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Papers authored by Valenzuela DM

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Angiomodulin is a specific marker of vasculature and regulates vascular endothelial growth factor-a-dependent neoangiogenesis.

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Hooper AT, Shmelkov SV, Gupta S, Milde T, Bambino K, Gillen K, Goetz M, Chavala S, Baljevic M, Murphy AJ, Valenzuela DM, Gale NW, Thurston G, Yancopoulos GD, Vahdat L, Evans T,

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Circulation research 105(2):201-8, 2009 Jul 17 - Who cited this? | PubMed ID: 19542015 | Fulltext

During muscle atrophy, thick, but not thin, filament components are degraded by MuRF1-dependent ubiquitylation.

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Cohen S, Brault JJ, Gygi SP, Glass DJ, Valenzuela DM, Gartner C, Latres E, and Goldberg AL

The Journal of cell biology 185(6):1083-95, 2009 Jun 15 - Who cited this? | PubMed ID: 19506036 | Fulltext

Alternatively activated macrophage-derived RELM-{alpha} is a negative regulator of type 2 inflammation in the lung.

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Nair MG, Du Y, Perrigoue JG, Zaph C, Taylor JJ, Goldschmidt M, Swain GP, Yancopoulos GD, Valenzuela DM, Murphy A, Karow M, Stevens S, Pearce EJ, and Artis D

The Journal of experimental medicine 206(4):937-52, 2009 Apr 13 - Who cited this? | PubMed ID: 19349464 | Fulltext

Connective Tissue Growth Factor (CTGF) Inactivation Leads to Defects in Islet Cell Lineage Allocation and {beta}-Cell Proliferation during Embryogenesis.

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Crawford LA, Guney MA, Oh YA, Deyoung RA, Valenzuela DM, Murphy AJ, Yancopoulos GD, Lyons KM, Brigstock DR, Economides A, and Gannon M

Molecular endocrinology (Baltimore, Md.) 23(3):324-36, 2009 Mar - Who cited this? | PubMed ID: 19131512 | Fulltext

Connective Tissue Growth Factor (CTGF) Inactivation Leads to Defects in Islet Cell Lineage Allocation and Cell Proliferation During Embryogenesis.

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Crawford LA, Guney MA, Oh YA, Deyoung RA, Valenzuela DM, Murphy AJ, Yancopoulos GD, Lyons KM, Brigstock DR, Economides A, and Gannon M

The Journal of clinical endocrinology and metabolism 94(2):703, 2009 Feb - Who cited this? | PubMed ID: 19193926 | Fulltext

RORgamma-Expressing Th17 Cells Induce Murine Chronic Intestinal Inflammation via Redundant Effects of IL-17A and IL-17F.

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Leppkes M, Becker C, Ivanov II, Hirth S, Wirtz S, Neufert C, Pouly S, Murphy AJ, Valenzuela DM, Yancopoulos GD, Becher B, Littman DR, and Neurath MF

Gastroenterology 136(1):257-67, 2009 Jan - Who cited this? | PubMed ID: 18992745 | Fulltext

VelociMouse: Fully ES Cell-Derived F0-Generation Mice Obtained from the Injection of ES Cells into Eight-Cell-Stage Embryos.

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Dechiara TM, Poueymirou WT, Auerbach W, Frendewey D, Yancopoulos GD, and Valenzuela DM

Methods in molecular biology (Clifton, N.J.) 530:1-14, 2009 - Who cited this? | PubMed ID: 19266341 | Fulltext

Generation and functional characterization of mice with a conditional BMP7 allele.

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Zouvelou V, Passa O, Segklia K, Tsalavos S, Valenzuela DM, Economides AN, and Graf D

The International journal of developmental biology 53(4):597-603, 2009 - Who cited this? | PubMed ID: 19247966 | Fulltext

Innate and adaptive interleukin-22 protects mice from inflammatory bowel disease.

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Zenewicz LA, Yancopoulos GD, Valenzuela DM, Murphy AJ, Stevens S, and Flavell RA

Immunity 29(6):947-57, 2008 Dec - Who cited this? | PubMed ID: 19100701 | Fulltext

Goblet Cell-Derived Resistin-Like Molecule {beta} Augments CD4+ T Cell Production of IFN-{gamma} and Infection-Induced Intestinal Inflammation.

