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Papers authored by Tinker A

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Overexpression of the transcription factor Hand1 causes predisposition towards arrhythmia in mice.

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Breckenridge RA, Zuberi Z, Gomes J, Orford R, Dupays L, Felkin LE, Clark JE, Magee AI, Ehler E, Birks EJ, Barton PJ, Tinker A, and Mohun TJ

Journal of molecular and cellular cardiology 47(1):133-41, 2009 Jul - Who cited this? | PubMed ID: 19376125 | Fulltext

Ca2+/calcineurin regulation of cloned vascular K ATP channels: crosstalk with the protein kinase A pathway.

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Orie NN, Thomas AM, Perrino BA, Tinker A, and Clapp LH

British journal of pharmacology 157(4):554-64, 2009 Jun - Who cited this? | PubMed ID: 19422382 | Fulltext

Intraepithelial T cells and prognosis in ovarian carcinoma: novel associations with stage, tumor type, and BRCA1 loss.

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Clarke B, Tinker AV, Lee CH, Subramanian S, van de Rijn M, Turbin D, Kalloger S, Han G, Ceballos K, Cadungog MG, Huntsman DG, Coukos G, and Gilks CB

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 22(3):393-402, 2009 Mar - Who cited this? | PubMed ID: 19060844 | Fulltext

Integrated genome-wide DNA copy number and expression analysis identifies distinct mechanisms of primary chemoresistance in ovarian carcinomas.

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Etemadmoghadam D, Defazio A, Beroukhim R, Mermel C, George J, Getz G, Tothill R, Okamoto A, Raeder MB, AOCS Study Group, Harnett P, Lade S, Akslen LA, Tinker AV, Locandro B, Alsop K,

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Clinical cancer research : an official journal of the American Association for Cancer Research 15(4):1417-27, 2009 Feb 15 - Who cited this? | PubMed ID: 19193619 | Fulltext

Determination of phosphoinositide binding to k(+) channel subunits using a protein-lipid overlay assay.

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Thomas AM and Tinker A

Methods in molecular biology (Clifton, N.J.) 491:103-11, 2009 - Who cited this? | PubMed ID: 18998087 | Fulltext

Mistreatment of older people in the United kingdom: findings from the first national prevalence study.

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Biggs S, Manthorpe J, Tinker A, Doyle M, and Erens B

Journal of elder abuse & neglect 21(1):1-14, 2009 - Who cited this? | PubMed ID: 19197619 | Fulltext

The role of inhibitory heterotrimeric G proteins in the control of in vivo heart rate dynamics.

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Zuberi Z, Birnbaumer L, and Tinker A

American journal of physiology. Regulatory, integrative and comparative physiology 295(6):R1822-30, 2008 Dec - Who cited this? | PubMed ID: 18832081 | Fulltext

Mutation of ERBB2 Provides a Novel Alternative Mechanism for the Ubiquitous Activation of RAS-MAPK in Ovarian Serous Low Malignant Potential Tumors.

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Anglesio MS, Arnold JM, George J, Tinker AV, Tothill R, Waddell N, Simms L, Locandro B, Fereday S, Traficante N, Russell P, Sharma R, Birrer MJ, AOCS Study Group, Defazio A, Chenevix-Trench G,

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Molecular cancer research : MCR 6(11):1678-90, 2008 Nov - Who cited this? | PubMed ID: 19010816 | Fulltext

Anchored plasticity opens doors for selective inhibitor design in nitric oxide synthase.

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Garcin ED, Arvai AS, Rosenfeld RJ, Kroeger MD, Crane BR, Andersson G, Andrews G, Hamley PJ, Mallinder PR, Nicholls DJ, St-Gallay SA, Tinker AC, Gensmantel NP, Mete A, Cheshire DR, Connolly S,

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Nature chemical biology, 2008 Oct 12 - Who cited this? | PubMed ID: 18849972 | Fulltext

Primary health care: making Alma-Ata a reality.

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Walley J, Lawn JE, Tinker A, de Francisco A, Chopra M, Rudan I, Bhutta ZA, Black RE, and

Lancet 372(9642):1001, 2008 Sep 13 - Who cited this? | PubMed ID: 18790322 | Fulltext

Differences in the mechanism of metabolic regulation of ATP-sensitive K+ channels containing Kir6.1 and Kir6.2 subunits.

