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Papers authored by Sleph P

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N-Aryl-oxazolidin-2-imine Muscle Selective Androgen Receptor Modulators Enhance Potency through Pharmacophore Reorientation (dagger) ( big up tri, open).

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Nirschl AA, Zou Y, Krystek SR, Sutton JC, Simpkins LM, Lupisella JA, Kuhns JE, Seethala R, Golla R, Sleph PG, Beehler BC, Grover GJ, Egan D, Fura A, Vyas VP, Li YX,

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Journal of medicinal chemistry 52(9):2794-8, 2009 May 14 - Who cited this? | PubMed ID: 19351168 | Fulltext

(d)-2-tert-Butoxycarbonylamino-5,5-difluoro-5-phenyl-pentanoic acid: Synthesis and incorporation into the growth hormone secretagogues.

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Li J, Chen SY, Murphy BJ, Flynn N, Seethala R, Slusarchyk D, Yan M, Sleph P, Zhang H, Humphreys WG, Ewing WR, Robl JA, Gordon D, and Tino JA

Bioorganic & medicinal chemistry letters 18(14):4072-4, 2008 Jul 15 - Who cited this? | PubMed ID: 18554903 | Fulltext

Tetrazole based amides as growth hormone secretagogues.

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Li JJ, Wang H, Li J, Qu F, Swartz SG, Hernández AS, Biller SA, Robl JA, Tino JA, Slusarchyk D, Seethala R, Sleph P, Yan M, Grover G, Flynn N, Murphy BJ,

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Bioorganic & medicinal chemistry letters 18(8):2536-9, 2008 Apr 15 - Who cited this? | PubMed ID: 18378446 | Fulltext

Optimization of 1H-tetrazole-1-alkanenitriles as potent orally bioavailable growth hormone secretagogues.

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Hernández AS, Swartz SG, Slusarchyk D, Yan M, Seethala RK, Sleph P, Grover G, Dickinson K, Giupponi L, Harper TW, Humphreys WG, Longhi DA, Flynn N, Murphy BJ, Gordon DA, Biller SA,

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Bioorganic & medicinal chemistry letters 18(6):2067-72, 2008 Mar 15 - Who cited this? | PubMed ID: 18282707 | Fulltext

Design and synthesis of tetrazole-based growth hormone secretagogue: the SAR studies of the O-benzyl serine side chain.

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Li J, Chen SY, Tao S, Wang H, Li JJ, Swartz S, Musial C, Hernandez AA, Flynn N, Murphy BJ, Beehler B, Dickinson KE, Giupponi L, Grover G, Seethala R, Sleph P,

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Bioorganic & medicinal chemistry letters 18(6):1825-9, 2008 Mar 15 - Who cited this? | PubMed ID: 18295486 | Fulltext

Discovery of a Tetrazole-Based Growth Hormone Secretagogue: 4-(Hydroxybutyl)carbamic Acid 2-{5-[1-(2-Amino-2-methylpropionylamino)-2- benzyloxyethyl]tetrazol-1-yl}ethyl Ester (BMS-317180).

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Li J, Chen SY, Li JJ, Wang H, Hernandez AS, Tao S, Musial CM, Qu F, Swartz S, Chao ST, Flynn N, Murphy BJ, Slusarchyk DA, Seethala R, Yan M, Sleph P,

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Journal of medicinal chemistry 50(24):5890-3, 2007 Nov 29 - Who cited this? | PubMed ID: 17973363 | Fulltext

Synthesis and SAR of tetrahydropyrrolo[1,2-b][1,2,5]thiadiazol-2(3H)-one 1,1-dioxide analogues as highly potent selective androgen receptor modulators.

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Manfredi MC, Bi Y, Nirschl AA, Sutton JC, Seethala R, Golla R, Beehler BC, Sleph PG, Grover GJ, Ostrowski J, and Hamann LG

Bioorganic & medicinal chemistry letters 17(16):4487-90, 2007 Aug 15 - Who cited this? | PubMed ID: 17574413 | Fulltext

Discovery of potent and muscle selective androgen receptor modulators through scaffold modifications.

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Li JJ, Sutton JC, Nirschl A, Zou Y, Wang H, Sun C, Pi Z, Johnson R, Krystek SR, Seethala R, Golla R, Sleph PG, Beehler BC, Grover GJ, Fura A, Vyas VP,

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Journal of medicinal chemistry 50(13):3015-25, 2007 Jun 28 - Who cited this? | PubMed ID: 17552509 | Fulltext

Discovery of tertiary aminoacids as dual PPARalpha/gamma agonists-I.

