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Papers authored by Sleph PG

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N-Aryl-oxazolidin-2-imine Muscle Selective Androgen Receptor Modulators Enhance Potency through Pharmacophore Reorientation (dagger) ( big up tri, open).

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Nirschl AA, Zou Y, Krystek SR, Sutton JC, Simpkins LM, Lupisella JA, Kuhns JE, Seethala R, Golla R, Sleph PG, Beehler BC, Grover GJ, Egan D, Fura A, Vyas VP, Li YX,

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Journal of medicinal chemistry 52(9):2794-8, 2009 May 14 - Who cited this? | PubMed ID: 19351168 | Fulltext

Synthesis and SAR of tetrahydropyrrolo[1,2-b][1,2,5]thiadiazol-2(3H)-one 1,1-dioxide analogues as highly potent selective androgen receptor modulators.

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Manfredi MC, Bi Y, Nirschl AA, Sutton JC, Seethala R, Golla R, Beehler BC, Sleph PG, Grover GJ, Ostrowski J, and Hamann LG

Bioorganic & medicinal chemistry letters 17(16):4487-90, 2007 Aug 15 - Who cited this? | PubMed ID: 17574413 | Fulltext

Discovery of potent and muscle selective androgen receptor modulators through scaffold modifications.

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Li JJ, Sutton JC, Nirschl A, Zou Y, Wang H, Sun C, Pi Z, Johnson R, Krystek SR, Seethala R, Golla R, Sleph PG, Beehler BC, Grover GJ, Fura A, Vyas VP,

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Journal of medicinal chemistry 50(13):3015-25, 2007 Jun 28 - Who cited this? | PubMed ID: 17552509 | Fulltext

Pharmacological and x-ray structural characterization of a novel selective androgen receptor modulator: potent hyperanabolic stimulation of skeletal muscle with hypostimulation of prostate in rats.

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Ostrowski J, Kuhns JE, Lupisella JA, Manfredi MC, Beehler BC, Krystek SR, Bi Y, Sun C, Seethala R, Golla R, Sleph PG, Fura A, An Y, Kish KF, Sack JS, Mookhtiar KA,

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Endocrinology 148(1):4-12, 2007 Jan - Who cited this? | PubMed ID: 17008401 | Fulltext

Discovery of potent, orally-active, and muscle-selective androgen receptor modulators based on an N-aryl-hydroxybicyclohydantoin scaffold.

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Sun C, Robl JA, Wang TC, Huang Y, Kuhns JE, Lupisella JA, Beehler BC, Golla R, Sleph PG, Seethala R, Fura A, Krystek SR, An Y, Malley MF, Sack JS, Salvati ME,

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Journal of medicinal chemistry 49(26):7596-9, 2006 Dec 28 - Who cited this? | PubMed ID: 17181141 | Fulltext

Reduction of skeletal muscle atrophy by a proteasome inhibitor in a rat model of denervation.

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Beehler BC, Sleph PG, Benmassaoud L, and Grover GJ

Experimental biology and medicine (Maywood, N.J.) 231(3):335-41, 2006 Mar - Who cited this? | PubMed ID: 16514182 | Fulltext

Excessive ATP hydrolysis in ischemic myocardium by mitochondrial F1F0-ATPase: effect of selective pharmacological inhibition of mitochondrial ATPase hydrolase activity.

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Grover GJ, Atwal KS, Sleph PG, Wang FL, Monshizadegan H, Monticello T, and Green DW

American journal of physiology. Heart and circulatory physiology 287(4):H1747-55, 2004 Oct - Who cited this? | PubMed ID: 15371268 | Fulltext

Effects of the thyroid hormone receptor agonist GC-1 on metabolic rate and cholesterol in rats and primates: selective actions relative to 3,5,3'-triiodo-L-thyronine.

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Grover GJ, Egan DM, Sleph PG, Beehler BC, Chiellini G, Nguyen NH, Baxter JD, and Scanlan TS

Endocrinology 145(4):1656-61, 2004 Apr - Who cited this? | PubMed ID: 14701670 | Fulltext

Selective thyroid hormone receptor-beta activation: a strategy for reduction of weight, cholesterol, and lipoprotein (a) with reduced cardiovascular liability.

