Please enable Javascript

Labmeeting uses lots of Javascript - basically you can't use the site without it. So please enable Javascript in your browser. If your browser does not support Javascript, we recommend Firefox.

Papers authored by Watterson DM

Collect these papers and discover other ones on Labmeeting. Learn more.

Effect of potential amine prodrugs of selective neuronal nitric oxide synthase inhibitors on blood-brain barrier penetration.

+ cite this

+ View Abstract

Silverman RB, Lawton GR, Ralay Ranaivo H, Chico LK, Seo J, and Watterson DM

Bioorganic & medicinal chemistry 17(21):7593-605, 2009 Nov 1 - Who cited this? | PubMed ID: 19796958 | Fulltext

Molecular Properties and CYP2D6 Substrates: Central Nervous System Therapeutics Case Study and Pattern Analysis of a Substrate Database.

+ cite this

+ View Abstract

Chico LK, Behanna HA, Hu W, Zhong G, Roy SM, and Watterson DM

Drug metabolism and disposition: the biological fate of chemicals 37(11):2204-11, 2009 Nov - Who cited this? | PubMed ID: 19661215 | Fulltext

Targeting protein kinases in central nervous system disorders.

+ cite this

+ View Abstract

Chico LK, Van Eldik LJ, and Watterson DM

Nature reviews. Drug discovery 8(11):892-909, 2009 Nov - Who cited this? | PubMed ID: 19876042 | Fulltext

Enhanced microglial activation and proinflammatory cytokine upregulation are linked to increased susceptibility to seizures and neurologic injury in a 'two-hit' seizure model.

+ cite this

+ View Abstract

Somera-Molina KC, Nair S, Van Eldik LJ, Watterson DM, and Wainwright MS

Brain research 1282:162-72, 2009 Jul 28 - Who cited this? | PubMed ID: 19501063 | Fulltext

Analogues of 2-aminopyridine-based selective inhibitors of neuronal nitric oxide synthase with increased bioavailability.

+ cite this

+ View Abstract

Lawton GR, Ralay Ranaivo H, Chico LK, Ji H, Xue F, Martásek P, Roman LJ, Watterson DM, and Silverman RB

Bioorganic & medicinal chemistry 17(6):2371-80, 2009 Mar 15 - Who cited this? | PubMed ID: 19268602 | Fulltext

Structural insight into nucleotide recognition by human death-associated protein kinase.

+ cite this

+ View Abstract

McNamara LK, Watterson DM, and Brunzelle JS

Acta crystallographica. Section D, Biological crystallography 65(Pt 3):241-8, 2009 Mar - Who cited this? | PubMed ID: 19237746 | Fulltext

Inhibition of experimental autoimmune encephalomyelitis by a novel small molecular weight proinflammatory cytokine suppressing drug.

+ cite this

+ View Abstract

Karpus WJ, Reynolds N, Behanna HA, Van Eldik LJ, and Watterson DM

Journal of neuroimmunology, 2008 Aug 2 - Who cited this? | PubMed ID: 18678415 | Fulltext

Suppression of acute proinflammatory cytokine and chemokine upregulation by post-injury administration of a novel small molecule improves long-term neurologic outcome in a mouse model of traumatic brain injury.

+ cite this

+ View Abstract

Lloyd E, Somera-Molina K, Van Eldik LJ, Watterson DM, and Wainwright MS

Journal of neuroinflammation 5(1):28, 2008 Jun 30 - Who cited this? | PubMed ID: 18590543 | Fulltext

The p38alpha mitogen-activated protein kinase as a central nervous system drug discovery target.

+ cite this

+ View Abstract

Borders AS, de Almeida L, Van Eldik LJ, and Watterson DM

BMC neuroscience 9 Suppl 2:S12, 2008 - Who cited this? | PubMed ID: 19090985 | Fulltext

Inhibition of glial cell activation ameliorates the severity of experimental autoimmune encephalomyelitis.

+ cite this

+ View Abstract

Guo X, Nakamura K, Kohyama K, Harada C, Behanna HA, Watterson DM, Matsumoto Y, and Harada T

Neuroscience research 59(4):457, 2007 Dec - Who cited this? | PubMed ID: 17920148 | Fulltext

A role for long chain myosin light chain kinase (MLCK-210) in microvascular hyperpermeability during severe burns.

