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Papers authored by Shiloh Y

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Conditional inactivation of the NBS1 gene in the mouse central nervous system leads to neurodegeneration and disorganization of the visual system.

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Baranes K, Raz-Prag D, Nitzan A, Galron R, Ashery-Padan R, Rotenstreich Y, Assaf Y, Shiloh Y, Wang ZQ, Barzilai A, and Solomon AS

Experimental neurology 218(1):24-32, 2009 Jul - Who cited this? | PubMed ID: 19345213 | Fulltext

Analysis of the relationships between ATM and the Rad54 paralogs involved in homologous recombination repair.

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Kirshner M, Rathavs M, Nizan A, Essers J, Kanaar R, Shiloh Y, and Barzilai A

DNA repair 8(2):253-61, 2009 Feb 1 - Who cited this? | PubMed ID: 19061978 | Fulltext

Citrate Boosts the Performance of Phosphopeptide Analysis by UPLC-ESI-MS/MS.

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Winter D, Seidler J, Ziv Y, Shiloh Y, and Lehmann WD

Journal of proteome research 8(1):418-24, 2009 Jan - Who cited this? | PubMed ID: 19053530 | Fulltext

Activation of ATM depends on chromatin interactions occurring before induction of DNA damage.

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Kim YC, Gerlitz G, Furusawa T, Catez F, Nussenzweig A, Oh KS, Kraemer KH, Shiloh Y, and Bustin M

Nature cell biology 11(1):92-6, 2009 Jan - Who cited this? | PubMed ID: 19079244 | Fulltext

FBXO31: a new player in the ever-expanding DNA damage response orchestra.

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Shiloh Y

Science signaling 2(96):pe73, 2009 - Who cited this? | PubMed ID: 19903939 | Fulltext

The histone H2B-specific ubiquitin ligase RNF20/hBRE1 acts as a putative tumor suppressor through selective regulation of gene expression.

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Shema E, Tirosh I, Aylon Y, Huang J, Ye C, Moskovits N, Raver-Shapira N, Minsky N, Pirngruber J, Tarcic G, Hublarova P, Moyal L, Gana-Weisz M, Shiloh Y, Yarden Y, Johnsen SA,

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Genes & development 22(19):2664-76, 2008 Oct 1 - Who cited this? | PubMed ID: 18832071 | Fulltext

ATM signaling facilitates repair of DNA double-strand breaks associated with heterochromatin.

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Goodarzi AA, Noon AT, Deckbar D, Ziv Y, Shiloh Y, Löbrich M, and Jeggo PA

Molecular cell 31(2):167, 2008 Jul 25 - Who cited this? | PubMed ID: 18657500 | Fulltext

WRN Is Required for ATM Activation and the S-Phase Checkpoint in Response to Interstrand Crosslink-induced DNA Double Strand Breaks.

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Cheng WH, Muftic D, Muftuoglu M, Dawut L, Morris C, Helleday T, Shiloh Y, and Bohr VA

Molecular biology of the cell, 2008 Jul 2 - Who cited this? | PubMed ID: 18596239 | Fulltext

The neurological phenotype of ataxia-telangiectasia: Solving a persistent puzzle.

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Biton S, Barzilai A, and Shiloh Y

DNA repair 7(7):1028, 2008 Jul 1 - Who cited this? | PubMed ID: 18456574 | Fulltext

The role of the DNA damage response in neuronal development, organization and maintenance.

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Barzilai A, Biton S, and Shiloh Y

DNA repair 7(7):1010-27, 2008 Jul 1 - Who cited this? | PubMed ID: 18458000 | Fulltext

SPIKE--a database, visualization and analysis tool of cellular signaling pathways.

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Elkon R, Vesterman R, Amit N, Ulitsky I, Zohar I, Weisz M, Mass G, Orlev N, Sternberg G, Blekhman R, Assa J, Shiloh Y, and Shamir R

BMC bioinformatics 9:110, 2008 - Who cited this? | PubMed ID: 18289391 | Fulltext

MRI evidence of white matter damage in a mouse model of Nijmegen breakage syndrome.

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Assaf Y, Galron R, Shapira I, Nitzan A, Blumenfeld-Katzir T, Solomon AS, Holdengreber V, Wang ZQ, Shiloh Y, and Barzilai A

Experimental neurology 209(1):181-91, 2008 Jan - Who cited this? | PubMed ID: 17976584 | Fulltext

Ataxia-telangiectasia: mild neurological presentation despite null ATM mutation and severe cellular phenotype.

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Alterman N, Fattal-Valevski A, Moyal L, Crawford TO, Lederman HM, Ziv Y, and Shiloh Y

American journal of medical genetics. Part A 143(16):1827-34, 2007 Aug 15 - Who cited this? | PubMed ID: 17632790 | Fulltext

ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

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Matsuoka S, Ballif BA, Smogorzewska A, McDonald ER, Hurov KE, Luo J, Bakalarski CE, Zhao Z, Solimini N, Lerenthal Y, Shiloh Y, Gygi SP, and Elledge SJ

Science (New York, N.Y.) 316(5828):1160, 2007 May 25 - Who cited this? | PubMed ID: 17525332 | Fulltext

Programs for cell death: apoptosis is only one way to go.

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Blank M and Shiloh Y

Cell cycle (Georgetown, Tex.) 6(6):686-95, 2007 Mar 15 - Who cited this? | PubMed ID: 17361099 | Fulltext

Ataxia telangiectasia mutated (ATM) is essential for DNA-PKcs phosphorylations at the Thr-2609 cluster upon DNA double strand break.

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Chen BP, Uematsu N, Kobayashi J, Lerenthal Y, Krempler A, Yajima H, Löbrich M, Shiloh Y, and Chen DJ

The Journal of biological chemistry 282(9):6582, 2007 Mar 2 - Who cited this? | PubMed ID: 17189255 | Fulltext

ATM-mediated response to DNA double strand breaks in human neurons derived from stem cells.

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Biton S, Gropp M, Itsykson P, Pereg Y, Mittelman L, Johe K, Reubinoff B, and Shiloh Y

DNA repair 6(1):128-34, 2007 Jan 4 - Who cited this? | PubMed ID: 17178256 | Fulltext

Functional genomic delineation of TLR-induced transcriptional networks.

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Elkon R, Linhart C, Halperin Y, Shiloh Y, and Shamir R

BMC genomics 8:394, 2007 - Who cited this? | PubMed ID: 17967192 | Fulltext

Inhibition of transforming growth factor-beta1 signaling attenuates ataxia telangiectasia mutated activity in response to genotoxic stress.

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Kirshner J, Jobling MF, Pajares MJ, Ravani SA, Glick AB, Lavin MJ, Koslov S, Shiloh Y, and Barcellos-Hoff MH

Cancer research 66(22):10861-9, 2006 Nov 15 - Who cited this? | PubMed ID: 17090522 | Fulltext

Differential roles of ATM- and Chk2-mediated phosphorylations of Hdmx in response to DNA damage.

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Pereg Y, Lam S, Teunisse A, Biton S, Meulmeester E, Mittelman L, Buscemi G, Okamoto K, Taya Y, Shiloh Y, and Jochemsen AG

Molecular and cellular biology 26(18):6819-31, 2006 Sep - Who cited this? | PubMed ID: 16943424 | Fulltext

Chromatin relaxation in response to DNA double-strand breaks is modulated by a novel ATM- and KAP-1 dependent pathway.

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Ziv Y, Bielopolski D, Galanty Y, Lukas C, Taya Y, Schultz DC, Lukas J, Bekker-Jensen S, Bartek J, and Shiloh Y

Nature cell biology 8(8):870-6, 2006 Aug - Who cited this? | PubMed ID: 16862143 | Fulltext

Analysis of the ataxia telangiectasia mutated-mediated DNA damage response in murine cerebellar neurons.

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Dar I, Biton S, Shiloh Y, and Barzilai A

The Journal of neuroscience : the official journal of the Society for Neuroscience 26(29):7767-74, 2006 Jul 19 - Who cited this? | PubMed ID: 16855104 | Fulltext

Condensin I recruitment and uneven chromatin condensation precede mitotic cell death in response to DNA damage.

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Blank M, Lerenthal Y, Mittelman L, and Shiloh Y

The Journal of cell biology 174(2):195-206, 2006 Jul 17 - Who cited this? | PubMed ID: 16847100 | Fulltext

The ATM-mediated DNA-damage response: taking shape.

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Shiloh Y

Trends in biochemical sciences 31(7):402-10, 2006 Jul - Who cited this? | PubMed ID: 16774833 | