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Papers authored by Shuldiner AR

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Glucokinase regulatory protein gene polymorphism affects postprandial lipemic response in a dietary intervention study.

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Shen H, Pollin TI, Damcott CM, McLenithan JC, Mitchell BD, and Shuldiner AR

Human genetics 126(4):567-74, 2009 Oct - Who cited this? | PubMed ID: 19526250 | Fulltext

Association of cytochrome P450 2C19 genotype with the antiplatelet effect and clinical efficacy of clopidogrel therapy.

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Shuldiner AR, O'Connell JR, Bliden KP, Gandhi A, Ryan K, Horenstein RB, Damcott CM, Pakyz R, Tantry US, Gibson Q, Pollin TI, Post W, Parsa A, Mitchell BD, Faraday N, Herzog W,

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JAMA : the journal of the American Medical Association 302(8):849-57, 2009 Aug 26 - Who cited this? | PubMed ID: 19706858 | Fulltext

Aspirin Resistance in healthy drug-naive men versus women (from the Heredity and Phenotype Intervention Heart Study).

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Shen H, Herzog W, Drolet M, Pakyz R, Newcomer S, Sack P, Karon H, Ryan KA, Zhao Y, Shi X, Mitchell BD, and Shuldiner AR

The American journal of cardiology 104(4):606-12, 2009 Aug 15 - Who cited this? | PubMed ID: 19660620 | Fulltext

Common variants in the SLCO1B3 locus are associated with bilirubin levels and unconjugated hyperbilirubinemia.

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Sanna S, Busonero F, Maschio A, McArdle PF, Usala G, Dei M, Lai S, Mulas A, Piras MG, Perseu L, Masala M, Marongiu M, Crisponi L, Naitza S, Galanello R, Abecasis GR,

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Human molecular genetics 18(14):2711-8, 2009 Jul 15 - Who cited this? | PubMed ID: 19419973 | Fulltext

Linkage disequilibrium mapping of the replicated type 2 diabetes linkage signal on chromosome 1q.

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Prokopenko I, Zeggini E, Hanson RL, Mitchell BD, Rayner NW, Akan P, Baier L, Das SK, Elliott KS, Fu M, Frayling TM, Groves CJ, Gwilliam R, Scott LJ, Voight BF, Hattersley AT,

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Diabetes 58(7):1704-9, 2009 Jul - Who cited this? | PubMed ID: 19389826 | Fulltext

NRXN3 Is a Novel Locus for Waist Circumference: A Genome-Wide Association Study from the CHARGE Consortium.

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Heard-Costa NL, Zillikens MC, Monda KL, Johansson A, Harris TB, Fu M, Haritunians T, Feitosa MF, Aspelund T, Eiriksdottir G, Garcia M, Launer LJ, Smith AV, Mitchell BD, McArdle PF, Shuldiner AR,

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PLoS genetics 5(6):e1000539, 2009 Jun - Who cited this? | PubMed ID: 19557197 | Fulltext

Serum 25-hydroxyvitamin d levels are not associated with subclinical vascular disease or C-reactive protein in the old order amish.

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Michos ED, Streeten EA, Ryan KA, Rampersaud E, Peyser PA, Bielak LF, Shuldiner AR, Mitchell BD, and Post W

Calcified tissue international 84(3):195-202, 2009 Mar - Who cited this? | PubMed ID: 19148561 | Fulltext

From the Cover: Whole-genome association study identifies STK39 as a hypertension susceptibility gene.

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Wang Y, O'Connell JR, McArdle PF, Wade JB, Dorff SE, Shah SJ, Shi X, Pan L, Rampersaud E, Shen H, Kim JD, Subramanya AR, Steinle NI, Parsa A, Ober CC, Welling PA,

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Proceedings of the National Academy of Sciences of the United States of America 106(1):226-31, 2009 Jan 6 - Who cited this? | PubMed ID: 19114657 | Fulltext

Association of APOE polymorphism with chronic kidney disease in a nationally representative sample: a Third National Health and Nutrition Examination Survey (NHANES III) Genetic Study.

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Chu AY, Parekh RS, Astor BC, Coresh J, Berthier-Schaad Y, Smith MW, Shuldiner AR, and Kao WH

BMC medical genetics 10:108, 2009 - Who cited this? | PubMed ID: 19852818 | Fulltext

A null mutation in human APOC3 confers a favorable plasma lipid profile and apparent cardioprotection.