+ cite this

+ View Abstract

Reynoso R, Perrin RM, Breslin JW, Daines DA, Watson KD, Watterson DM, Wu MH, and Yuan S

Shock (Augusta, Ga.) 28(5):589-95, 2007 Nov - Who cited this? | PubMed ID: 17577141 | Fulltext

Glial activation links early-life seizures and long-term neurologic dysfunction: evidence using a small molecule inhibitor of proinflammatory cytokine upregulation.

+ cite this

+ View Abstract

Somera-Molina KC, Robin B, Somera CA, Anderson C, Stine C, Koh S, Behanna HA, Van Eldik LJ, Watterson DM, and Wainwright MS

Epilepsia 48(9):1785-800, 2007 Sep - Who cited this? | PubMed ID: 17521344 | Fulltext

MLCK210 gene knockout or kinase inhibition preserves lung function following endotoxin-induced lung injury in mice.

+ cite this

+ View Abstract

Rossi JL, Velentza AV, Steinhorn DM, Watterson DM, and Wainwright MS

American journal of physiology. Lung cellular and molecular physiology 292(6):L1327-34, 2007 Jun - Who cited this? | PubMed ID: 17307813 | Fulltext

Protection against endotoxic shock as a consequence of reduced nitrosative stress in MLCK210-null mice.

+ cite this

+ View Abstract

Ralay Ranaivo H, Carusio N, Wangensteen R, Ohlmann P, Loichot C, Tesse A, Chalupsky K, Lobysheva I, Haiech J, Watterson DM, and Andriantsitohaina R

The American journal of pathology 170(2):439-46, 2007 Feb - Who cited this? | PubMed ID: 17255312 | Fulltext

Development of a novel therapeutic suppressor of brain proinflammatory cytokine up-regulation that attenuates synaptic dysfunction and behavioral deficits.

+ cite this

+ View Abstract

Hu W, Ranaivo HR, Roy SM, Behanna HA, Wing LK, Munoz L, Guo L, Van Eldik LJ, and Watterson DM

Bioorganic & medicinal chemistry letters 17(2):414-8, 2007 Jan 15 - Who cited this? | PubMed ID: 17079143 | Fulltext

A novel p38 alpha MAPK inhibitor suppresses brain proinflammatory cytokine up-regulation and attenuates synaptic dysfunction and behavioral deficits in an Alzheimer's disease mouse model.

+ cite this

+ View Abstract

Munoz L, Ranaivo HR, Roy SM, Hu W, Craft JM, McNamara LK, Chico LW, Van Eldik LJ, and Watterson DM

Journal of neuroinflammation 4:21, 2007 - Who cited this? | PubMed ID: 17784957 | Fulltext

Death-associated protein kinase phosphorylates mammalian ribosomal protein S6 and reduces protein synthesis.

+ cite this

+ View Abstract

Schumacher AM, Velentza AV, Watterson DM, and Dresios J

Biochemistry 45(45):13614-21, 2006 Nov 14 - Who cited this? | PubMed ID: 17087515 | Fulltext

Development of a novel bioavailable inhibitor of the calmodulin-regulated protein kinase MLCK: a lead compound that attenuates vascular leak.

+ cite this

+ View Abstract

Behanna HA, Watterson DM, and Ranaivo HR

Biochimica et biophysica acta 1763(11):1266-74, 2006 Nov - Who cited this? | PubMed ID: 16996151 | Fulltext

Myosin light chain kinase colocalizes with nonmuscle myosin IIB in myofibril precursors and sarcomeric Z-lines of cardiomyocytes.

+ cite this

+ View Abstract

Dudnakova TV, Stepanova OV, Dergilev KV, Chadin AV, Shekhonin BV, Watterson DM, and Shirinsky VP

Cell motility and the cytoskeleton 63(7):375-83, 2006 Jul - Who cited this? | PubMed ID: 16634081 | Fulltext

De novo and molecular target-independent discovery of orally bioavailable lead compounds for neurological disorders.

+ cite this

+ View Abstract

Wing LK, Behanna HA, Van Eldik LJ, Watterson DM, and Ralay Ranaivo H

Current Alzheimer research 3(3):205-14, 2006 Jul - Who cited this? | PubMed ID: 16842097 | Fulltext

Human amyloid beta-induced neuroinflammation is an early event in neurodegeneration.

