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Papers authored by Takeuchi O

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Stepwise activation of BAX and BAK by tBID, BIM, and PUMA initiates mitochondrial apoptosis.

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Kim H, Tu HC, Ren D, Takeuchi O, Jeffers JR, Zambetti GP, Hsieh JJ, and Cheng EH

Molecular cell 36(3):487-99, 2009 Nov 13 - Who cited this? | PubMed ID: 19917256 | Fulltext

Experimental study of combination therapy with S-1 against pancreatic cancer.

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Yoshizawa J, Takizawa A, Takeuchi O, Hiraku O, Sasaki K, Morimoto Y, Atsuda K, Inoue G, Suzuki Y, Asanuma F, and Yamada Y

Cancer chemotherapy and pharmacology 64(6):1211-9, 2009 Nov - Who cited this? | PubMed ID: 19337733 | Fulltext

[Control of inflammatory responses by a novel RNase, Zc3h12a].

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Takeuchi O, Matsushita K, and Akira S

Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 54(14):1837-41, 2009 Nov - Who cited this? | PubMed ID: 19894584 | Fulltext

A selective contribution of the RIG-I-like receptor pathway to type I interferon responses activated by cytosolic DNA.

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Choi MK, Wang Z, Ban T, Yanai H, Lu Y, Koshiba R, Nakaima Y, Hangai S, Savitsky D, Nakasato M, Negishi H, Takeuchi O, Honda K, Akira S, Tamura T, and Taniguchi T

Proceedings of the National Academy of Sciences of the United States of America 106(42):17870-5, 2009 Oct 20 - Who cited this? | PubMed ID: 19805092 | Fulltext

Activation of MDA5 requires higher-order RNA structures generated during virus infection.

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Pichlmair A, Schulz O, Tan CP, Rehwinkel J, Kato H, Takeuchi O, Akira S, Way M, Schiavo G, and Reis e Sousa C

Journal of virology 83(20):10761-9, 2009 Oct - Who cited this? | PubMed ID: 19656871 | Fulltext

TANK is a negative regulator of Toll-like receptor signaling and is critical for the prevention of autoimmune nephritis.

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Kawagoe T, Takeuchi O, Takabatake Y, Kato H, Isaka Y, Tsujimura T, and Akira S

Nature immunology 10(9):965-72, 2009 Sep - Who cited this? | PubMed ID: 19668221 | Fulltext

Poly I:C-induced activation of NK cells by CD8alpha+ dendritic cells via the IPS-1 and TRIF-dependent pathways.

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Miyake T, Kumagai Y, Kato H, Guo Z, Matsushita K, Satoh T, Kawagoe T, Kumar H, Jang MH, Kawai T, Tani T, Takeuchi O, and Akira S

Journal of immunology (Baltimore, Md. : 1950) 183(4):2522-8, 2009 Aug 15 - Who cited this? | PubMed ID: 19635904 | Fulltext

Baculovirus Induces Type I Interferon Production through Toll-Like Receptor-Dependent and -Independent Pathways in a Cell-Type-Specific Manner.

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Abe T, Kaname Y, Wen X, Tani H, Moriishi K, Uematsu S, Takeuchi O, Ishii KJ, Kawai T, Akira S, and Matsuura Y

Journal of virology 83(15):7629-40, 2009 Aug - Who cited this? | PubMed ID: 19474102 | Fulltext

Recognition of 5' triphosphate by RIG-I helicase requires short blunt double-stranded RNA as contained in panhandle of negative-strand virus.

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Schlee M, Roth A, Hornung V, Hagmann CA, Wimmenauer V, Barchet W, Coch C, Janke M, Mihailovic A, Wardle G, Juranek S, Kato H, Kawai T, Poeck H, Fitzgerald KA, Takeuchi O,

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Immunity 31(1):25-34, 2009 Jul 17 - Who cited this? | PubMed ID: 19576794 | Fulltext

Zc3h12a is an RNase essential for controlling immune responses by regulating mRNA decay.

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Matsushita K, Takeuchi O, Standley DM, Kumagai Y, Kawagoe T, Miyake T, Satoh T, Kato H, Tsujimura T, Nakamura H, and Akira S

Nature 458(7242):1185-90, 2009 Apr 30 - Who cited this? | PubMed ID: 19322177 | Fulltext

Cutting Edge: TLR-Dependent viral recognition along with type I IFN positive feedback signaling masks the requirement of viral replication for IFN-{alpha} production in plasmacytoid dendritic cells.

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Kumagai Y, Kumar H, Koyama S, Kawai T, Takeuchi O, and Akira S

Journal of immunology (Baltimore, Md. : 1950) 182(7):3960-4, 2009 Apr 1 - Who cited this? | PubMed ID: 19299691 | Fulltext

The Triacylated ATP Binding Cluster Transporter Substrate-binding Lipoprotein of Staphylococcus aureus Functions as a Native Ligand for Toll-like Receptor 2.

