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Papers authored by Varughese KI

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Crystal structures of a therapeutic single chain antibody in complex with two drugs of abuse-Methamphetamine and 3,4-methylenedioxymethamphetamine.

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Celikel R, Peterson EC, Owens SM, and Varughese KI

Protein science : a publication of the Protein Society 18(11):2336-45, 2009 Nov - Who cited this? | PubMed ID: 19760665 | Fulltext

In vivo relevance for platelet glycoprotein Ibalpha residue Tyr276 in thrombus formation.

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Guerrero JA, Shafirstein G, Russell S, Varughese KI, Kanaji T, Liu J, Gartner TK, Bäumler W, Jarvis GE, and Ware J

Journal of thrombosis and haemostasis : JTH 6(4):684, 2008 Apr - Who cited this? | PubMed ID: 18339097 | Fulltext

Platelet dysfunction and a high bone mass phenotype in a murine model of platelet-type von Willebrand disease.

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Suva LJ, Hartman E, Dilley JD, Russell S, Akel NS, Skinner RA, Hogue WR, Budde U, Varughese KI, Kanaji T, and Ware J

The American journal of pathology 172(2):430, 2008 Feb - Who cited this? | PubMed ID: 18187573 | Fulltext

Sporulation phosphorelay proteins and their complexes: crystallographic characterization.

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Varughese KI, Zhao H, Veldore VH, and Zapf J

Methods in enzymology 422:102-22, 2007 - Who cited this? | PubMed ID: 17628136 | Fulltext

The crystal structure of beryllofluoride Spo0F in complex with the phosphotransferase Spo0B represents a phosphotransfer pretransition state.

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Varughese KI, Tsigelny I, and Zhao H

Journal of bacteriology 188(13):4970-7, 2006 Jul - Who cited this? | PubMed ID: 16788205 | Fulltext

The crystal structure of YycH involved in the regulation of the essential YycFG two-component system in Bacillus subtilis reveals a novel tertiary structure.

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Szurmant H, Zhao H, Mohan MA, Hoch JA, and Varughese KI

Protein science : a publication of the Protein Society 15(4):929, 2006 Apr - Who cited this? | PubMed ID: 16600972 | Fulltext

Interactions between the YycFG and PhoPR two-component systems in Bacillus subtilis: the PhoR kinase phosphorylates the non-cognate YycF response regulator upon phosphate limitation.

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Howell A, Dubrac S, Noone D, Varughese KI, and Devine K

Molecular microbiology 59(4):1199, 2006 Feb - Who cited this? | PubMed ID: 16430694 | Fulltext

Conformational changes of Spo0F along the phosphotransfer pathway.

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Varughese KI

Journal of bacteriology 187(24):8221-7, 2005 Dec - Who cited this? | PubMed ID: 16321923 | Fulltext

Rebuttal: beryllofluoride binding mimics phosphorylation of aspartate in response regulators.

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Varughese KI

Journal of bacteriology 187(24):8231, 2005 Dec - Who cited this? | PubMed ID: 16321926 | Fulltext

A computational analysis on the specificity of interactions between histidine kinases and response regulators.

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Mukhopadhyay D and Varughese KI

Journal of biomolecular structure & dynamics 22(5):555-62, 2005 Apr - Who cited this? | PubMed ID: 15702927 | Fulltext

Metals in the sporulation phosphorelay: manganese binding by the response regulator Spo0F.

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Mukhopadhyay D, Sen U, Zapf J, and Varughese KI

Acta crystallographica. Section D, Biological crystallography 60(Pt 4):638-45, 2004 Apr - Who cited this? | PubMed ID: 15039551 | Fulltext

Platinum-induced space-group transformation in crystals of the platelet glycoprotein Ib alpha N-terminal domain.

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Varughese KI, Ruggeri ZM, and Celikel R

Acta crystallographica. Section D, Biological crystallography 60(Pt 3):405-11, 2004 Mar - Who cited this? | PubMed ID: 14993663 | Fulltext

A single amino acid change in the binding pocket alters specificity of an anti-integrin antibody AP7.4 as revealed by its crystal structure.