+ cite this

+ View Abstract

Craft JM, Watterson DM, and Van Eldik LJ

Glia 53(5):484-90, 2006 Apr 1 - Who cited this? | PubMed ID: 16369931 | Fulltext

Glia as a therapeutic target: selective suppression of human amyloid-beta-induced upregulation of brain proinflammatory cytokine production attenuates neurodegeneration.

+ cite this

+ View Abstract

Ralay Ranaivo H, Craft JM, Hu W, Guo L, Wing LK, Van Eldik LJ, and Watterson DM

The Journal of neuroscience : the official journal of the Society for Neuroscience 26(2):662-70, 2006 Jan 11 - Who cited this? | PubMed ID: 16407564 | Fulltext

Deletion of MLCK210 induces subtle changes in vascular reactivity but does not affect cardiac function.

+ cite this

+ View Abstract

Ohlmann P, Tesse A, Loichot C, Ralay Ranaivo H, Roul G, Philippe C, Watterson DM, Haiech J, and Andriantsitohaina R

American journal of physiology. Heart and circulatory physiology 289(6):H2342-9, 2005 Dec - Who cited this? | PubMed ID: 16055522 | Fulltext

Neuroinflammation: a potential therapeutic target.

+ cite this

+ View Abstract

Craft JM, Watterson DM, and Van Eldik LJ

Expert opinion on therapeutic targets 9(5):887-900, 2005 Oct - Who cited this? | PubMed ID: 16185146 | Fulltext

Epithelial myosin light chain kinase-dependent barrier dysfunction mediates T cell activation-induced diarrhea in vivo.

+ cite this

+ View Abstract

Clayburgh DR, Barrett TA, Tang Y, Meddings JB, Van Eldik LJ, Watterson DM, Clarke LL, Mrsny RJ, and Turner JR

The Journal of clinical investigation 115(10):2702-15, 2005 Oct - Who cited this? | PubMed ID: 16184195 | Fulltext

Enhanced susceptibility of S-100B transgenic mice to neuroinflammation and neuronal dysfunction induced by intracerebroventricular infusion of human beta-amyloid.

+ cite this

+ View Abstract

Craft JM, Watterson DM, Marks A, and Van Eldik LJ

Glia 51(3):209-16, 2005 Aug 15 - Who cited this? | PubMed ID: 15810011 | Fulltext

Interleukin 1 receptor antagonist knockout mice show enhanced microglial activation and neuronal damage induced by intracerebroventricular infusion of human beta-amyloid.

+ cite this

+ View Abstract

Craft JM, Watterson DM, Hirsch E, and Van Eldik LJ

Journal of neuroinflammation 2:15, 2005 Jun 20 - Who cited this? | PubMed ID: 15967035 | Fulltext

Validation of the neuroinflammation cycle as a drug discovery target using integrative chemical biology and lead compound development with an Alzheimer's disease-related mouse model.

+ cite this

+ View Abstract

Hu W, Ralay Ranaivo H, Craft JM, Van Eldik LJ, and Watterson DM

Current Alzheimer research 2(2):197-205, 2005 Apr - Who cited this? | PubMed ID: 15974919 | Fulltext

Myosin light chain kinase (210 kDa) is a potential cytoskeleton integrator through its unique N-terminal domain.

+ cite this

+ View Abstract

Kudryashov DS, Stepanova OV, Vilitkevich EL, Nikonenko TA, Nadezhdina ES, Shanina NA, Lukas TJ, Van Eldik LJ, Watterson DM, and Shirinsky VP

Experimental cell research 298(2):407-17, 2004 Aug 15 - Who cited this? | PubMed ID: 15265689 | Fulltext

A calmodulin-regulated protein kinase linked to neuron survival is a substrate for the calmodulin-regulated death-associated protein kinase.

+ cite this

+ View Abstract

Schumacher AM, Schavocky JP, Velentza AV, Mirzoeva S, and Watterson DM

Biochemistry 43(25):8116-24, 2004 Jun 29 - Who cited this? | PubMed ID: 15209507 | Fulltext

Aminopyridazines attenuate hippocampus-dependent behavioral deficits induced by human beta-amyloid in a murine model of neuroinflammation.

