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Papers authored by Tortorella D

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TRAM1 Participates in Human Cytomegalovirus US2- and US11-mediated Dislocation of an Endoplasmic Reticulum Membrane Glycoprotein.

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Oresic K, Ng CL, and Tortorella D

The Journal of biological chemistry 284(9):5905-14, 2009 Feb 27 - Who cited this? | PubMed ID: 19121997 | Fulltext

Human cytomegalovirus-encoded immune modulators partner to downregulate major histocompatibility complex class I molecules.

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Noriega VM and Tortorella D

Journal of virology 83(3):1359-67, 2009 Feb - Who cited this? | PubMed ID: 19004944 | Fulltext

Cln6 mutants associated with neuronal ceroid lipofuscinosis are degraded in a proteasome dependent manner.

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Oresic K, Mueller B, and Tortorella D

Bioscience reports, 2008 Sep 24 - Who cited this? | PubMed ID: 18811591 | Fulltext

Endoplasmic reticulum chaperones participate in human cytomegalovirus US2-mediated degradation of class I major histocompatibility complex molecules.

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Oresic K and Tortorella D

The Journal of general virology 89(Pt 5):1122, 2008 May - Who cited this? | PubMed ID: 18420789 | Fulltext

A bipartite trigger for dislocation directs the proteasomal degradation of an endoplasmic reticulum membrane glycoprotein.

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Noriega VM and Tortorella D

The Journal of biological chemistry 283(7):4031-43, 2008 Feb 15 - Who cited this? | PubMed ID: 18086679 | Fulltext

Cold neutron energy dependent production of ultracold neutrons in solid deuterium.

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Atchison F, Blau B, Bodek K, van den Brandt B, Bryś T, Daum M, Fierlinger P, Frei A, Geltenbort P, Hautle P, Henneck R, Heule S, Holley A, Kasprzak M, Kirch K, Knecht A,

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Physical review letters 99(26):262502, 2007 Dec 28 - Who cited this? | PubMed ID: 18233572 | Fulltext

Dislocation of an endoplasmic reticulum membrane glycoprotein involves the formation of partially dislocated ubiquitinated polypeptides.

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Baker BM and Tortorella D

The Journal of biological chemistry 282(37):26845-56, 2007 Sep 14 - Who cited this? | PubMed ID: 17650499 | Fulltext

A structural determinant of human cytomegalovirus US2 dictates the down-regulation of class I major histocompatibility molecules.

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Oresic K, Noriega V, Andrews L, and Tortorella D

The Journal of biological chemistry 281(28):19395-406, 2006 Jul 14 - Who cited this? | PubMed ID: 16687410 | Fulltext

Signal peptide peptidase is required for dislocation from the endoplasmic reticulum.

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Loureiro J, Lilley BN, Spooner E, Noriega V, Tortorella D, and Ploegh HL

Nature 441(7095):894-7, 2006 Jun 15 - Who cited this? | PubMed ID: 16738546 | Fulltext

Cotranslational endoplasmic reticulum assembly of FcepsilonRI controls the formation of functional IgE-binding receptors.

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Fiebiger E, Tortorella D, Jouvin MH, Kinet JP, and Ploegh HL

The Journal of experimental medicine 201(2):267-77, 2005 Jan 17 - Who cited this? | PubMed ID: 15642744 | Fulltext

Dissection of the dislocation pathway for type I membrane proteins with a new small molecule inhibitor, eeyarestatin.

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Fiebiger E, Hirsch C, Vyas JM, Gordon E, Ploegh HL, and Tortorella D

Molecular biology of the cell 15(4):1635, 2004 Apr - Who cited this? | PubMed ID: 14767067 | Fulltext

A glycosylated type I membrane protein becomes cytosolic when peptide: N-glycanase is compromised.

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Blom D, Hirsch C, Stern P, Tortorella D, and Ploegh HL

The EMBO journal 23(3):650-8, 2004 Feb 11 - Who cited this? | PubMed ID: 14749736 | Fulltext

Ubiquitinylation of the cytosolic domain of a type I membrane protein is not required to initiate its dislocation from the endoplasmic reticulum.

