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Papers authored by Sippl W

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3D-QSAR CoMFA/CoMSIA models based on theoretical active conformers of HOE/BAY-793 analogs derived from HIV-1 protease inhibitor complexes.

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da Cunha EF, Sippl W, de Castro Ramalho T, Ceva Antunes OA, de Alencastro RB, and Albuquerque MG

European journal of medicinal chemistry 44(11):4344-52, 2009 Nov - Who cited this? | PubMed ID: 19616874 | Fulltext

The emerging therapeutic potential of histone methyltransferase and demethylase inhibitors.

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Spannhoff A, Hauser AT, Heinke R, Sippl W, and Jung M

ChemMedChem 4(10):1568-82, 2009 Oct - Who cited this? | PubMed ID: 19739196 | Fulltext

First total synthesis of 1,2-dipalmitoyl-3-(N-palmitoyl-6'-amino-6'-deoxy-alpha-D-glucosyl)-sn-glycerol-a glycoglycerolipid of a marine alga with a high inhibitor activity against human Myt1-kinase.

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Göllner C, Philipp C, Dobner B, Sippl W, and Schmidt M

Carbohydrate research 344(13):1628-31, 2009 Sep 8 - Who cited this? | PubMed ID: 19555926 | Fulltext

Histone deacetylase inhibitors that target tubulin.

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Schemies J, Sippl W, and Jung M

Cancer letters 280(2):222-32, 2009 Aug 8 - Who cited this? | PubMed ID: 19268440 | Fulltext

Small-molecule inhibitor of USP7/HAUSP ubiquitin protease stabilizes and activates p53 in cells.

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Colland F, Formstecher E, Jacq X, Reverdy C, Planquette C, Conrath S, Trouplin V, Bianchi J, Aushev VN, Camonis J, Calabrese A, Borg-Capra C, Sippl W, Collura V, Boissy G, Rain JC,

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Molecular cancer therapeutics 8(8):2286-95, 2009 Aug - Who cited this? | PubMed ID: 19671755 | Fulltext

Receptor-based 3D-QSAR studies of checkpoint Wee1 kinase inhibitors.

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Wichapong K, Lindner M, Pianwanit S, Kokpol S, and Sippl W

European journal of medicinal chemistry 44(4):1383-95, 2009 Apr - Who cited this? | PubMed ID: 18976834 | Fulltext

Pyridylalanine-containing hydroxamic acids as selective HDAC6 inhibitors.

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Schäfer S, Saunders L, Schlimme S, Valkov V, Wagner JM, Kratz F, Sippl W, Verdin E, and Jung M

ChemMedChem 4(2):283-90, 2009 Feb - Who cited this? | PubMed ID: 19090524 | Fulltext

Cancer treatment of the future: Inhibitors of histone methyltransferases.

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Spannhoff A, Sippl W, and Jung M

The international journal of biochemistry & cell biology 41(1):4-11, 2009 - Who cited this? | PubMed ID: 18773966 | Fulltext

Virtual Screening and Biological Characterization of Novel Histone Arginine Methyltransferase PRMT1 Inhibitors.

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Heinke R, Spannhoff A, Meier R, Trojer P, Bauer I, Jung M, and Sippl W

ChemMedChem 4(1):69-77, 2009 Jan - Who cited this? | PubMed ID: 19085993 | Fulltext

Masitinib (AB1010), a Potent and Selective Tyrosine Kinase Inhibitor Targeting KIT.

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Dubreuil P, Letard S, Ciufolini M, Gros L, Humbert M, Castéran N, Borge L, Hajem B, Lermet A, Sippl W, Voisset E, Arock M, Auclair C, Leventhal PS, Mansfield CD, Moussy A,

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PLoS ONE 4(9):e7258, 2009 - Who cited this? | PubMed ID: 19789626 | Fulltext

Thiobarbiturates as sirtuin inhibitors: virtual screening, free-energy calculations, and biological testing.

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Uciechowska U, Schemies J, Neugebauer RC, Huda EM, Schmitt ML, Meier R, Verdin E, Jung M, and Sippl W

ChemMedChem 3(12):1965-76, 2008 Dec - Who cited this? | PubMed ID: 18985648 | Fulltext

Insights into ligand-elicited activation of human constitutive androstane receptor based on novel agonists and three-dimensional quantitative structure-activity relationship.

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Jyrkkärinne J, Windshügel B, Rönkkö T, Tervo AJ, Küblbeck J, Lahtela-Kakkonen M, Sippl W, Poso A, and Honkakoski P

Journal of medicinal chemistry 51(22):7181-92, 2008 Nov 27 - Who cited this? | PubMed ID: 18983136 | Fulltext

Discovery of substituted sulfonamides and thiazolidin-4-one derivatives as agonists of human constitutive androstane receptor.

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Küblbeck J, Jyrkkärinne J, Poso A, Turpeinen M, Sippl W, Honkakoski P, and Windshügel B

Biochemical pharmacology, 2008 Aug 22 - Who cited this? | PubMed ID: 18786510 | Fulltext

Novel insight into inhibitor binding of highly symmetric HIV-1 protease.

