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Papers authored by Sussman JL

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Characterization of gene-activated human acid-{beta}-glucosidase: Crystal structure, glycan composition, and internalization into macrophages.

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Brumshtein B, Salinas P, Peterson B, Chan V, Silman I, Sussman JL, Savickas PJ, Robinson GS, and Futerman AH

Glycobiology 20(1):24-32, 2010 Jan - Who cited this? | PubMed ID: 19741058 | Fulltext

Crystallographic Snapshots of Nonaged and Aged Conjugates of Soman with Acetylcholinesterase, and of a Ternary Complex of the Aged Conjugate with Pralidoxime (dagger).

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Sanson B, Nachon F, Colletier JP, Froment MT, Toker L, Greenblatt HM, Sussman JL, Ashani Y, Masson P, Silman I, and Weik M

Journal of medicinal chemistry 52(23):7593-603, 2009 Dec 10 - Who cited this? | PubMed ID: 19642642 | Fulltext

The quaternary structure of amalgam, a Drosophila neuronal adhesion protein, explains its dual adhesion properties.

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Zeev-Ben-Mordehai T, Mylonas E, Paz A, Peleg Y, Toker L, Silman I, Svergun DI, and Sussman JL

Biophysical journal 97(8):2316-26, 2009 Oct 21 - Who cited this? | PubMed ID: 19843464 | Fulltext

Design, expression and characterization of mutants of fasciculin optimized for interaction with its target, acetylcholinesterase.

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Sharabi O, Peleg Y, Mashiach E, Vardy E, Ashani Y, Silman I, Sussman JL, and Shifman JM

Protein engineering, design & selection : PEDS 22(10):641-8, 2009 Oct - Who cited this? | PubMed ID: 19643977 | Fulltext

Directed Evolution of Serum Paraoxonase PON3 by Family Shuffling and Ancestor/Consensus Mutagenesis, and Its Biochemical Characterization.

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Khersonsky O, Rosenblat M, Toker L, Yacobson S, Hugenmatter A, Silman I, Sussman JL, Aviram M, and Tawfik DS

Biochemistry 48(28):6644-54, 2009 Jul 21 - Who cited this? | PubMed ID: 19492856 | Fulltext

6-Amino-6-deoxy-5,6-di-N-(N'-octyliminomethylidene)nojirimycin: synthesis, biological evaluation, and crystal structure in complex with acid beta-glucosidase.

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Brumshtein B, Aguilar-Moncayo M, García-Moreno MI, Ortiz Mellet C, García Fernández JM, Silman I, Shaaltiel Y, Aviezer D, Sussman JL, and Futerman AH

Chembiochem : a European journal of chemical biology 10(9):1480-5, 2009 Jun 15 - Who cited this? | PubMed ID: 19437524 | Fulltext

The crystal structure of a complex of acetylcholinesterase with a Bis-(-)-nor-meptazinol derivative reveals disruption of the catalytic triad.

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Paz A, Xie Q, Greenblatt HM, Fu W, Tang Y, Silman I, Qiu Z, and Sussman JL

Journal of medicinal chemistry 52(8):2543-9, 2009 Apr 23 - Who cited this? | PubMed ID: 19326912 | Fulltext

An encyclopedic effort to make 3D structures easier to understand.

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Hodis E and Sussman JL

Trends in biochemical sciences 34(3):100-1, 2009 Mar - Who cited this? | PubMed ID: 19230677 | Fulltext

Amalgam, an axon guidance Drosophila adhesion protein belonging to the immunoglobulin superfamily: Over-expression, purification and biophysical characterization.

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Zeev-Ben-Mordehai T, Paz A, Peleg Y, Toker L, Wolf SG, Rydberg EH, Sussman JL, and Silman I

Protein expression and purification 63(2):147-57, 2009 Feb - Who cited this? | PubMed ID: 18938249 | Fulltext

Assessment of CASP8 structure predictions for template free targets.

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Ben-David M, Noivirt-Brik O, Paz A, Prilusky J, Sussman JL, and Levy Y

Proteins 77 Suppl 9:50-65, 2009 - Who cited this? | PubMed ID: 19774550 | Fulltext

Assessment of disorder predictions in CASP8.

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Noivirt-Brik O, Prilusky J, and Sussman JL

Proteins 77 Suppl 9:210-6, 2009 - Who cited this? | PubMed ID: 19774619 | Fulltext

Function and structure of inherently disordered proteins.

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Dunker AK, Silman I, Uversky VN, and Sussman JL

Current opinion in structural biology 18(6):756-64, 2008 Dec - Who cited this? | PubMed ID: 18952168 | Fulltext

Acetylcholinesterase: How is structure related to function?.