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Grover GJ, Mellström K, Ye L, Malm J, Li YL, Bladh LG, Sleph PG, Smith MA, George R, Vennström B, Mookhtiar K, Horvath R, Speelman J, Egan D, and Baxter JD

Proceedings of the National Academy of Sciences of the United States of America 100(17):10067-72, 2003 Aug 19 - Who cited this? | PubMed ID: 12888625 | Fulltext

Thyroid receptor ligands. 1. Agonist ligands selective for the thyroid receptor beta1.

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Ye L, Li YL, Mellström K, Mellin C, Bladh LG, Koehler K, Garg N, Garcia Collazo AM, Litten C, Husman B, Persson K, Ljunggren J, Grover G, Sleph PG, George R, and Malm J

Journal of medicinal chemistry 46(9):1580-8, 2003 Apr 24 - Who cited this? | PubMed ID: 12699376 | Fulltext

Pharmacologic characterization of BMS-191095, a mitochondrial K(ATP) opener with no peripheral vasodilator or cardiac action potential shortening activity.

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Grover GJ, D'Alonzo AJ, Garlid KD, Bajgar R, Lodge NJ, Sleph PG, Darbenzio RB, Hess TA, Smith MA, Paucek P, and Atwal KS

The Journal of pharmacology and experimental therapeutics 297(3):1184-92, 2001 Jun - Who cited this? | PubMed ID: 11356945 | Fulltext

Cardioselective antiischemic ATP-sensitive potassium channel (K(ATP)) openers. 6. Effect of modifications at C6 of benzopyranyl cyanoguanidines.

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Ding CZ, Rovnyak GC, Misra RN, Grover GJ, Miller AV, Ahmed SZ, Kelly Y, Normandin DE, Sleph PG, and Atwal KS

Journal of medicinal chemistry 42(18):3711-7, 1999 Sep 9 - Who cited this? | PubMed ID: 10479302 | Fulltext

Binding of ATP-sensitive potassium channel (KATP) openers to cardiac membranes: correlation of binding affinities with cardioprotective and smooth muscle relaxing potencies.

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Atwal KS, Grover GJ, Lodge NJ, Normandin DE, Traeger SC, Sleph PG, Cohen RB, Bryson CC, and Dickinson KE

Journal of medicinal chemistry 41(3):271-5, 1998 Jan 29 - Who cited this? | PubMed ID: 9464357 | Fulltext

Preconditioning in rat hearts is independent of mitochondrial F1F0 ATPase inhibition.

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Green DW, Murray HN, Sleph PG, Wang FL, Baird AJ, Rogers WL, and Grover GJ

The American journal of physiology 274(1 Pt 2):H90-7, 1998 Jan - Who cited this? | PubMed ID: 9458856 | Fulltext

Adenosine A1 receptor blockade does not abolish the cardioprotective effects of the adenosine triphosphate-sensitive potassium channel opener bimakalim.

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Gross GJ, Mei DA, Sleph PG, and Grover GJ

The Journal of pharmacology and experimental therapeutics 280(2):533-40, 1997 Feb - Who cited this? | PubMed ID: 9023261 | Fulltext

Cardioselective antiischemic ATP-sensitive potassium channel (KATP) openers. 5. Identification of 4-(N-aryl)-substituted benzopyran derivatives with high selectivity.

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Rovnyak GC, Ahmed SZ, Ding CZ, Dzwonczyk S, Ferrara FN, Humphreys WG, Grover GJ, Santafianos D, Atwal KS, Baird AJ, McLaughlin LG, Normandin DE, Sleph PG, and Traeger SC

Journal of medicinal chemistry 40(1):24-34, 1997 Jan 3 - Who cited this? | PubMed ID: 9016325 | Fulltext

Glyburide-reversible cardioprotective effects of BMS-180448: functional and energetic considerations.

