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Papers authored by Takimoto CH

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Phase I and pharmacokinetic study of cisplatin and troxacitabine administered intravenously every 28 days in patients with advanced solid malignancies.

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Lin CC, Beeram M, Rowinsky EK, Takimoto CH, Ng CM, Geyer CE, Denis LJ, De Bono JS, Hao D, Tolcher AW, Rha SY, Jolivet J, and Patnaik A

Cancer chemotherapy and pharmacology 65(1):167-75, 2009 Dec - Who cited this? | PubMed ID: 19449006 | Fulltext

Pharmacokinetics and pharmacodynamic biomarkers in early oncology drug development.

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Takimoto CH

European journal of cancer (Oxford, England : 1990) 45 Suppl 1:436-8, 2009 Sep - Who cited this? | PubMed ID: 19775662 | Fulltext

Phase I study of paclitaxel poliglumex administered weekly for patients with advanced solid malignancies.

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Mita M, Mita A, Sarantopoulos J, Takimoto CH, Rowinsky EK, Romero O, Angiuli P, Allievi C, Eisenfeld A, and Verschraegen CF

Cancer chemotherapy and pharmacology 64(2):287-95, 2009 Jul - Who cited this? | PubMed ID: 19034451 | Fulltext

Phase II Study of Sorafenib in Patients With Metastatic or Recurrent Sarcomas.

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Maki RG, D'Adamo DR, Keohan ML, Saulle M, Schuetze SM, Undevia SD, Livingston MB, Cooney MM, Hensley ML, Mita MM, Takimoto CH, Kraft AS, Elias AD, Brockstein B, Blachère NE, Edgar MA,

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Journal of clinical oncology : official journal of the American Society of Clinical Oncology 27(19):3133-40, 2009 Jul 1 - Who cited this? | PubMed ID: 19451436 | Fulltext

A phase I study of eribulin mesylate (E7389), a mechanistically novel inhibitor of microtubule dynamics, in patients with advanced solid malignancies.

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Goel S, Mita AC, Mita M, Rowinsky EK, Chu QS, Wong N, Desjardins C, Fang F, Jansen M, Shuster DE, Mani S, and Takimoto CH

Clinical cancer research : an official journal of the American Association for Cancer Research 15(12):4207-12, 2009 Jun 15 - Who cited this? | PubMed ID: 19509177 | Fulltext

Castration-resistant prostate cancer: locking up the molecular escape routes.

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Attar RM, Takimoto CH, and Gottardis MM

Clinical cancer research : an official journal of the American Association for Cancer Research 15(10):3251-5, 2009 May 15 - Who cited this? | PubMed ID: 19447877 | Fulltext

Maximum tolerated dose: clinical endpoint for a bygone era?.

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Takimoto CH

Targeted oncology 4(2):143-7, 2009 Apr - Who cited this? | PubMed ID: 19377851 | Fulltext

Phase 0 clinical trials in oncology: a paradigm shift for early drug development?.

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Takimoto CH

Cancer chemotherapy and pharmacology 63(4):703-9, 2009 Mar - Who cited this? | PubMed ID: 18615251 | Fulltext

Population Pharmacokinetic/Pharmacodynamic Analyses of Pemetrexed and Neutropenia: Effect of Vitamin Supplementation and Differences between Japanese and Western Patients.

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Latz JE, Schneck KL, Nakagawa K, Miller MA, and Takimoto CH

Clinical cancer research : an official journal of the American Association for Cancer Research 15(1):346-54, 2009 Jan 1 - Who cited this? | PubMed ID: 19118064 | Fulltext

Commentary: tumor growth, patient survival, and the search for the optimal phase II efficacy endpoint.

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Takimoto CH

The oncologist 13(10):1043-5, 2008 Oct - Who cited this? | PubMed ID: 18832191 | Fulltext

Phase I study of cetuximab, erlotinib, and bevacizumab in patients with advanced solid tumors.

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Lin CC, Calvo E, Papadopoulos KP, Patnaik A, Sarantopoulos J, Mita AC, Preston GG, Mita MM, Rodon J, Mays T, Yeh IT, O'Rourke P, Takimoto CH, Dancey JE, Chen H, and Tolcher AW

Cancer chemotherapy and pharmacology, 2008 Sep 16 - Who cited this? | PubMed ID: 18795291 | Fulltext

Safety and anti-tumor activity of sorafenib (Nexavar((R))) in combination with other anti-cancer agents: a review of clinical trials.

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Takimoto CH and Awada A

Cancer chemotherapy and pharmacology 61(4):535-48, 2008 Apr - Who cited this? | PubMed ID: 18026728 | Fulltext

Dietary genistein inhibits metastasis of human prostate cancer in mice.

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Lakshman M, Xu L, Ananthanarayanan V, Cooper J, Takimoto CH, Helenowski I, Pelling JC, and Bergan RC

Cancer research 68(6):2024, 2008 Mar 15 - Who cited this? | PubMed ID: 18339885 | Fulltext

Phase I and pharmacokinetic study of imatinib mesylate in patients with advanced malignancies and varying degrees of liver dysfunction: a study by the National Cancer Institute Organ Dysfunction Working Group.

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Ramanathan RK, Egorin MJ, Takimoto CH, Remick SC, Doroshow JH, LoRusso PA, Mulkerin DL, Grem JL, Hamilton A, Murgo AJ, Potter DM, Belani CP, Hayes MJ, Peng B, Ivy SP, and National Cancer Institute Organ Dysfunction Working Group

Journal of clinical oncology : official journal of the American Society of Clinical Oncology 26(4):563-9, 2008 Feb 1 - Who cited this? | PubMed ID: 18235115 | Fulltext

Phase I and pharmacokinetic study of imatinib mesylate in patients with advanced malignancies and varying degrees of renal dysfunction: a study by the National Cancer Institute Organ Dysfunction Working Group.

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Gibbons J, Egorin MJ, Ramanathan RK, Fu P, Mulkerin DL, Shibata S, Takimoto CH, Mani S, LoRusso PA, Grem JL, Pavlick A, Lenz HJ, Flick SM, Reynolds S, Lagattuta TF, Parise RA,

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Journal of clinical oncology : official journal of the American Society of Clinical Oncology 26(4):570-6, 2008 Feb 1 - Who cited this? | PubMed ID: 18235116 | Fulltext

Oxaliplatin pharmacokinetics and pharmacodynamics in adult cancer patients with impaired renal function.

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Takimoto CH, Graham MA, Lockwood G, Ng CM, Goetz A, Greenslade D, Remick SC, Sharma S, Mani S, Ramanathan RK, Synold TW, Doroshow JH, Hamilton A, Mulkerin DL, Ivy P, Egorin MJ,

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Clinical cancer research : an official journal of the American Association for Cancer Research 13(16):4832-9, 2007 Aug 15 - Who cited this? | PubMed ID: 17699862 | Fulltext

Expression of epiregulin and amphiregulin and K-ras mutation status predict disease control in metastatic colorectal cancer patients treated with cetuximab.

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Khambata-Ford S, Garrett CR, Meropol NJ, Basik M, Harbison CT, Wu S, Wong TW, Huang X, Takimoto CH, Godwin AK, Tan BR, Krishnamurthi SS, Burris HA, Poplin EA, Hidalgo M, Baselga J,

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Journal of clinical oncology : official journal of the American Society of Clinical Oncology 25(22):3230-7, 2007 Aug 1 - Who cited this? | PubMed ID: 17664471 | Fulltext

Dose-escalating and pharmacologic study of oxaliplatin in adult cancer patients with impaired hepatic function: a National Cancer Institute Organ Dysfunction Working Group study.

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Synold TW, Takimoto CH, Doroshow JH, Gandara D, Mani S, Remick SC, Mulkerin DL, Hamilton A, Sharma S, Ramanathan RK, Lenz HJ, Graham M, Longmate J, Kaufman BM, Ivy P, and National Cancer Institute Organ Dysfunction Working Group

Clinical cancer research : an official journal of the American Association for Cancer Research 13(12):3660-6, 2007 Jun 15 - Who cited this? | PubMed ID: 17575231 | Fulltext

Phase I and pharmacokinetic study of pemetrexed with high-dose folic acid supplementation or multivitamin supplementation in patients with locally advanced or metastatic cancer.

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Takimoto CH, Hammond-Thelin LA, Latz JE, Forero L, Beeram M, Forouzesh B, de Bono J, Tolcher AW, Patnaik A, Monroe P, Wood L, Schneck KB, Clark R, and Rowinsky EK

Clinical cancer research : an official journal of the American Association for Cancer Research 13(9):2675-83, 2007 May 1 - Who cited this? | PubMed ID: 17473199 | Fulltext

Can tamoxifen therapy be optimized for patients with breast cancer on the basis of CYP2D6 activity assessments?.