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Farzaneh T and Tinker A

Cardiovascular research 79(4):621-31, 2008 Sep 1 - Who cited this? | PubMed ID: 18522960 | Fulltext

Novel molecular subtypes of serous and endometrioid ovarian cancer linked to clinical outcome.

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Tothill RW, Tinker AV, George J, Brown R, Fox SB, Lade S, Johnson DS, Trivett MK, Etemadmoghadam D, Locandro B, Traficante N, Fereday S, Hung JA, Chiew YE, Haviv I, ,

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Clinical cancer research : an official journal of the American Association for Cancer Research 14(16):5198, 2008 Aug 15 - Who cited this? | PubMed ID: 18698038 | Fulltext

Regulation of mitochondrial structure and function by the F1Fo-ATPase inhibitor protein, IF1.

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Campanella M, Casswell E, Chong S, Farah Z, Wieckowski MR, Abramov AY, Tinker A, and Duchen MR

Cell metabolism 8(1):13, 2008 Jul - Who cited this? | PubMed ID: 18590689 | Fulltext

Monitoring changes in membrane phosphatidylinositol 4,5-bisphosphate in living cells using a domain from the transcription factor tubby.

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Quinn KV, Behe P, and Tinker A

The Journal of physiology 586(Pt 12):2855-71, 2008 Jun 15 - Who cited this? | PubMed ID: 18420701 | Fulltext

Carboplatin plus paclitaxel for advanced or recurrent uterine malignant mixed mullerian tumors. The British Columbia Cancer Agency experience.

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Hoskins PJ, Le N, Ellard S, Lee U, Ann Martin L, Swenerton KD, and Tinker AV

Gynecologic oncology 108(1):58-62, 2008 Jan - Who cited this? | PubMed ID: 17935761 | Fulltext

The role of abnormal trafficking of KCNE1 in long QT syndrome 5.

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Harmer SC and Tinker A

Biochemical Society transactions 35(Pt 5):1074-6, 2007 Nov - Who cited this? | PubMed ID: 17956282 | Fulltext

PIP(2)-dependent inhibition of M-type (Kv7.2/7.3) potassium channels: direct on-line assessment of PIP(2) depletion by Gq-coupled receptors in single living neurons.

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Hughes S, Marsh SJ, Tinker A, and Brown DA

Pflugers Archiv : European journal of physiology 455(1):115-24, 2007 Oct - Who cited this? | PubMed ID: 17447081 | Fulltext

The U.K. national study of abuse and neglect among older people.

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Manthorpe J, Biggs S, McCreadie C, Tinker A, Hills A, O'Keefe M, Doyle M, Constantine R, Scholes S, and Erens B

Nursing older people 19(8):24-6, 2007 Oct - Who cited this? | PubMed ID: 17972781 | Fulltext

IP receptor-dependent activation of PPARgamma by stable prostacyclin analogues.

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Falcetti E, Flavell DM, Staels B, Tinker A, Haworth SG, and Clapp LH

Biochemical and biophysical research communications 360(4):821, 2007 Sep 7 - Who cited this? | PubMed ID: 17624303 | Fulltext

Regulation of M(Kv7.2/7.3) channels in neurons by PIP(2) and products of PIP(2) hydrolysis: significance for receptor-mediated inhibition.

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Brown DA, Hughes SA, Marsh SJ, and Tinker A

The Journal of physiology 582(Pt 3):917-25, 2007 Aug 1 - Who cited this? | PubMed ID: 17395626 | Fulltext

Complex ABCC8 DNA variations in congenital hyperinsulinism: lessons from functional studies.

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Muzyamba M, Farzaneh T, Behe P, Thomas A, Christesen HB, Brusgaard K, Hussain K, and Tinker A

Clinical endocrinology 67(1):115-24, 2007 Jul - Who cited this? | PubMed ID: 17466004 | Fulltext

Phase II trial of weekly docetaxel for patients with relapsed ovarian cancer who have previously received paclitaxel--ANZGOG 02-01.

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Tinker AV, Gebski V, Fitzharris B, Buck M, Stuart-Harris R, Beale P, Goldrick A, and Rischin D

Gynecologic oncology 104(3):647-53, 2007 Mar - Who cited this? | PubMed ID: 17079006 | Fulltext

Where is maternal and child health now?.