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Furman MH, Loureiro J, Ploegh HL, and Tortorella D

The Journal of biological chemistry 278(37):34804-11, 2003 Sep 12 - Who cited this? | PubMed ID: 12832421 | Fulltext

Dislocation of a type I membrane protein requires interactions between membrane-spanning segments within the lipid bilayer.

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Lilley BN, Tortorella D, and Ploegh HL

Molecular biology of the cell 14(9):3690, 2003 Sep - Who cited this? | PubMed ID: 12972557 | Fulltext

Protein unfolding is not a prerequisite for endoplasmic reticulum-to-cytosol dislocation.

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Tirosh B, Furman MH, Tortorella D, and Ploegh HL

The Journal of biological chemistry 278(9):6664-72, 2003 Feb 28 - Who cited this? | PubMed ID: 12482753 | Fulltext

The human cytomegalovirus US10 gene product delays trafficking of major histocompatibility complex class I molecules.

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Furman MH, Dey N, Tortorella D, and Ploegh HL

Journal of virology 76(22):11753-6, 2002 Nov - Who cited this? | PubMed ID: 12388737 | Fulltext

Human cytomegalovirus gene products US2 and US11 differ in their ability to attack major histocompatibility class I heavy chains in dendritic cells.

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Rehm A, Engelsberg A, Tortorella D, Körner IJ, Lehmann I, Ploegh HL, and Höpken UE

Journal of virology 76(10):5043-50, 2002 May - Who cited this? | PubMed ID: 11967320 | Fulltext

US2, a human cytomegalovirus-encoded type I membrane protein, contains a non-cleavable amino-terminal signal peptide.

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Gewurz BE, Ploegh HL, and Tortorella D

The Journal of biological chemistry 277(13):11306-13, 2002 Mar 29 - Who cited this? | PubMed ID: 11790769 | Fulltext

Visualization of the ER-to-cytosol dislocation reaction of a type I membrane protein.

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Fiebiger E, Story C, Ploegh HL, and Tortorella D

The EMBO journal 21(5):1041-53, 2002 Mar 1 - Who cited this? | PubMed ID: 11867532 | Fulltext

Membrane-specific, host-derived factors are required for US2- and US11-mediated degradation of major histocompatibility complex class I molecules.

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Furman MH, Ploegh HL, and Tortorella D

The Journal of biological chemistry 277(5):3258-67, 2002 Feb 1 - Who cited this? | PubMed ID: 11717308 | Fulltext

Extended peptide-based inhibitors efficiently target the proteasome and reveal overlapping specificities of the catalytic beta-subunits.

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Kessler BM, Tortorella D, Altun M, Kisselev AF, Fiebiger E, Hekking BG, Ploegh HL, and Overkleeft HS

Chemistry & biology 8(9):913, 2001 Sep - Who cited this? | PubMed ID: 11564559 | Fulltext

Virus subversion of immunity: a structural perspective.

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Gewurz BE, Gaudet R, Tortorella D, Wang EW, and Ploegh HL

Current opinion in immunology 13(4):442-50, 2001 Aug - Who cited this? | PubMed ID: 11498300 | Fulltext

Antigen presentation subverted: Structure of the human cytomegalovirus protein US2 bound to the class I molecule HLA-A2.

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Gewurz BE, Gaudet R, Tortorella D, Wang EW, Ploegh HL, and Wiley DC

Proceedings of the National Academy of Sciences of the United States of America 98(12):6794-9, 2001 Jun 5 - Who cited this? | PubMed ID: 11391001 | Fulltext

Human cytomegalovirus US2 endoplasmic reticulum-lumenal domain dictates association with major histocompatibility complex class I in a locus-specific manner.

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Gewurz BE, Wang EW, Tortorella D, Schust DJ, and Ploegh HL

Journal of virology 75(11):5197-204, 2001 Jun - Who cited this? | PubMed ID: 11333901 | Fulltext

Signal peptide cleavage of a type I membrane protein, HCMV US11, is dependent on its membrane anchor.

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Rehm A, Stern P, Ploegh HL, and Tortorella D

The EMBO journal 20(7):1573-82, 2001 Apr 2 - Who cited this? | PubMed ID: 11285222 | Fulltext

Down-regulation of MHC class I antigen presentation by HCMV; lessons for tumor immunology.