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Wollmann J, Baumert C, Erlenkamp G, Sippl W, and Hilgeroth A

Chembiochem : a European journal of chemical biology 9(6):874-8, 2008 Apr 14 - Who cited this? | PubMed ID: 18318035 | Fulltext

Structure-activity studies on splitomicin derivatives as sirtuin inhibitors and computational prediction of binding mode.

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Neugebauer RC, Uchiechowska U, Meier R, Hruby H, Valkov V, Verdin E, Sippl W, and Jung M

Journal of medicinal chemistry 51(5):1203, 2008 Mar 13 - Who cited this? | PubMed ID: 18269226 | Fulltext

Phenylalanine-containing hydroxamic acids as selective inhibitors of class IIb histone deacetylases (HDACs).

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Schäfer S, Saunders L, Eliseeva E, Velena A, Jung M, Schwienhorst A, Strasser A, Dickmanns A, Ficner R, Schlimme S, Sippl W, Verdin E, and Jung M

Bioorganic & medicinal chemistry 16(4):2011-33, 2008 Feb 15 - Who cited this? | PubMed ID: 18054239 | Fulltext

Inhibitors of NAD+ dependent histone deacetylases (sirtuins).

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Neugebauer RC, Sippl W, and Jung M

Current pharmaceutical design 14(6):562, 2008 - Who cited this? | PubMed ID: 18336301 | Fulltext

Stereochemical and steric control of the UDP-glucuronosyltransferase-catalyzed conjugation reaction: a rational approach for the design of inhibitors for the human UGT2B7.

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Bichlmaier I, Finel M, Sippl W, and Yli-Kauhaluoma J

ChemMedChem 2(12):1730-40, 2007 Dec - Who cited this? | PubMed ID: 17943712 | Fulltext

Structure-activity studies on suramin analogues as inhibitors of NAD+-dependent histone deacetylases (sirtuins).

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Trapp J, Meier R, Hongwiset D, Kassack MU, Sippl W, and Jung M

ChemMedChem 2(10):1419-31, 2007 Oct - Who cited this? | PubMed ID: 17628866 | Fulltext

A novel arginine methyltransferase inhibitor with cellular activity.

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Spannhoff A, Machmur R, Heinke R, Trojer P, Bauer I, Brosch G, Schüle R, Hanefeld W, Sippl W, and Jung M

Bioorganic & medicinal chemistry letters 17(15):4150-3, 2007 Aug 1 - Who cited this? | PubMed ID: 17570663 | Fulltext

Generation of a homology model of the human histamine H(3) receptor for ligand docking and pharmacophore-based screening.

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Schlegel B, Laggner C, Meier R, Langer T, Schnell D, Seifert R, Stark H, Höltje HD, and Sippl W

Journal of computer-aided molecular design 21(8):437-53, 2007 Aug - Who cited this? | PubMed ID: 17668276 | Fulltext

Target-based approach to inhibitors of histone arginine methyltransferases.

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Spannhoff A, Heinke R, Bauer I, Trojer P, Metzger E, Gust R, Schüle R, Brosch G, Sippl W, and Jung M

Journal of medicinal chemistry 50(10):2319-25, 2007 May 17 - Who cited this? | PubMed ID: 17432842 | Fulltext

Comparison of homology models and X-ray structures of the nuclear receptor CAR: assessing the structural basis of constitutive activity.

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Windshügel B, Jyrkkärinne J, Vanamo J, Poso A, Honkakoski P, and Sippl W

Journal of molecular graphics & modelling 25(5):644-57, 2007 Jan - Who cited this? | PubMed ID: 16831563 | Fulltext

Adenosine mimetics as inhibitors of NAD+-dependent histone deacetylases, from kinase to sirtuin inhibition.

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Trapp J, Jochum A, Meier R, Saunders L, Marshall B, Kunick C, Verdin E, Goekjian P, Sippl W, and Jung M

Journal of medicinal chemistry 49(25):7307-16, 2006 Dec 14 - Who cited this? | PubMed ID: 17149860 | Fulltext

Molecular dynamics simulations of bovine rhodopsin: influence of protonation states and different membrane-mimicking environments.

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Schlegel B, Sippl W, and Höltje HD

Journal of molecular modeling 12(1):49-64, 2005 Dec - Who cited this? | PubMed ID: 16247601 | Fulltext

Model of a specific human histamine H3 receptor (hH3R) binding pocket suitable for virtual drug design.

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Schlegel B, Stark H, Sippl W, and Höltje HD

Inflammation research : official journal of the European Histamine Research Society ... [et al.] 54 Suppl 1:S50-1, 2005 Apr - Who cited this? | PubMed ID: 15928832 | Fulltext

Amino acids important for ligand specificity of the human constitutive androstane receptor.

