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Papers authored by Tokita S

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Melanin-concentrating hormone 1-receptor antagonist suppresses body weight gain correlated with high receptor occupancy levels in diet-induced obesity mice.

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Ito M, Ishihara A, Gomori A, Egashira S, Matsushita H, Mashiko S, Ito J, Ito M, Nakase K, Haga Y, Iwaasa H, Suzuki T, Ohtake N, Moriya M, Sato N, Macneil DJ,

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European journal of pharmacology 624(1-3):77-83, 2009 Dec 10 - Who cited this? | PubMed ID: 19836369 | Fulltext

Inverse agonist histamine H3 receptor PET tracers labelled with carbon-11 or fluorine-18.

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Hamill TG, Sato N, Jitsuoka M, Tokita S, Sanabria S, Eng W, Ryan C, Krause S, Takenaga N, Patel S, Zeng Z, Williams D, Sur C, Hargreaves R, and Burns HD

Synapse (New York, N.Y.) 63(12):1122-32, 2009 Dec - Who cited this? | PubMed ID: 19670309 | Fulltext

Liquid-cooled 24 W mid-infrared Er:ZBLAN fiber laser.

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Tokita S, Murakami M, Shimizu S, Hashida M, and Sakabe S

Optics letters 34(20):3062-4, 2009 Oct 15 - Who cited this? | PubMed ID: 19838226 | Fulltext

Discovery of novel diarylketoxime derivatives as selective and orally active melanin-concentrating hormone 1 receptor antagonists.

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Suzuki T, Kameda M, Ando M, Miyazoe H, Sekino E, Ito S, Masutani K, Kamijo K, Takezawa A, Moriya M, Ito M, Ito J, Nakase K, Matsushita H, Ishihara A, Takenaga N,

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Bioorganic & medicinal chemistry letters 19(18):5339-45, 2009 Sep 15 - Who cited this? | PubMed ID: 19683441 | Fulltext

Synthesis and evaluation of a series of 2,4-diaminopyridine derivatives as potential positron emission tomography tracers for neuropeptide Y Y1 receptors.

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Kameda M, Ando M, Nakama C, Kobayashi K, Kawamoto H, Ito S, Suzuki T, Tani T, Ozaki S, Tokita S, and Sato N

Bioorganic & medicinal chemistry letters 19(17):5124-7, 2009 Sep 1 - Who cited this? | PubMed ID: 19640706 | Fulltext

Identification and characterization of a selective radioligand for ELOVL6.

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Shimamura K, Takahashi H, Kitazawa H, Miyamoto Y, Nagumo A, Tang C, Dean D, Nagase T, Sato N, and Tokita S

Journal of biochemistry 146(3):429-37, 2009 Sep - Who cited this? | PubMed ID: 19505953 | Fulltext

Design, synthesis and evaluation of a novel cyclohexanamine class of neuropeptide Y Y1 receptor antagonists.

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Cho K, Ando M, Kobayashi K, Miyazoe H, Tsujino T, Ito S, Suzuki T, Tanaka T, Tokita S, and Sato N

Bioorganic & medicinal chemistry letters 19(16):4781-5, 2009 Aug 15 - Who cited this? | PubMed ID: 19596193 | Fulltext

Optimization of a series of 2,4-diaminopyridines as neuropeptide Y Y1 receptor antagonists with reduced hERG activity.

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Kameda M, Kobayashi K, Ito H, Miyazoe H, Tsujino T, Nakama C, Kawamoto H, Ando M, Ito S, Suzuki T, Kanno T, Tanaka T, Tahara Y, Tani T, Tanaka S, Tokita S,

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Bioorganic & medicinal chemistry letters 19(15):4325-9, 2009 Aug 1 - Who cited this? | PubMed ID: 19487123 | Fulltext

Synthesis, structure-activity relationships, and biological profiles of a dihydrobenzoxathiin class of histamine H(3) receptor inverse agonists.

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Sasaki T, Takahashi T, Nagase T, Mizutani T, Ito S, Mitobe Y, Miyamoto Y, Kanesaka M, Yoshimoto R, Tanaka T, Takenaga N, Tokita S, and Sato N

Bioorganic & medicinal chemistry letters 19(15):4232-6, 2009 Aug 1 - Who cited this? | PubMed ID: 19520574 | Fulltext

Development of a selective and potent radioactive ligand for histamine H(3) receptors: A compound potentially useful for receptor occupancy studies.