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Vasudevan S, Celikel R, Ruggeri ZM, Varughese KI, and Kunicki TJ

Blood cells, molecules & diseases 32(1):176-81, 2004 - Who cited this? | PubMed ID: 14757433 | Fulltext

Structure of pteridine reductase (PTR1) from Leishmania tarentolae.

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Zhao H, Bray T, Ouellette M, Zhao M, Ferre RA, Matthews D, Whiteley JM, and Varughese KI

Acta crystallographica. Section D, Biological crystallography 59(Pt 9):1539-44, 2003 Sep - Who cited this? | PubMed ID: 12925782 | Fulltext

Modulation of alpha-thrombin function by distinct interactions with platelet glycoprotein Ibalpha.

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Celikel R, McClintock RA, Roberts JR, Mendolicchio GL, Ware J, Varughese KI, and Ruggeri ZM

Science (New York, N.Y.) 301(5630):218-21, 2003 Jul 11 - Who cited this? | PubMed ID: 12855810 | Fulltext

Red cell adenylate kinase deficiency: molecular study of 3 new mutations (118G>A, 190G>A, and GAC deletion) associated with hereditary nonspherocytic hemolytic anemia.

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Corrons JL, Garcia E, Tusell JJ, Varughese KI, West C, and Beutler E

Blood 102(1):353-6, 2003 Jul 1 - Who cited this? | PubMed ID: 12649162 | Fulltext

DNA complexed structure of the key transcription factor initiating development in sporulating bacteria.

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Zhao H, Msadek T, Zapf J, Madhusudan, Hoch JA, and Varughese KI

Structure (London, England : 1993) 10(8):1041-50, 2002 Aug - Who cited this? | PubMed ID: 12176382 | Fulltext

Structure and function of the von Willebrand factor A1 domain.

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Varughese KI, Celikel R, and Ruggeri ZM

Current protein & peptide science 3(3):301-12, 2002 Jun - Who cited this? | PubMed ID: 12188898 | Fulltext

Molecular recognition of bacterial phosphorelay proteins.

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Varughese KI

Current opinion in microbiology 5(2):142-8, 2002 Apr - Who cited this? | PubMed ID: 11934609 | Fulltext

Keeping signals straight in phosphorelay signal transduction.

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Hoch JA and Varughese KI

Journal of bacteriology 183(17):4941-9, 2001 Sep - Who cited this? | PubMed ID: 11489844 | Fulltext

Crystal structure of the von Willebrand factor modulator botrocetin.

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Sen U, Vasudevan S, Subbarao G, McClintock RA, Celikel R, Ruggeri ZM, and Varughese KI

Biochemistry 40(2):345-52, 2001 Jan 16 - Who cited this? | PubMed ID: 11148028 | Fulltext

von Willebrand factor conformation and adhesive function is modulated by an internalized water molecule.

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Celikel R, Ruggeri ZM, and Varughese KI

Nature structural biology 7(10):881-4, 2000 Oct - Who cited this? | PubMed ID: 11017197 | Fulltext

A transient interaction between two phosphorelay proteins trapped in a crystal lattice reveals the mechanism of molecular recognition and phosphotransfer in signal transduction.

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Zapf J, Sen U, Madhusudan, Hoch JA, and Varughese KI

Structure (London, England : 1993) 8(8):851-62, 2000 Aug 15 - Who cited this? | PubMed ID: 10997904 | Fulltext

Modeling and functional analysis of the interaction between von Willebrand factor A1 domain and glycoprotein Ibalpha.

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Vasudevan S, Roberts JR, McClintock RA, Dent JA, Celikel R, Ware J, Varughese KI, and Ruggeri ZM

The Journal of biological chemistry 275(17):12763-8, 2000 Apr 28 - Who cited this? | PubMed ID: 10777573 | Fulltext

Comparative properties of three pteridine reductases.

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Chang CF, Bray T, Varughese KI, and Whiteley JM

Advances in experimental medicine and biology 463:403-10, 1999 - Who cited this? | PubMed ID: 10352712 | Fulltext

Formation of a novel four-helix bundle and molecular recognition sites by dimerization of a response regulator phosphotransferase.

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Varughese KI, Madhusudan, Zhou XZ, Whiteley JM, and Hoch JA

Molecular cell 2(4):485-93, 1998 Oct - Who cited this? | PubMed ID: 9809070 | Fulltext

Six previously undescribed pyruvate kinase mutations causing enzyme deficiency.