+ cite this

+ View Abstract

Craft JM, Van Eldik LJ, Zasadzki M, Hu W, and Watterson DM

Journal of molecular neuroscience : MN 24(1):115-22, 2004 - Who cited this? | PubMed ID: 15314259 | Fulltext

Aminopyridazines inhibit beta-amyloid-induced glial activation and neuronal damage in vivo.

+ cite this

+ View Abstract

Craft JM, Watterson DM, Frautschy SA, and Van Eldik LJ

Neurobiology of aging 25(10):1283-92, 2004 - Who cited this? | PubMed ID: 15465624 | Fulltext

An aminopyridazine-based inhibitor of a pro-apoptotic protein kinase attenuates hypoxia-ischemia induced acute brain injury.

+ cite this

+ View Abstract

Velentza AV, Wainwright MS, Zasadzki M, Mirzoeva S, Schumacher AM, Haiech J, Focia PJ, Egli M, and Watterson DM

Bioorganic & medicinal chemistry letters 13(20):3465-70, 2003 Oct 20 - Who cited this? | PubMed ID: 14505650 | Fulltext

Protein kinase involved in lung injury susceptibility: evidence from enzyme isoform genetic knockout and in vivo inhibitor treatment.

+ cite this

+ View Abstract

Wainwright MS, Rossi J, Schavocky J, Crawford S, Steinhorn D, Velentza AV, Zasadzki M, Shirinsky V, Jia Y, Haiech J, Van Eldik LJ, and Watterson DM

Proceedings of the National Academy of Sciences of the United States of America 100(10):6233-8, 2003 May 13 - Who cited this? | PubMed ID: 12730364 | Fulltext

Discovery of a new class of synthetic protein kinase inhibitors that suppress selective aspects of glial activation and protect against beta-amyloid induced injury: a foundation for future medicinal chemistry efforts focused on targeting Alzheimer's disease progression.

+ cite this

+ View Abstract

Watterson DM, Velentza AV, Zasadzki M, Craft JM, Haiech J, and Van Eldik LJ

Journal of molecular neuroscience : MN 20(3):411-23, 2003 - Who cited this? | PubMed ID: 14501026 | Fulltext

DAPK catalytic activity in the hippocampus increases during the recovery phase in an animal model of brain hypoxic-ischemic injury.

+ cite this

+ View Abstract

Schumacher AM, Velentza AV, Watterson DM, and Wainwright MS

Biochimica et biophysica acta 1600(1-2):128-37, 2002 Nov 4 - Who cited this? | PubMed ID: 12445468 | Fulltext

Death-associated protein kinase as a potential therapeutic target.

+ cite this

+ View Abstract

Schumacher AM, Velentza AV, and Watterson DM

Expert opinion on therapeutic targets 6(4):497-506, 2002 Aug - Who cited this? | PubMed ID: 12223064 | Fulltext

Discovery of a 3-amino-6-phenyl-pyridazine derivative as a new synthetic antineuroinflammatory compound.

+ cite this

+ View Abstract

Mirzoeva S, Sawkar A, Zasadzki M, Guo L, Velentza AV, Dunlap V, Bourguignon JJ, Ramstrom H, Haiech J, Van Eldik LJ, and Watterson DM

Journal of medicinal chemistry 45(3):563-6, 2002 Jan 31 - Who cited this? | PubMed ID: 11806708 | Fulltext

Barriers to Alzheimer disease drug discovery and development in academia.

+ cite this

+ View Abstract

Van Eldik LJ, Koppal T, and Watterson DM

Alzheimer disease and associated disorders 16 Suppl 1:S18-28, 2002 - Who cited this? | PubMed ID: 12070358 | Fulltext

Structure, activity, regulation, and inhibitor discovery for a protein kinase associated with apoptosis and neuronal death.

+ cite this

+ View Abstract

Velentza AV, Schumacher AM, and Watterson DM

Pharmacology & therapeutics 93(2-3):217-24, 2002 - Who cited this? | PubMed ID: 12191613 | Fulltext

Discovery of new chemical classes of synthetic ligands that suppress neuroinflammatory responses.