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Grover GJ, Sleph PG, Dzwonczyk S, Malone HJ, and Behling RW

Journal of cardiovascular pharmacology 29(1):28-38, 1997 Jan - Who cited this? | PubMed ID: 9007667 | Fulltext

Lack of a pharmacologic interaction between ATP-sensitive potassium channels and adenosine A1 receptors in ischemic rat hearts.

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Grover GJ, Baird AJ, and Sleph PG

Cardiovascular research 31(4):511-7, 1996 Apr - Who cited this? | PubMed ID: 8689642 | Fulltext

Hemodynamic and cardiac effects of BMS-180448, a novel K+ATP opener, in anesthetized dogs and isolated rat hearts.

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D'Alonzo AJ, Grover GJ, Darbenzio RB, Sewter JC, Hess TA, Dzwonczyk S, and Sleph PG

Pharmacology 52(2):101-12, 1996 Feb - Who cited this? | PubMed ID: 8851631 | Fulltext

Cardioselective antiischemic ATP-sensitive potassium channel openers. 4. Structure-activity studies on benzopyranylcyanoguanidines: replacement of the benzopyran portion.

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Atwal KS, Ferrara FN, Ding CZ, Grover GJ, Sleph PG, Dzwonczyk S, Baird AJ, and Normandin DE

Journal of medicinal chemistry 39(1):304-13, 1996 Jan 5 - Who cited this? | PubMed ID: 8568821 | Fulltext

A comparison between the effects of BMS-180448, a novel K+ channel opener, and cromakalim in rat and dog.

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D'Alonzo AJ, Darbenzio RB, Sewter JC, Hess TA, Grover GJ, Sleph PG, Normandin DE, and Lodge NJ

European journal of pharmacology 294(1):271-80, 1995 Dec 27 - Who cited this? | PubMed ID: 8788441 | Fulltext

Glyburide-reversible cardioprotective effect of BMS-180448 is independent of action potential shortening.

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Grover GJ, D'Alonzo AJ, Hess T, Sleph PG, and Darbenzio RB

Cardiovascular research 30(5):731-8, 1995 Nov - Who cited this? | PubMed ID: 8595620 | Fulltext

Protective effect of K(ATP) openers in ischemic rat hearts treated with a potassium cardioplegic solution.

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Grover GJ and Sleph PG

Journal of cardiovascular pharmacology 26(5):698-706, 1995 Nov - Who cited this? | PubMed ID: 8637183 | Fulltext

Cardioselective anti-ischemic ATP-sensitive potassium channel openers. 3. Structure-activity studies on benzopyranyl cyanoguanidines: modification of the cyanoguanidine portion.

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Atwal KS, Grover GJ, Ahmed SZ, Sleph PG, Dzwonczyk S, Baird AJ, and Normandin DE

Journal of medicinal chemistry 38(17):3236-45, 1995 Aug 18 - Who cited this? | PubMed ID: 7650676 | Fulltext

Pharmacologic profile of the dihydropyrimidine calcium channel blockers SQ 32,547 and SQ 32,926 [correction of SQ 32,946].

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Grover GJ, Dzwonczyk S, McMullen DM, Normandin DE, Parham CS, Sleph PG, and Moreland S

Journal of cardiovascular pharmacology 26(2):289-94, 1995 Aug - Who cited this? | PubMed ID: 7475054 | Fulltext

Cardioselective antiischemic ATP-sensitive potassium channel openers. 2. Structure-activity studies on benzopyranylcyanoguanidines: modification of the benzopyran ring.

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Atwal KS, Grover GJ, Ferrara FN, Ahmed SZ, Sleph PG, Dzwonczyk S, and Normandin DE

Journal of medicinal chemistry 38(11):1966-73, 1995 May 26 - Who cited this? | PubMed ID: 7783128 | Fulltext

In vitro effects of capsaicin: antiarrhythmic and antiischemic activity.

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D'Alonzo AJ, Grover GJ, Darbenzio RB, Hess TA, Sleph PG, Dzwonczyk S, Zhu JL, and Sewter JC

European journal of pharmacology 272(2-3):269-78, 1995 Jan 16 - Who cited this? | PubMed ID: 7713171 | Fulltext

Endogenous catecholamines are not necessary for ischaemic preconditioning in the isolated perfused rat heart.