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Lawn JE, Tinker A, Munjanja SP, and Cousens S

Lancet 368(9546):1474-7, 2006 Oct 28 - Who cited this? | PubMed ID: 17071267 | Fulltext

The right to a healthy newborn.

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Tinker AG, Paul VK, and Ruben JD

International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics 94(3):269-76, 2006 Sep - Who cited this? | PubMed ID: 16839556 | Fulltext

Syntaxin-1A actions on sulfonylurea receptor 2A can block acidic pH-induced cardiac K(ATP) channel activation.

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Kang Y, Ng B, Leung YM, He Y, Xie H, Lodwick D, Norman RI, Tinker A, Tsushima RG, and Gaisano HY

The Journal of biological chemistry 281(28):19019-28, 2006 Jul 14 - Who cited this? | PubMed ID: 16672225 | Fulltext

The selective interactions and functions of regulators of G-protein signalling.

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Tinker A

Seminars in cell & developmental biology 17(3):377-82, 2006 Jun - Who cited this? | PubMed ID: 16675274 | Fulltext

The challenges of gene expression microarrays for the study of human cancer.

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Tinker AV, Boussioutas A, and Bowtell DD

Cancer cell 9(5):333-9, 2006 May - Who cited this? | PubMed ID: 16697954 | Fulltext

Differential phosphoinositide binding to components of the G protein-gated K+ channel.

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Thomas AM, Brown SG, Leaney JL, and Tinker A

The Journal of membrane biology 211(1):43-53, 2006 May - Who cited this? | PubMed ID: 16988861 | Fulltext

A phase I dose finding study of cisplatin, gemcitabine, and weekly docetaxel for patients with advanced transitional cell cancer.

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Tinker A, Winquist E, Canil C, Moore M, Murray RN, and Chi KN

American journal of clinical oncology 29(1):3-7, 2006 Feb - Who cited this? | PubMed ID: 16462494 | Fulltext

Selective inhibitors of inducible nitric oxide synthase: potential agents for the treatment of inflammatory diseases?.

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Tinker AC and Wallace AV

Current topics in medicinal chemistry 6(2):77-92, 2006 - Who cited this? | PubMed ID: 16454760 | Fulltext

Functional expression of inward rectifier potassium channels in cultured human pulmonary smooth muscle cells: evidence for a major role of Kir2.4 subunits.

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Tennant BP, Cui Y, Tinker A, and Clapp LH

The Journal of membrane biology 213(1):19-29, 2006 - Who cited this? | PubMed ID: 17347781 | Fulltext

Heterotrimeric G proteins precouple with G protein-coupled receptors in living cells.

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Nobles M, Benians A, and Tinker A

Proceedings of the National Academy of Sciences of the United States of America 102(51):18706-11, 2005 Dec 20 - Who cited this? | PubMed ID: 16352729 | Fulltext

PKC-delta sensitizes Kir3.1/3.2 channels to changes in membrane phospholipid levels after M3 receptor activation in HEK-293 cells.

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Brown SG, Thomas A, Dekker LV, Tinker A, and Leaney JL

American journal of physiology. Cell physiology 289(3):C543-56, 2005 Sep - Who cited this? | PubMed ID: 15857907 | Fulltext

Abnormal KCNQ1 trafficking influences disease pathogenesis in hereditary long QT syndromes (LQT1).

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Wilson AJ, Quinn KV, Graves FM, Bitner-Glindzicz M, and Tinker A

Cardiovascular research 67(3):476-86, 2005 Aug 15 - Who cited this? | PubMed ID: 15935335 | Fulltext

Carboplatin and paclitaxel for advanced and recurrent cervical carcinoma: the British Columbia Cancer Agency experience.

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Tinker AV, Bhagat K, Swenerton KD, and Hoskins PJ

Gynecologic oncology 98(1):54-8, 2005 Jul - Who cited this? | PubMed ID: 15904950 | Fulltext

Regulators of G-protein signaling form a quaternary complex with the agonist, receptor, and G-protein. A novel explanation for the acceleration of signaling activation kinetics.

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Benians A, Nobles M, Hosny S, and Tinker A

The Journal of biological chemistry 280(14):13383-94, 2005 Apr 8 - Who cited this? | PubMed ID: 15677457 | Fulltext

Immunolocalization of KATP channel subunits in mouse and rat cardiac myocytes and the coronary vasculature.

