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Papers authored by Slusarchyk WA

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Structure of the complex of trypsin with a highly potent synthetic inhibitor at 0.97 A resolution.

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Sherawat M, Kaur P, Perbandt M, Betzel C, Slusarchyk WA, Bisacchi GS, Chang C, Jacobson BL, Einspahr HM, and Singh TP

Acta crystallographica. Section D, Biological crystallography 63(Pt 4):500-7, 2007 Apr - Who cited this? | PubMed ID: 17372355 | Fulltext

Synthesis of potent and highly selective nonguanidine azetidinone inhibitors of human tryptase.

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Bisacchi GS, Slusarchyk WA, Bolton SA, Hartl KS, Jacobs G, Mathur A, Meng W, Ogletree ML, Pi Z, Sutton JC, Treuner U, Zahler R, Zhao G, and Seiler SM

Bioorganic & medicinal chemistry letters 14(9):2227-31, 2004 May 3 - Who cited this? | PubMed ID: 15081014 | Fulltext

Solid-phase synthesis and SAR of 4-carboxy-2-azetidinone mechanism-based tryptase inhibitors.

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Sutton JC, Bolton SA, Davis ME, Hartl KS, Jacobson B, Mathur A, Ogletree ML, Slusarchyk WA, Zahler R, Seiler SM, and Bisacchi GS

Bioorganic & medicinal chemistry letters 14(9):2233-9, 2004 May 3 - Who cited this? | PubMed ID: 15081015 | Fulltext

Synthesis of potent and selective 2-azepanone inhibitors of human tryptase.

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Zhao G, Bolton SA, Kwon C, Hartl KS, Seiler SM, Slusarchyk WA, Sutton JC, and Bisacchi GS

Bioorganic & medicinal chemistry letters 14(2):309-12, 2004 Jan 19 - Who cited this? | PubMed ID: 14698147 | Fulltext

Synthesis and SAR of 4-carboxy-2-azetidinone mechanism-based tryptase inhibitors.

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Sutton JC, Bolton SA, Hartl KS, Huang MH, Jacobs G, Meng W, Ogletree ML, Pi Z, Schumacher WA, Seiler SM, Slusarchyk WA, Treuner U, Zahler R, Zhao G, and Bisacchi GS

Bioorganic & medicinal chemistry letters 12(21):3229-33, 2002 Nov 4 - Who cited this? | PubMed ID: 12372540 | Fulltext

Synthesis of potent and highly selective inhibitors of human tryptase.

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Slusarchyk WA, Bolton SA, Hartl KS, Huang MH, Jacobs G, Meng W, Ogletree ML, Pi Z, Schumacher WA, Seiler SM, Sutton JC, Treuner U, Zahler R, Zhao G, and Bisacchi GS

Bioorganic & medicinal chemistry letters 12(21):3235-8, 2002 Nov 4 - Who cited this? | PubMed ID: 12372541 | Fulltext

A novel series of highly potent benzimidazole-based microsomal triglyceride transfer protein inhibitors.

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Robl JA, Sulsky R, Sun CQ, Simpkins LM, Wang T, Dickson JK, Chen Y, Magnin DR, Taunk P, Slusarchyk WA, Biller SA, Lan SJ, Connolly F, Kunselman LK, Sabrah T, Jamil H,

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Journal of medicinal chemistry 44(6):851-6, 2001 Mar 15 - Who cited this? | PubMed ID: 11300866 | Fulltext

Discovery of (R)-7-cyano-2,3,4, 5-tetrahydro-1-(1H-imidazol-4-ylmethyl)-3- (phenylmethyl)-4-(2-thienylsulfonyl)-1H-1,4-benzodiazepine (BMS-214662), a farnesyltransferase inhibitor with potent preclinical antitumor activity.

