, Gamber GG, Hubbard RD, Pham SM, and Zhang L

Journal of the American Chemical Society 127(9):2836-7, 2005 Mar 9 - Who cited this? | PubMed ID: 15740103 | Fulltext

Adaptive translocation: the role of hydrogen bonding and membrane potential in the uptake of guanidinium-rich transporters into cells.

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Rothbard JB, Jessop TC, and Wender PA

Advanced drug delivery reviews 57(4):495-504, 2005 Feb 28 - Who cited this? | PubMed ID: 15722160 | Fulltext

Late-stage intermolecular CH activation for lead diversification: a highly chemoselective oxyfunctionalization of the C-9 position of potent bryostatin analogues.

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Wender PA, Hilinski MK, and Mayweg AV

Organic letters 7(1):79-82, 2005 Jan 6 - Who cited this? | PubMed ID: 15624982 | Fulltext

Effect of serum and antioxidants on the immunogenicity of protein kinase C-activated chronic lymphocytic leukemia cells.

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Hammond C, Shi Y, Mena J, Tomic J, Cervi D, He L, Millar AE, Debenedette M, Schuh AC, Baryza JL, Wender PA, Radvanyi L, and Spaner DE

Journal of immunotherapy (Hagerstown, Md. : 1997) 28(1):28-39, 2005 - Who cited this? | PubMed ID: 15614042 | Fulltext

Synthetic bryostatin analogues activate the RasGRP1 signaling pathway.

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Stone JC, Stang SL, Zheng Y, Dower NA, Brenner SE, Baryza JL, and Wender PA

Journal of medicinal chemistry 47(26):6638-44, 2004 Dec 16 - Who cited this? | PubMed ID: 15588099 | Fulltext

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