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Mitobe Y, Ito S, Mizutani T, Nagase T, Sato N, and Tokita S

Bioorganic & medicinal chemistry letters 19(15):4075-8, 2009 Aug 1 - Who cited this? | PubMed ID: 19553110 | Fulltext

Synthesis and evaluation of a novel 2-azabicyclo[2.2.2]octane class of long chain fatty acid elongase 6 (ELOVL6) inhibitors.

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Sasaki T, Nagase T, Takahashi T, Nagumo A, Shimamura K, Miyamoto Y, Kitazawa H, Kanesaka M, Yoshimoto R, Aragane K, Tokita S, and Sato N

Bioorganic & medicinal chemistry 17(15):5639-47, 2009 Aug 1 - Who cited this? | PubMed ID: 19596583 | Fulltext

Identification of a stable chemerin analog with potent activity toward ChemR23.

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Shimamura K, Matsuda M, Miyamoto Y, Yoshimoto R, Seo T, and Tokita S

Peptides 30(8):1529-38, 2009 Aug - Who cited this? | PubMed ID: 19540290 | Fulltext

Development of a High-Density Assay for Long-Chain Fatty Acyl-CoA Elongases.

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Kitazawa H, Miyamoto Y, Shimamura K, Nagumo A, and Tokita S

Lipids 44(8):765-73, 2009 Aug - Who cited this? | PubMed ID: 19575253 | Fulltext

Synthesis and biological evaluation of a novel 3-sulfonyl-8-azabicyclo[3.2.1]octane class of long chain fatty acid elongase 6 (ELOVL6) inhibitors.

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Nagase T, Takahashi T, Sasaki T, Nagumo A, Shimamura K, Miyamoto Y, Kitazawa H, Kanesaka M, Yoshimoto R, Aragane K, Tokita S, and Sato N

Journal of medicinal chemistry 52(14):4111-4, 2009 Jul 23 - Who cited this? | PubMed ID: 19522500 | Fulltext

Non-thermal ablation of expanded polytetrafluoroethylene with an intense femtosecond-pulse laser.

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Hashida M, Mishima H, Tokita S, and Sakabe S

Optics express 17(15):13116-21, 2009 Jul 20 - Who cited this? | PubMed ID: 19654716 | Fulltext

5,5-Dimethyl-3-(5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-1-phenyl-3-(trifluoromethyl)-3,5,6,7-tetrahydro-1H-indole-2,4-dione, a Potent Inhibitor for Mammalian Elongase of Long-Chain Fatty Acids Family 6: Examination of Its Potential Utility as a Pharmacological Tool.

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Shimamura K, Kitazawa H, Miyamoto Y, Kanesaka M, Nagumo A, Yoshimoto R, Aragane K, Morita N, Ohe T, Takahashi T, Nagase T, Sato N, and Tokita S

The Journal of pharmacology and experimental therapeutics 330(1):249-56, 2009 Jul - Who cited this? | PubMed ID: 19359527 | Fulltext

Discovery of novel spiro-piperidine derivatives as highly potent and selective melanin-concentrating hormone 1 receptor antagonists.

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Suzuki T, Moriya M, Sakamoto T, Suga T, Kishino H, Takahashi H, Ishikawa M, Nagai K, Imai Y, Sekino E, Ito M, Iwaasa H, Ishihara A, Tokita S, Kanatani A, Sato N,

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Bioorganic & medicinal chemistry letters 19(11):3072-7, 2009 Jun 1 - Who cited this? | PubMed ID: 19403308 | Fulltext

(-)-Ternatin inhibits adipogenesis and lipid metabolism in 3T3-L1 cells.

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Ito M, Ito J, Kitazawa H, Shimamura K, Fukami T, Tokita S, Shimokawa K, Yamada K, Kanatani A, and Uemura D

Peptides 30(6):1074-81, 2009 Jun - Who cited this? | PubMed ID: 19463739 | Fulltext

Synthesis and evaluation of a novel indoledione class of long chain fatty acid elongase 6 (ELOVL6) inhibitors.