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Takimoto CH

Nature clinical practice. Oncology 4(3):152-3, 2007 Mar - Who cited this? | PubMed ID: 17245346 | Fulltext

Design, conduct, and interpretation of organ impairment studies in oncology patients.

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Takimoto CH and Mita AC

Journal of clinical oncology : official journal of the American Society of Clinical Oncology 24(21):3509, 2006 Jul 20 - Who cited this? | PubMed ID: 16849773 | Fulltext

Chronomodulated chemotherapy for colorectal cancer: failing the test of time?.

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Takimoto CH

European journal of cancer (Oxford, England : 1990) 42(5):574-81, 2006 Mar - Who cited this? | PubMed ID: 16439112 | Fulltext

Phase I and pharmacokinetic study of pemetrexed administered every 3 weeks to advanced cancer patients with normal and impaired renal function.

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Mita AC, Sweeney CJ, Baker SD, Goetz A, Hammond LA, Patnaik A, Tolcher AW, Villalona-Calero M, Sandler A, Chaudhuri T, Molpus K, Latz JE, Simms L, Chaudhary AK, Johnson RD, Rowinsky EK,

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Journal of clinical oncology : official journal of the American Society of Clinical Oncology 24(4):552, 2006 Feb 1 - Who cited this? | PubMed ID: 16391300 | Fulltext

Two drug interaction studies evaluating the pharmacokinetics and toxicity of pemetrexed when coadministered with aspirin or Ibuprofen in patients with advanced cancer.

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Sweeney CJ, Takimoto CH, Latz JE, Baker SD, Murry DJ, Krull JH, Fife K, Battiato L, Cleverly A, Chaudhary AK, Chaudhuri T, Sandler A, Mita AC, and Rowinsky EK

Clinical cancer research : an official journal of the American Association for Cancer Research 12(2):536, 2006 Jan 15 - Who cited this? | PubMed ID: 16428497 | Fulltext

Phase I trial of sorafenib and gemcitabine in advanced solid tumors with an expanded cohort in advanced pancreatic cancer.

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Siu LL, Awada A, Takimoto CH, Piccart M, Schwartz B, Giannaris T, Lathia C, Petrenciuc O, and Moore MJ

Clinical cancer research : an official journal of the American Association for Cancer Research 12(1):144-51, 2006 Jan 1 - Who cited this? | PubMed ID: 16397036 | Fulltext

Phase I and pharmacokinetic study of sequences of the rebeccamycin analogue NSC 655649 and cisplatin in patients with advanced solid tumors.

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Ricart AD, Hammond LA, Kuhn JG, Takimoto CH, Goetz A, Forouzesh B, Forero L, Ochoa-Bayona JL, Berg K, Tolcher AW, and Rowinsky EK

Clinical cancer research : an official journal of the American Association for Cancer Research 11(24 Pt 1):8728, 2005 Dec 15 - Who cited this? | PubMed ID: 16361560 | Fulltext

Phase 1 study of weekly polyethylene glycol-camptothecin in patients with advanced solid tumors and lymphomas.

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Posey JA, Saif MW, Carlisle R, Goetz A, Rizzo J, Stevenson S, Rudoltz MS, Kwiatek J, Simmons P, Rowinsky EK, Takimoto CH, and Tolcher AW

Clinical cancer research : an official journal of the American Association for Cancer Research 11(21):7866-71, 2005 Nov 1 - Who cited this? | PubMed ID: 16278410 | Fulltext

Can docetaxel dosing be individualized based on cytochrome p450 activity?.

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Takimoto CH

Nature clinical practice. Oncology 2(9):446-7, 2005 Sep - Who cited this? | PubMed ID: 16265013 | Fulltext

Phase I and pharmacologic study of 17-(allylamino)-17-demethoxygeldanamycin in adult patients with solid tumors.

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Grem JL, Morrison G, Guo XD, Agnew E, Takimoto CH, Thomas R, Szabo E, Grochow L, Grollman F, Hamilton JM, Neckers L, and Wilson RH

Journal of clinical oncology : official journal of the American Society of Clinical Oncology 23(9):1885-93, 2005 Mar 20 - Who cited this? | PubMed ID: 15774780 | Fulltext

Thymidylate synthase inhibitors.