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Kurokawa K, Lee H, Roh KB, Asanuma M, Kim YS, Nakayama H, Shiratsuchi A, Choi Y, Takeuchi O, Kang HJ, Dohmae N, Nakanishi Y, Akira S, Sekimizu K, and Lee BL

The Journal of biological chemistry 284(13):8406-11, 2009 Mar 27 - Who cited this? | PubMed ID: 19139093 | Fulltext

Selective roles for antiapoptotic MCL-1 during granulocyte development and macrophage effector function.

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Steimer DA, Boyd K, Takeuchi O, Fisher JK, Zambetti GP, and Opferman JT

Blood 113(12):2805-15, 2009 Mar 19 - Who cited this? | PubMed ID: 19064728 | Fulltext

C-type lectin Mincle is an activating receptor for pathogenic fungus, Malassezia.

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Yamasaki S, Matsumoto M, Takeuchi O, Matsuzawa T, Ishikawa E, Sakuma M, Tateno H, Uno J, Hirabayashi J, Mikami Y, Takeda K, Akira S, and Saito T

Proceedings of the National Academy of Sciences of the United States of America 106(6):1897-902, 2009 Feb 10 - Who cited this? | PubMed ID: 19171887 | Fulltext

Innate immunity to virus infection.

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Takeuchi O and Akira S

Immunological reviews 227(1):75-86, 2009 Jan - Who cited this? | PubMed ID: 19120477 | Fulltext

TRAF6 Establishes Innate Immune Responses by Activating NF-kappaB and IRF7 upon Sensing Cytosolic Viral RNA and DNA.

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Konno H, Yamamoto T, Yamazaki K, Gohda J, Akiyama T, Semba K, Goto H, Kato A, Yujiri T, Imai T, Kawaguchi Y, Su B, Takeuchi O, Akira S, Tsunetsugu-Yokota Y, and Inoue J

PLoS ONE 4(5):e5674, 2009 - Who cited this? | PubMed ID: 19479062 | Fulltext

Regulation of lymphocyte progenitor survival by the proapoptotic activities of Bim and Bid.

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Mandal M, Crusio KM, Meng F, Liu S, Kinsella M, Clark MR, Takeuchi O, and Aifantis I

Proceedings of the National Academy of Sciences of the United States of America 105(52):20840-5, 2008 Dec 30 - Who cited this? | PubMed ID: 19088189 | Fulltext

TLR7-dependent and Fc{gamma}R-independent production of type I interferon in experimental mouse lupus.

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Lee PY, Kumagai Y, Li Y, Takeuchi O, Yoshida H, Weinstein J, Kellner ES, Nacionales D, Barker T, Kelly-Scumpia K, van Rooijen N, Kumar H, Kawai T, Satoh M, Akira S, and Reeves WH

The Journal of experimental medicine 205(13):2995-3006, 2008 Dec 22 - Who cited this? | PubMed ID: 19047436 | Fulltext

RIG-I-like antiviral protein in flies.

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Takeuchi O and Akira S

Nature immunology 9(12):1327-8, 2008 Dec - Who cited this? | PubMed ID: 19008930 | Fulltext

Polaprezinc attenuates liver fibrosis in a mouse model of non-alcoholic steatohepatitis.

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Sugino H, Kumagai N, Watanabe S, Toda K, Takeuchi O, Tsunematsu S, Morinaga S, and Tsuchimoto K

Journal of gastroenterology and hepatology 23(12):1909-16, 2008 Dec - Who cited this? | PubMed ID: 18422963 | Fulltext

Optical doping: active control of metal-insulator transition in nanowire.

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Terada Y, Yoshida S, Okubo A, Kanazawa K, Xu M, Takeuchi O, and Shigekawa H

Nano letters 8(11):3577-81, 2008 Nov - Who cited this? | PubMed ID: 18837564 | Fulltext

Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production.

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Saitoh T, Fujita N, Jang MH, Uematsu S, Yang BG, Satoh T, Omori H, Noda T, Yamamoto N, Komatsu M, Tanaka K, Kawai T, Tsujimura T, Takeuchi O, Yoshimori T, and Akira S

Nature, 2008 Oct 5 - Who cited this? | PubMed ID: 18849965 | Fulltext

Primary isolated extramedullary plasmacytoma of the colon.

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Doki T, Takeuchi O, Kaiho T, Tsuchiya S, Matsuzaki O, and Miyazaki M

International journal of colorectal disease 23(7):719, 2008 Jul - Who cited this? | PubMed ID: 18239923 | Fulltext

Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid-inducible gene-I and melanoma differentiation-associated gene 5.

