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Papers authored by Van Den Steen PE

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Neutrophil MMP-9 Proenzyme, Unencumbered by TIMP-1, Undergoes Efficient Activation in Vivo and Catalytically Induces Angiogenesis via a Basic Fibroblast Growth Factor (FGF-2)/FGFR-2 Pathway.

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Ardi VC, Van den Steen PE, Opdenakker G, Schweighofer B, Deryugina EI, and Quigley JP

The Journal of biological chemistry 284(38):25854-66, 2009 Sep 18 - Who cited this? | PubMed ID: 19608737 | Fulltext

"Reverse degradomics", monitoring of proteolytic trimming by multi-CE and confocal detection of fluorescent substrates and reaction products.

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Piccard H, Hu J, Fiten P, Proost P, Martens E, Van den Steen PE, Van Damme J, and Opdenakker G

Electrophoresis 30(13):2366-77, 2009 Jul - Who cited this? | PubMed ID: 19621364 | Fulltext

The collagen binding domain of gelatinase A modulates degradation of collagen IV by gelatinase B.

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Gioia M, Monaco S, Van Den Steen PE, Sbardella D, Grasso G, Marini S, Overall CM, Opdenakker G, and Coletta M

Journal of molecular biology 386(2):419-34, 2009 Feb 20 - Who cited this? | PubMed ID: 19109975 | Fulltext

Increased gelatinase B/matrix metalloproteinase 9 (MMP-9) activity in a murine model of acute coxsackievirus B4-induced pancreatitis.

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De Palma AM, Verbeken E, Aelst IV, Van den Steen PE, Opdenakker G, and Neyts J

Virology 382(1):20-7, 2008 Dec 5 - Who cited this? | PubMed ID: 18929380 | Fulltext

Virus entry inhibition by chlorite-oxidized oxyamylose versus induction of antiviral interferon by poly(I:C).

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Li S, Martens E, Dillen C, Van den Steen PE, and Opdenakker G

Biochemical pharmacology 76(7):831-40, 2008 Oct 1 - Who cited this? | PubMed ID: 18703022 | Fulltext

Adenylyl cyclase-associated protein-1/CAP1 as a biological target substrate of gelatinase B/MMP-9.

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Cauwe B, Martens E, Van den Steen PE, Proost P, Van Aelst I, Blockmans D, and Opdenakker G

Experimental cell research 314(15):2739, 2008 Sep 10 - Who cited this? | PubMed ID: 18671965 | Fulltext

Alpha4beta1 integrin and 190-kDa CD44v constitute a cell surface docking complex for gelatinase B/MMP-9 in chronic leukemic but not in normal B cells.

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Redondo-Muñoz J, Ugarte-Berzal E, García-Marco JA, del Cerro MH, Van den Steen PE, Opdenakker G, Terol MJ, and García-Pardo A

Blood 112(1):169, 2008 Jul 1 - Who cited this? | PubMed ID: 18326820 | Fulltext

CXCR3 determines strain susceptibility to murine cerebral malaria by mediating T lymphocyte migration toward IFN-gamma-induced chemokines.

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Van den Steen PE, Deroost K, Aelst IV, Geurts N, Martens E, Struyf S, Nie CQ, Hansen DS, Matthys P, Damme JV, and Opdenakker G

European journal of immunology 38(4):1082-95, 2008 Apr - Who cited this? | PubMed ID: 18383042 | Fulltext

beta-Hematin Interaction with the Hemopexin Domain of Gelatinase B/MMP-9 Provokes Autocatalytic Processing of the Propeptide, Thereby Priming Activation by MMP-3.

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Geurts N, Martens E, Aelst IV, Proost P, Opdenakker G, and Van den Steen PE

Biochemistry 47(8):2689-99, 2008 Feb 26 - Who cited this? | PubMed ID: 18237197 | Fulltext

Matrix metalloproteinase-9/gelatinase B is a putative therapeutic target of chronic obstructive pulmonary disease and multiple sclerosis.

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Muroski ME, Roycik MD, Newcomer RG, Van den Steen PE, Opdenakker G, Monroe HR, Sahab ZJ, and Sang QX

Current pharmaceutical biotechnology 9(1):34, 2008 Feb - Who cited this? | PubMed ID: 18289055 | Fulltext

Insights into the structure and domain flexibility of full-length pro-matrix metalloproteinase-9/gelatinase B.

