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Papers authored by Terstappen GC

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A primer on screening data management.

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Palmer M, Kremer A, and Terstappen GC

Journal of biomolecular screening : the official journal of the Society for Biomolecular Screening 14(8):999-1007, 2009 Sep - Who cited this? | PubMed ID: 19643981 | Fulltext

How to Achieve Confidence in Drug Discovery and Development: Managing Risk (from a Reductionist to a Holistic Approach).

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Bakker A, Caricasole A, Gaviraghi G, Pollio G, Robertson G, Terstappen GC, Salerno M, and Tunici P

ChemMedChem 4(6):923-33, 2009 Jun - Who cited this? | PubMed ID: 19434656 | Fulltext

Procognitive and neuroprotective activity of a novel alpha7 nicotinic acetylcholine receptor agonist for treatment of neurodegenerative and cognitive disorders.

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Roncarati R, Scali C, Comery TA, Grauer SM, Aschmi S, Bothmann H, Jow B, Kowal D, Gianfriddo M, Kelley C, Zanelli U, Ghiron C, Haydar S, Dunlop J, and Terstappen GC

The Journal of pharmacology and experimental therapeutics 329(2):459-68, 2009 May - Who cited this? | PubMed ID: 19223665 | Fulltext

Small molecule drug discovery for Huntington's Disease.

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Fecke W, Gianfriddo M, Gaviraghi G, Terstappen GC, and Heitz F

Drug discovery today 14(9-10):453-64, 2009 May - Who cited this? | PubMed ID: 19429504 | Fulltext

Robust MS quantification method for phospho-peptides using 18O/16O labeling.

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Andersen CA, Gotta S, Magnoni L, Raggiaschi R, Kremer A, and Terstappen GC

BMC bioinformatics 10:141, 2009 - Who cited this? | PubMed ID: 19432989 | Fulltext

Drug discovery and development for Huntington's disease - an orphan indication with high medical need.

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Heitz F, La Rosa S, Gonzalez-Couto E, Gaviraghi G, and Terstappen GC

IDrugs : the investigational drugs journal 11(9):653-60, 2008 Sep - Who cited this? | PubMed ID: 18763216 | Fulltext

Molecular cloning and characterization of a novel human variant of RIC-3, a putative chaperone of nicotinic acetylcholine receptors.

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Seredenina T, Ferraro T, Terstappen GC, Caricasole A, and Roncarati R

Bioscience reports, 2008 Aug 11 - Who cited this? | PubMed ID: 18691158 | Fulltext

A reporter assay for target validation in primary neuronal cultures.

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Pollio G, Roncarati R, Seredenina T, Terstappen GC, and Caricasole A

Journal of neuroscience methods 172(1):34-7, 2008 Jul 15 - Who cited this? | PubMed ID: 18485484 | Fulltext

Increased expression of the oligopeptidase THOP1 is a neuroprotective response to Abeta toxicity.

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Pollio G, Hoozemans JJ, Andersen CA, Roncarati R, Rosi MC, van Haastert ES, Seredenina T, Diamanti D, Gotta S, Fiorentini A, Magnoni L, Raggiaschi R, Rozemuller AJ, Casamenti F, Caricasole A, and Terstappen GC

Neurobiology of disease 31(1):145, 2008 Jul - Who cited this? | PubMed ID: 18571100 | Fulltext

Functional properties of alpha7 nicotinic acetylcholine receptors co-expressed with RIC-3 in a stable recombinant CHO-K1 cell line.

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Roncarati R, Seredenina T, Jow B, Jow F, Papini S, Kramer A, Bothmann H, Dunlop J, and Terstappen GC

Assay and drug development technologies 6(2):181, 2008 Apr - Who cited this? | PubMed ID: 18471073 | Fulltext

Sequential detergent fractionation of primary neurons for proteomics studies.

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Bernocco S, Fondelli C, Matteoni S, Magnoni L, Gotta S, Terstappen GC, and Raggiaschi R

Proteomics 8(5):930-8, 2008 Mar - Who cited this? | PubMed ID: 18219698 | Fulltext

Aryl azoles with neuroprotective activity-Parallel synthesis and attempts at target identification.