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Silman I and Sussman JL

Chemico-biological interactions 175(1-3):3-10, 2008 Sep 25 - Who cited this? | PubMed ID: 18586019 | Fulltext

Acid-beta-glucosidase: insights from structural analysis and relevance to Gaucher disease therapy.

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Kacher Y, Brumshtein B, Boldin-Adamsky S, Toker L, Shainskaya A, Silman I, Sussman JL, and Futerman AH

Biological chemistry, 2008 Sep 11 - Who cited this? | PubMed ID: 18783340 | Fulltext

Flexibility of aromatic residues in the active-site gorge of acetylcholinesterase: X-ray versus molecular dynamics.

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Xu Y, Colletier JP, Weik M, Jiang H, Moult J, Silman I, and Sussman JL

Biophysical journal 95(5):2500-11, 2008 Sep - Who cited this? | PubMed ID: 18502801 | Fulltext

Shoot-and-Trap: Use of specific x-ray damage to study structural protein dynamics by temperature-controlled cryo-crystallography.

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Colletier JP, Bourgeois D, Sanson B, Fournier D, Sussman JL, Silman I, and Weik M

Proceedings of the National Academy of Sciences of the United States of America, 2008 Aug 13 - Who cited this? | PubMed ID: 18701720 | Fulltext

Proteopedia - a scientific 'wiki' bridging the rift between 3D structure and function of biomacromolecules.

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Hodis E, Prilusky J, Martz E, Silman I, Moult J, and Sussman JL

Genome biology 9(8), 2008 Aug 3 - Who cited this? | PubMed ID: 18673581 | Fulltext

Crystal structure of thioflavin T bound to the peripheral site of Torpedo californica acetylcholinesterase reveals how thioflavin T acts as a sensitive fluorescent reporter of ligand binding to the acylation site.

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Harel M, Sonoda LK, Silman I, Sussman JL, and Rosenberry TL

Journal of the American Chemical Society 130(25):7856-61, 2008 Jun 25 - Who cited this? | PubMed ID: 18512913 | Fulltext

Crystal structure of YagE, a putative DHDPS-like protein from Escherichia coli K12.

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Manicka S, Peleg Y, Unger T, Albeck S, Dym O, Greenblatt HM, Bourenkov G, Lamzin V, Krishnaswamy S, and Sussman JL

Proteins 71(4):2102, 2008 Jun - Who cited this? | PubMed ID: 18361457 | Fulltext

Structural disorder serves as a weak signal for intracellular protein degradation.

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Tompa P, Prilusky J, Silman I, and Sussman JL

Proteins 71(2):903-9, 2008 May 1 - Who cited this? | PubMed ID: 18004785 | Fulltext

Induced-fit or preexisting equilibrium dynamics? Lessons from protein crystallography and MD simulations on acetylcholinesterase and implications for structure-based drug design.

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Xu Y, Colletier JP, Jiang H, Silman I, Sussman JL, and Weik M

Protein science : a publication of the Protein Society 17(4):601, 2008 Apr - Who cited this? | PubMed ID: 18359854 | Fulltext

Operational definition of intrinsically unstructured protein sequences based on susceptibility to the 20S proteasome.

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Tsvetkov P, Asher G, Paz A, Reuven N, Sussman JL, Silman I, and Shaul Y

Proteins 70(4):1357-66, 2008 Mar - Who cited this? | PubMed ID: 17879262 | Fulltext

Protein production and purification.

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Structural Genomics Consortium, Gräslund S, Nordlund P, Weigelt J, Bray J, Gileadi O, Knapp S, Oppermann U, Arrowsmith C, Hui R, Ming J, dhe-Paganon S, Park HW, Savchenko A, Yee A, Edwards A,

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Nature methods 5(2):135-46, 2008 Feb - Who cited this? | PubMed ID: 18235434 | Fulltext

High throughput pH optimization of protein crystallization.

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Meged R, Dym O, and Sussman JL

Methods in molecular biology (Clifton, N.J.) 426:411, 2008 - Who cited this? | PubMed ID: 18542880 | Fulltext

Use of a 'caged' analogue to study the traffic of choline within acetylcholinesterase by kinetic crystallography.

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Colletier JP, Royant A, Specht A, Sanson B, Nachon F, Masson P, Zaccai G, Sussman JL, Goeldner M, Silman I, Bourgeois D, and Weik M

Acta crystallographica. Section D, Biological crystallography 63(Pt 11):1115-28, 2007 Nov - Who cited this? | PubMed ID: 18007027 | Fulltext

Crystal structures of complexes of N-butyl- and N-nonyl-deoxynojirimycin bound to acid beta-glucosidase: insights into the mechanism of chemical chaperone action in Gaucher disease.

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Brumshtein B, Greenblatt HM, Butters TD, Shaaltiel Y, Aviezer D, Silman I, Futerman AH, and Sussman JL

The Journal of biological chemistry 282(39):29052-8, 2007 Sep 28 - Who cited this? | PubMed ID: 17666401 | Fulltext

Production of glucocerebrosidase with terminal mannose glycans for enzyme replacement therapy of Gaucher's disease using a plant cell system.

