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Papers authored by Uto Y

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Downregulation of matrix metalloprotease-9 and urokinase plasminogen activator by TX-1877 results in decreased tumor growth and metastasis on xenograft model of rectal cancer.

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Miyake K, Shimada M, Nishioka M, Sugimoto K, Batmunkh E, Uto Y, Nagasawa H, and Hori H

Cancer chemotherapy and pharmacology 64(5):885-92, 2009 Oct - Who cited this? | PubMed ID: 19214512 | Fulltext

Design of a bioreductively-activated fluorescent pH probe for tumor hypoxia imaging.

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Nakata E, Yukimachi Y, Kariyazono H, Im S, Abe C, Uto Y, Maezawa H, Hashimoto T, Okamoto Y, and Hori H

Bioorganic & medicinal chemistry 17(19):6952-8, 2009 Oct 1 - Who cited this? | PubMed ID: 19736018 | Fulltext

Novel and potent inhibitors of stearoyl-CoA desaturase-1. Part I: Discovery of 3-(2-hydroxyethoxy)-4-methoxy-N-[5-(3-trifluoromethylbenzyl)thiazol-2-yl]benzamide.

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Uto Y, Ogata T, Harada J, Kiyotsuka Y, Ueno Y, Miyazawa Y, Kurata H, Deguchi T, Watanabe N, Takagi T, Wakimoto S, Okuyama R, Abe M, Kurikawa N, Kawamura S, Yamato M,

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Bioorganic & medicinal chemistry letters 19(15):4151-8, 2009 Aug 1 - Who cited this? | PubMed ID: 19540759 | Fulltext

Novel and potent inhibitors of stearoyl-CoA desaturase-1. Part II: Identification of 4-ethylamino-3-(2-hydroxyethoxy)-N-[5-(3-trifluoromethylbenzyl)thiazol-2-yl]benzamide and its biological evaluation.

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Uto Y, Ogata T, Kiyotsuka Y, Miyazawa Y, Ueno Y, Kurata H, Deguchi T, Yamada M, Watanabe N, Takagi T, Wakimoto S, Okuyama R, Konishi M, Kurikawa N, Kono K, and Osumi J

Bioorganic & medicinal chemistry letters 19(15):4159-66, 2009 Aug 1 - Who cited this? | PubMed ID: 19541482 | Fulltext

Correlation between antiangiogenic activity and antioxidant activity of various components from propolis.

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Ahn MR, Kunimasa K, Kumazawa S, Nakayama T, Kaji K, Uto Y, Hori H, Nagasawa H, and Ohta T

Molecular nutrition & food research 53(5):643-51, 2009 May - Who cited this? | PubMed ID: 19065585 | Fulltext

Artepillin C (ARC) in Brazilian green propolis selectively blocks oncogenic PAK1 signaling and suppresses the growth of NF tumors in mice.

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Messerli SM, Ahn MR, Kunimasa K, Yanagihara M, Tatefuji T, Hashimoto K, Mautner V, Uto Y, Hori H, Kumazawa S, Kaji K, Ohta T, and Maruta H

Phytotherapy research : PTR 23(3):423-7, 2009 Mar - Who cited this? | PubMed ID: 19003952 | Fulltext

A chemical biosynthesis design for an antiatherosclerosis drug by acyclic tocopherol intermediate analogue based on "isoprenomics".

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Uto Y, Koyama D, Otsuki M, Otomo N, Shirai T, Abe C, Nakata E, Nagasawa H, and Hori H

Advances in experimental medicine and biology 645:109-14, 2009 - Who cited this? | PubMed ID: 19227458 | Fulltext

Examination of nursing dependency for admission fee and measurement of nurses' work load for nursing care.

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Uto Y, Torigoe C, Mukaikubo S, and Kumamoto I

Studies in health technology and informatics 146:712, 2009 - Who cited this? | PubMed ID: 19592938 | Fulltext

The development of the nursing action master file.

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Nakanishi M, Tsuru S, Watanabe C, Inoue M, Uchiyama M, Kawamura S, Takami M, Ishigaki K, and Uto Y

Studies in health technology and informatics 146:771, 2009 - Who cited this? | PubMed ID: 19592971 | Fulltext

The novel hypoxic cell radiosensitizer, TX-1877 has antitumor activity through suppression of angiogenesis and inhibits liver metastasis on xenograft model of pancreatic cancer.