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Cocconcelli G, Diodato E, Caricasole A, Gaviraghi G, Genesio E, Ghiron C, Magnoni L, Pecchioli E, Plazzi PV, and Terstappen GC

Bioorganic & medicinal chemistry 16(4):2043-52, 2008 Feb 15 - Who cited this? | PubMed ID: 18024137 | Fulltext

Target deconvolution strategies in drug discovery.

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Terstappen GC, Schlüpen C, Raggiaschi R, and Gaviraghi G

Nature reviews. Drug discovery 6(11):891-903, 2007 Nov - Who cited this? | PubMed ID: 17917669 | Fulltext

In vitro screening strategies for nicotinic receptor ligands.

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Dunlop J, Roncarati R, Jow B, Bothmann H, Lock T, Kowal D, Bowlby M, and Terstappen GC

Biochemical pharmacology 74(8):1172-81, 2007 Oct 15 - Who cited this? | PubMed ID: 17706607 | Fulltext

Inhibition of Wnt signaling, modulation of Tau phosphorylation and induction of neuronal cell death by DKK1.

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Scali C, Caraci F, Gianfriddo M, Diodato E, Roncarati R, Pollio G, Gaviraghi G, Copani A, Nicoletti F, Terstappen GC, and Caricasole A

Neurobiology of disease 24(2):254-65, 2006 Nov - Who cited this? | PubMed ID: 16919965 | Fulltext

Inhibition of the canonical Wnt signaling pathway by apolipoprotein E4 in PC12 cells.

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Caruso A, Motolese M, Iacovelli L, Caraci F, Copani A, Nicoletti F, Terstappen GC, Gaviraghi G, and Caricasole A

Journal of neurochemistry 98(2):364, 2006 Jul - Who cited this? | PubMed ID: 16805831 | Fulltext

Detection of phosphorylation patterns in rat cortical neurons by combining phosphatase treatment and DIGE technology.

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Raggiaschi R, Lorenzetto C, Diodato E, Caricasole A, Gotta S, and Terstappen GC

Proteomics 6(3):748-56, 2006 Feb - Who cited this? | PubMed ID: 16372257 | Fulltext

The Wnt signaling pathway as a target for the treatment of neurodegenerative disorders.

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Terstappen GC, Gaviraghi G, and Caricasole A

IDrugs : the investigational drugs journal 9(1):35-8, 2006 Jan - Who cited this? | PubMed ID: 16374731 | Fulltext

Differential inhibition of rat alpha3* and alpha7 nicotinic acetylcholine receptors by tetrandrine and closely related bis-benzylisoquinoline derivatives.

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Virginio C, Graziani F, and Terstappen GC

Neuroscience letters 381(3):299-304, 2005 Jun 24 - Who cited this? | PubMed ID: 15896488 | Fulltext

A continuous time-resolved fluorescence assay for identification of BACE1 inhibitors.

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Porcari V, Magnoni L, Terstappen GC, and Fecke W

Assay and drug development technologies 3(3):287-97, 2005 Jun - Who cited this? | PubMed ID: 15971990 | Fulltext

Phosphoproteome analysis.

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Raggiaschi R, Gotta S, and Terstappen GC

Bioscience reports 25(1-2):33-44, 2005 - Who cited this? | PubMed ID: 16222418 | Fulltext

A bioinformatics perspective on proteomics: data storage, analysis, and integration.

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Kremer A, Schneider R, and Terstappen GC

Bioscience reports 25(1-2):95-106, 2005 - Who cited this? | PubMed ID: 16222422 | Fulltext

Two sides of the same coin: Wnt signaling in neurodegeneration and neuro-oncology.

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Caricasole A, Bakker A, Copani A, Nicoletti F, Gaviraghi G, and Terstappen GC

Bioscience reports 25(5-6):309-27, 2005 - Who cited this? | PubMed ID: 16307379 | Fulltext

Nonradioactive rubidium ion efflux assay and its applications in drug discovery and development.