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Rosenblum G, Van den Steen PE, Cohen SR, Grossmann JG, Frenkel J, Sertchook R, Slack N, Strange RW, Opdenakker G, and Sagi I

Structure (London, England : 1993) 15(10):1227, 2007 Oct - Who cited this? | PubMed ID: 17937912 | Fulltext

Matrix metalloproteinase inhibitors as therapy for inflammatory and vascular diseases.

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Hu J, Van den Steen PE, Sang QX, and Opdenakker G

Nature reviews. Drug discovery 6(6):480-98, 2007 Jun - Who cited this? | PubMed ID: 17541420 | Fulltext

Hemopexin domains as multifunctional liganding modules in matrix metalloproteinases and other proteins.

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Piccard H, Van den Steen PE, and Opdenakker G

Journal of leukocyte biology 81(4):870-92, 2007 Apr - Who cited this? | PubMed ID: 17185359 | Fulltext

A monoclonal antibody inhibits gelatinase B/MMP-9 by selective binding to part of the catalytic domain and not to the fibronectin or zinc binding domains.

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Martens E, Leyssen A, Van Aelst I, Fiten P, Piccard H, Hu J, Descamps FJ, Van den Steen PE, Proost P, Van Damme J, Liuzzi GM, Riccio P, Polverini E, and Opdenakker G

Biochimica et biophysica acta 1770(2):178-86, 2007 Feb - Who cited this? | PubMed ID: 17137715 | Fulltext

Expression of angiogenic and fibrogenic factors in proliferative vitreoretinal disorders.

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Abu El-Asrar AM, Van den Steen PE, Al-Amro SA, Missotten L, Opdenakker G, and Geboes K

International ophthalmology 27(1):11-22, 2007 Feb - Who cited this? | PubMed ID: 17375263 | Fulltext

The biochemical, biological, and pathological kaleidoscope of cell surface substrates processed by matrix metalloproteinases.

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Cauwe B, Van den Steen PE, and Opdenakker G

Critical reviews in biochemistry and molecular biology 42(3):113-85, 2007 - Who cited this? | PubMed ID: 17562450 | Fulltext

Cancer-associated glycoforms of gelatinase B exhibit a decreased level of binding to galectin-3.

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Fry SA, Van den Steen PE, Royle L, Wormald MR, Leathem AJ, Opdenakker G, McDonnell JM, Dwek RA, and Rudd PM

Biochemistry 45(51):15249-58, 2006 Dec 26 - Who cited this? | PubMed ID: 17176047 | Fulltext

Matrix metalloproteinases, tissue inhibitors of MMPs and TACE in experimental cerebral malaria.

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Van den Steen PE, Van Aelst I, Starckx S, Maskos K, Opdenakker G, and Pagenstecher A

Laboratory investigation; a journal of technical methods and pathology 86(9):873, 2006 Sep - Who cited this? | PubMed ID: 16865090 | Fulltext

Inhibition of lethal endotoxin shock with an L-pyridylalanine containing metalloproteinase inhibitor selected by high-throughput screening of a new peptide library.

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Hu J, Dubois V, Chaltin P, Fiten P, Dillen C, Van den Steen PE, and Opdenakker G

Combinatorial chemistry & high throughput screening 9(8):599-611, 2006 Sep - Who cited this? | PubMed ID: 17017880 | Fulltext

The hemopexin and O-glycosylated domains tune gelatinase B/MMP-9 bioavailability via inhibition and binding to cargo receptors.

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Van den Steen PE, Van Aelst I, Hvidberg V, Piccard H, Fiten P, Jacobsen C, Moestrup SK, Fry S, Royle L, Wormald MR, Wallis R, Rudd PM, Dwek RA, and Opdenakker G

The Journal of biological chemistry 281(27):18626-37, 2006 Jul 7 - Who cited this? | PubMed ID: 16672230 | Fulltext

Remnant epitopes, autoimmunity and glycosylation.

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Opdenakker G, Dillen C, Fiten P, Martens E, Van Aelst I, Van den Steen PE, Nelissen I, Starckx S, Descamps FJ, Hu J, Piccard H, Van Damme J, Wormald MR, Rudd PM, and Dwek RA

Biochimica et biophysica acta 1760(4):610-5, 2006 Apr - Who cited this? | PubMed ID: 16439062 | Fulltext

Targeting neutrophil collagenase/matrix metalloproteinase-8 and gelatinase B/matrix metalloproteinase-9 with a peptidomimetic inhibitor protects against endotoxin shock.