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Miyake K, Shimada M, Nishioka M, Sugimoto K, Batmunkh E, Uto Y, Nagasawa H, and Hori H

Cancer letters 272(2):325-35, 2008 Dec 18 - Who cited this? | PubMed ID: 18762366 | Fulltext

Synthesis and biological activity of 1-methyl-tryptophan-tirapazamine hybrids as hypoxia-targeting indoleamine 2,3-dioxygenase inhibitors.

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Nakashima H, Uto Y, Nakata E, Nagasawa H, Ikkyu K, Hiraoka N, Nakashima K, Sasaki Y, Sugimoto H, Shiro Y, Hashimoto T, Okamoto Y, Asakawa Y, and Hori H

Bioorganic & medicinal chemistry 16(18):8661-9, 2008 Sep 15 - Who cited this? | PubMed ID: 18715787 | Fulltext

TX-2152: a conformationally rigid and electron-rich diyne analogue of FTY720 with in vivo antiangiogenic activity.

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Nakayama S, Uto Y, Tanimoto K, Okuno Y, Sasaki Y, Nagasawa H, Nakata E, Arai K, Momose K, Fujita T, Hashimoto T, Okamoto Y, Asakawa Y, Goto S, and Hori H

Bioorganic & medicinal chemistry 16(16):7705-14, 2008 Aug 15 - Who cited this? | PubMed ID: 18678496 | Fulltext

Anti-inflammatory effects of a bioavailable compound, Artepillin C, in Brazilian propolis.

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Paulino N, Abreu SR, Uto Y, Koyama D, Nagasawa H, Hori H, Dirsch VM, Vollmar AM, Scremin A, and Bretz WA

European journal of pharmacology 587(1-3):296-301, 2008 Jun 10 - Who cited this? | PubMed ID: 18474366 | Fulltext

Design of antiangiogenic hypoxic cell radiosensitizers: 2-Nitroimidazoles containing a 2-aminomethylene-4-cyclopentene-1,3-dione moiety.

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Uto Y, Nagasawa H, Jin CZ, Nakayama S, Tanaka A, Kiyoi S, Nakashima H, Shimamura M, Inayama S, Fujiwara T, Takeuchi Y, Uehara Y, Kirk KL, Nakata E, and Hori H

Bioorganic & medicinal chemistry 16(11):6042-53, 2008 Jun 1 - Who cited this? | PubMed ID: 18474428 | Fulltext

Enhanced radical-scavenging activity of naturally-oriented artepillin C derivatives.

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Manda S, Nakanishi I, Ohkubo K, Uto Y, Kawashima T, Hori H, Fukuhara K, Okuda H, Ozawa T, Ikota N, Fukuzumi S, and Anzai K

Chemical communications (Cambridge, England)(5):626-8, 2008 Feb 7 - Who cited this? | PubMed ID: 18209811 | Fulltext

Design, synthesis, and radiosensitizing activities of sugar-hybrid hypoxic cell radiosensitizers.

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Nakae T, Uto Y, Tanaka M, Shibata H, Nakata E, Tominaga M, Maezawa H, Hashimoto T, Kirk KL, Nagasawa H, and Hori H

Bioorganic & medicinal chemistry 16(2):675-82, 2008 Jan 15 - Who cited this? | PubMed ID: 18029186 | Fulltext

Sequential aldol condensation catalyzed by hyperthermophilic 2-deoxy-d-ribose-5-phosphate aldolase.

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Sakuraba H, Yoneda K, Yoshihara K, Satoh K, Kawakami R, Uto Y, Tsuge H, Takahashi K, Hori H, and Ohshima T

Applied and environmental microbiology 73(22):7427-34, 2007 Nov - Who cited this? | PubMed ID: 17905878 | Fulltext

Suppression of tumor-induced angiogenesis by Brazilian propolis: major component artepillin C inhibits in vitro tube formation and endothelial cell proliferation.