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Takimoto CH and Diggikar S

Cancer chemotherapy and biological response modifiers 22:1-18, 2005 - Who cited this? | PubMed ID: 16110605 | Fulltext

A phase I and pharmacologic study of weekly gemcitabine in combination with infusional 5-fluorodeoxyuridine and oral calcium leucovorin.

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Grem JL, Quinn MG, Keith B, Monahan BP, Hamilton JM, Xu Y, Harold N, Nguyen D, Takimoto CH, Rowedder A, Pang J, Morrison G, and Chen A

Cancer chemotherapy and pharmacology 52(6):487-96, 2003 Dec - Who cited this? | PubMed ID: 12955469 | Fulltext

A phase I and pharmacokinetic study of ILX-295501, an oral diarylsulfonylurea, on a weekly for 3 weeks every 4-week schedule in patients with advanced solid malignancies.

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Forouzesh B, Takimoto CH, Goetz A, Diab S, Hammond LA, Smetzer L, Schwartz G, Gazak R, Callaghan JT, Von Hoff DD, and Rowinsky EK

Clinical cancer research : an official journal of the American Association for Cancer Research 9(15):5540-9, 2003 Nov 15 - Who cited this? | PubMed ID: 14654534 | Fulltext

Phase I pharmacokinetic and pharmacodynamic analysis of unconjugated soy isoflavones administered to individuals with cancer.

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Takimoto CH, Glover K, Huang X, Hayes SA, Gallot L, Quinn M, Jovanovic BD, Shapiro A, Hernandez L, Goetz A, Llorens V, Lieberman R, Crowell JA, Poisson BA, and Bergan RC

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 12(11 Pt 1):1213-21, 2003 Nov - Who cited this? | PubMed ID: 14652284 | Fulltext

A phase I, pharmacokinetic, and biological study of the farnesyltransferase inhibitor tipifarnib in combination with gemcitabine in patients with advanced malignancies.

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Patnaik A, Eckhardt SG, Izbicka E, Tolcher AA, Hammond LA, Takimoto CH, Schwartz G, McCreery H, Goetz A, Mori M, Terada K, Gentner L, Rybak ME, Richards H, Zhang S, and Rowinsky EK

Clinical cancer research : an official journal of the American Association for Cancer Research 9(13):4761-71, 2003 Oct 15 - Who cited this? | PubMed ID: 14581347 | Fulltext

A phase I study of 9-aminocamptothecin as a colloidal dispersion formulation given as a fortnightly 72-h infusion.

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Leguizamo J, Quinn M, Takimoto CH, Liang MD, Ismail AS, Pang J, Dahut W, and Grem JL

Cancer chemotherapy and pharmacology 52(4):333-8, 2003 Oct - Who cited this? | PubMed ID: 12819941 | Fulltext

Are there any better camptothecins than the ones we have?.

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Takimoto CH

Clinical advances in hematology & oncology : H&O 1(10):578-9, 600, 2003 Oct - Who cited this? | PubMed ID: 16258452 | Fulltext

Dose-intense paclitaxel: deja vu all over again?.

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Takimoto CH and Rowinsky EK

Journal of clinical oncology : official journal of the American Society of Clinical Oncology 21(15):2810-4, 2003 Aug 1 - Who cited this? | PubMed ID: 12807932 | Fulltext

Pharmacology of oxaliplatin in solid tumor patients with hepatic dysfunction: a preliminary report of the National Cancer Institute Organ Dysfunction Working Group.

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Doroshow JH, Synold TW, Gandara D, Mani S, Remick SC, Mulkerin D, Hamilton A, Sharma S, Ramanathan RK, Lenz HJ, Graham M, Longmate J, Takimoto CH, and Ivy P

Seminars in oncology 30(4 Suppl 15):14-9, 2003 Aug - Who cited this? | PubMed ID: 14523790 | Fulltext

Administration of oxaliplatin to patients with renal dysfunction: a preliminary report of the national cancer institute organ dysfunction working group.

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Takimoto CH, Remick SC, Sharma S, Mani S, Ramanathan RK, Doroshow JH, Hamilton A, Mulkerin D, Graham M, Lockwood GF, Ivy P, Egorin M, Greenslade D, Goetz A, and Grem JL

Seminars in oncology 30(4 Suppl 15):20-5, 2003 Aug - Who cited this? | PubMed ID: 14523791 | Fulltext

Dose-escalating and pharmacological study of oxaliplatin in adult cancer patients with impaired renal function: a National Cancer Institute Organ Dysfunction Working Group Study.