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Nair MG, Guild KJ, Du Y, Zaph C, Yancopoulos GD, Valenzuela DM, Murphy A, Stevens S, Karow M, and Artis D

Journal of immunology (Baltimore, Md. : 1950) 181(7):4709, 2008 Oct 1 - Who cited this? | PubMed ID: 18802073 | Fulltext

CD133 expression is not restricted to stem cells, and both CD133+ and CD133- metastatic colon cancer cells initiate tumors.

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Shmelkov SV, Butler JM, Hooper AT, Hormigo A, Kushner J, Milde T, St Clair R, Baljevic M, White I, Jin DK, Chadburn A, Murphy AJ, Valenzuela DM, Gale NW, Thurston G, Yancopoulos GD,

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The Journal of clinical investigation 118(6):2111, 2008 Jun - Who cited this? | PubMed ID: 18497886 | Fulltext

The mutation ROR2W749X, linked to human BDB, is a recessive mutation in the mouse, causing brachydactyly, mediating patterning of joints and modeling recessive Robinow syndrome.

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Raz R, Stricker S, Gazzerro E, Clor JL, Witte F, Nistala H, Zabski S, Pereira RC, Stadmeyer L, Wang X, Gowen L, Sleeman MW, Yancopoulos GD, Canalis E, Mundlos S, Valenzuela DM,

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Development (Cambridge, England) 135(9):1713, 2008 May - Who cited this? | PubMed ID: 18353862 | Fulltext

Puromycin-Sensitive Aminopeptidase Limits MHC Class I Presentation in Dendritic Cells but Does Not Affect CD8 T Cell Responses during Viral Infections.

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Towne CF, York IA, Neijssen J, Karow ML, Murphy AJ, Valenzuela DM, Yancopoulos GD, Neefjes JJ, and Rock KL

Journal of immunology (Baltimore, Md. : 1950) 180(3):1704-12, 2008 Feb 1 - Who cited this? | PubMed ID: 18209067 | Fulltext

Unique functions of the type II interleukin 4 receptor identified in mice lacking the interleukin 13 receptor alpha1 chain.

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Ramalingam TR, Pesce JT, Sheikh F, Cheever AW, Mentink-Kane MM, Wilson MS, Stevens S, Valenzuela DM, Murphy AJ, Yancopoulos GD, Urban JF, Donnelly RP, and Wynn TA

Nature immunology 9(1):25-33, 2008 Jan - Who cited this? | PubMed ID: 18066066 | Fulltext

Expression of BMP-7 and USAG-1 (a BMP antagonist) in kidney development and injury.

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Tanaka M, Endo S, Okuda T, Economides AN, Valenzuela DM, Murphy AJ, Robertson E, Sakurai T, Fukatsu A, Yancopoulos GD, Kita T, and Yanagita M

Kidney international 73(2):181-91, 2008 Jan - Who cited this? | PubMed ID: 17943079 | Fulltext

Interleukin-22 but not interleukin-17 provides protection to hepatocytes during acute liver inflammation.

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Zenewicz LA, Yancopoulos GD, Valenzuela DM, Murphy AJ, Karow M, and Flavell RA

Immunity 27(4):647-59, 2007 Oct - Who cited this? | PubMed ID: 17919941 | Fulltext

Generation of functional multipotent adult stem cells from GPR125+ germline progenitors.

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Seandel M, James D, Shmelkov SV, Falciatori I, Kim J, Chavala S, Scherr DS, Zhang F, Torres R, Gale NW, Yancopoulos GD, Murphy A, Valenzuela DM, Hobbs RM, Pandolfi PP, and Rafii S

Nature 449(7160):346-50, 2007 Sep 20 - Who cited this? | PubMed ID: 17882221 | Fulltext

Mice genetically deficient in neuromedin U receptor 2, but not neuromedin U receptor 1, have impaired nociceptive responses.

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Torres R, Croll SD, Vercollone J, Reinhardt J, Griffiths J, Zabski S, Anderson KD, Adams NC, Gowen L, Sleeman MW, Valenzuela DM, Wiegand SJ, Yancopoulos GD, and Murphy AJ

Pain 130(3):267-78, 2007 Aug - Who cited this? | PubMed ID: 17379411 | Fulltext

Vascular endothelial tyrosine phosphatase (VE-PTP)-null mice undergo vasculogenesis but die embryonically because of defects in angiogenesis.

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Dominguez MG, Hughes VC, Pan L, Simmons M, Daly C, Anderson K, Noguera-Troise I, Murphy AJ, Valenzuela DM, Davis S, Thurston G, Yancopoulos GD, and Gale NW

Proceedings of the National Academy of Sciences of the United States of America 104(9):3243-8, 2007 Feb 27 - Who cited this? | PubMed ID: 17360632 | Fulltext

F0 generation mice fully derived from gene-targeted embryonic stem cells allowing immediate phenotypic analyses.