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Takahashi T, Nagase T, Sasaki T, Nagumo A, Shimamura K, Miyamoto Y, Kitazawa H, Kanesaka M, Yoshimoto R, Aragane K, Tokita S, and Sato N

Journal of medicinal chemistry 52(10):3142-5, 2009 May 28 - Who cited this? | PubMed ID: 19388647 | Fulltext

Terahertz pulse radiation from argon clusters.

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Nagashima T, Hirayama H, Shibuya K, Hangyo M, Hashida M, Tokita S, and Sakabe S

Optics express 17(11):8907-12, 2009 May 25 - Who cited this? | PubMed ID: 19466139 | Fulltext

Identification and characterization of a selective radioligand for melanin-concentrating hormone 1-receptor (MCH1R).

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Ito M, Sakamoto T, Suzuki T, Egashira S, Moriya M, Ishihara A, Iwaasa H, Matsushita H, Nakase K, Wallace MA, Dean D, Sato N, Tokita S, and Kanatani A

Bioorganic & medicinal chemistry letters 19(10):2835-9, 2009 May 15 - Who cited this? | PubMed ID: 19361985 | Fulltext

High-Throughput Assay for Long Chain Fatty Acyl-CoA Elongase Using Homogeneous Scintillation Proximity Format.

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Shimamura K, Miyamoto Y, Kitazawa H, Kobayashi T, Kotani H, and Tokita S

Assay and drug development technologies 7(2):124-32, 2009 Apr - Who cited this? | PubMed ID: 19505229 | Fulltext

[Unilateral total pulmonary lavage for pulmonary alveolar proteinosis and an algorithm to select lavage procedures].

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Ichiwata T, Tokita S, Soma R, Kikuchi K, Akasaka K, Kojima T, Kouyama K, Abe T, Fujiwara H, and Nagao K

Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society 47(3):185-90, 2009 Mar - Who cited this? | PubMed ID: 19348263 | Fulltext

Development of novel 2-[4-(aminoalkoxy)phenyl]-4(3H)-quinazolinone derivatives as potent and selective histamine H(3) receptor inverse agonists.

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Mizutani T, Nagase T, Ito S, Miyamoto Y, Tanaka T, Takenaga N, Tokita S, and Sato N

Bioorganic & medicinal chemistry letters 18(23):6041-5, 2008 Dec 1 - Who cited this? | PubMed ID: 18952421 | Fulltext

Synthesis and evaluation of structurally constrained quinazolinone derivatives as potent and selective histamine h3 receptor inverse agonists.

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Nagase T, Mizutani T, Sekino E, Ishikawa S, Ito S, Mitobe Y, Miyamoto Y, Yoshimoto R, Tanaka T, Ishihara A, Takenaga N, Tokita S, and Sato N

Journal of medicinal chemistry 51(21):6889-901, 2008 Nov 13 - Who cited this? | PubMed ID: 18841880 | Fulltext

Azacalix[7]arene Heptamethyl Ether: Preparation, Nanochannel Crystal Structure, and Selective Adsorption of Carbon Dioxide.

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Tsue H, Matsui K, Ishibashi K, Takahashi H, Tokita S, Ono K, and Tamura R

The Journal of organic chemistry 73(19):7748-55, 2008 Oct 3 - Who cited this? | PubMed ID: 18720993 | Fulltext

Synthesis and evaluation of a spiro-isobenzofuranone class of histamine H3 receptor inverse agonists.

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Jitsuoka M, Tsukahara D, Ito S, Tanaka T, Takenaga N, Tokita S, and Sato N

Bioorganic & medicinal chemistry letters 18(18):5101-6, 2008 Sep 15 - Who cited this? | PubMed ID: 18768318 | Fulltext

0.3% energy stability, 100-millijoule-class, Ti:sapphire chirped-pulse eight-pass amplification system.

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Tokita S, Hashida M, Masuno S, Namba S, and Sakabe S

Optics express 16(19):14875-81, 2008 Sep 15 - Who cited this? | PubMed ID: 18795024 | Fulltext

Synthesis, structure-activity relationships, and biological profiles of a quinazolinone class of histamine h3 receptor inverse agonists.