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Ahn MR, Kunimasa K, Ohta T, Kumazawa S, Kamihira M, Kaji K, Uto Y, Hori H, Nagasawa H, and Nakayama T

Cancer letters 252(2):235-43, 2007 Jul 18 - Who cited this? | PubMed ID: 17343983 | Fulltext

The usefulness of mild temperature hyperthermia combined with continuous tirapazamine administration under reduced dose-rate irradiation with gamma-rays.

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Masunaga S, Nagasawa H, Uto Y, Hori H, Nagata K, Suzuki M, Kashino G, Kinashi Y, and Ono K

International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 23(1):29, 2007 Feb - Who cited this? | PubMed ID: 17575721 | Fulltext

Dependency of the effect of a vascular disrupting agent on sensitivity to tirapazamine and gamma-ray irradiation upon the timing of its administration and tumor size, with reference to the effect on intratumor quiescent cells.

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Masunaga S, Nagasawa H, Nagata K, Suzuki M, Uto Y, Hori H, Kinashi Y, and Ono K

Journal of cancer research and clinical oncology 133(1):47, 2007 Jan - Who cited this? | PubMed ID: 16924543 | Fulltext

Effect of molecular chirality and side chain bulkiness on angiogenesis of haloacetylcarbamoyl-2-nitroimidazole compounds.

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Ohkura K, Uto Y, Nagasawa H, and Hori H

Anticancer research 27(6A):3693-700, 2007 - Who cited this? | PubMed ID: 17970030 | Fulltext

Development of Hospital Data Warehouse for Cost Analysis of DPC Based on Medical Costs.

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Muranaga F, Kumamoto I, and Uto Y

Methods of information in medicine 46(6):679-85, 2007 - Who cited this? | PubMed ID: 18066419 | Fulltext

The usefulness of a continuous administration of tirapazamine combined with reduced dose-rate irradiation using {gamma}-rays or reactor thermal neutrons.

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Masunaga S, Sakurai Y, Nagata K, Suzuki M, Maruhashi A, Kinashi Y, Nagasawa H, Uto Y, Hori H, and Ono K

The British journal of radiology 79(948):991, 2006 Dec - Who cited this? | PubMed ID: 16916808 | Fulltext

Hypoxia accelerates cancer invasion of hepatoma cells by upregulating MMP expression in an HIF-1alpha-independent manner.

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Miyoshi A, Kitajima Y, Ide T, Ohtaka K, Nagasawa H, Uto Y, Hori H, and Miyazaki K

International journal of oncology 29(6):1533-9, 2006 Dec - Who cited this? | PubMed ID: 17088993 | Fulltext

Design of hypoxia-targeting drugs as new cancer chemotherapeutics.

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Nagasawa H, Uto Y, Kirk KL, and Hori H

Biological & pharmaceutical bulletin 29(12):2335-42, 2006 Dec - Who cited this? | PubMed ID: 17142959 | Fulltext

Artepillin C isoprenomics: design and synthesis of artepillin C isoprene analogues as lipid peroxidation inhibitor having low mitochondrial toxicity.

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Uto Y, Ae S, Koyama D, Sakakibara M, Otomo N, Otsuki M, Nagasawa H, Kirk KL, and Hori H

Bioorganic & medicinal chemistry 14(16):5721-8, 2006 Aug 15 - Who cited this? | PubMed ID: 16697207 | Fulltext

The usefulness of mild temperature hyperthermia combined with a newly developed hypoxia-oriented 10B conjugate compound, TX-2100, for boron neutron capture therapy.

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Masunaga S, Nagasawa H, Sakurai Y, Uto Y, Hori H, Nagata K, Suzuki M, Maruhashi A, Kinashi Y, and Ono K

International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 22(4):287-99, 2006 Jun - Who cited this? | PubMed ID: 16754350 | Fulltext

Evaluation of hypoxia-specific cytotoxic bioreductive agent-sodium borocaptate-10B conjugates as 10B-carriers in boron neutron capture therapy.

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Masunaga S, Nagasawa H, Gotoh K, Sakurai Y, Uto Y, Hori H, Nagata K, Suzuki M, Maruhashi A, Kinashi Y, and Ono K

Radiation medicine 24(2):98-107, 2006 Feb - Who cited this? | PubMed ID: 16715670 | Fulltext

Evaluation of hypoxic cell radio-sensitizers in terms of radio-sensitizing and repair-inhibiting potential. Dependency on p53 status of tumor cells and the effects on intratumor quiescent cells.