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Demina A, Varughese KI, Barbot J, Forman L, and Beutler E

Blood 92(2):647-52, 1998 Jul 15 - Who cited this? | PubMed ID: 9657767 | Fulltext

A source of response regulator autophosphatase activity: the critical role of a residue adjacent to the Spo0F autophosphorylation active site.

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Zapf J, Madhusudan M, Grimshaw CE, Hoch JA, Varughese KI, and Whiteley JM

Biochemistry 37(21):7725-32, 1998 May 26 - Who cited this? | PubMed ID: 9601032 | Fulltext

Crystal structure of the von Willebrand factor A1 domain in complex with the function blocking NMC-4 Fab.

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Celikel R, Varughese KI, Madhusudan, Yoshioka A, Ware J, and Ruggeri ZM

Nature structural biology 5(3):189-94, 1998 Mar - Who cited this? | PubMed ID: 9501911 | Fulltext

A response regulatory protein with the site of phosphorylation blocked by an arginine interaction: crystal structure of Spo0F from Bacillus subtilis.

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Madhusudan M, Zapf J, Hoch JA, Whiteley JM, Xuong NH, and Varughese KI

Biochemistry 36(42):12739-45, 1997 Oct 21 - Who cited this? | PubMed ID: 9335530 | Fulltext

Crystal structures of the copper and nickel complexes of RNase A: metal-induced interprotein interactions and identification of a novel copper binding motif.

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Balakrishnan R, Ramasubbu N, Varughese KI, and Parthasarathy R

Proceedings of the National Academy of Sciences of the United States of America 94(18):9620-5, 1997 Sep 2 - Who cited this? | PubMed ID: 9275172 | Fulltext

Purification and preliminary crystallographic studies on the sporulation response regulatory phosphotransferase protein, Spo0B, from Bacillus subtilis.

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Zhou XZ, Madhusudan, Whiteley JM, Hoch JA, and Varughese KI

Proteins 27(4):597-600, 1997 Apr - Who cited this? | PubMed ID: 9141138 | Fulltext

Crystal structure of NMC-4 fab anti-von Willebrand factor A1 domain.

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Celikel R, Madhusudan, Varughese KI, Shima M, Yoshioka A, Ware J, and Ruggeri ZM

Blood cells, molecules & diseases 23(1):123-34, 1997 - Who cited this? | PubMed ID: 9215757 | Fulltext

Crystal structure of a phosphatase-resistant mutant of sporulation response regulator Spo0F from Bacillus subtilis.

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Madhusudan, Zapf J, Whiteley JM, Hoch JA, Xuong NH, and Varughese KI

Structure (London, England : 1993) 4(6):679-90, 1996 Jun 15 - Who cited this? | PubMed ID: 8805550 | Fulltext

Crystallization and preliminary X-ray analysis of a Y13S mutant of Spo0F from Bacillus subtilis.

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Madhusudan, Zapf J, Whiteley JM, Hoch JA, Xuong NH, and Varughese KI

Acta crystallographica. Section D, Biological crystallography 52(Pt 3):589-90, 1996 May 1 - Who cited this? | PubMed ID: 15299688 | Fulltext

Altered structural and mechanistic properties of mutant dihydropteridine reductases.

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Kiefer PM, Varughese KI, Su Y, Xuong NH, Chang CF, Gupta P, Bray T, and Whiteley JM

The Journal of biological chemistry 271(7):3437-44, 1996 Feb 16 - Who cited this? | PubMed ID: 8631945 | Fulltext

Regulatory subunit of protein kinase A: structure of deletion mutant with cAMP binding domains.

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Su Y, Dostmann WR, Herberg FW, Durick K, Xuong NH, Ten Eyck L, Taylor SS, and Varughese KI

Science (New York, N.Y.) 269(5225):807-13, 1995 Aug 11 - Who cited this? | PubMed ID: 7638597 | Fulltext

Crystal structure of a monoclinic form of dihydropteridine reductase from rat liver.

