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Papers authored by Tuddenham EG

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Structural analysis of eight novel and 112 previously reported missense mutations in the interactive FXI mutation database reveals new insight on FXI deficiency.

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Saunders RE, Shiltagh N, Gomez K, Mellars G, Cooper C, Perry DJ, Tuddenham EG, and Perkins SJ

Thrombosis and haemostasis 102(2):287-301, 2009 Aug - Who cited this? | PubMed ID: 19652879 | Fulltext

Optimizing warfarin reversal--an ex vivo study.

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Gatt A, Riddell A, van Veen JJ, Kitchen S, Tuddenham EG, and Makris M

Journal of thrombosis and haemostasis : JTH 7(7):1123-7, 2009 Jul - Who cited this? | PubMed ID: 19575759 | Fulltext

Alpha1-antitrypsin Pittsburgh in a family with bleeding tendency.

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Hua B, Fan L, Liang Y, Zhao Y, and Tuddenham EG

Haematologica 94(6):881-4, 2009 Jun - Who cited this? | PubMed ID: 19483159 | Fulltext

Consensus protocol for the use of recombinant activated factor VII [eptacog alfa (activated); NovoSeven] in elective orthopaedic surgery in haemophilic patients with inhibitors.

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Giangrande PL, Wilde JT, Madan B, Ludlam CA, Tuddenham EG, Goddard NJ, Dolan G, and Ingerslev J

Haemophilia : the official journal of the World Federation of Hemophilia 15(2):501-8, 2009 Mar - Who cited this? | PubMed ID: 19187194 | Fulltext

Killing 2 birds with 1 stone.

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Tuddenham EG

Blood 112(7):2595, 2008 Oct 1 - Who cited this? | PubMed ID: 18809765 | Fulltext

Consideration of platelet function disorders in patients with reduced VWF levels.

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Millar CM, Riddell AF, and Tuddenham EG

Haemophilia : the official journal of the World Federation of Hemophilia 14(5):1131-2, 2008 Sep - Who cited this? | PubMed ID: 18665850 | Fulltext

Autosomal dominant erythrocytosis and pulmonary arterial hypertension associated with an activating HIF2{alpha} mutation.

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Gale DP, Harten SK, Reid CD, Tuddenham EG, and Maxwell PH

Blood 112(3):919-21, 2008 Aug 1 - Who cited this? | PubMed ID: 18650473 | Fulltext

Genetic aspects and research development in haemostasis.

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Tuddenham EG, Ingerslev J, Sørensen LN, Christiansen K, Mariani G, Peyvandi F, Waddington SN, Buckley SM, Kochanek S, Chuah MK, Vandendriessche T, and Berntorp E

Haemophilia : the official journal of the World Federation of Hemophilia 14 Suppl 3:113-8, 2008 Jul - Who cited this? | PubMed ID: 18510530 | Fulltext

Therapeutic shoulder arthroscopy in patients with clotting disorders.

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Thomas JM, Tuddenham EG, and Ahrens PM

Haemophilia : the official journal of the World Federation of Hemophilia 14(4):859-61, 2008 Jul - Who cited this? | PubMed ID: 18422609 | Fulltext

Genotype-phenotype correlation in combined deficiency of factor V and factor VIII.

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Zhang B, Spreafico M, Zheng C, Yang A, Platzer P, Callaghan MU, Avci Z, Ozbek N, Mahlangu J, Haw T, Kaufman RJ, Marchant K, Tuddenham EG, Seligsohn U, Peyvandi F, and Ginsburg D

Blood 111(12):5592-600, 2008 Jun 15 - Who cited this? | PubMed ID: 18391077 | Fulltext

Safe and efficient transduction of the liver after peripheral vein infusion of self-complementary AAV vector results in stable therapeutic expression of human FIX in nonhuman primates.

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Nathwani AC, Gray JT, McIntosh J, Ng CY, Zhou J, Spence Y, Cochrane M, Gray E, Tuddenham EG, and Davidoff AM

Blood 109(4):1414-21, 2007 Feb 15 - Who cited this? | PubMed ID: 17090654 | Fulltext

Identification of factor IX mutations in Iranian haemophilia B patients by SSCP and sequencing.

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Karimipoor M, Zeinali S, Nafissi N, Tuddenham EG, Lak M, and Safaee R

Thrombosis research 120(1):135-9, 2007 - Who cited this? | PubMed ID: 17014892 | Fulltext

Postinjury vascular intimal hyperplasia in mice is completely inhibited by CD34+ bone marrow-derived progenitor cells expressing membrane-tethered anticoagulant fusion proteins.