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Hu J, Van den Steen PE, Dillen C, and Opdenakker G

Biochemical pharmacology 70(4):535-44, 2005 Aug 15 - Who cited this? | PubMed ID: 15992779 | Fulltext

Simulation of evolution-selected propeptide by high-throughput selection of a peptidomimetic inhibitor on a capillary DNA sequencer platform.

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Hu J, Fiten P, Van den Steen PE, Chaltin P, and Opdenakker G

Analytical chemistry 77(7):2116-24, 2005 Apr 1 - Who cited this? | PubMed ID: 15801745 | Fulltext

Gelatinase B/matrix metalloproteinase-9 provokes cataract by cleaving lens betaB1 crystallin.

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Descamps FJ, Martens E, Proost P, Starckx S, Van den Steen PE, Van Damme J, and Opdenakker G

The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 19(1):29-35, 2005 Jan - Who cited this? | PubMed ID: 15629892 | Fulltext

Gelatinase B participates in collagen II degradation and releases glycosylated remnant epitopes in rheumatoid arthritis.

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Van den Steen PE, Grillet B, and Opdenakker G

Advances in experimental medicine and biology 564:45-55, 2005 - Who cited this? | PubMed ID: 16400806 | Fulltext

Differential glycosylation of gelatinase B from neutrophils and breast cancer cells.

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Fry SA, Van den Steen PE, Royle L, Wormald MR, Leathem AJ, Opdenakker G, Rudd PM, and Dwek RA

Advances in experimental medicine and biology 564:103-12, 2005 - Who cited this? | PubMed ID: 16400814 | Fulltext

Generation of glycosylated remnant epitopes from human collagen type II by gelatinase B.

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Van den Steen PE, Proost P, Brand DD, Kang AH, Van Damme J, and Opdenakker G

Biochemistry 43(33):10809-16, 2004 Aug 24 - Who cited this? | PubMed ID: 15311942 | Fulltext

Inhibitors of gelatinase B/matrix metalloproteinase-9 activity comparison of a peptidomimetic and polyhistidine with single-chain derivatives of a neutralizing monoclonal antibody.

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Hu J, Van den Steen PE, Houde M, Ilenchuk TT, and Opdenakker G

Biochemical pharmacology 67(5):1001-9, 2004 Mar 1 - Who cited this? | PubMed ID: 15104254 | Fulltext

Carboxyterminal cleavage of the chemokines MIG and IP-10 by gelatinase B and neutrophil collagenase.

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Van den Steen PE, Husson SJ, Proost P, Van Damme J, and Opdenakker G

Biochemical and biophysical research communications 310(3):889-96, 2003 Oct 24 - Who cited this? | PubMed ID: 14550288 | Fulltext

Gelatinase B/MMP-9 and neutrophil collagenase/MMP-8 process the chemokines human GCP-2/CXCL6, ENA-78/CXCL5 and mouse GCP-2/LIX and modulate their physiological activities.

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Van Den Steen PE, Wuyts A, Husson SJ, Proost P, Van Damme J, and Opdenakker G

European journal of biochemistry / FEBS 270(18):3739-49, 2003 Sep - Who cited this? | PubMed ID: 12950257 | Fulltext

A novel rationale for inhibition of gelatinase B in multiple sclerosis: MMP-9 destroys alpha B-crystallin and generates a promiscuous T cell epitope.

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Starckx S, Van den Steen PE, Verbeek R, van Noort JM, and Opdenakker G

Journal of neuroimmunology 141(1-2):47-57, 2003 Aug - Who cited this? | PubMed ID: 12965253 | Fulltext

Gelatinase B/matrix metalloproteinase-9 cleaves interferon-beta and is a target for immunotherapy.

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Nelissen I, Martens E, Van den Steen PE, Proost P, Ronsse I, and Opdenakker G

Brain : a journal of neurology 126(Pt 6):1371-81, 2003 Jun - Who cited this? | PubMed ID: 12764058 | Fulltext

Gelatinase B is diabetogenic in acute and chronic pancreatitis by cleaving insulin.

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Descamps FJ, Van den Steen PE, Martens E, Ballaux F, Geboes K, and Opdenakker G

The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 17(8):887-9, 2003 May - Who cited this? | PubMed ID: 12626433 | Fulltext

Neutralizing antibodies in gene-defective hosts.