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Shaaltiel Y, Bartfeld D, Hashmueli S, Baum G, Brill-Almon E, Galili G, Dym O, Boldin-Adamsky SA, Silman I, Sussman JL, Futerman AH, and Aviezer D

Plant biotechnology journal 5(5):579-90, 2007 Sep - Who cited this? | PubMed ID: 17524049 | Fulltext

3-D structure of serum paraoxonase 1 sheds light on its activity, stability, solubility and crystallizability.

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Harel M, Brumshtein B, Meged R, Dvir H, Ravelli RB, McCarthy A, Toker L, Silman I, and Sussman JL

Arhiv za higijenu rada i toksikologiju 58(3):347-53, 2007 Sep - Who cited this? | PubMed ID: 17913690 | Fulltext

A server and database for dipole moments of proteins.

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Felder CE, Prilusky J, Silman I, and Sussman JL

Nucleic acids research 35(Web Server issue):W512-21, 2007 Jul 1 - Who cited this? | PubMed ID: 17526523 | Fulltext

eMovie: a storyboard-based tool for making molecular movies.

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Hodis E, Schreiber G, Rother K, and Sussman JL

Trends in biochemical sciences 32(5):199-204, 2007 May - Who cited this? | PubMed ID: 17448663 | Fulltext

RIKEN aids international structural genomics efforts.

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Yokoyama S, Terwilliger TC, Kuramitsu S, Moras D, and Sussman JL

Nature 445(7123):21, 2007 Jan 4 - Who cited this? | PubMed ID: 17203040 | Fulltext

Structural proteomics: from the molecule to the system.

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Banci L, Baumeister W, Enfedaque J, Heinemann U, Schneider G, Silman I, and Sussman JL

Nature structural & molecular biology 14(1):3-4, 2007 Jan - Who cited this? | PubMed ID: 17203065 | Fulltext

Bivalent ligands derived from Huperzine A as acetylcholinesterase inhibitors.

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Haviv H, Wong DM, Silman I, and Sussman JL

Current topics in medicinal chemistry 7(4):375-87, 2007 - Who cited this? | PubMed ID: 17305579 | Fulltext

An idea whose time has come.

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Banci L, Baumeister W, Heinemann U, Schneider G, Silman I, Stuart DI, and Sussman JL

Genome biology 8(11):408, 2007 - Who cited this? | PubMed ID: 18001498 | Fulltext

Structural comparison of differently glycosylated forms of acid-beta-glucosidase, the defective enzyme in Gaucher disease.

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Brumshtein B, Wormald MR, Silman I, Futerman AH, and Sussman JL

Acta crystallographica. Section D, Biological crystallography 62(Pt 12):1458-65, 2006 Dec - Who cited this? | PubMed ID: 17139081 | Fulltext

Eukaryotic expression: developments for structural proteomics.

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Aricescu AR, Assenberg R, Bill RM, Busso D, Chang VT, Davis SJ, Dubrovsky A, Gustafsson L, Hedfalk K, Heinemann U, Jones IM, Ksiazek D, Lang C, Maskos K, Messerschmidt A, Macieira S,

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Acta crystallographica. Section D, Biological crystallography 62(Pt 10):1114-24, 2006 Oct - Who cited this? | PubMed ID: 17001089 | Fulltext

SPINE high-throughput crystallization, crystal imaging and recognition techniques: current state, performance analysis, new technologies and future aspects.

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Berry IM, Dym O, Esnouf RM, Harlos K, Meged R, Perrakis A, Sussman JL, Walter TS, Wilson J, and Messerschmidt A

Acta crystallographica. Section D, Biological crystallography 62(Pt 10):1137-49, 2006 Oct - Who cited this? | PubMed ID: 17001091 | Fulltext

SPINE bioinformatics and data-management aspects of high-throughput structural biology.

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Albeck S, Alzari P, Andreini C, Banci L, Berry IM, Bertini I, Cambillau C, Canard B, Carter L, Cohen SX, Diprose JM, Dym O, Esnouf RM, Felder C, Ferron F, Guillemot F,

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Acta crystallographica. Section D, Biological crystallography 62(Pt 10):1184-95, 2006 Oct - Who cited this? | PubMed ID: 17001095 | Fulltext

First steps towards effective methods in exploiting high-throughput technologies for the determination of human protein structures of high biomedical value.