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Su Y, Skinner MM, Xuong NH, Matthews DA, Whiteley JM, and Varughese KI

Acta crystallographica. Section D, Biological crystallography 50(Pt 6):884-8, 1994 Nov 1 - Who cited this? | PubMed ID: 15299357 | Fulltext

Structural and mechanistic implications of incorporating naturally occurring aberrant mutations of human dihydropteridine reductase into a rat model.

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Varughese KI, Xuong NH, and Whiteley JM

International journal of peptide and protein research 44(3):278-87, 1994 Sep - Who cited this? | PubMed ID: 7822105 | Fulltext

Structural and mechanistic characteristics of dihydropteridine reductase: a member of the Tyr-(Xaa)3-Lys-containing family of reductases and dehydrogenases.

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Varughese KI, Xuong NH, Kiefer PM, Matthews DA, and Whiteley JM

Proceedings of the National Academy of Sciences of the United States of America 91(12):5582-6, 1994 Jun 7 - Who cited this? | PubMed ID: 8202530 | Fulltext

Characterization of a linear pentapeptide containing two consecutive beta-turns.

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Ramnarayan K, Balaji VN, and Varughese KI

Peptide research 7(5):270-8, 1994 - Who cited this? | PubMed ID: 7849421 | Fulltext

The crystallographic structure of a human dihydropteridine reductase NADH binary complex expressed in Escherichia coli by a cDNA constructed from its rat homologue.

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Su Y, Varughese KI, Xuong NH, Bray TL, Roche DJ, and Whiteley JM

The Journal of biological chemistry 268(36):26836-41, 1993 Dec 25 - Who cited this? | PubMed ID: 8262916 | Fulltext

Crystallization of a deletion mutant of the R-subunit of cAMP dependent protein kinase.

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Su Y, Taylor SS, Dostmann WR, Xuong NH, and Varughese KI

Journal of molecular biology 230(3):1091-3, 1993 Apr 5 - Who cited this? | PubMed ID: 8478923 | Fulltext

Is dihydropteridine reductase an anomalous dihydrofolate reductase, a flavin-like enzyme, or a short-chain dehydrogenase?.

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Whiteley JM, Xuong NH, and Varughese KI

Advances in experimental medicine and biology 338:115-21, 1993 - Who cited this? | PubMed ID: 8304093 | Fulltext

Two crystal structures of rat liver dihydropteridine reductase.

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Varughese KI, Su Y, Skinner MM, Xuong NH, Matthews DA, and Whiteley JM

Advances in experimental medicine and biology 338:123-6, 1993 - Who cited this? | PubMed ID: 8304094 | Fulltext

Characterization and nucleotide binding properties of a mutant dihydropteridine reductase containing an aspartate 37-isoleucine replacement.

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Grimshaw CE, Matthews DA, Varughese KI, Skinner M, Xuong NH, Bray T, Hoch J, and Whiteley JM

The Journal of biological chemistry 267(22):15334-9, 1992 Aug 5 - Who cited this? | PubMed ID: 1639779 | Fulltext

Crystal structure of rat liver dihydropteridine reductase.

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Varughese KI, Skinner MM, Whiteley JM, Matthews DA, and Xuong NH

Proceedings of the National Academy of Sciences of the United States of America 89(13):6080-4, 1992 Jul 1 - Who cited this? | PubMed ID: 1631094 | Fulltext

Crystal structure of an actinidin-E-64 complex.

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Varughese KI, Su Y, Cromwell D, Hasnain S, and Xuong NH

Biochemistry 31(22):5172-6, 1992 Jun 9 - Who cited this? | PubMed ID: 1606141 | Fulltext

Role of aspartate-37 in determining cofactor specificity and binding in rat liver dihydropteridine reductase.

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Matthews DA, Varughese KI, Skinner M, Xuong NH, Hoch J, Trach K, Schneider M, Bray T, and Whiteley JM

Archives of biochemistry and biophysics 287(2):234-9, 1991 Jun - Who cited this? | PubMed ID: 1898002 | Fulltext

Crystal structure of a papain-E-64 complex.

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Varughese KI, Ahmed FR, Carey PR, Hasnain S, Huber CP, and Storer AC

Biochemistry 28(3):1330-2, 1989 Feb 7 - Who cited this? | PubMed ID: 2713367 | Fulltext

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