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Opdenakker G, Van den Steen PE, Laureys G, Hunninck K, and Arnold B

Trends in immunology 24(2):94-100, 2003 Feb - Who cited this? | PubMed ID: 12547507 | Fulltext

Remnant epitopes generate autoimmunity: from rheumatoid arthritis and multiple sclerosis to diabetes.

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Descamps FJ, Van den Steen PE, Nelissen I, Van Damme J, and Opdenakker G

Advances in experimental medicine and biology 535:69-77, 2003 - Who cited this? | PubMed ID: 14714889 | Fulltext

Biochemistry and molecular biology of gelatinase B or matrix metalloproteinase-9 (MMP-9).

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Van den Steen PE, Dubois B, Nelissen I, Rudd PM, Dwek RA, and Opdenakker G

Critical reviews in biochemistry and molecular biology 37(6):375-536, 2002 Dec - Who cited this? | PubMed ID: 12540195 | Fulltext

Cleavage of denatured natural collagen type II by neutrophil gelatinase B reveals enzyme specificity, post-translational modifications in the substrate, and the formation of remnant epitopes in rheumatoid arthritis.

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Van den Steen PE, Proost P, Grillet B, Brand DD, Kang AH, Van Damme J, and Opdenakker G

The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 16(3):379-89, 2002 Mar - Who cited this? | PubMed ID: 11874987 | Fulltext

Neutrophil gelatinase B and chemokines in leukocytosis and stem cell mobilization.

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Starckx S, Van den Steen PE, Wuyts A, Van Damme J, and Opdenakker G

Leukemia & lymphoma 43(2):233-41, 2002 Feb - Who cited this? | PubMed ID: 11999552 | Fulltext

Matrix remodelling enzymes, the protease cascade and glycosylation.

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Van den Steen PE, Opdenakker G, Wormald MR, Dwek RA, and Rudd PM

Biochimica et biophysica acta 1528(2-3):61-73, 2001 Oct 3 - Who cited this? | PubMed ID: 11687291 | Fulltext

Gelatinase B: a tuner and amplifier of immune functions.

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Opdenakker G, Van den Steen PE, and Van Damme J

Trends in immunology 22(10):571-9, 2001 Oct - Who cited this? | PubMed ID: 11574282 | Fulltext

Gelatinase B functions as regulator and effector in leukocyte biology.

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Opdenakker G, Van den Steen PE, Dubois B, Nelissen I, Van Coillie E, Masure S, Proost P, and Van Damme J

Journal of leukocyte biology 69(6):851-9, 2001 Jun - Who cited this? | PubMed ID: 11404367 | Fulltext

O-glycan analysis of natural human neutrophil gelatinase B using a combination of normal phase-HPLC and online tandem mass spectrometry: implications for the domain organization of the enzyme.

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Mattu TS, Royle L, Langridge J, Wormald MR, Van den Steen PE, Van Damme J, Opdenakker G, Harvey DJ, Dwek RA, and Rudd PM

Biochemistry 39(51):15695-704, 2000 Dec 26 - Who cited this? | PubMed ID: 11123894 | Fulltext

Structural characterization of the catalytic active site in the latent and active natural gelatinase B from human neutrophils.

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Kleifeld O, Van den Steen PE, Frenkel A, Cheng F, Jiang HL, Opdenakker G, and Sagi I

The Journal of biological chemistry 275(44):34335, 2000 Nov 3 - Who cited this? | PubMed ID: 10938090 | Fulltext

Neutrophil gelatinase B potentiates interleukin-8 tenfold by aminoterminal processing, whereas it degrades CTAP-III, PF-4, and GRO-alpha and leaves RANTES and MCP-2 intact.

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Van den Steen PE, Proost P, Wuyts A, Van Damme J, and Opdenakker G

Blood 96(8):2673-81, 2000 Oct 15 - Who cited this? | PubMed ID: 11023497 | Fulltext

Glycosylation of natural human neutrophil gelatinase B and neutrophil gelatinase B-associated lipocalin.

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Rudd PM, Mattu TS, Masure S, Bratt T, Van den Steen PE, Wormald MR, Küster B, Harvey DJ, Borregaard N, Van Damme J, Dwek RA, and Opdenakker G

Biochemistry 38(42):13937-50, 1999 Oct 19 - Who cited this? | PubMed ID: 10529240 | Fulltext

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