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Nagase T, Mizutani T, Ishikawa S, Sekino E, Sasaki T, Fujimura T, Ito S, Mitobe Y, Miyamoto Y, Yoshimoto R, Tanaka T, Ishihara A, Takenaga N, Tokita S, Fukami T, and Sato N

Journal of medicinal chemistry 51(15):4780-9, 2008 Aug 14 - Who cited this? | PubMed ID: 18598020 | Fulltext

Azacalix[4]arene cation radicals: spin-delocalised doublet- and triplet-ground states observed in the macrocyclic m-phenylene system connected with nitrogen atoms.

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Ishibashi K, Tsue H, Sakai N, Tokita S, Matsui K, Yamauchi J, and Tamura R

Chemical communications (Cambridge, England)(24):2812-4, 2008 Jun 28 - Who cited this? | PubMed ID: 18688319 | Fulltext

[A case of septic pulmonary embolism with endogenous endophthalmitis in a healthy adult].

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Akasaka K, Tokita S, Koyama A, Ikegami G, Koyama K, Fujihara H, Ichiwata T, and Nagao K

Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society 46(4):291-6, 2008 Apr - Who cited this? | PubMed ID: 18516992 | Fulltext

Distinctive role of central histamine H(3) receptor in various orexigenic pathways.

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Yoshimoto R, Kanatani A, and Tokita S

European journal of pharmacology 579(1-3):229-32, 2008 Jan 28 - Who cited this? | PubMed ID: 18037404 | Fulltext

Azacalix[6]arene Hexamethyl Ether: Synthesis, Structure, and Selective Uptake of Carbon Dioxide in the Solid State.

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Tsue H, Ishibashi K, Tokita S, Takahashi H, Matsui K, and Tamura R

Chemistry (Weinheim an der Bergstrasse, Germany) 14(20):6125-34, 2008 - Who cited this? | PubMed ID: 18506858 | Fulltext

Cryogenic temperature characteristics of Verdet constant on terbium gallium garnet ceramics.

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Yasuhara R, Tokita S, Kawanaka J, Kawashima T, Kan H, Yagi H, Nozawa H, Yanagitani T, Fujimoto Y, Yoshida H, and Nakatsuka M

Optics express 15(18):11255-61, 2007 Sep 3 - Who cited this? | PubMed ID: 19547482 | Fulltext

Multi-millijoule, diode-pumped, cryogenically-cooled Yb:KY(WO(4))(2) chirped-pulse regenerative amplifier.

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Ogawa K, Akahane Y, Aoyama M, Tsuji K, Tokita S, Kawanaka J, Nishioka H, and Yamakawa K

Optics express 15(14):8598-602, 2007 Jul 9 - Who cited this? | PubMed ID: 19547193 | Fulltext

High-energy, diode-pumped, picosecond Yb:YAG chirped-pulse regenerative amplifier for pumping optical parametric chirped-pulse amplification.

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Akahane Y, Aoyama M, Ogawa K, Tsuji K, Tokita S, Kawanaka J, Nishioka H, and Yamakawa K

Optics letters 32(13):1899-901, 2007 Jul 1 - Who cited this? | PubMed ID: 17603607 | Fulltext

Development of a potent and selective GPR7 (NPBW1) agonist: a systematic structure-activity study of neuropeptide B.

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Kanesaka M, Matsuda M, Hirano A, Tanaka K, Kanatani A, and Tokita S

Journal of peptide science : an official publication of the European Peptide Society 13(6):379-85, 2007 Jun - Who cited this? | PubMed ID: 17486669 | Fulltext

Novel mutation assay with high sensitivity based on direct measurement of genomic DNA alterations: comparable results to the Ames test.

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Futakami M, Salimullah M, Miura T, Tokita S, and Nishigaki K

Journal of biochemistry 141(5):675-86, 2007 May - Who cited this? | PubMed ID: 17383979 | Fulltext

23.7-W picosecond cryogenic-Yb:YAG multipass amplifier.

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Tokita S, Kawanaka J, Izawa Y, Fujita M, and Kawashima T

Optics express 15(7):3955-61, 2007 Apr 2 - Who cited this? | PubMed ID: 19532638 | Fulltext

[Emerging progress and strategies for the exploration of therapeutic targets].