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Hunt JT, Ding CZ, Batorsky R, Bednarz M, Bhide R, Cho Y, Chong S, Chao S, Gullo-Brown J, Guo P, Kim SH, Lee FY, Leftheris K, Miller A, Mitt T, Patel M,

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Journal of medicinal chemistry 43(20):3587-95, 2000 Oct 5 - Who cited this? | PubMed ID: 11020273 | Fulltext

Discovery and structure-activity relationships of imidazole-containing tetrahydrobenzodiazepine inhibitors of farnesyltransferase.

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Ding CZ, Batorsky R, Bhide R, Chao HJ, Cho Y, Chong S, Gullo-Brown J, Guo P, Kim SH, Lee F, Leftheris K, Miller A, Mitt T, Patel M, Penhallow BA, Ricca C,

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Journal of medicinal chemistry 42(25):5241-53, 1999 Dec 16 - Who cited this? | PubMed ID: 10602709 | Fulltext

An MTP inhibitor that normalizes atherogenic lipoprotein levels in WHHL rabbits.

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Wetterau JR, Gregg RE, Harrity TW, Arbeeny C, Cap M, Connolly F, Chu CH, George RJ, Gordon DA, Jamil H, Jolibois KG, Kunselman LK, Lan SJ, Maccagnan TJ, Ricci B, Yan M,

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Science (New York, N.Y.) 282(5389):751-4, 1998 Oct 23 - Who cited this? | PubMed ID: 9784135 | Fulltext

Dual metalloprotease inhibitors: mercaptoacetyl-based fused heterocyclic dipeptide mimetics as inhibitors of angiotensin-converting enzyme and neutral endopeptidase.

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Robl JA, Sun CQ, Stevenson J, Ryono DE, Simpkins LM, Cimarusti MP, Dejneka T, Slusarchyk WA, Chao S, Stratton L, Misra RN, Bednarz MS, Asaad MM, Cheung HS, Abboa-Offei BE, Smith PL,

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Journal of medicinal chemistry 40(11):1570-7, 1997 May 23 - Who cited this? | PubMed ID: 9171867 | Fulltext

Synthesis and antiviral activity of novel isonucleoside analogs.

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Tino JA, Clark JM, Field AK, Jacobs GA, Lis KA, Michalik TL, McGeever-Rubin B, Slusarchyk WA, Spergel SH, and Sundeen JE

Journal of medicinal chemistry 36(9):1221-9, 1993 Apr 30 - Who cited this? | PubMed ID: 8387600 | Fulltext

Synthesis and antiviral activity of 1-cyclobutyl-5-(2-bromovinyl)uracil nucleoside analogues and related compounds.

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Slusarchyk WA, Bisacchi GS, Field AK, Hockstein DR, Jacobs GA, McGeever-Rubin B, Tino JA, Tuomari AV, Yamanaka GA, and Young MG

Journal of medicinal chemistry 35(10):1799-806, 1992 May 15 - Who cited this? | PubMed ID: 1316966 | Fulltext

Synthesis and antiviral activity of enantiomeric forms of cyclobutyl nucleoside analogues.

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Bisacchi GS, Braitman A, Cianci CW, Clark JM, Field AK, Hagen ME, Hockstein DR, Malley MF, Mitt T, and Slusarchyk WA

Journal of medicinal chemistry 34(4):1415-21, 1991 Apr - Who cited this? | PubMed ID: 1849998 | Fulltext

(+-)-(1 alpha,2 beta,3 alpha)-9-[2,3-bis(hydroxymethyl)-cyclobutyl] guanine [(+-)-BHCG or SQ 33,054]: a potent and selective inhibitor of herpesviruses.

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Field AK, Tuomari AV, McGeever-Rubin B, Terry BJ, Mazina KE, Haffey ML, Hagen ME, Clark JM, Braitman A, and Slusarchyk WA

Antiviral research 13(1):41-52, 1990 Jan - Who cited this? | PubMed ID: 2159261 | Fulltext

Broad-spectrum antiviral activity of the acyclic guanosine phosphonate (R,S)-HPMPG.