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Pollin TI, Damcott CM, Shen H, Ott SH, Shelton J, Horenstein RB, Post W, McLenithan JC, Bielak LF, Peyser PA, Mitchell BD, Miller M, O'Connell JR, and Shuldiner AR

Science (New York, N.Y.) 322(5908):1702-5, 2008 Dec 12 - Who cited this? | PubMed ID: 19074352 | Fulltext

Mammographic breast density--evidence for genetic correlations with established breast cancer risk factors.

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Douglas JA, Roy-Gagnon MH, Zhou C, Mitchell BD, Shuldiner AR, Chan HP, and Helvie MA

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 17(12):3509-16, 2008 Dec - Who cited this? | PubMed ID: 19029399 | Fulltext

Obesity genes and gene-environment-behavior interactions: recommendations for a way forward.

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Shuldiner AR

Obesity (Silver Spring, Md.) 16 Suppl 3:S79-81, 2008 Dec - Who cited this? | PubMed ID: 19037219 | Fulltext

The association of coronary artery calcification and carotid artery intima-media thickness with distinct, traditional coronary artery disease risk factors in asymptomatic adults.

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Rampersaud E, Bielak LF, Parsa A, Shen H, Post W, Ryan KA, Donnelly P, Rumberger JA, Sheedy PF, Peyser PA, Shuldiner AR, and Mitchell BD

American journal of epidemiology 168(9):1016-23, 2008 Nov 1 - Who cited this? | PubMed ID: 18805900 | Fulltext

Physical Activity and the Association of Common FTO Gene Variants With Body Mass Index and Obesity.

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Rampersaud E, Mitchell BD, Pollin TI, Fu M, Shen H, O'Connell JR, Ducharme JL, Hines S, Sack P, Naglieri R, Shuldiner AR, and Snitker S

Archives of internal medicine 168(16):1791, 2008 Sep 8 - Who cited this? | PubMed ID: 18779467 | Fulltext

Extension of type 2 diabetes genome-wide association scan results in the diabetes prevention program.

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Moore AF, Jablonski KA, McAteer JB, Saxena R, Pollin TI, Franks PW, Hanson RL, Shuldiner AR, Knowler WC, Altshuler D, Florez JC, and

Diabetes 57(9):2503, 2008 Sep - Who cited this? | PubMed ID: 18544707 | Fulltext

Autosome-wide linkage analysis of hip structural phenotypes in the Old Order Amish.

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Streeten EA, Beck TJ, O'Connell JR, Rampersand E, McBride DJ, Takala SL, Pollin TI, Uusi-Rasi K, Mitchell BD, and Shuldiner AR

Bone 43(3):607-12, 2008 Sep - Who cited this? | PubMed ID: 18555766 | Fulltext

Association of a common nonsynonymous variant in GLUT9 with serum uric acid levels in old order amish.

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McArdle PF, Parsa A, Chang YP, Weir MR, O'Connell JR, Mitchell BD, and Shuldiner AR

Arthritis and rheumatism 58(9):2874, 2008 Aug 29 - Who cited this? | PubMed ID: 18759275 | Fulltext

Expression, purification, and initial characterization of human alanine aminotransferase (ALT) isoenzyme 1 and 2 in High-five insect cells.

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Liu L, Zhong S, Yang R, Hu H, Yu D, Zhu D, Hua Z, Shuldiner AR, Goldstein R, Reagan WJ, and Gong DW

Protein expression and purification 60(2):225-31, 2008 Aug - Who cited this? | PubMed ID: 18508279 | Fulltext

TCF7L2 Variants Associate with CKD Progression and Renal Function in Population-Based Cohorts.

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Köttgen A, Hwang SJ, Rampersaud E, Coresh J, North KE, Pankow JS, Meigs JB, Florez JC, Parsa A, Levy D, Boerwinkle E, Shuldiner AR, Fox CS, and Kao WH

Journal of the American Society of Nephrology : JASN, 2008 Jul 23 - Who cited this? | PubMed ID: 18650481 | Fulltext

Variations in the G6PC2/ABCB11 genomic region are associated with fasting glucose levels.

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Chen WM, Erdos MR, Jackson AU, Saxena R, Sanna S, Silver KD, Timpson NJ, Hansen T, Orrù M, Grazia Piras M, Bonnycastle LL, Willer CJ, Lyssenko V, Shen H, Kuusisto J, Ebrahim S,

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The Journal of clinical investigation 118(7):2620, 2008 Jul 1 - Who cited this? | PubMed ID: 18521185 | Fulltext

Phosphodiesterase 8B gene variants are associated with serum TSH levels and thyroid function.