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Devasthale PV, Chen S, Jeon Y, Qu F, Ryono DE, Wang W, Zhang H, Cheng L, Farrelly D, Golla R, Grover G, Ma Z, Moore L, Seethala R, Sun W, Doweyko AM,

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Bioorganic & medicinal chemistry letters 17(8):2312-6, 2007 Apr 15 - Who cited this? | PubMed ID: 17292606 | Fulltext

Pharmacological and x-ray structural characterization of a novel selective androgen receptor modulator: potent hyperanabolic stimulation of skeletal muscle with hypostimulation of prostate in rats.

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Ostrowski J, Kuhns JE, Lupisella JA, Manfredi MC, Beehler BC, Krystek SR, Bi Y, Sun C, Seethala R, Golla R, Sleph PG, Fura A, An Y, Kish KF, Sack JS, Mookhtiar KA,

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Endocrinology 148(1):4-12, 2007 Jan - Who cited this? | PubMed ID: 17008401 | Fulltext

Discovery of potent, orally-active, and muscle-selective androgen receptor modulators based on an N-aryl-hydroxybicyclohydantoin scaffold.

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Sun C, Robl JA, Wang TC, Huang Y, Kuhns JE, Lupisella JA, Beehler BC, Golla R, Sleph PG, Seethala R, Fura A, Krystek SR, An Y, Malley MF, Sack JS, Salvati ME,

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Journal of medicinal chemistry 49(26):7596-9, 2006 Dec 28 - Who cited this? | PubMed ID: 17181141 | Fulltext

Reduction of skeletal muscle atrophy by a proteasome inhibitor in a rat model of denervation.

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Beehler BC, Sleph PG, Benmassaoud L, and Grover GJ

Experimental biology and medicine (Maywood, N.J.) 231(3):335-41, 2006 Mar - Who cited this? | PubMed ID: 16514182 | Fulltext

Tetrahydroisoquinoline 1-carboxamides as growth hormone secretagogues.

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Li JJ, Wang H, Qu F, Musial C, Tino JA, Robl JA, Slusarchyk D, Golla R, Seethala R, Dickinson K, Giupponi L, Grover G, Sleph P, Flynn N, Murphy BJ, Gordon D,

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Bioorganic & medicinal chemistry letters 15(7):1799-802, 2005 Apr 1 - Who cited this? | PubMed ID: 15780609 | Fulltext

Design and synthesis of N-[(4-methoxyphenoxy)carbonyl]-N-[[4-[2-(5- methyl-2-phenyl-4-oxazolyl)ethoxy]phenyl]methyl]glycine [Muraglitazar/BMS-298585], a novel peroxisome proliferator-activated receptor alpha/gamma dual agonist with efficacious glucose and lipid-lowering activities.

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Devasthale PV, Chen S, Jeon Y, Qu F, Shao C, Wang W, Zhang H, Cap M, Farrelly D, Golla R, Grover G, Harrity T, Ma Z, Moore L, Ren J, Seethala R,

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Journal of medicinal chemistry 48(6):2248-50, 2005 Mar 24 - Who cited this? | PubMed ID: 15771468 | Fulltext

Excessive ATP hydrolysis in ischemic myocardium by mitochondrial F1F0-ATPase: effect of selective pharmacological inhibition of mitochondrial ATPase hydrolase activity.

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Grover GJ, Atwal KS, Sleph PG, Wang FL, Monshizadegan H, Monticello T, and Green DW

American journal of physiology. Heart and circulatory physiology 287(4):H1747-55, 2004 Oct - Who cited this? | PubMed ID: 15371268 | Fulltext

Effects of the thyroid hormone receptor agonist GC-1 on metabolic rate and cholesterol in rats and primates: selective actions relative to 3,5,3'-triiodo-L-thyronine.

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Grover GJ, Egan DM, Sleph PG, Beehler BC, Chiellini G, Nguyen NH, Baxter JD, and Scanlan TS

Endocrinology 145(4):1656-61, 2004 Apr - Who cited this? | PubMed ID: 14701670 | Fulltext

Small molecule mitochondrial F1F0 ATPase hydrolase inhibitors as cardioprotective agents. Identification of 4-(N-arylimidazole)-substituted benzopyran derivatives as selective hydrolase inhibitors.