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Morrissey A, Rosner E, Lanning J, Parachuru L, Dhar Chowdhury P, Han S, Lopez G, Tong X, Yoshida H, Nakamura TY, Artman M, Giblin JP, Tinker A, and Coetzee WA

BMC physiology 5(1):1, 2005 - Who cited this? | PubMed ID: 15647111 | Fulltext

A continuum of care to save newborn lives.

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Tinker A, ten Hoope-Bender P, Azfar S, Bustreo F, and Bell R

Lancet 365(9462):822-5, 2005 - Who cited this? | PubMed ID: 15752509 | Fulltext

Components of successful lead generation.

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Davis AM, Keeling DJ, Steele J, Tomkinson NP, and Tinker AC

Current topics in medicinal chemistry 5(4):421-39, 2005 - Who cited this? | PubMed ID: 15892684 | Fulltext

Introducing assistive technology into the existing homes of older people: feasibility, acceptability, costs and outcomes.

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Tinker A and Lansley P

Journal of telemedicine and telecare 11 Suppl 1:1-3, 2005 - Who cited this? | PubMed ID: 16035974 | Fulltext

Participation of RGS8 in the ternary complex of agonist, receptor and G-protein.

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Benians A, Nobles M, and Tinker A

Biochemical Society transactions 32(Pt 6):1045-7, 2004 Dec - Who cited this? | PubMed ID: 15506959 | Fulltext

Can adapting the homes of older people and providing assistive technology pay its way?.

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Lansley P, McCreadie C, and Tinker A

Age and ageing 33(6):571-6, 2004 Nov - Who cited this? | PubMed ID: 15347537 | Fulltext

University research ethics committees: their role, remit and conduct.

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Tinker A and Coomber V

Bulletin of medical ethics(203):7-8, 2004 Nov - Who cited this? | PubMed ID: 15816096 | Fulltext

Rapid desensitization of G protein-gated inwardly rectifying K(+) currents is determined by G protein cycle.

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Leaney JL, Benians A, Brown S, Nobles M, Kelly D, and Tinker A

American journal of physiology. Cell physiology 287(1):C182-91, 2004 Jul - Who cited this? | PubMed ID: 15013952 | Fulltext

2-aminopyridines as highly selective inducible nitric oxide synthase inhibitors. Differential binding modes dependent on nitrogen substitution.

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Connolly S, Aberg A, Arvai A, Beaton HG, Cheshire DR, Cook AR, Cooper S, Cox D, Hamley P, Mallinder P, Millichip I, Nicholls DJ, Rosenfeld RJ, St-Gallay SA, Tainer J, Tinker AC,

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Journal of medicinal chemistry 47(12):3320-3, 2004 Jun 3 - Who cited this? | PubMed ID: 15163211 | Fulltext

Multisite phosphorylation mechanism for protein kinase A activation of the smooth muscle ATP-sensitive K+ channel.

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Quinn KV, Giblin JP, and Tinker A

Circulation research 94(10):1359-66, 2004 May 28 - Who cited this? | PubMed ID: 15087422 | Fulltext

The large-conductance Ca2+-activated K+ channel is essential for innate immunity.

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Ahluwalia J, Tinker A, Clapp LH, Duchen MR, Abramov AY, Pope S, Nobles M, and Segal AW

Nature 427(6977):853-8, 2004 Feb 26 - Who cited this? | PubMed ID: 14985765 | Fulltext

Do anionic phospholipids serve as cofactors or second messengers for the regulation of activity of cloned ATP-sensitive K+ channels?.

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Quinn KV, Cui Y, Giblin JP, Clapp LH, and Tinker A

Circulation research 93(7):646-55, 2003 Oct 3 - Who cited this? | PubMed ID: 12970116 | Fulltext

Agonist unbinding from receptor dictates the nature of deactivation kinetics of G protein-gated K+ channels.

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Benians A, Leaney JL, and Tinker A

Proceedings of the National Academy of Sciences of the United States of America 100(10):6239-44, 2003 May 13 - Who cited this? | PubMed ID: 12719528 | Fulltext

Different molecular sites of action for the KATP channel inhibitors, PNU-99963 and PNU-37883A.

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Cui Y, Tinker A, and Clapp LH

British journal of pharmacology 139(1):122-8, 2003 May - Who cited this? | PubMed ID: 12746230 | Fulltext

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