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Arnaud-Lopez L, Usala G, Ceresini G, Mitchell BD, Pilia MG, Piras MG, Sestu N, Maschio A, Busonero F, Albai G, Dei M, Lai S, Mulas A, Crisponi L, Tanaka T, Bandinelli S,

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American journal of human genetics 82(6):1270, 2008 Jun - Who cited this? | PubMed ID: 18514160 | Fulltext

The Association of Podocin R229Q Polymorphism With Increased Albuminuria or Reduced Estimated GFR in a Large Population-Based Sample of US Adults.

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Köttgen A, Hsu CC, Coresh J, Shuldiner AR, Berthier-Schaad Y, Gambhir TR, Smith MW, Boerwinkle E, and Kao WH

American journal of kidney diseases : the official journal of the National Kidney Foundation, 2008 May 20 - Who cited this? | PubMed ID: 18499321 | Fulltext

Adiponectin levels and genotype: a potential regulator of life span in humans.

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Atzmon G, Pollin TI, Crandall J, Tanner K, Schechter CB, Scherer PE, Rincon M, Siegel G, Katz M, Lipton RB, Shuldiner AR, and Barzilai N

The journals of gerontology. Series A, Biological sciences and medical sciences 63(5):447, 2008 May - Who cited this? | PubMed ID: 18511746 | Fulltext

The genetic response to short-term interventions affecting cardiovascular function: rationale and design of the Heredity and Phenotype Intervention (HAPI) Heart Study.

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Mitchell BD, McArdle PF, Shen H, Rampersaud E, Pollin TI, Bielak LF, Jaquish C, Douglas JA, Roy-Gagnon MH, Sack P, Naglieri R, Hines S, Horenstein RB, Chang YP, Post W, Ryan KA,

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American heart journal 155(5):823-8, 2008 May - Who cited this? | PubMed ID: 18440328 | Fulltext

Genetic influences on blood pressure response to the cold pressor test: results from the Heredity and Phenotype Intervention Heart Study.

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Roy-Gagnon MH, Weir MR, Sorkin JD, Ryan KA, Sack PA, Hines S, Bielak LF, Peyser PA, Post W, Mitchell BD, Shuldiner AR, and Douglas JA

Journal of hypertension 26(4):729-36, 2008 Apr - Who cited this? | PubMed ID: 18327083 | Fulltext

Newly identified loci that influence lipid concentrations and risk of coronary artery disease.

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Willer CJ, Sanna S, Jackson AU, Scuteri A, Bonnycastle LL, Clarke R, Heath SC, Timpson NJ, Najjar SS, Stringham HM, Strait J, Duren WL, Maschio A, Busonero F, Mulas A, Albai G,

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Nature genetics 40(2):161, 2008 Feb - Who cited this? | PubMed ID: 18193043 | Fulltext

Common variants in the GDF5-UQCC region are associated with variation in human height.

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Sanna S, Jackson AU, Nagaraja R, Willer CJ, Chen WM, Bonnycastle LL, Shen H, Timpson N, Lettre G, Usala G, Chines PS, Stringham HM, Scott LJ, Dei M, Lai S, Albai G,

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Nature genetics 40(2):198-203, 2008 Feb - Who cited this? | PubMed ID: 18193045 | Fulltext

Differences in prevalence and severity of coronary artery calcification between two non-Hispanic white populations with diverse lifestyles.

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Bielak LF, Yu P, Ryan KA, Rumberger JA, Sheedy PF, Turner ST, Post W, Shuldiner AR, Mitchell BD, and Peyser PA

Atherosclerosis 196(2):888-95, 2008 Feb - Who cited this? | PubMed ID: 17368463 | Fulltext

Investigations of the Y chromosome, male founder structure and YSTR mutation rates in the Old Order Amish.

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Pollin TI, McBride DJ, Agarwala R, Schäffer AA, Shuldiner AR, Mitchell BD, and O'Connell JR

Human heredity 65(2):91-104, 2008 - Who cited this? | PubMed ID: 17898540 | Fulltext

Identification of novel candidate genes for type 2 diabetes from a genome-wide association scan in the Old Order Amish: evidence for replication from diabetes-related quantitative traits and from independent populations.

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Rampersaud E, Damcott CM, Fu M, Shen H, McArdle P, Shi X, Shelton J, Yin J, Chang YP, Ott SH, Zhang L, Zhao Y, Mitchell BD, O'Connell J, and Shuldiner AR

Diabetes 56(12):3053-62, 2007 Dec - Who cited this? | PubMed ID: 17846126 | Fulltext

A genome-wide linkage scan of insulin level derived traits: the Amish Family Diabetes Study.

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Hsueh WC, Silver KD, Pollin TI, Bell CJ, O'Connell JR, Mitchell BD, and Shuldiner AR

Diabetes 56(10):2643-8, 2007 Oct - Who cited this? | PubMed ID: 17646211 | Fulltext

Telomere length is paternally inherited and is associated with parental lifespan.

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Njajou OT, Cawthon RM, Damcott CM, Wu SH, Ott S, Garant MJ, Blackburn EH, Mitchell BD, Shuldiner AR, and Hsueh WC

Proceedings of the National Academy of Sciences of the United States of America 104(29):12135-9, 2007 Jul 17 - Who cited this? | PubMed ID: 17623782 | Fulltext

Omentin plasma levels and gene expression are decreased in obesity.

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de Souza Batista CM, Yang RZ, Lee MJ, Glynn NM, Yu DZ, Pray J, Ndubuizu K, Patil S, Schwartz A, Kligman M, Fried SK, Gong DW, Shuldiner AR, Pollin TI, and McLenithan JC

Diabetes 56(6):1655, 2007 Jun - Who cited this? | PubMed ID: 17329619 | Fulltext

Genetic nondiscrimination legislation: a critical prerequisite for pharmacogenomics data sharing.

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Altman RB, Benowitz N, Gurwitz D, Lunshof J, Relling M, Lamba J, Wieben E, Mooney S, Giacomini K, Weiss S, Johnson JA, McLeod H, Flockhart D, Weinshilboum R, Shuldiner AR, Roden D,

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Pharmacogenomics 8(5):519, 2007 May - Who cited this? | PubMed ID: 17465717 | Fulltext

Evidence that Rho guanine nucleotide exchange factor 11 (ARHGEF11) on 1q21 is a type 2 diabetes susceptibility gene in the Old Order Amish.

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Fu M, Sabra MM, Damcott C, Pollin TI, Ma L, Ott S, Shelton JC, Shi X, Reinhart L, O'Connell J, Mitchell BD, Baier LJ, and Shuldiner AR

Diabetes 56(5):1363, 2007 May - Who cited this? | PubMed ID: 17369523 | Fulltext

Variants in ARHGEF11, a candidate gene for the linkage to type 2 diabetes on chromosome 1q, are nominally associated with insulin resistance and type 2 diabetes in Pima Indians.

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Ma L, Hanson RL, Que LN, Cali AM, Fu M, Mack JL, Infante AM, Kobes S, International Type 2 Diabetes 1q Consortium, Bogardus C, Shuldiner AR, and Baier LJ

Diabetes 56(5):1454-9, 2007 May - Who cited this? | PubMed ID: 17287471 | Fulltext

Relationship between vascular calcification and bone mineral density in the Old-order Amish.

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Shen H, Bielak LF, Streeten EA, Ryan KA, Rumberger JA, Sheedy PF, Shuldiner AR, Peyser PA, and Mitchell BD

Calcified tissue international 80(4):244-50, 2007 Apr - Who cited this? | PubMed ID: 17431532 | Fulltext

The pharmacogenetics research network: from SNP discovery to clinical drug response.

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Giacomini KM, Brett CM, Altman RB, Benowitz NL, Dolan ME, Flockhart DA, Johnson JA, Hayes DF, Klein T, Krauss RM, Kroetz DL, McLeod HL, Nguyen AT, Ratain MJ, Relling MV, Reus V,

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Clinical pharmacology and therapeutics 81(3):328, 2007 Mar - Who cited this? | PubMed ID: 17339863 | Fulltext

Activating transcription factor 6 (ATF6) sequence polymorphisms in type 2 diabetes and pre-diabetic traits.

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Chu WS, Das SK, Wang H, Chan JC, Deloukas P, Froguel P, Baier LJ, Jia W, McCarthy MI, Ng MC, Damcott C, Shuldiner AR, Zeggini E, and Elbein SC

Diabetes 56(3):856, 2007 Mar - Who cited this? | PubMed ID: 17327457 | Fulltext

Common variation in the LMNA gene (encoding lamin A/C) and type 2 diabetes: association analyses in 9,518 subjects.

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Owen KR, Groves CJ, Hanson RL, Knowler WC, Shuldiner AR, Elbein SC, Mitchell BD, Froguel P, Ng MC, Chan JC, Jia W, Deloukas P, Hitman GA, Walker M, Frayling TM, Hattersley AT,

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Diabetes 56(3):879, 2007 Mar - Who cited this? | PubMed ID: 17327460 | Fulltext

Determinants of coronary artery and aortic calcification in the Old Order Amish.

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Post W, Bielak LF, Ryan KA, Cheng YC, Shen H, Rumberger JA, Sheedy PF, Shuldiner AR, Peyser PA, and Mitchell BD

Circulation 115(6):717-24, 2007 Feb 13 - Who cited this? | PubMed ID: 17261661 | Fulltext

FABP2 Ala54Thr genotype is associated with glucoregulatory function and lipid oxidation after a high-fat meal in sedentary nondiabetic men and women.

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Weiss EP, Brandauer J, Kulaputana O, Ghiu IA, Wohn CR, Phares DA, Shuldiner AR, and Hagberg JM

The American journal of clinical nutrition 85(1):102-8, 2007 Jan - Who cited this? | PubMed ID: 17209184 | Fulltext

Associations between genetic variants in the NOS1AP (CAPON) gene and cardiac repolarization in the old order Amish.

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Post W, Shen H, Damcott C, Arking DE, Kao WH, Sack PA, Ryan KA, Chakravarti A, Mitchell BD, and Shuldiner AR

Human heredity 64(4):214-9, 2007 - Who cited this? | PubMed ID: 17565224 | Fulltext

Accounting for relatedness in family based genetic association studies.

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McArdle PF, O'Connell JR, Pollin TI, Baumgarten M, Shuldiner AR, Peyser PA, and Mitchell BD

Human heredity 64(4):234-42, 2007 - Who cited this? | PubMed ID: 17570925 | Fulltext

Variants in scavenger receptor class B type I gene are associated with HDL cholesterol levels in younger women.

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Roberts CG, Shen H, Mitchell BD, Damcott CM, Shuldiner AR, and Rodriguez A

Human heredity 64(2):107-13, 2007 - Who cited this? | PubMed ID: 17476110 | Fulltext

Homozygosity by descent mapping of blood pressure in the Old Order Amish: evidence for sex specific genetic architecture.

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McArdle PF, Dytch H, O'Connell JR, Shuldiner AR, Mitchell BD, and Abney M

BMC genetics 8:66, 2007 - Who cited this? | PubMed ID: 17908314 | Fulltext

Pharmacogenomics: challenges and opportunities.

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Roden DM, Altman RB, Benowitz NL, Flockhart DA, Giacomini KM, Johnson JA, Krauss RM, McLeod HL, Ratain MJ, Relling MV, Ring HZ, Shuldiner AR, Weinshilboum RM, Weiss ST, and

Annals of internal medicine 145(10):749, 2006 Nov 21 - Who cited this? | PubMed ID: 17116919 | Fulltext

Role of a proline insertion in the insulin promoter factor 1 (IPF1) gene in African Americans with type 2 diabetes.

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Elbein SC, Wang X, Karim MA, Freedman BI, Bowden DW, Shuldiner AR, Brancati FL, and Kao WH

Diabetes 55(10):2909, 2006 Oct - Who cited this? | PubMed ID: 17003361 | Fulltext

Variation within the gene encoding the upstream stimulatory factor 1 does not influence susceptibility to type 2 diabetes in samples from populations with replicated evidence of linkage to chromosome 1q.

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Zeggini E, Damcott CM, Hanson RL, Karim MA, Rayner NW, Groves CJ, Baier LJ, Hale TC, Hattersley AT, Hitman GA, Hunt SE, Knowler WC, Mitchell BD, Ng MC, O'Connell JR, Pollin TI,

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Diabetes 55(9):2541, 2006 Sep - Who cited this? | PubMed ID: 16936202 | Fulltext

Polymorphisms in the transcription factor 7-like 2 (TCF7L2) gene are associated with type 2 diabetes in the Amish: replication and evidence for a role in both insulin secretion and insulin resistance.

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Damcott CM, Pollin TI, Reinhart LJ, Ott SH, Shen H, Silver KD, Mitchell BD, and Shuldiner AR

Diabetes 55(9):2654, 2006 Sep - Who cited this? | PubMed ID: 16936218 | Fulltext

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Papers authored by Shuldiner AR

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