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Weselcouch EO, Baird AJ, Sleph PG, Dzwonczyk S, Murray HN, and Grover GJ

Cardiovascular research 29(1):126-32, 1995 Jan - Who cited this? | PubMed ID: 7895230 | Fulltext

Effect of potassium on the action of the KATP modulators cromakalim, pinacidil, or glibenclamide on arrhythmias in isolated perfused rat heart subjected to regional ischaemia.

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D'Alonzo AJ, Darbenzio RB, Hess TA, Sewter JC, Sleph PG, and Grover GJ

Cardiovascular research 28(6):881-7, 1994 Jun - Who cited this? | PubMed ID: 7923295 | Fulltext

The cardioprotective and electrophysiological effects of cromakalim are attenuated by meclofenamate through a cyclooxygenase-independent mechanism.

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Grover GJ, D'Alonzo AJ, Sleph PG, Dzwonczyk S, Hess TA, and Darbenzio RB

The Journal of pharmacology and experimental therapeutics 269(2):536-40, 1994 May - Who cited this? | PubMed ID: 8182522 | Fulltext

The cardioprotective effects of R 75231 and lidoflazine are not caused by adenosine A1 receptor activation.

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Grover GJ and Sleph PG

The Journal of pharmacology and experimental therapeutics 268(1):90-6, 1994 Jan - Who cited this? | PubMed ID: 8301599 | Fulltext

Cardioselective anti-ischemic ATP-sensitive potassium channel openers.

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Atwal KS, Grover GJ, Ahmed SZ, Ferrara FN, Harper TW, Kim KS, Sleph PG, Dzwonczyk S, Russell AD, and Moreland S

Journal of medicinal chemistry 36(24):3971-4, 1993 Nov 26 - Who cited this? | PubMed ID: 8254626 | Fulltext

Cardioprotective effects of a novel calcium antagonist related to the structure of cromakalim.

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Grover GJ, Sleph PG, Dzwonczyk S, and McCullough JR

The Journal of pharmacology and experimental therapeutics 267(1):102-7, 1993 Oct - Who cited this? | PubMed ID: 8229736 | Fulltext

Cardioprotective effects of the cyanoguanidine potassium channel opener P-1075.

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Sargent CA, Sleph PG, Dzwonczyk S, Normandin D, Antonaccio MJ, and Grover GJ

Journal of cardiovascular pharmacology 22(4):564-70, 1993 Oct - Who cited this? | PubMed ID: 7505358 | Fulltext

The ATP-sensitive potassium channel blocker glibenclamide (glyburide) does not abolish preconditioning in isolated ischemic rat hearts.

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Grover GJ, Dzwonczyk S, Sleph PG, and Sargent CA

The Journal of pharmacology and experimental therapeutics 265(2):559-64, 1993 May - Who cited this? | PubMed ID: 8496806 | Fulltext

Cardioprotection in ischemic rat hearts with the SH-containing angiotensin-converting enzyme inhibitor zofenopril: possible involvement of the ATP-sensitive potassium channel.

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Sargent CA, Sleph PG, Dzwonczyk S, Smith MA, Normandin D, Antonaccio MJ, and Grover GJ

The Journal of pharmacology and experimental therapeutics 265(2):609-18, 1993 May - Who cited this? | PubMed ID: 8496812 | Fulltext

Role of endothelin-1 and big endothelin-1 in modulating coronary vascular tone, contractile function and severity of ischemia in rat hearts.

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Grover GJ, Sleph PG, Fox M, and Trippodo NC

The Journal of pharmacology and experimental therapeutics 263(3):1074-82, 1992 Dec - Who cited this? | PubMed ID: 1469621 | Fulltext

Role of myocardial ATP-sensitive potassium channels in mediating preconditioning in the dog heart and their possible interaction with adenosine A1-receptors.

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Grover GJ, Sleph PG, and Dzwonczyk S

Circulation 86(4):1310-6, 1992 Oct - Who cited this? | PubMed ID: 1394937 | Fulltext

Effect of calmodulin and protein kinase C inhibitors on globally ischemic rat hearts.