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Terstappen GC

Assay and drug development technologies 2(5):553-9, 2004 Oct - Who cited this? | PubMed ID: 15671653 | Fulltext

Induction of Dickkopf-1, a negative modulator of the Wnt pathway, is associated with neuronal degeneration in Alzheimer's brain.

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Caricasole A, Copani A, Caraci F, Aronica E, Rozemuller AJ, Caruso A, Storto M, Gaviraghi G, Terstappen GC, and Nicoletti F

The Journal of neuroscience : the official journal of the Society for Neuroscience 24(26):6021-7, 2004 Jun 30 - Who cited this? | PubMed ID: 15229249 | Fulltext

Functional characterization of WNT7A signaling in PC12 cells: interaction with A FZD5 x LRP6 receptor complex and modulation by Dickkopf proteins.

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Caricasole A, Ferraro T, Iacovelli L, Barletta E, Caruso A, Melchiorri D, Terstappen GC, and Nicoletti F

The Journal of biological chemistry 278(39):37024-31, 2003 Sep 26 - Who cited this? | PubMed ID: 12857724 | Fulltext

The antidepressant fluoxetine blocks the human small conductance calcium-activated potassium channels SK1, SK2 and SK3.

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Terstappen GC, Pellacani A, Aldegheri L, Graziani F, Carignani C, Pula G, and Virginio C

Neuroscience letters 346(1-2):85-8, 2003 Jul 31 - Who cited this? | PubMed ID: 12850554 | Fulltext

The Wnt pathway, cell-cycle activation and beta-amyloid: novel therapeutic strategies in Alzheimer's disease?.

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Caricasole A, Copani A, Caruso A, Caraci F, Iacovelli L, Sortino MA, Terstappen GC, and Nicoletti F

Trends in pharmacological sciences 24(5):233-8, 2003 May - Who cited this? | PubMed ID: 12767722 | Fulltext

Pharmacological properties of rat alpha 7 nicotinic receptors expressed in native and recombinant cell systems.

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Virginio C, Giacometti A, Aldegheri L, Rimland JM, and Terstappen GC

European journal of pharmacology 445(3):153-61, 2002 Jun 12 - Who cited this? | PubMed ID: 12079679 | Fulltext

Pharmacological and molecular characterisation of SK3 channels in the TE671 human medulloblastoma cell line.

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Carignani C, Roncarati R, Rimini R, and Terstappen GC

Brain research 939(1-2):11-8, 2002 Jun 7 - Who cited this? | PubMed ID: 12020846 | Fulltext

Molecular cloning and initial characterization of the MG61/PORC gene, the human homologue of the Drosophila segment polarity gene Porcupine.

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Caricasole A, Ferraro T, Rimland JM, and Terstappen GC

Gene 288(1-2):147-57, 2002 Apr 17 - Who cited this? | PubMed ID: 12034504 | Fulltext

Molecular cloning and characterization of the human diacylglycerol kinase beta (DGKbeta) gene: alternative splicing generates DGKbeta isotypes with different properties.

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Caricasole A, Bettini E, Sala C, Roncarati R, Kobayashi N, Caldara F, Goto K, and Terstappen GC

The Journal of biological chemistry 277(7):4790-6, 2002 Feb 15 - Who cited this? | PubMed ID: 11719522 | Fulltext

Lithium induces gene expression through lymphoid enhancer-binding factor/T-cell factor responsive element in rat PC12 cells.

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Bettini E, Magnani E, and Terstappen GC

Neuroscience letters 317(1):50-2, 2002 Jan 4 - Who cited this? | PubMed ID: 11750994 | Fulltext

Pharmacological characterisation of the human small conductance calcium-activated potassium channel hSK3 reveals sensitivity to tricyclic antidepressants and antipsychotic phenothiazines.