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Atwal KS, Wang P, Rogers WL, Sleph P, Monshizadegan H, Ferrara FN, Traeger S, Green DW, and Grover GJ

Journal of medicinal chemistry 47(5):1081-4, 2004 Feb 26 - Who cited this? | PubMed ID: 14971888 | Fulltext

Selective thyroid hormone receptor-beta activation: a strategy for reduction of weight, cholesterol, and lipoprotein (a) with reduced cardiovascular liability.

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Grover GJ, Mellström K, Ye L, Malm J, Li YL, Bladh LG, Sleph PG, Smith MA, George R, Vennström B, Mookhtiar K, Horvath R, Speelman J, Egan D, and Baxter JD

Proceedings of the National Academy of Sciences of the United States of America 100(17):10067-72, 2003 Aug 19 - Who cited this? | PubMed ID: 12888625 | Fulltext

Thyroid receptor ligands. 1. Agonist ligands selective for the thyroid receptor beta1.

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Ye L, Li YL, Mellström K, Mellin C, Bladh LG, Koehler K, Garg N, Garcia Collazo AM, Litten C, Husman B, Persson K, Ljunggren J, Grover G, Sleph PG, George R, and Malm J

Journal of medicinal chemistry 46(9):1580-8, 2003 Apr 24 - Who cited this? | PubMed ID: 12699376 | Fulltext

Pharmacologic characterization of BMS-191095, a mitochondrial K(ATP) opener with no peripheral vasodilator or cardiac action potential shortening activity.

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Grover GJ, D'Alonzo AJ, Garlid KD, Bajgar R, Lodge NJ, Sleph PG, Darbenzio RB, Hess TA, Smith MA, Paucek P, and Atwal KS

The Journal of pharmacology and experimental therapeutics 297(3):1184-92, 2001 Jun - Who cited this? | PubMed ID: 11356945 | Fulltext

Cardioselective antiischemic ATP-sensitive potassium channel (K(ATP)) openers. 6. Effect of modifications at C6 of benzopyranyl cyanoguanidines.

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Ding CZ, Rovnyak GC, Misra RN, Grover GJ, Miller AV, Ahmed SZ, Kelly Y, Normandin DE, Sleph PG, and Atwal KS

Journal of medicinal chemistry 42(18):3711-7, 1999 Sep 9 - Who cited this? | PubMed ID: 10479302 | Fulltext

Binding of ATP-sensitive potassium channel (KATP) openers to cardiac membranes: correlation of binding affinities with cardioprotective and smooth muscle relaxing potencies.

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Atwal KS, Grover GJ, Lodge NJ, Normandin DE, Traeger SC, Sleph PG, Cohen RB, Bryson CC, and Dickinson KE

Journal of medicinal chemistry 41(3):271-5, 1998 Jan 29 - Who cited this? | PubMed ID: 9464357 | Fulltext

Preconditioning in rat hearts is independent of mitochondrial F1F0 ATPase inhibition.

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Green DW, Murray HN, Sleph PG, Wang FL, Baird AJ, Rogers WL, and Grover GJ

The American journal of physiology 274(1 Pt 2):H90-7, 1998 Jan - Who cited this? | PubMed ID: 9458856 | Fulltext

Adenosine A1 receptor blockade does not abolish the cardioprotective effects of the adenosine triphosphate-sensitive potassium channel opener bimakalim.

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Gross GJ, Mei DA, Sleph PG, and Grover GJ

The Journal of pharmacology and experimental therapeutics 280(2):533-40, 1997 Feb - Who cited this? | PubMed ID: 9023261 | Fulltext

Cardioselective antiischemic ATP-sensitive potassium channel (KATP) openers. 5. Identification of 4-(N-aryl)-substituted benzopyran derivatives with high selectivity.

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Rovnyak GC, Ahmed SZ, Ding CZ, Dzwonczyk S, Ferrara FN, Humphreys WG, Grover GJ, Santafianos D, Atwal KS, Baird AJ, McLaughlin LG, Normandin DE, Sleph PG, and Traeger SC

Journal of medicinal chemistry 40(1):24-34, 1997 Jan 3 - Who cited this? | PubMed ID: 9016325 | Fulltext

Glyburide-reversible cardioprotective effects of BMS-180448: functional and energetic considerations.

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Grover GJ, Sleph PG, Dzwonczyk S, Malone HJ, and Behling RW

Journal of cardiovascular pharmacology 29(1):28-38, 1997 Jan - Who cited this? | PubMed ID: 9007667 | Fulltext

Lack of a pharmacologic interaction between ATP-sensitive potassium channels and adenosine A1 receptors in ischemic rat hearts.