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Masunaga S, Uto Y, Nagasawa H, Hori H, Nagata K, Suzuki M, Kinashi Y, and Ono K

Anticancer research 26(2A):1261-70, 2006 - Who cited this? | PubMed ID: 16619533 | Fulltext

Artepillin C isoprenomics: design and synthesis of artepillin C analogues as antiatherogenic antioxidants.

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Uto Y, Ae S, Hotta A, Terao J, Nagasawa H, and Hori H

Advances in experimental medicine and biology 578:113-8, 2006 - Who cited this? | PubMed ID: 16927679 | Fulltext

Study on weighting of amount of nursing care using data on index of patient's need for nursing.

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Uto Y and Kumamoto I

Studies in health technology and informatics 122:372-5, 2006 - Who cited this? | PubMed ID: 17102282 | Fulltext

The role of Gc protein oligosaccharide structure as a risk factor for COPD.

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Ohkura K, Nagasawa H, Uto Y, Okamura N, Murakami A, and Hori H

Anticancer research 26(6A):4073-8, 2006 - Who cited this? | PubMed ID: 17195460 | Fulltext

Reevaluation of the radiosensitizing effects of sanazole and nimorazole in vitro and in vivo.

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Sugie C, Shibamoto Y, Ito M, Ogino H, Suzuki H, Uto Y, Nagasawa H, and Hori H

Journal of radiation research 46(4):453-9, 2005 Dec - Who cited this? | PubMed ID: 16394636 | Fulltext

TX-1877, a bifunctional hypoxic cell radiosensitizer, enhances anticancer host response: immune cell migration and nitric oxide production.

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Oshikawa T, Okamoto M, Ahmed SU, Furuichi S, Tano T, Sasai A, Kan S, Kasai S, Uto Y, Nagasawa H, Hori H, and Sato M

International journal of cancer. Journal international du cancer 116(4):571-8, 2005 Sep 10 - Who cited this? | PubMed ID: 15825172 | Fulltext

Combination of the antivascular agent ZD6126 with hypoxic cytotoxin treatment, with reference to the effect on quiescent tumor cells and the dependency on p53 status of tumor cells.

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Masunaga S, Nagasawa H, Uto Y, Hori H, Ohnishi K, Takahashi A, Ohnishi T, Suzuki M, Nagata K, Kinashi Y, and Ono K

Oncology reports 14(2):393, 2005 Aug - Who cited this? | PubMed ID: 16012721 | Fulltext

Napthalimidobenzamide DB-51630: a novel DNA binding agent inducing p300 gene expression and exerting a potent anti-cancer activity.

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Suzuki K, Nagasawa H, Uto Y, Sugimoto Y, Noguchi K, Wakida M, Wierzba K, Terada T, Asao T, Yamada Y, Kitazato K, and Hori H

Bioorganic & medicinal chemistry 13(12):4014-21, 2005 Jun 2 - Who cited this? | PubMed ID: 15911314 | Fulltext

The usefulness of continuous administration of hypoxic cytotoxin combined with mild temperature hyperthermia, with reference to effects on quiescent tumour cell populations.

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Masunaga S, Nagasawa H, Uto Y, Hori H, Suzuki M, Nagata K, Kinashi Y, and Ono K

International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 21(4):305, 2005 Jun - Who cited this? | PubMed ID: 16019857 | Fulltext

Study on weighting of amount of nursing care using data on index of patient's need for nursing and system approach.

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Uto Y and Kumamoto I

Journal of medical systems 29(2):165-77, 2005 Apr - Who cited this? | PubMed ID: 15931802 | Fulltext

Gc protein (vitamin D-binding protein): Gc genotyping and GcMAF precursor activity.

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Nagasawa H, Uto Y, Sasaki H, Okamura N, Murakami A, Kubo S, Kirk KL, and Hori H

Anticancer research 25(6A):3689-95, 2005 - Who cited this? | PubMed ID: 16302727 | Fulltext

The usefulness of 2-nitroimidazole-sodium borocaptate-10B conjugates as 10B-carriers in boron neutron capture therapy.