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Kato H, Takeuchi O, Mikamo-Satoh E, Hirai R, Kawai T, Matsushita K, Hiiragi A, Dermody TS, Fujita T, and Akira S

The Journal of experimental medicine, 2008 Jun 30 - Who cited this? | PubMed ID: 18591409 | Fulltext

Sequential control of Toll-like receptor-dependent responses by IRAK1 and IRAK2.

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Kawagoe T, Sato S, Matsushita K, Kato H, Matsui K, Kumagai Y, Saitoh T, Kawai T, Takeuchi O, and Akira S

Nature immunology 9(6):684, 2008 Jun - Who cited this? | PubMed ID: 18438411 | Fulltext

Effect of the herbal medicine Inchin-Ko-To for serum bilirubin in hepatectomized patients.

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Kaiho T, Tsuchiya S, Yanagisawa S, Takeuchi O, Togawa A, Okamoto R, Saigusa N, and Miyazaki M

Hepato-gastroenterology 55(81):150 - Who cited this? | PubMed ID: 18507096 | Fulltext

TLR9 as a key receptor for the recognition of DNA.

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Kumagai Y, Takeuchi O, and Akira S

Advanced drug delivery reviews 60(7):795-804, 2008 Apr 29 - Who cited this? | PubMed ID: 18262306 | Fulltext

Pathogen recognition by innate receptors.

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Kumagai Y, Takeuchi O, and Akira S

Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 14(2):86, 2008 Apr - Who cited this? | PubMed ID: 18622669 | Fulltext

TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines.

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Ishii KJ, Kawagoe T, Koyama S, Matsui K, Kumar H, Kawai T, Uematsu S, Takeuchi O, Takeshita F, Coban C, and Akira S

Nature 451(7179):725-9, 2008 Feb 7 - Who cited this? | PubMed ID: 18256672 | Fulltext

MDA5/RIG-I and virus recognition.

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Takeuchi O and Akira S

Current opinion in immunology 20(1):17-22, 2008 Feb - Who cited this? | PubMed ID: 18272355 | Fulltext

Translocation of VP1686 upregulates RhoB and accelerates phagocytic activity of macrophage through actin remodeling.

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Bhattacharjee RN, Park KS, Chen X, Iida T, Honda T, Takeuchi O, and Akira S

Journal of microbiology and biotechnology 18(1):171, 2008 Jan - Who cited this? | PubMed ID: 18239436 | Fulltext

Akirins are highly conserved nuclear proteins required for NF-kappaB-dependent gene expression in drosophila and mice.

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Goto A, Matsushita K, Gesellchen V, El Chamy L, Kuttenkeuler D, Takeuchi O, Hoffmann JA, Akira S, Boutros M, and Reichhart JM

Nature immunology 9(1):97, 2008 Jan - Who cited this? | PubMed ID: 18066067 | Fulltext

Lymphocytoid choriomeningitis virus activates plasmacytoid dendritic cells and induces a cytotoxic T-cell response via MyD88.

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Jung A, Kato H, Kumagai Y, Kumar H, Kawai T, Takeuchi O, and Akira S

Journal of virology 82(1):196-206, 2008 Jan - Who cited this? | PubMed ID: 17942529 | Fulltext

A patient with adenocarcinoma of the jejunum successfully diagnosed by preoperative endoscopy for the small intestine.

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Sakai Y, Tsuyuguchi T, Ohara T, Yukisawa S, Tsuchiya S, Sugiyama H, Miyakhawa K, Ohbu M, Kato K, Kimura M, Kaiho T, Takeuchi O, Matsuzaki O, Miyazaki M, and Yokosuka O

Hepato-gastroenterology 55(85):1367-9, 2008 - Who cited this? | PubMed ID: 18795691 | Fulltext

Recognition of viruses by innate immunity.

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Takeuchi O and Akira S

Immunological reviews 220(1):214-24, 2007 Dec - Who cited this? | PubMed ID: 17979849 | Fulltext

Reversible defect engineering of single-walled carbon nanotubes using scanning tunneling microscopy.

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Berthe M, Yoshida S, Ebine Y, Kanazawa K, Okada A, Taninaka A, Takeuchi O, Fukui N, Shinohara H, Suzuki S, Sumitomo K, Kobayashi Y, Grandidier B, Stiévenard D, and Shigekawa H

Nano letters 7(12):3623-7, 2007 Dec - Who cited this? | PubMed ID: 18034501 | Fulltext

What orchestrates the self-assembly of glycine molecules on cu(100)?.

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Kanazawa K, Taninaka A, Takeuchi O, and Shigekawa H

Physical review letters 99(21):216102, 2007 Nov 23 - Who cited this? | PubMed ID: 18233231 | Fulltext

Genetic analysis of resistance to viral infection.