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Grover GJ, Baird AJ, and Sleph PG

Cardiovascular research 31(4):511-7, 1996 Apr - Who cited this? | PubMed ID: 8689642 | Fulltext

Hemodynamic and cardiac effects of BMS-180448, a novel K+ATP opener, in anesthetized dogs and isolated rat hearts.

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D'Alonzo AJ, Grover GJ, Darbenzio RB, Sewter JC, Hess TA, Dzwonczyk S, and Sleph PG

Pharmacology 52(2):101-12, 1996 Feb - Who cited this? | PubMed ID: 8851631 | Fulltext

Cardioselective antiischemic ATP-sensitive potassium channel openers. 4. Structure-activity studies on benzopyranylcyanoguanidines: replacement of the benzopyran portion.

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Atwal KS, Ferrara FN, Ding CZ, Grover GJ, Sleph PG, Dzwonczyk S, Baird AJ, and Normandin DE

Journal of medicinal chemistry 39(1):304-13, 1996 Jan 5 - Who cited this? | PubMed ID: 8568821 | Fulltext

A comparison between the effects of BMS-180448, a novel K+ channel opener, and cromakalim in rat and dog.

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D'Alonzo AJ, Darbenzio RB, Sewter JC, Hess TA, Grover GJ, Sleph PG, Normandin DE, and Lodge NJ

European journal of pharmacology 294(1):271-80, 1995 Dec 27 - Who cited this? | PubMed ID: 8788441 | Fulltext

Glyburide-reversible cardioprotective effect of BMS-180448 is independent of action potential shortening.

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Grover GJ, D'Alonzo AJ, Hess T, Sleph PG, and Darbenzio RB

Cardiovascular research 30(5):731-8, 1995 Nov - Who cited this? | PubMed ID: 8595620 | Fulltext

Protective effect of K(ATP) openers in ischemic rat hearts treated with a potassium cardioplegic solution.

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Grover GJ and Sleph PG

Journal of cardiovascular pharmacology 26(5):698-706, 1995 Nov - Who cited this? | PubMed ID: 8637183 | Fulltext

Cardioselective anti-ischemic ATP-sensitive potassium channel openers. 3. Structure-activity studies on benzopyranyl cyanoguanidines: modification of the cyanoguanidine portion.

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Atwal KS, Grover GJ, Ahmed SZ, Sleph PG, Dzwonczyk S, Baird AJ, and Normandin DE

Journal of medicinal chemistry 38(17):3236-45, 1995 Aug 18 - Who cited this? | PubMed ID: 7650676 | Fulltext

Pharmacologic profile of the dihydropyrimidine calcium channel blockers SQ 32,547 and SQ 32,926 [correction of SQ 32,946].

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Grover GJ, Dzwonczyk S, McMullen DM, Normandin DE, Parham CS, Sleph PG, and Moreland S

Journal of cardiovascular pharmacology 26(2):289-94, 1995 Aug - Who cited this? | PubMed ID: 7475054 | Fulltext

Cardioselective antiischemic ATP-sensitive potassium channel openers. 2. Structure-activity studies on benzopyranylcyanoguanidines: modification of the benzopyran ring.

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Atwal KS, Grover GJ, Ferrara FN, Ahmed SZ, Sleph PG, Dzwonczyk S, and Normandin DE

Journal of medicinal chemistry 38(11):1966-73, 1995 May 26 - Who cited this? | PubMed ID: 7783128 | Fulltext

In vitro effects of capsaicin: antiarrhythmic and antiischemic activity.

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D'Alonzo AJ, Grover GJ, Darbenzio RB, Hess TA, Sleph PG, Dzwonczyk S, Zhu JL, and Sewter JC

European journal of pharmacology 272(2-3):269-78, 1995 Jan 16 - Who cited this? | PubMed ID: 7713171 | Fulltext

Inhibition of nitric oxide synthesis does not affect ischemic preconditioning in isolated perfused rat hearts.

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Weselcouch EO, Baird AJ, Sleph P, and Grover GJ

The American journal of physiology 268(1 Pt 2):H242-9, 1995 Jan - Who cited this? | PubMed ID: 7530919 | Fulltext

Endogenous catecholamines are not necessary for ischaemic preconditioning in the isolated perfused rat heart.

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Weselcouch EO, Baird AJ, Sleph PG, Dzwonczyk S, Murray HN, and Grover GJ

Cardiovascular research 29(1):126-32, 1995 Jan - Who cited this? | PubMed ID: 7895230 | Fulltext

Pyruvate increases threshold for preconditioning in globally ischemic rat hearts.