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Masunaga S, Nagasawa H, Hiraoka M, Sakurai Y, Uto Y, Hori H, Nagata K, Suzuki M, Maruhashi A, Kinashi Y, and Ono K

Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine 61(5):953-8, 2004 Nov - Who cited this? | PubMed ID: 15308174 | Fulltext

Angiogenesis inhibitor TX-1898: syntheses of the enantiomers of sterically diverse haloacetylcarbamoyl-2-nitroimidazole hypoxic cell radiosensitizers.

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Jin CZ, Nagasawa H, Shimamura M, Uto Y, Inayama S, Takeuchi Y, Kirk KL, and Hori H

Bioorganic & medicinal chemistry 12(18):4917-27, 2004 Sep 15 - Who cited this? | PubMed ID: 15336271 | Fulltext

Design of hypoxia-targeting protein tyrosine kinase inhibitor using an innovative pharmacophore 2-methylene-4-cyclopentene-1,3-dione.

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Hori H, Nagasawa H, Uto Y, Ohkura K, Kirk KL, Uehara Y, and Shimamura M

Biochimica et biophysica acta 1697(1-2):29-38, 2004 Mar 11 - Who cited this? | PubMed ID: 15023348 | Fulltext

Synthesis of the new mannosidase inhibitors, diversity-oriented 5-substituted swainsonine analogues, via stereoselective Mannich reaction.

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Fujita T, Nagasawa H, Uto Y, Hashimoto T, Asakawa Y, and Hori H

Organic letters 6(5):827-30, 2004 Mar 4 - Who cited this? | PubMed ID: 14986985 | Fulltext

Association of the macrophage activating factor (MAF) precursor activity with polymorphism in vitamin D-binding protein.

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Nagasawa H, Sasaki H, Uto Y, Kubo S, and Hori H

Anticancer research 24(5C):3361-6, 2004 - Who cited this? | PubMed ID: 15515432 | Fulltext

Applicability of the 2-nitroimidazole-sodium borocaptate-10B conjugate, TX-2060, as a 10B-carrier in boron neutron capture therapy.

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Masunaga S, Nagasawa H, Hiraoka M, Sakurai Y, Uto Y, Hori H, Nagata K, Suzuki M, Maruhashi A, Kinashi Y, and Ono K

Anticancer research 24(5A):2975-83, 2004 - Who cited this? | PubMed ID: 15517904 | Fulltext

Antiangiogenic hypoxic cytotoxin TX-402 inhibits hypoxia-inducible factor 1 signaling pathway.

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Nagasawa H, Mikamo N, Nakajima Y, Matsumoto H, Uto Y, and Hori H

Anticancer research 23(6a):4427 - Who cited this? | PubMed ID: 14666730 | Fulltext

Efficient radical scavenging ability of artepillin C, a major component of Brazilian propolis, and the mechanism.

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Nakanishi I, Uto Y, Ohkubo K, Miyazaki K, Yakumaru H, Urano S, Okuda H, Ueda J, Ozawa T, Fukuhara K, Fukuzumi S, Nagasawa H, Hori H, and Ikota N

Organic & biomolecular chemistry 1(9):1452-4, 2003 May 7 - Who cited this? | PubMed ID: 12926271 | Fulltext

A novel hypoxia-dependent 2-nitroimidazole KIN-841 inhibits tumour-specific angiogenesis by blocking production of angiogenic factors.

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Shimamura M, Nagasawa H, Ashino H, Yamamoto Y, Hazato T, Uto Y, Hori H, and Inayama S

British journal of cancer 88(2):307-13, 2003 Jan 27 - Who cited this? | PubMed ID: 12610518 | Fulltext

Gc protein-derived macrophage activating factor (GcMAF): isoelectric focusing pattern and tumoricidal activity.

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Mohamad SB, Nagasawa H, Sasaki H, Uto Y, Nakagawa Y, Kawashima K, and Hori H

Anticancer research 23(6a):4451-7, 2003 - Who cited this? | PubMed ID: 14666733 | Fulltext

Characterization of human Gc protein-derived macrophage activation factor (GcMAF) and its functional role in macrophage tumoricidal activity.

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Mohamad SB, Hori H, Nagasawa H, Usui K, and Uto Y

Advances in experimental medicine and biology 510:77-82, 2003 - Who cited this? | PubMed ID: 12580408 | Fulltext

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