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Chen D, Weber M, Shiels PG, Dong R, Webster Z, McVey JH, Kemball-Cook G, Tuddenham EG, Lechler RI, and Dorling A

Journal of thrombosis and haemostasis : JTH 4(10):2191-8, 2006 Oct - Who cited this? | PubMed ID: 16803463 | Fulltext

Detection of functional differences between different platelet membrane glycoprotein Ibalpha variable number tandem repeat and Kozak genotypes as shown by the PFA-100 system.

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Douglas H, Davies GJ, Michaelides K, Gorog DA, Timlin H, Ahmed N, and Tuddenham EG

Heart (British Cardiac Society) 92(5):676-8, 2006 May - Who cited this? | PubMed ID: 16614281 | Fulltext

Self-complementary adeno-associated virus vectors containing a novel liver-specific human factor IX expression cassette enable highly efficient transduction of murine and nonhuman primate liver.

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Nathwani AC, Gray JT, Ng CY, Zhou J, Spence Y, Waddington SN, Tuddenham EG, Kemball-Cook G, McIntosh J, Boon-Spijker M, Mertens K, and Davidoff AM

Blood 107(7):2653-61, 2006 Apr 1 - Who cited this? | PubMed ID: 16322469 | Fulltext

Combined deficiency of factor V and factor VIII is due to mutations in either LMAN1 or MCFD2.

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Zhang B, McGee B, Yamaoka JS, Guglielmone H, Downes KA, Minoldo S, Jarchum G, Peyvandi F, de Bosch NB, Ruiz-Saez A, Chatelain B, Olpinski M, Bockenstedt P, Sperl W, Kaufman RJ, Nichols WC,

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Blood 107(5):1903-7, 2006 Mar 1 - Who cited this? | PubMed ID: 16304051 | Fulltext

Live birth following the first mutation specific pre-implantation genetic diagnosis for haemophilia A.

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Michaelides K, Tuddenham EG, Turner C, Lavender B, and Lavery SA

Thrombosis and haemostasis 95(2):373-9, 2006 Feb - Who cited this? | PubMed ID: 16493501 | Fulltext

Ways to bypass a blocked tenase complex.

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Tuddenham EG

Thrombosis and haemostasis 95(1):1-2, 2006 Jan - Who cited this? | PubMed ID: 16543953 | Fulltext

A common ancestral glycoprotein (GP) 9 1828A>G (Asn45Ser) gene mutation occurring in European families from Australia and Northern Europe with Bernard-Soulier Syndrome (BSS).

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Liang HP, Morel-Kopp MC, Clemetson JM, Clemetson KJ, Kekomaki R, Kroll H, Michaelides K, Tuddenham EG, Vanhoorelbeke K, and Ward CM

Thrombosis and haemostasis 94(3):599-605, 2005 Sep - Who cited this? | PubMed ID: 16268478 | Fulltext

A novel missense mutation in ABCA1 results in altered protein trafficking and reduced phosphatidylserine translocation in a patient with Scott syndrome.

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Albrecht C, McVey JH, Elliott JI, Sardini A, Kasza I, Mumford AD, Naoumova RP, Tuddenham EG, Szabo K, and Higgins CF

Blood 106(2):542-9, 2005 Jul 15 - Who cited this? | PubMed ID: 15790791 | Fulltext

Gene therapy for hemophilia? Gene therapy for hemophilia is both desirable and achievable in the near future.

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Tuddenham EG

Journal of thrombosis and haemostasis : JTH 3(6):1314, 2005 Jun - Who cited this? | PubMed ID: 15946224 | Fulltext

Characterisation of blood coagulation factor XI T475I.

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McVey JH, Lal K, Imanaka Y, Kemball-Cook G, Bolton-Maggs PH, and Tuddenham EG

Thrombosis and haemostasis 93(6):1082-8, 2005 Jun - Who cited this? | PubMed ID: 15968392 | Fulltext

Factor VII and cardiovascular risk.

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Tuddenham EG

Thrombosis and haemostasis 93(2):189, 2005 Feb - Who cited this? | PubMed ID: 15711730 | Fulltext

Pharmacodynamic resistance to warfarin associated with a Val66Met substitution in vitamin K epoxide reductase complex subunit 1.

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Harrington DJ, Underwood S, Morse C, Shearer MJ, Tuddenham EG, and Mumford AD

Thrombosis and haemostasis 93(1):23-6, 2005 Jan - Who cited this? | PubMed ID: 15630486 | Fulltext

Complete inhibition of acute humoral rejection using regulated expression of membrane-tethered anticoagulants on xenograft endothelium.