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Terstappen GC, Pula G, Carignani C, Chen MX, and Roncarati R

Neuropharmacology 40(6):772, 2001 May - Who cited this? | PubMed ID: 11369031 | Fulltext

In silico research in drug discovery.

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Terstappen GC and Reggiani A

Trends in pharmacological sciences 22(1):23-6, 2001 Jan - Who cited this? | PubMed ID: 11165668 | Fulltext

Distribution of the messenger RNA for the small conductance calcium-activated potassium channel SK3 in the adult rat brain and correlation with immunoreactivity.

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Tacconi S, Carletti R, Bunnemann B, Plumpton C, Merlo Pich E, and Terstappen GC

Neuroscience 102(1):209-15, 2001 - Who cited this? | PubMed ID: 11226685 | Fulltext

Presynaptic localization of the small conductance calcium-activated potassium channel SK3 at the neuromuscular junction.

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Roncarati R, Di Chio M, Sava A, Terstappen GC, and Fumagalli G

Neuroscience 104(1):253-62, 2001 - Who cited this? | PubMed ID: 11311547 | Fulltext

Quantitative expression analysis of the small conductance calcium-activated potassium channels, SK1, SK2 and SK3, in human brain.

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Rimini R, Rimland JM, and Terstappen GC

Brain research. Molecular brain research 85(1-2):218-20, 2000 Dec 28 - Who cited this? | PubMed ID: 11146124 | Fulltext

Cloning and characterization of the human phosphoinositide-specific phospholipase C-beta 1 (PLC beta 1).

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Caricasole A, Sala C, Roncarati R, Formenti E, and Terstappen GC

Biochimica et biophysica acta 1517(1):63-72, 2000 Dec 15 - Who cited this? | PubMed ID: 11118617 | Fulltext

Development of a functional reporter gene HTS assay for the identification of mGluR7 modulators.

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Terstappen GC, Giacometti A, Ballini E, and Aldegheri L

Journal of biomolecular screening : the official journal of the Society for Biomolecular Screening 5(4):255-62, 2000 Aug - Who cited this? | PubMed ID: 10992046 | Fulltext

Identification, gene structure, and expression of human frizzled-3 (FZD3).

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Sala CF, Formenti E, Terstappen GC, and Caricasole A

Biochemical and biophysical research communications 273(1):27-34, 2000 Jun 24 - Who cited this? | PubMed ID: 10873558 | Fulltext

Cloud-point extraction of gangliosides using nonionic detergent C14EO6.

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Terstappen GC, Futerman AH, and Schwarz A

Methods in enzymology 312:187-96, 2000 - Who cited this? | PubMed ID: 11070872 | Fulltext

Functional analysis of native and recombinant ion channels using a high-capacity nonradioactive rubidium efflux assay.

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Terstappen GC

Analytical biochemistry 272(2):149-55, 1999 Aug 1 - Who cited this? | PubMed ID: 10415083 | Fulltext

Isolation of gangliosides by cloud-point extraction with a nonionic detergent.

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Schwarz A, Terstappen GC, and Futerman AH

Analytical biochemistry 254(2):221-5, 1997 Dec 15 - Who cited this? | PubMed ID: 9417780 | Fulltext

Protein partitioning in detergent-based aqueous two-phase systems.

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Terstappen GC, Ramelmeier RA, and Kula MR

Journal of biotechnology 28(2-3):263-75, 1993 Apr - Who cited this? | PubMed ID: 7763561 | Fulltext

The use of detergent-based aqueous two-phase systems for the isolation of extracellular proteins: purification of a lipase from Pseudomonas cepacia.

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Terstappen GC, Geerts AJ, and Kula MR

Biotechnology and applied biochemistry 16(3):228-35, 1992 Dec - Who cited this? | PubMed ID: 1282322 | Fulltext

The partitioning of cholesterol oxidase in Triton X-114-based aqueous two-phase systems.

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Ramelmeier RA, Terstappen GC, and Kula MR

Bioseparation 2(5):315-24, 1991 - Who cited this? | PubMed ID: 1368208 | Fulltext

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