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Tortorella D, Gewurz B, Schust D, Furman M, and Ploegh H

Immunological investigations 29(2):97-100, 2000 May - Who cited this? | PubMed ID: 10854174 | Fulltext

Viral subversion of the immune system.

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Tortorella D, Gewurz BE, Furman MH, Schust DJ, and Ploegh HL

Annual review of immunology 18:861-926, 2000 - Who cited this? | PubMed ID: 10837078 | Fulltext

Viral immunoevasive strategies and trophoblast class I major histocompatibility complex antigens.

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Schust DJ, Tortorella D, and Ploegh HL

Journal of reproductive immunology 43(2):243-51, 1999 Jul - Who cited this? | PubMed ID: 10479060 | Fulltext

HLA-G and HLA-C at the feto-maternal interface: lessons learned from pathogenic viruses.

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Schust DJ, Tortorella D, and Ploegh HL

Seminars in cancer biology 9(1):37-46, 1999 Feb - Who cited this? | PubMed ID: 10092549 | Fulltext

Trophoblast class I major histocompatibility complex (MHC) products are resistant to rapid degradation imposed by the human cytomegalovirus (HCMV) gene products US2 and US11.

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Schust DJ, Tortorella D, Seebach J, Phan C, and Ploegh HL

The Journal of experimental medicine 188(3):497-503, 1998 Aug 3 - Who cited this? | PubMed ID: 9687527 | Fulltext

Dislocation of type I membrane proteins from the ER to the cytosol is sensitive to changes in redox potential.

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Tortorella D, Story CM, Huppa JB, Wiertz EJ, Jones TR, Bacik I, Bennink JR, Yewdell JW, and Ploegh HL

The Journal of cell biology 142(2):365-76, 1998 Jul 27 - Who cited this? | PubMed ID: 9679137 | Fulltext

Covalent modification of the active site threonine of proteasomal beta subunits and the Escherichia coli homolog HslV by a new class of inhibitors.

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Bogyo M, McMaster JS, Gaczynska M, Tortorella D, Goldberg AL, and Ploegh H

Proceedings of the National Academy of Sciences of the United States of America 94(13):6629-34, 1997 Jun 24 - Who cited this? | PubMed ID: 9192616 | Fulltext

Cytomegaloviruses use multiple mechanisms to elude the host immune response.

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Wiertz E, Hill A, Tortorella D, and Ploegh H

Immunology letters 57(1-3):213-6, 1997 Jun 1 - Who cited this? | PubMed ID: 9232454 | Fulltext

Sec61-mediated transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destruction.

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Wiertz EJ, Tortorella D, Bogyo M, Yu J, Mothes W, Jones TR, Rapoport TA, and Ploegh HL

Nature 384(6608):432-8, 1996 Dec 5 - Who cited this? | PubMed ID: 8945469 | Fulltext

Immunochemical analysis of the structure of diphtheria toxin shows all three domains undergo structural changes at low pH.

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Tortorella D, Sesardic D, Dawes CS, and London E

The Journal of biological chemistry 270(46):27439-45, 1995 Nov 17 - Who cited this? | PubMed ID: 7499200 | Fulltext

Immunochemical analysis shows all three domains of diphtheria toxin penetrate across model membranes.

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Tortorella D, Sesardic D, Dawes CS, and London E

The Journal of biological chemistry 270(46):27446-52, 1995 Nov 17 - Who cited this? | PubMed ID: 7499201 | Fulltext

Method for efficient pelleting of small unilamellar model membrane vesicles.

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Tortorella D and London E

Analytical biochemistry 217(2):176-80, 1994 Mar - Who cited this? | PubMed ID: 8203744 | Fulltext

Simple centrifugation method for efficient pelleting of both small and large unilamellar vesicles that allows convenient measurement of protein binding.

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Tortorella D, Ulbrandt ND, and London E

Biochemistry 32(35):9181-8, 1993 Sep 7 - Who cited this? | PubMed ID: 8369285 | Fulltext

Insights into membrane protein folding and translocation from the behavior of bacterial toxins: models for membrane translocation.

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London E, Ulbrandt ND, Tortorella D, Jiang JX, and Abrams FS

Society of General Physiologists series 48:45-61, 1993 - Who cited this? | PubMed ID: 8503054 | Fulltext

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