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Chen D, Weber M, McVey JH, Kemball-Cook G, Tuddenham EG, Lechler RI, and Dorling A

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 4(12):1958-63, 2004 Dec - Who cited this? | PubMed ID: 15575897 | Fulltext

Permanent phenotypic correction of hemophilia B in immunocompetent mice by prenatal gene therapy.

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Waddington SN, Nivsarkar MS, Mistry AR, Buckley SM, Kemball-Cook G, Mosley KL, Mitrophanous K, Radcliffe P, Holder MV, Brittan M, Georgiadis A, Al-Allaf F, Bigger BW, Gregory LG, Cook HT, Ali RR,

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Blood 104(9):2714-21, 2004 Nov 1 - Who cited this? | PubMed ID: 15231566 | Fulltext

Two novel mutations in severe factor VII deficiency.

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Gomez K, Laffan MA, Kemball-Cook G, Pasi J, Layton M, Singer JD, Tuddenham EG, and McVey JH

British journal of haematology 126(1):105-10, 2004 Jul - Who cited this? | PubMed ID: 15198740 | Fulltext

Prospects for gene therapy of haemophilia.

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Nathwani AC, Davidoff AM, and Tuddenham EG

Haemophilia : the official journal of the World Federation of Hemophilia 10(4):309-18, 2004 Jul - Who cited this? | PubMed ID: 15230943 | Fulltext

Functional characterization of factor V-Ile359Thr: a novel mutation associated with thrombosis.

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Steen M, Norstrøm EA, Tholander AL, Bolton-Maggs PH, Mumford A, McVey JH, Tuddenham EG, and Dahlbäck B

Blood 103(9):3381-7, 2004 May 1 - Who cited this? | PubMed ID: 14695241 | Fulltext

Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2.

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Rost S, Fregin A, Ivaskevicius V, Conzelmann E, Hörtnagel K, Pelz HJ, Lappegard K, Seifried E, Scharrer I, Tuddenham EG, Müller CR, Strom TM, and Oldenburg J

Nature 427(6974):537-41, 2004 Feb 5 - Who cited this? | PubMed ID: 14765194 | Fulltext

Characterisation of lymphocyte responses to Ca2+ in Scott syndrome.

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Elliott JI, Mumford AD, Albrecht C, Collins PW, Giddings JC, Higgins CF, Tuddenham EG, and McVey JH

Thrombosis and haemostasis 91(2):412-5, 2004 Feb - Who cited this? | PubMed ID: 14961172 | Fulltext

Factor V I359T: a novel mutation associated with thrombosis and resistance to activated protein C.

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Mumford AD, McVey JH, Morse CV, Gomez K, Steen M, Norstrom EA, Tuddenham EG, Dahlback B, and Bolton-Maggs PH

British journal of haematology 123(3):496-501, 2003 Nov - Who cited this? | PubMed ID: 14617013 | Fulltext

Factor Xa and thrombin, but not factor VIIa, elicit specific cellular responses in dermal fibroblasts.

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Bachli EB, Pech CM, Johnson KM, Johnson DJ, Tuddenham EG, and McVey JH

Journal of thrombosis and haemostasis : JTH 1(9):1935-44, 2003 Sep - Who cited this? | PubMed ID: 12941034 | Fulltext

450 million years of hemostasis.

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Davidson CJ, Tuddenham EG, and McVey JH

Journal of thrombosis and haemostasis : JTH 1(7):1487-94, 2003 Jul - Who cited this? | PubMed ID: 12871284 | Fulltext

Bleeding due to disruption of a cargo-specific ER-to-Golgi transport complex.

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Zhang B, Cunningham MA, Nichols WC, Bernat JA, Seligsohn U, Pipe SW, McVey JH, Schulte-Overberg U, de Bosch NB, Ruiz-Saez A, White GC, Tuddenham EG, Kaufman RJ, and Ginsburg D

Nature genetics 34(2):220-5, 2003 Jun - Who cited this? | PubMed ID: 12717434 | Fulltext

In search of the eighth factor: a personal reminiscence.

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Tuddenham EG

Journal of thrombosis and haemostasis : JTH 1(3):403-9, 2003 Mar - Who cited this? | PubMed ID: 12871437 | Fulltext

Molecular evolution of the vertebrate blood coagulation network.

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Davidson CJ, Hirt RP, Lal K, Snell P, Elgar G, Tuddenham EG, and McVey JH

Thrombosis and haemostasis 89(3):420-8, 2003 Mar - Who cited this? | PubMed ID: 12624623 | Fulltext

Analysis of the consequences of premature termination codons within factor VIII coding sequences.