+ cite this

+ View Abstract

Watterson DM, Haiech J, and Van Eldik LJ

Journal of molecular neuroscience : MN 19(1-2):89-93, 2002 - Who cited this? | PubMed ID: 12212800 | Fulltext

Smooth muscle myosin filament assembly under control of a kinase-related protein (KRP) and caldesmon.

+ cite this

+ View Abstract

Kudryashov DS, Vorotnikov AV, Dudnakova TV, Stepanova OV, Lukas TJ, Sellers JR, Watterson DM, and Shirinsky VP

Journal of muscle research and cell motility 23(4):341-51, 2002 - Who cited this? | PubMed ID: 12630709 | Fulltext

A protein kinase associated with apoptosis and tumor suppression: structure, activity, and discovery of peptide substrates.

+ cite this

+ View Abstract

Velentza AV, Schumacher AM, Weiss C, Egli M, and Watterson DM

The Journal of biological chemistry 276(42):38956, 2001 Oct 19 - Who cited this? | PubMed ID: 11483604 | Fulltext

Crystal structures of the catalytic domain of human protein kinase associated with apoptosis and tumor suppression.

+ cite this

+ View Abstract

Tereshko V, Teplova M, Brunzelle J, Watterson DM, and Egli M

Nature structural biology 8(10):899-907, 2001 Oct - Who cited this? | PubMed ID: 11573098 | Fulltext

Replacement of Lys-75 of calmodulin affects its interaction with smooth muscle caldesmon.

+ cite this

+ View Abstract

Medvedeva MV, Djemuchadze DR, Watterson DM, Marston SB, and Gusev NB

Biochimica et biophysica acta 1544(1-2):143-50, 2001 Jan 12 - Who cited this? | PubMed ID: 11341924 | Fulltext

Ligand modulation of glial activation: cell permeable, small molecule inhibitors of serine-threonine protein kinases can block induction of interleukin 1 beta and nitric oxide synthase II.

+ cite this

+ View Abstract

Watterson DM, Mirzoeva S, Guo L, Whyte A, Bourguignon JJ, Hibert M, Haiech J, and Van Eldik LJ

Neurochemistry international 39(5-6):459-68, 2001 - Who cited this? | PubMed ID: 11578781 | Fulltext

Mechanism of glial activation by S100B: involvement of the transcription factor NFkappaB.

+ cite this

+ View Abstract

Lam AG, Koppal T, Akama KT, Guo L, Craft JM, Samy B, Schavocky JP, Watterson DM, and Van Eldik LJ

Neurobiology of aging 22(5):765-72, 2001 - Who cited this? | PubMed ID: 11705636 | Fulltext

Similar activation of glial cultures from different rat brain regions by neuroinflammatory stimuli and downregulation of the activation by a new class of small molecule ligands.

+ cite this

+ View Abstract

Guo L, Sawkar A, Zasadzki M, Watterson DM, and Van Eldik LJ

Neurobiology of aging 22(6):975-81, 2001 - Who cited this? | PubMed ID: 11755006 | Fulltext

Phosphorylation of kinase-related protein (telokin) in tonic and phasic smooth muscles.

+ cite this

+ View Abstract

Krymsky MA, Kudryashov DS, Shirinsky VP, Lukas TJ, Watterson DM, and Vorotnikov AV

Journal of muscle research and cell motility 22(5):425-37, 2001 - Who cited this? | PubMed ID: 11964068 | Fulltext

Unique sequence of a high molecular weight myosin light chain kinase is involved in interaction with actin cytoskeleton.

+ cite this

+ View Abstract

Kudryashov DS, Chibalina MV, Birukov KG, Lukas TJ, Sellers JR, Van Eldik LJ, Watterson DM, and Shirinsky VP

FEBS letters 463(1-2):67-71, 1999 Dec 10 - Who cited this? | PubMed ID: 10601640 | Fulltext

Search Google Scholar for Watterson DM

Join Labmeeting

Organize and search your PDF collection
Collect papers
Search millions of papers
Keep up to date with paper alerts
Read your papers from anywhere
Recommend papers to colleagues
Manage your lab

Labmeeting is a web service for researchers. Sign up with your academic email address.

Individuals or corporations not affiliated with an academic institution can request a trial subscription.

Got a question?
The Labmeeting Network
has the answer.
Ask scientists at top universities like Harvard, Stanford, and MIT for their expert opinion!