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Beutler B, Eidenschenk C, Crozat K, Imler JL, Takeuchi O, Hoffmann JA, and Akira S

Nature reviews. Immunology 7(10):753-66, 2007 Oct - Who cited this? | PubMed ID: 17893693 | Fulltext

Enhanced TLR-mediated NF-IL6 dependent gene expression by Trib1 deficiency.

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Yamamoto M, Uematsu S, Okamoto T, Matsuura Y, Sato S, Kumar H, Satoh T, Saitoh T, Takeda K, Ishii KJ, Takeuchi O, Kawai T, and Akira S

The Journal of experimental medicine 204(9):2233-9, 2007 Sep 3 - Who cited this? | PubMed ID: 17724128 | Fulltext

Hepatitis C virus nonstructural protein 5A modulates the toll-like receptor-MyD88-dependent signaling pathway in macrophage cell lines.

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Abe T, Kaname Y, Hamamoto I, Tsuda Y, Wen X, Taguwa S, Moriishi K, Takeuchi O, Kawai T, Kanto T, Hayashi N, Akira S, and Matsuura Y

Journal of virology 81(17):8953-66, 2007 Sep - Who cited this? | PubMed ID: 17567694 | Fulltext

A spatially and temporally restricted mouse model of soft tissue sarcoma.

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Kirsch DG, Dinulescu DM, Miller JB, Grimm J, Santiago PM, Young NP, Nielsen GP, Quade BJ, Chaber CJ, Schultz CP, Takeuchi O, Bronson RT, Crowley D, Korsmeyer SJ, Yoon SS, Hornicek FJ,

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Nature medicine 13(8):992-7, 2007 Aug - Who cited this? | PubMed ID: 17676052 | Fulltext

Alveolar macrophages are the primary interferon-alpha producer in pulmonary infection with RNA viruses.

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Kumagai Y, Takeuchi O, Kato H, Kumar H, Matsui K, Morii E, Aozasa K, Kawai T, and Akira S

Immunity 27(2):240-52, 2007 Aug - Who cited this? | PubMed ID: 17723216 | Fulltext

[Pathogen recognition by innate immunity].

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Takeuchi O and Akira S

Arerugī = [Allergy] 56(6):558, 2007 Jun - Who cited this? | PubMed ID: 17615498 | Fulltext

Essential role of IRAK-4 protein and its kinase activity in Toll-like receptor-mediated immune responses but not in TCR signaling.

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Kawagoe T, Sato S, Jung A, Yamamoto M, Matsui K, Kato H, Uematsu S, Takeuchi O, and Akira S

The Journal of experimental medicine 204(5):1013-24, 2007 May 14 - Who cited this? | PubMed ID: 17485511 | Fulltext

TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity.

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Gack MU, Shin YC, Joo CH, Urano T, Liang C, Sun L, Takeuchi O, Akira S, Chen Z, Inoue S, and Jung JU

Nature 446(7138):916-920, 2007 Apr 19 - Who cited this? | PubMed ID: 17392790 | Fulltext

Signaling pathways activated by microorganisms.

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Takeuchi O and Akira S

Current opinion in cell biology 19(2):185-91, 2007 Apr - Who cited this? | PubMed ID: 17303405 | Fulltext

Anisotropic free-electron-like dispersions and standing waves realized in self-assembled monolayers of glycine on Cu(100).

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Kanazawa K, Sainoo Y, Konishi Y, Yoshida S, Taninaka A, Okada A, Berthe M, Kobayashi N, Takeuchi O, and Shigekawa H

Journal of the American Chemical Society 129(4):740-1, 2007 Jan 31 - Who cited this? | PubMed ID: 17243792 | Fulltext

Microscopic basis for the mechanism of carrier dynamics in an operating p-n junction examined by using light-modulated scanning tunneling spectroscopy.

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Yoshida S, Kanitani Y, Oshima R, Okada Y, Takeuchi O, and Shigekawa H

Physical review letters 98(2):026802, 2007 Jan 12 - Who cited this? | PubMed ID: 17358630 | Fulltext

Pathological role of Toll-like receptor signaling in cerebral malaria.

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Coban C, Ishii KJ, Uematsu S, Arisue N, Sato S, Yamamoto M, Kawai T, Takeuchi O, Hisaeda H, Horii T, and Akira S

International immunology 19(1):67-79, 2007 Jan - Who cited this? | PubMed ID: 17135446 | Fulltext

Cutting Edge: Pivotal function of Ubc13 in thymocyte TCR signaling.

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Yamamoto M, Sato S, Saitoh T, Sakurai H, Uematsu S, Kawai T, Ishii KJ, Takeuchi O, and Akira S

Journal of immunology (Baltimore, Md. : 1950) 177(11):7520, 2006 Dec 1 - Who cited this? | PubMed ID: 17114420 | Fulltext

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