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Banci L, Bertini I, Cusack S, de Jong RN, Heinemann U, Jones EY, Kozielski F, Maskos K, Messerschmidt A, Owens R, Perrakis A, Poterszman A, Schneider G, Siebold C, Silman I, Sixma T,

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Acta crystallographica. Section D, Biological crystallography 62(Pt 10):1208-17, 2006 Oct - Who cited this? | PubMed ID: 17001097 | Fulltext

Co-expression of protein complexes in prokaryotic and eukaryotic hosts: experimental procedures, database tracking and case studies.

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Romier C, Ben Jelloul M, Albeck S, Buchwald G, Busso D, Celie PH, Christodoulou E, De Marco V, van Gerwen S, Knipscheer P, Lebbink JH, Notenboom V, Poterszman A, Rochel N, Cohen SX, Unger T,

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Acta crystallographica. Section D, Biological crystallography 62(Pt 10):1232-42, 2006 Oct - Who cited this? | PubMed ID: 17001100 | Fulltext

Honing the in silico toolkit for detecting protein disorder.

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Esnouf RM, Hamer R, Sussman JL, Silman I, Trudgian D, Yang ZR, and Prilusky J

Acta crystallographica. Section D, Biological crystallography 62(Pt 10):1260-6, 2006 Oct - Who cited this? | PubMed ID: 17001103 | Fulltext

Complexes of alkylene-linked tacrine dimers with Torpedo californica acetylcholinesterase: Binding of Bis5-tacrine produces a dramatic rearrangement in the active-site gorge.

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Rydberg EH, Brumshtein B, Greenblatt HM, Wong DM, Shaya D, Williams LD, Carlier PR, Pang YP, Silman I, and Sussman JL

Journal of medicinal chemistry 49(18):5491-500, 2006 Sep 7 - Who cited this? | PubMed ID: 16942022 | Fulltext

Structural insights into substrate traffic and inhibition in acetylcholinesterase.

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Colletier JP, Fournier D, Greenblatt HM, Stojan J, Sussman JL, Zaccai G, Silman I, and Weik M

The EMBO journal 25(12):2746, 2006 Jun 21 - Who cited this? | PubMed ID: 16763558 | Fulltext

Shedding UV light on the phase problem.

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Sussman JL and Silman I

Structure (London, England : 1993) 14(4):629, 2006 Apr - Who cited this? | PubMed ID: 16615902 | Fulltext

Inhibition of acetylcholinesterase by the anticancer prodrug CPT-11.

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Hyatt JL, Tsurkan L, Morton CL, Yoon KJ, Harel M, Brumshtein B, Silman I, Sussman JL, Wadkins RM, and Potter PM

Chemico-biological interactions 157-158:247-52, 2005 Dec 15 - Who cited this? | PubMed ID: 16257398 | Fulltext

The 3D structure of the anticancer prodrug CPT-11 with Torpedo californica acetylcholinesterase rationalizes its inhibitory action on AChE and its hydrolysis by butyrylcholinesterase and carboxylesterase.

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Harel M, Hyatt JL, Brumshtein B, Morton CL, Wadkins RM, Silman I, Sussman JL, and Potter PM

Chemico-biological interactions 157-158:153-7, 2005 Dec 15 - Who cited this? | PubMed ID: 16289500 | Fulltext

Dynamic mechanism of E2020 binding to acetylcholinesterase: a steered molecular dynamics simulation.

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Niu C, Xu Y, Xu Y, Luo X, Duan W, Silman I, Sussman JL, Zhu W, Chen K, Shen J, and Jiang H

The journal of physical chemistry. B 109(49):23730-8, 2005 Dec 15 - Who cited this? | PubMed ID: 16375354 | Fulltext

Three-dimensional structure determination of proteins related to human health in their functional context at The Israel Structural Proteomics Center (ISPC). This paper was presented at ICCBM10.

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Albeck S, Burstein Y, Dym O, Jacobovitch Y, Levi N, Meged R, Michael Y, Peleg Y, Prilusky J, Schreiber G, Silman I, Unger T, and Sussman JL

Acta crystallographica. Section D, Biological crystallography 61(Pt 10):1364-72, 2005 Oct - Who cited this? | PubMed ID: 16204888 | Fulltext

Towards rationalization of crystallization screening for small- to medium-sized academic laboratories: the PACT/JCSG+ strategy.

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Newman J, Egan D, Walter TS, Meged R, Berry I, Ben Jelloul M, Sussman JL, Stuart DI, and Perrakis A

Acta crystallographica. Section D, Biological crystallography 61(Pt 10):1426-31, 2005 Oct - Who cited this? | PubMed ID: 16204897 | Fulltext

FoldIndex: a simple tool to predict whether a given protein sequence is intrinsically unfolded.

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Prilusky J, Felder CE, Zeev-Ben-Mordehai T, Rydberg EH, Man O, Beckmann JS, Silman I, and Sussman JL

Bioinformatics (Oxford, England) 21(16):3435, 2005 Aug 15 - Who cited this? | PubMed ID: 15955783 | Fulltext

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