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Terry BJ, Mazina KE, Tuomari AV, Haffey ML, Hagen M, Feldman A, Slusarchyk WA, Young MG, Zahler R, and Field AK

Antiviral research 10(4-5):235-51, 1988 Dec 1 - Who cited this? | PubMed ID: 2852486 | Fulltext

Monobactams: isolation and structure determination.

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Parker WL, Cimarusti CM, Floyd DM, Koster WH, Liu WC, Principe PA, Rathnum ML, and Slusarchyk WA

The Journal of antimicrobial chemotherapy 8 Suppl E:17-20, 1981 Dec - Who cited this? | PubMed ID: 7199043 | Fulltext

Monobactams--structure-activity relationships leading to SQ 26,776.

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Breuer H, Cimarusti CM, Denzel T, Koster WH, Slusarchyk WA, and Treuner UD

The Journal of antimicrobial chemotherapy 8 Suppl E:21-8, 1981 Dec - Who cited this? | PubMed ID: 7199044 | Fulltext

Monocyclic beta-lactam antibiotics produced by bacteria.

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Sykes RB, Cimarusti CM, Bonner DP, Bush K, Floyd DM, Georgopapadakou NH, Koster WM, Liu WC, Parker WL, Principe PA, Rathnum ML, Slusarchyk WA, Trejo WH, and Wells JS

Nature 291(5815):489-91, 1981 Jun 11 - Who cited this? | PubMed ID: 7015152 | Fulltext

Diastereomeric 7-ureidoacetyl cephalosporins. II. 7beta [[[(Aminocarbonyl) amino]-2-thienylacetyl] amino]-7-methoxy-3-[[(1-methyl-1H-tetrazol-5-yl) thio] methyl]-8-oxo-5-thia-1-azabicyclo [4.2.0] oct-2-ene-2-carboxylic acid.

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Applegate HE, Cimarusti CM, Dolfini JE, Koster WH, Ondetti MA, Slusarchyk WA, Young MG, Breuer H, and Treuner UD

The Journal of antibiotics 31(6):561-9, 1978 Jun - Who cited this? | PubMed ID: 681237 | Fulltext

Diumycin A' and diumycin B', new members of the diumycin family of antibiotics.

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Slusarchyk WA, Bouchard-Ewing JL, and Weisenborn FL

The Journal of antibiotics 26(7):391-3, 1973 Jul - Who cited this? | PubMed ID: 4782056 | Fulltext

Synthesis of 6-methylthiopenicillins and 7-heteroatom-substituted cephalosporins.

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Slusarchyk WA, Applegate HE, Funke P, Koster W, Puar MS, Young M, and Dolfini JE

The Journal of organic chemistry 38(5):943-50, 1973 Mar 9 - Who cited this? | PubMed ID: 4689156 | Fulltext

Chemical and biological aspects of a new family of phosphorus-containing antibiotics.

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Slusarchyk WA

Biotechnology and bioengineering 13(3):399-407, 1971 May - Who cited this? | PubMed ID: 5130177 | Fulltext

The structure of a novel lipid from the antibiotic diumycin.

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Slusarchyk WA, Osband JA, and Weisenborn FL

Journal of the American Chemical Society 92(14):4486-8, 1970 Jul 15 - Who cited this? | PubMed ID: 5428390 | Fulltext

Intermolecular bonding of the antibiotic diumycin.

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Kirschbaum J, Slusarchyk WA, and Weisenborn FL

Journal of pharmaceutical sciences 59(6):749-51, 1970 Jun - Who cited this? | PubMed ID: 5423073 | Fulltext

The structure of the lipid portion of the antibiotic prasinomycin.

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Slusarchyk WA and Weisenborn FL

Tetrahedron letters 8:659-62, 1969 Feb - Who cited this? | PubMed ID: 5795640 | Fulltext

The problem of the 1,2,9,10-tetraoxygenated aporphines and the structure of the quaternary aporphine from Fagara tinguassoiba.

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Shamma M and Slusarchyk WA

Tetrahedron 23(6):2563-70, 1967 Jun - Who cited this? | PubMed ID: 6047524 | Fulltext

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