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David D, Santos IM, Johnson K, Tuddenham EG, and McVey JH

Journal of thrombosis and haemostasis : JTH 1(1):139-46, 2003 Jan - Who cited this? | PubMed ID: 12871551 | Fulltext

Factor VIII - novel insights into form and function.

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Saenko EL, Ananyeva NM, Tuddenham EG, and Kemball-Cook G

British journal of haematology 119(2):323-31, 2002 Nov - Who cited this? | PubMed ID: 12406064 | Fulltext

Use of a non-depleting anti-CD4 antibody to modulate the immune response to coagulation factors VIII and IX.

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Salooja N, Kemball-Cook G, Tuddenham EG, and Dyson J

British journal of haematology 118(3):839-42, 2002 Sep - Who cited this? | PubMed ID: 12181056 | Fulltext

Platelet membrane glycoprotein Ibalpha gene -5T/C Kozak sequence polymorphism as an independent risk factor for the occurrence of coronary thrombosis.

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Douglas H, Michaelides K, Gorog DA, Durante-Mangoni E, Ahmed N, Davies GJ, and Tuddenham EG

Heart (British Cardiac Society) 87(1):70-4, 2002 Jan - Who cited this? | PubMed ID: 11751671 | Fulltext

Human thrombin and FXa mediate porcine endothelial cell activation; modulation by expression of TFPI-CD4 and hirudin-CD4 fusion proteins.

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Chen D, Riesbeck K, McVey JH, Kemball-Cook G, Tuddenham EG, Lechler RI, and Dorling A

Xenotransplantation 8(4):258-65, 2001 Nov - Who cited this? | PubMed ID: 11737851 | Fulltext

The hemophilias--from royal genes to gene therapy.

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Mannucci PM and Tuddenham EG

The New England journal of medicine 344(23):1773-9, 2001 Jun 7 - Who cited this? | PubMed ID: 11396445 | Fulltext

Stable recombinant expression and characterization of the two haemophilic factor VIII variants C329S (CRM(-)) and G1948D (CRM(r)).

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David D, Saenko EL, Santos IM, Johnson DJ, Tuddenham EG, McVey JH, and Kemball-Cook G

British journal of haematology 113(3):604-15, 2001 Jun - Who cited this? | PubMed ID: 11380445 | Fulltext

Factor VII deficiency and the FVII mutation database.

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McVey JH, Boswell E, Mumford AD, Kemball-Cook G, and Tuddenham EG

Human mutation 17(1):3-17, 2001 - Who cited this? | PubMed ID: 11139238 | Fulltext

Molecular analysis of the genotype-phenotype relationship in factor VII deficiency.

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Millar DS, Kemball-Cook G, McVey JH, Tuddenham EG, Mumford AD, Attock GB, Reverter JC, Lanir N, Parapia LA, Reynaud J, Meili E, von Felton A, Martinowitz U, Prangnell DR, Krawczak M, and Cooper DN

Human genetics 107(4):327-42, 2000 Oct - Who cited this? | PubMed ID: 11129332 | Fulltext

An alloantibody recognizing the FVIII A1 domain in a patient with CRM reduced haemophilia A due to deletion of a large portion of the A1 domain DNA sequence.

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Shibata M, Shima M, Morichika S, McVey J, Tuddenham EG, Tanaka I, Suzuki H, Nogami K, Minamoto Y, Hato T, Saenko EL, Scandella D, and Yoshioka A

Thrombosis and haemostasis 84(3):442-8, 2000 Sep - Who cited this? | PubMed ID: 11019969 | Fulltext

Regulated endothelial cell expression of novel anticoagulants: a strategy for the prevention and therapy of intravascular thrombosis.

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Dorling A, Chen D, Riesbeck K, McVey J, Kemball-Cook G, Tuddenham EG, and Lechler RI

Transplantation proceedings 32(5):971, 2000 Aug - Who cited this? | PubMed ID: 10936303 | Fulltext

Crystal structure of active site-inhibited human coagulation factor VIIa (des-Gla).

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Kemball-Cook G, Johnson DJ, Tuddenham EG, and Harlos K

Journal of structural biology 127(3):213-23, 1999 Oct - Who cited this? | PubMed ID: 10544046 | Fulltext

Regulated inhibition of coagulation by porcine endothelial cells expressing P-selectin-tagged hirudin and tissue factor pathway inhibitor fusion proteins.

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Chen D, Riesbeck K, McVey JH, Kemball-Cook G, Tuddenham EG, Lechler RI, and Dorling A

Transplantation 68(6):832-9, 1999 Sep 27 - Who cited this? | PubMed ID: 10515384 | Fulltext

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