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Takimoto CH, Remick SC, Sharma S, Mani S, Ramanathan RK, Doroshow J, Hamilton A, Mulkerin D, Graham M, Lockwood GF, Ivy P, Egorin M, Schuler B, Greenslade D, Goetz A, Knight R,

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Journal of clinical oncology : official journal of the American Society of Clinical Oncology 21(14):2664-72, 2003 Jul 15 - Who cited this? | PubMed ID: 12860942 | Fulltext

Pharmacokinetic and pharmacodynamic effects of oral eniluracil, fluorouracil and leucovorin given on a weekly schedule.

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Guo XD, Harold N, Saif MW, Schuler B, Szabo E, Hamilton JM, Monahan BP, Quinn MG, Cliatt J, Nguyen D, Grollman F, Thomas RR, McQuigan EA, Wilson R, Takimoto CH, and Grem JL

Cancer chemotherapy and pharmacology 52(1):79-85, 2003 Jul - Who cited this? | PubMed ID: 12707718 | Fulltext

Anticancer drug development at the US National Cancer Institute.

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Takimoto CH

Cancer chemotherapy and pharmacology 52 Suppl 1:S29-33, 2003 Jul - Who cited this? | PubMed ID: 12819935 | Fulltext

A Phase I and pharmacokinetic study of squalamine, an aminosterol angiogenesis inhibitor.

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Hao D, Hammond LA, Eckhardt SG, Patnaik A, Takimoto CH, Schwartz GH, Goetz AD, Tolcher AW, McCreery HA, Mamun K, Williams JI, Holroyd KJ, and Rowinsky EK

Clinical cancer research : an official journal of the American Association for Cancer Research 9(7):2465-71, 2003 Jul - Who cited this? | PubMed ID: 12855619 | Fulltext

A Phase I and pharmocokinetic study of exatecan mesylate administered as a protracted 21-day infusion in patients with advanced solid malignancies.

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Garrison MA, Hammond LA, Geyer CE, Schwartz G, Tolcher AW, Smetzer L, Figueroa JA, Ducharme M, Coyle J, Takimoto CH, De Jager RL, and Rowinsky EK

Clinical cancer research : an official journal of the American Association for Cancer Research 9(7):2527-37, 2003 Jul - Who cited this? | PubMed ID: 12855627 | Fulltext

Epidermal growth factor receptor and other molecular targets in the treatment of cancer.

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Takimoto CH

Clinical colorectal cancer 2(4):252, 2003 Feb - Who cited this? | PubMed ID: 12620147 | Fulltext

Doege-Potter syndrome: hypoglycemia associated with malignant solitary fibrous tumor.

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Zafar H, Takimoto CH, and Weiss G

Medical oncology (Northwood, London, England) 20(4):403-8, 2003 - Who cited this? | PubMed ID: 14716039 | Fulltext

A phase I and pharmacokinetic study of pegylated camptothecin as a 1-hour infusion every 3 weeks in patients with advanced solid malignancies.

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Rowinsky EK, Rizzo J, Ochoa L, Takimoto CH, Forouzesh B, Schwartz G, Hammond LA, Patnaik A, Kwiatek J, Goetz A, Denis L, McGuire J, and Tolcher AW

Journal of clinical oncology : official journal of the American Society of Clinical Oncology 21(1):148-57, 2003 Jan 1 - Who cited this? | PubMed ID: 12506184 | Fulltext

Pineal germinoma followed by hematogenous metastases.

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Saif MW and Takimoto CH

Southern medical journal 96(1):117-9, 2003 Jan - Who cited this? | PubMed ID: 12602751 | Fulltext

The multifunctional, multi-institutional, and sometimes even global phase I study: a better life for phase I evaluations or just "living large"?.

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Tolcher AW, Takimoto CH, and Rowinsky EK

Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20(21):4276-8, 2002 Nov 1 - Who cited this? | PubMed ID: 12409324 | Fulltext

Heat shock protein and proteasome targeting agents.

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Takimoto CH and Diggikar S

Hematology/oncology clinics of North America 16(5):1269-85, 2002 Oct - Who cited this? | PubMed ID: 12512392 | Fulltext

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Papers authored by Takimoto CH

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