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Jyrkkärinne J, Windshügel B, Mäkinen J, Ylisirniö M, Peräkylä M, Poso A, Sippl W, and Honkakoski P

The Journal of biological chemistry 280(7):5960-71, 2005 Feb 18 - Who cited this? | PubMed ID: 15572376 | Fulltext

Molecular dynamics simulations of the human CAR ligand-binding domain: deciphering the molecular basis for constitutive activity.

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Windshügel B, Jyrkkärinne J, Poso A, Honkakoski P, and Sippl W

Journal of molecular modeling 11(1):69-79, 2005 Feb - Who cited this? | PubMed ID: 15616833 | Fulltext

Medicinal chemical and pharmacological aspects of imidazole-containing histamine H3 receptor antagonists.

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Stark H, Kathmann M, Schlicker E, Schunack W, Schlegel B, and Sippl W

Mini reviews in medicinal chemistry 4(9):965-77, 2004 Nov - Who cited this? | PubMed ID: 15544557 | Fulltext

N-(omega-(4-(2-methoxyphenyl)piperazin-1-yl)alkyl)carboxamides as dopamine D2 and D3 receptor ligands.

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Hackling A, Ghosh R, Perachon S, Mann A, Höltje HD, Wermuth CG, Schwartz JC, Sippl W, Sokoloff P, and Stark H

Journal of medicinal chemistry 46(18):3883-99, 2003 Aug 28 - Who cited this? | PubMed ID: 12930150 | Fulltext

Imidazole derivatives as a novel class of hybrid compounds with inhibitory histamine N-methyltransferase potencies and histamine hH3 receptor affinities.

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Grassmann S, Apelt J, Sippl W, Ligneau X, Pertz HH, Zhao YH, Arrang JM, Ganellin CR, Schwartz JC, Schunack W, and Stark H

Bioorganic & medicinal chemistry 11(10):2163-74, 2003 May 15 - Who cited this? | PubMed ID: 12713826 | Fulltext

Glucocorticoid receptor interactions with glucocorticoids: evaluation by molecular modeling and functional analysis of glucocorticoid receptor mutants.

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Hammer S, Spika I, Sippl W, Jessen G, Kleuser B, Höltje HD, and Schäfer-Korting M

Steroids 68(4):329-39, 2003 Apr - Who cited this? | PubMed ID: 12787894 | Fulltext

[News of the old histamine. I. A widening of the receptor family].

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Stark H, Schlegel B, and Sippl W

Pharmazie in unserer Zeit 32(2):92-3, 2003 - Who cited this? | PubMed ID: 12677959 | Fulltext

Binding affinity prediction of novel estrogen receptor ligands using receptor-based 3-D QSAR methods.

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Sippl W

Bioorganic & medicinal chemistry 10(12):3741-55, 2002 Dec - Who cited this? | PubMed ID: 12413831 | Fulltext

Development of biologically active compounds by combining 3D QSAR and structure-based design methods.

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Sippl W

Journal of computer-aided molecular design 16(11):825-30, 2002 Nov - Who cited this? | PubMed ID: 12825795 | Fulltext

Design, synthesis, and structure-activity relationships of a series of 3-[2-(1-benzylpiperidin-4-yl)ethylamino]pyridazine derivatives as acetylcholinesterase inhibitors.

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Contreras JM, Parrot I, Sippl W, Rival YM, and Wermuth CG

Journal of medicinal chemistry 44(17):2707-18, 2001 Aug 16 - Who cited this? | PubMed ID: 11495583 | Fulltext

Structure-based 3D QSAR and design of novel acetylcholinesterase inhibitors.

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Sippl W, Contreras JM, Parrot I, Rival YM, and Wermuth CG

Journal of computer-aided molecular design 15(5):395-410, 2001 May - Who cited this? | PubMed ID: 11394735 | Fulltext

Different antagonist binding properties of human and rat histamine H3 receptors.

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Stark H, Sippl W, Ligneau X, Arrang JM, Ganellin CR, Schwartz JC, and Schunack W

Bioorganic & medicinal chemistry letters 11(7):951-4, 2001 Apr 9 - Who cited this? | PubMed ID: 11294398 | Fulltext

Receptor-based 3D QSAR analysis of estrogen receptor ligands--merging the accuracy of receptor-based alignments with the computational efficiency of ligand-based methods.

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Sippl W

Journal of computer-aided molecular design 14(6):559-72, 2000 Aug - Who cited this? | PubMed ID: 10921772 | Fulltext

Skin penetration and metabolism of topical glucocorticoids in reconstructed epidermis and in excised human skin.

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Gysler A, Kleuser B, Sippl W, Lange K, Korting HC, Höltje HD, and Korting HC

Pharmaceutical research 16(9):1386-91, 1999 Sep - Who cited this? | PubMed ID: 10496654 | Fulltext

Development of a binding site model for histamine H3-receptor agonists.

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Sippl W, Stark H, and Höltje HD

Die Pharmazie 53(7):433-7, 1998 Jul - Who cited this? | PubMed ID: 9699219 | Fulltext

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