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Sargent CA, Sleph PG, Dzwonczyk S, Smith MA, and Grover GJ

Journal of cardiovascular pharmacology 20(2):251-60, 1992 Aug - Who cited this? | PubMed ID: 1381016 | Fulltext

Effect of potassium channel blockade on the anti-ischemic actions of mechanistically diverse agents.

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Sargent CA, Smith MA, Dzwonczyk S, Sleph PG, and Grover GJ

The Journal of pharmacology and experimental therapeutics 259(1):97-103, 1991 Oct - Who cited this? | PubMed ID: 1920138 | Fulltext

Specific block of the anti-ischemic actions of cromakalim by sodium 5-hydroxydecanoate.

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McCullough JR, Normandin DE, Conder ML, Sleph PG, Dzwonczyk S, and Grover GJ

Circulation research 69(4):949-58, 1991 Oct - Who cited this? | PubMed ID: 1934346 | Fulltext

Effects of different angiotensin-converting enzyme (ACE) inhibitors on ischemic isolated rat hearts: relationship between cardiac ACE inhibition and cardioprotection.

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Grover GJ, Sleph PG, Dzwonczyk S, Wang P, Fung W, Tobias D, and Cushman DW

The Journal of pharmacology and experimental therapeutics 257(3):919-29, 1991 Jun - Who cited this? | PubMed ID: 1646329 | Fulltext

Cardioprotective effects of the potassium channel opener cromakalim: stereoselectivity and effects on myocardial adenine nucleotides.

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Grover GJ, Newburger J, Sleph PG, Dzwonczyk S, Taylor SC, Ahmed SZ, and Atwal KS

The Journal of pharmacology and experimental therapeutics 257(1):156-62, 1991 Apr - Who cited this? | PubMed ID: 2019983 | Fulltext

Pharmacologic profile of cromakalim in the treatment of myocardial ischemia in isolated rat hearts and anesthetized dogs.

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Grover GJ, Sleph PG, and Dzwonczyk S

Journal of cardiovascular pharmacology 16(6):853-64, 1990 Dec - Who cited this? | PubMed ID: 1704976 | Fulltext

Reduction of ischemic damage in isolated rat hearts by the potassium channel opener, RP 52891.

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Grover GJ, Dzwonczyk S, and Sleph PG

European journal of pharmacology 191(1):11-8, 1990 Nov 20 - Who cited this? | PubMed ID: 2128745 | Fulltext

Ruthenium red improves postischemic contractile function in isolated rat hearts.

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Grover GJ, Dzwonczyk S, and Sleph PG

Journal of cardiovascular pharmacology 16(5):783-9, 1990 Nov - Who cited this? | PubMed ID: 1703601 | Fulltext

Myosin light-chain phosphorylation and vascular resistance in canine anterior tibial arteries in situ.

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Moreland S, Antes LM, McMullen DM, Sleph PG, and Grover GJ

Pflugers Archiv : European journal of physiology 417(2):180-4, 1990 Oct - Who cited this? | PubMed ID: 2084614 | Fulltext

Anti-ischemic activity of the novel benzazepine calcium antagonist SQ 31,486.

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Grover GJ, Sleph PG, Parham CS, Brittain RJ, Krapcho J, and Moreland S

Journal of cardiovascular pharmacology 16(2):219-27, 1990 Aug - Who cited this? | PubMed ID: 1697377 | Fulltext

Effect of thromboxane receptor blockade on oxygen supply/consumption variables during reperfusion in the anesthetized dog.

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Grover GJ, Sleph PG, and Weiss HR

The Journal of pharmacology and experimental therapeutics 253(3):1097-102, 1990 Jun - Who cited this? | PubMed ID: 2141635 | Fulltext

Nicorandil improves postischemic contractile function independently of direct myocardial effects.

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Grover GJ, Sleph PG, and Parham CS

Journal of cardiovascular pharmacology 15(5):698-705, 1990 May - Who cited this? | PubMed ID: 1692928 | Fulltext

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