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Poueymirou WT, Auerbach W, Frendewey D, Hickey JF, Escaravage JM, Esau L, Doré AT, Stevens S, Adams NC, Dominguez MG, Gale NW, Yancopoulos GD, DeChiara TM, and Valenzuela DM

Nature biotechnology 25(1):91-9, 2007 Jan - Who cited this? | PubMed ID: 17187059 | Fulltext

SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells.

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Haigis MC, Mostoslavsky R, Haigis KM, Fahie K, Christodoulou DC, Murphy AJ, Valenzuela DM, Yancopoulos GD, Karow M, Blander G, Wolberger C, Prolla TA, Weindruch R, Alt FW, and Guarente L

Cell 126(5):941, 2006 Sep 8 - Who cited this? | PubMed ID: 16959573 | Fulltext

Cutting edge: IL-23 cross-regulates IL-12 production in T cell-dependent experimental colitis.

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Becker C, Dornhoff H, Neufert C, Fantini MC, Wirtz S, Huebner S, Nikolaev A, Lehr HA, Murphy AJ, Valenzuela DM, Yancopoulos GD, Galle PR, Karow M, and Neurath MF

Journal of immunology (Baltimore, Md. : 1950) 177(5):2760, 2006 Sep 1 - Who cited this? | PubMed ID: 16920909 | Fulltext

Resistin-like molecule beta regulates innate colonic function: barrier integrity and inflammation susceptibility.

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Hogan SP, Seidu L, Blanchard C, Groschwitz K, Mishra A, Karow ML, Ahrens R, Artis D, Murphy AJ, Valenzuela DM, Yancopoulos GD, and Rothenberg ME

The Journal of allergy and clinical immunology 118(1):257-68, 2006 Jul - Who cited this? | PubMed ID: 16815164 | Fulltext

Peripheral myelin protein 22 is in complex with alpha6beta4 integrin, and its absence alters the Schwann cell basal lamina.

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Amici SA, Dunn WA, Murphy AJ, Adams NC, Gale NW, Valenzuela DM, Yancopoulos GD, and Notterpek L

The Journal of neuroscience : the official journal of the Society for Neuroscience 26(4):1179-89, 2006 Jan 25 - Who cited this? | PubMed ID: 16436605 | Fulltext

Leucine aminopeptidase is not essential for trimming peptides in the cytosol or generating epitopes for MHC class I antigen presentation.

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Towne CF, York IA, Neijssen J, Karow ML, Murphy AJ, Valenzuela DM, Yancopoulos GD, Neefjes JJ, and Rock KL

Journal of immunology (Baltimore, Md. : 1950) 175(10):6605-14, 2005 Nov 15 - Who cited this? | PubMed ID: 16272315 | Fulltext

Functional characterization of mouse RDH11 as a retinol dehydrogenase involved in dark adaptation in vivo.

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Kasus-Jacobi A, Ou J, Birch DG, Locke KG, Shelton JM, Richardson JA, Murphy AJ, Valenzuela DM, Yancopoulos GD, and Edwards AO

The Journal of biological chemistry 280(21):20413-20, 2005 May 27 - Who cited this? | PubMed ID: 15790565 | Fulltext

Lhx6 delineates a pathway mediating innate reproductive behaviors from the amygdala to the hypothalamus.

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Choi GB, Dong HW, Murphy AJ, Valenzuela DM, Yancopoulos GD, Swanson LW, and Anderson DJ

Neuron 46(4):647, 2005 May 19 - Who cited this? | PubMed ID: 15944132 | Fulltext

Resistance to diet-induced obesity in mice globally overexpressing OGH/GPB5.

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Macdonald LE, Wortley KE, Gowen LC, Anderson KD, Murray JD, Poueymirou WT, Simmons MV, Barber D, Valenzuela DM, Economides AN, Wiegand SJ, Yancopoulos GD, Sleeman MW, and Murphy AJ

Proceedings of the National Academy of Sciences of the United States of America 102(7):2496-501, 2005 Feb 15 - Who cited this? | PubMed ID: 15699348 | Fulltext

Haploinsufficiency of delta-like 4 ligand results in embryonic lethality due to major defects in arterial and vascular development.