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Sargent CA, Dzwonczyk S, Sleph P, Wilde M, and Grover GJ

The American journal of physiology 267(4 Pt 2):H1403-9, 1994 Oct - Who cited this? | PubMed ID: 7943385 | Fulltext

Effect of potassium on the action of the KATP modulators cromakalim, pinacidil, or glibenclamide on arrhythmias in isolated perfused rat heart subjected to regional ischaemia.

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D'Alonzo AJ, Darbenzio RB, Hess TA, Sewter JC, Sleph PG, and Grover GJ

Cardiovascular research 28(6):881-7, 1994 Jun - Who cited this? | PubMed ID: 7923295 | Fulltext

The cardioprotective and electrophysiological effects of cromakalim are attenuated by meclofenamate through a cyclooxygenase-independent mechanism.

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Grover GJ, D'Alonzo AJ, Sleph PG, Dzwonczyk S, Hess TA, and Darbenzio RB

The Journal of pharmacology and experimental therapeutics 269(2):536-40, 1994 May - Who cited this? | PubMed ID: 8182522 | Fulltext

The cardioprotective effects of R 75231 and lidoflazine are not caused by adenosine A1 receptor activation.

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Grover GJ and Sleph PG

The Journal of pharmacology and experimental therapeutics 268(1):90-6, 1994 Jan - Who cited this? | PubMed ID: 8301599 | Fulltext

Cardioselective anti-ischemic ATP-sensitive potassium channel openers.

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Atwal KS, Grover GJ, Ahmed SZ, Ferrara FN, Harper TW, Kim KS, Sleph PG, Dzwonczyk S, Russell AD, and Moreland S

Journal of medicinal chemistry 36(24):3971-4, 1993 Nov 26 - Who cited this? | PubMed ID: 8254626 | Fulltext

Cardioprotective effects of a novel calcium antagonist related to the structure of cromakalim.

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Grover GJ, Sleph PG, Dzwonczyk S, and McCullough JR

The Journal of pharmacology and experimental therapeutics 267(1):102-7, 1993 Oct - Who cited this? | PubMed ID: 8229736 | Fulltext

Cardioprotective effects of the cyanoguanidine potassium channel opener P-1075.

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Sargent CA, Sleph PG, Dzwonczyk S, Normandin D, Antonaccio MJ, and Grover GJ

Journal of cardiovascular pharmacology 22(4):564-70, 1993 Oct - Who cited this? | PubMed ID: 7505358 | Fulltext

The ATP-sensitive potassium channel blocker glibenclamide (glyburide) does not abolish preconditioning in isolated ischemic rat hearts.

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Grover GJ, Dzwonczyk S, Sleph PG, and Sargent CA

The Journal of pharmacology and experimental therapeutics 265(2):559-64, 1993 May - Who cited this? | PubMed ID: 8496806 | Fulltext

Cardioprotection in ischemic rat hearts with the SH-containing angiotensin-converting enzyme inhibitor zofenopril: possible involvement of the ATP-sensitive potassium channel.

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Sargent CA, Sleph PG, Dzwonczyk S, Smith MA, Normandin D, Antonaccio MJ, and Grover GJ

The Journal of pharmacology and experimental therapeutics 265(2):609-18, 1993 May - Who cited this? | PubMed ID: 8496812 | Fulltext

Role of endothelin-1 and big endothelin-1 in modulating coronary vascular tone, contractile function and severity of ischemia in rat hearts.

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Grover GJ, Sleph PG, Fox M, and Trippodo NC

The Journal of pharmacology and experimental therapeutics 263(3):1074-82, 1992 Dec - Who cited this? | PubMed ID: 1469621 | Fulltext

Role of myocardial ATP-sensitive potassium channels in mediating preconditioning in the dog heart and their possible interaction with adenosine A1-receptors.

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Grover GJ, Sleph PG, and Dzwonczyk S

Circulation 86(4):1310-6, 1992 Oct - Who cited this? | PubMed ID: 1394937 | Fulltext

Effect of calmodulin and protein kinase C inhibitors on globally ischemic rat hearts.

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Sargent CA, Sleph PG, Dzwonczyk S, Smith MA, and Grover GJ

Journal of cardiovascular pharmacology 20(2):251-60, 1992 Aug - Who cited this? | PubMed ID: 1381016 | Fulltext

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