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Tokita S

Nippon yakurigaku zasshi. Folia pharmacologica Japonica 129(2):119-23, 2007 Feb - Who cited this? | PubMed ID: 17299239 | Fulltext

Regioselectively N-methylated azacalix[8]arene octamethyl ether prepared by catalytic aryl amination reaction using a temporal N-silylation protocol.

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Ishibashi K, Tsue H, Tokita S, Matsui K, Takahashi H, and Tamura R

Organic letters 8(26):5991-4, 2006 Dec 21 - Who cited this? | PubMed ID: 17165912 | Fulltext

Therapeutic potential of histamine H3 receptor agonist for the treatment of obesity and diabetes mellitus.

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Yoshimoto R, Miyamoto Y, Shimamura K, Ishihara A, Takahashi K, Kotani H, Chen AS, Chen HY, Macneil DJ, Kanatani A, and Tokita S

Proceedings of the National Academy of Sciences of the United States of America 103(37):13866-71, 2006 Sep 12 - Who cited this? | PubMed ID: 16954192 | Fulltext

Impaired drinking response in histamine H3 receptor knockout mice following dehydration or angiotensin-II challenge.

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Yoshimoto R, Miyamoto Y, Takahashi K, Kotani H, Kanatani A, and Tokita S

Pharmacology, biochemistry, and behavior 84(3):504-10, 2006 Jul - Who cited this? | PubMed ID: 16887177 | Fulltext

Recent advances in molecular pharmacology of the histamine systems: physiology and pharmacology of histamine H3 receptor: roles in feeding regulation and therapeutic potential for metabolic disorders.

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Tokita S, Takahashi K, and Kotani H

Journal of pharmacological sciences 101(1):12-8, 2006 May - Who cited this? | PubMed ID: 16648667 | Fulltext

Detailed pharmacological characterization of GT-2331 for the rat histamine H3 receptor.

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Ito S, Yoshimoto R, Miyamoto Y, Mitobe Y, Nakamura T, Ishihara A, MacNeil DJ, Kanatani A, and Tokita S

European journal of pharmacology 529(1-3):40-6, 2006 Jan 4 - Who cited this? | PubMed ID: 16316645 | Fulltext

Simultaneous fluorometric measurement of histamine and tele-methylhistamine levels in rodent brain by high-performance liquid chromatography.

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Miyamoto Y, Yoshimoto R, Yumoto M, Ishihara A, Takahashi K, Kotani H, Kanatani A, and Tokita S

Analytical biochemistry 334(1):89-96, 2004 Nov 1 - Who cited this? | PubMed ID: 15464956 | Fulltext

Variants of the orexin2/hcrt2 receptor gene identified in patients with excessive daytime sleepiness and patients with Tourette's syndrome comorbidity.

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Thompson MD, Comings DE, Abu-Ghazalah R, Jereseh Y, Lin L, Wade J, Sakurai T, Tokita S, Yoshida T, Tanaka H, Yanagisawa M, Burnham WM, and Moldofsky H

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 129(1):69-75, 2004 Aug 15 - Who cited this? | PubMed ID: 15274044 | Fulltext

Effective cation-assisted chirality induction using a dibenzo-diaza-30-crown-10 with bis(zinc(II) porphyrin) units.

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Kubo Y, Ishii Y, Yoshizawa T, and Tokita S

Chemical communications (Cambridge, England)(12):1394-5, 2004 Jun 21 - Who cited this? | PubMed ID: 15179481 | Fulltext

Identification of soluble NH2-terminal fragment of glypican-3 as a serological marker for early-stage hepatocellular carcinoma.

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Hippo Y, Watanabe K, Watanabe A, Midorikawa Y, Yamamoto S, Ihara S, Tokita S, Iwanari H, Ito Y, Nakano K, Nezu J, Tsunoda H, Yoshino T, Ohizumi I, Tsuchiya M, Ohnishi S,

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Cancer research 64(7):2418-23, 2004 Apr 1 - Who cited this? | PubMed ID: 15059894 | Fulltext

Generation and characterization of highly constitutive active histamine H3 receptors.

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Takahashi K, Tokita S, and Kotani H

The Journal of pharmacology and experimental therapeutics 307(1):213-8, 2003 Oct - Who cited this? | PubMed ID: 12954820 | Fulltext

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