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Gale NW, Dominguez MG, Noguera I, Pan L, Hughes V, Valenzuela DM, Murphy AJ, Adams NC, Lin HC, Holash J, Thurston G, and Yancopoulos GD

Proceedings of the National Academy of Sciences of the United States of America 101(45):15949-54, 2004 Nov 9 - Who cited this? | PubMed ID: 15520367 | Fulltext

High-throughput engineering of the mouse genome coupled with high-resolution expression analysis.

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Valenzuela DM, Murphy AJ, Frendewey D, Gale NW, Economides AN, Auerbach W, Poueymirou WT, Adams NC, Rojas J, Yasenchak J, Chernomorsky R, Boucher M, Elsasser AL, Esau L, Zheng J, Griffiths JA,

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Nature biotechnology 21(6):652-9, 2003 Jun - Who cited this? | PubMed ID: 12730667 | Fulltext

Identification of ubiquitin ligases required for skeletal muscle atrophy.

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Bodine SC, Latres E, Baumhueter S, Lai VK, Nunez L, Clarke BA, Poueymirou WT, Panaro FJ, Na E, Dharmarajan K, Pan ZQ, Valenzuela DM, DeChiara TM, Stitt TN, Yancopoulos GD, and Glass DJ

Science (New York, N.Y.) 294(5547):1704, 2001 Nov 23 - Who cited this? | PubMed ID: 11679633 | Fulltext

Ror2, encoding a receptor-like tyrosine kinase, is required for cartilage and growth plate development.

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DeChiara TM, Kimble RB, Poueymirou WT, Rojas J, Masiakowski P, Valenzuela DM, and Yancopoulos GD

Nature genetics 24(3):271-4, 2000 Mar - Who cited this? | PubMed ID: 10700181 | Fulltext

Dominant mutations in ROR2, encoding an orphan receptor tyrosine kinase, cause brachydactyly type B.

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Oldridge M, Fortuna AM, Maringa M, Propping P, Mansour S, Pollitt C, DeChiara TM, Kimble RB, Valenzuela DM, Yancopoulos GD, and Wilkie AO

Nature genetics 24(3):275-8, 2000 Mar - Who cited this? | PubMed ID: 10700182 | Fulltext

Angiopoietins 3 and 4: diverging gene counterparts in mice and humans.

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Valenzuela DM, Griffiths JA, Rojas J, Aldrich TH, Jones PF, Zhou H, McClain J, Copeland NG, Gilbert DJ, Jenkins NA, Huang T, Papadopoulos N, Maisonpierre PC, Davis S, and Yancopoulos GD

Proceedings of the National Academy of Sciences of the United States of America 96(5):1904-9, 1999 Mar 2 - Who cited this? | PubMed ID: 10051567 | Fulltext

Localization and regulation of MuSK at the neuromuscular junction.

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Bowen DC, Park JS, Bodine S, Stark JL, Valenzuela DM, Stitt TN, Yancopoulos GD, Lindsay RM, Glass DJ, and DiStefano PS

Developmental biology 199(2):309-19, 1998 Jul 15 - Who cited this? | PubMed ID: 9698449 | Fulltext

Political identification and perceptions of homelessness: attributed causality and attitudes on public policy.

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Pellegrini RJ, Queirolo SS, Monarrez VE, and Valenzuela DM

Psychological reports 80(3 Pt 2):1139-48, 1997 Jun - Who cited this? | PubMed ID: 9246880 | Fulltext

Eph receptors and ligands comprise two major specificity subclasses and are reciprocally compartmentalized during embryogenesis.

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Gale NW, Holland SJ, Valenzuela DM, Flenniken A, Pan L, Ryan TE, Henkemeyer M, Strebhardt K, Hirai H, Wilkinson DG, Pawson T, Davis S, and Yancopoulos GD

Neuron 17(1):9-19, 1996 Jul - Who cited this? | PubMed ID: 8755474 | Fulltext

The receptor tyrosine kinase MuSK is required for neuromuscular junction formation in vivo.

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DeChiara TM, Bowen DC, Valenzuela DM, Simmons MV, Poueymirou WT, Thomas S, Kinetz E, Compton DL, Rojas E, Park JS, Smith C, DiStefano PS, Glass DJ, Burden SJ, and Yancopoulos GD

Cell 85(4):501-12, 1996 May 17 - Who cited this? | PubMed ID: 8653786 | Fulltext

Agrin acts via a MuSK receptor complex.

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Glass DJ, Bowen DC, Stitt TN, Radziejewski C, Bruno J, Ryan TE, Gies DR, Shah S, Mattsson K, Burden SJ, DiStefano PS, Valenzuela DM, DeChiara TM, and Yancopoulos GD

Cell 85(4):513-23, 1996 May 17 - Who cited this? | PubMed ID: 8653787 | Fulltext

The receptor tyrosine kinase MuSK is required for neuromuscular junction formation and is a functional receptor for agrin.

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Glass DJ, DeChiara TM, Stitt TN, DiStefano PS, Valenzuela DM, and Yancopoulos GD

Cold Spring Harbor symposia on quantitative biology 61:435-44, 1996 - Who cited this? | PubMed ID: 9246472 | Fulltext

Identification of mammalian noggin and its expression in the adult nervous system.

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Valenzuela DM, Economides AN, Rojas E, Lamb TM, Nuñez L, Jones P, Lp NY, Espinosa R, Brannan CI, and Gilbert DJ

The Journal of neuroscience : the official journal of the Society for Neuroscience 15(9):6077-84, 1995 Sep - Who cited this? | PubMed ID: 7666191 | Fulltext

Receptor tyrosine kinase specific for the skeletal muscle lineage: expression in embryonic muscle, at the neuromuscular junction, and after injury.

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Valenzuela DM, Stitt TN, DiStefano PS, Rojas E, Mattsson K, Compton DL, Nuñez L, Park JS, Stark JL, and Gies DR

Neuron 15(3):573-84, 1995 Sep - Who cited this? | PubMed ID: 7546737 | Fulltext

Characterization of a rat gene, rMAL, encoding a protein with four hydrophobic domains in central and peripheral myelin.

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Schaeren-Wiemers N, Valenzuela DM, Frank M, and Schwab ME

The Journal of neuroscience : the official journal of the Society for Neuroscience 15(8):5753-64, 1995 Aug - Who cited this? | PubMed ID: 7643216 | Fulltext

Identification of new oligodendrocyte- and myelin-specific genes by a differential screening approach.

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Schaeren-Wiemers N, Schaefer C, Valenzuela DM, Yancopoulos GD, and Schwab ME

Journal of neurochemistry 65(1):10-22, 1995 Jul - Who cited this? | PubMed ID: 7790852 | Fulltext

Identification of full-length and truncated forms of Ehk-3, a novel member of the Eph receptor tyrosine kinase family.

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Valenzuela DM, Rojas E, Griffiths JA, Compton DL, Gisser M, Ip NY, Goldfarb M, and Yancopoulos GD

Oncogene 10(8):1573-80, 1995 Apr 20 - Who cited this? | PubMed ID: 7731712 | Fulltext

Genomic organization and chromosomal localization of the human and mouse genes encoding the alpha receptor component for ciliary neurotrophic factor.

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Valenzuela DM, Rojas E, Le Beau MM, Espinosa R, Brannan CI, McClain J, Masiakowski P, Ip NY, Copeland NG, and Jenkins NA

Genomics 25(1):157-63, 1995 Jan 1 - Who cited this? | PubMed ID: 7774913 | Fulltext

Alternative forms of rat TrkC with different functional capabilities.

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Valenzuela DM, Maisonpierre PC, Glass DJ, Rojas E, Nuñez L, Kong Y, Gies DR, Stitt TN, Ip NY, and Yancopoulos GD

Neuron 10(5):963-74, 1993 May - Who cited this? | PubMed ID: 8494647 | Fulltext

The receptor for ciliary neurotrophic factor.

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Davis S, Aldrich TH, Valenzuela DM, Wong VV, Furth ME, Squinto SP, and Yancopoulos GD

Science (New York, N.Y.) 253(5015):59-63, 1991 Jul 5 - Who cited this? | PubMed ID: 1648265 | Fulltext

trkB encodes a functional receptor for brain-derived neurotrophic factor and neurotrophin-3 but not nerve growth factor.

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Squinto SP, Stitt TN, Aldrich TH, Davis S, Bianco SM, Radziejewski C, Glass DJ, Masiakowski P, Furth ME, and Valenzuela DM

Cell 65(5):885-93, 1991 May 31 - Who cited this? | PubMed ID: 1710174 | Fulltext

Immunological identification and distribution of parathyroid hormone-like protein polypeptides in normal and malignant tissues.

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Kramer S, Reynolds FH, Castillo M, Valenzuela DM, Thorikay M, and Sorvillo JM

Endocrinology 128(4):1927-37, 1991 Apr - Who cited this? | PubMed ID: 2004611 | Fulltext

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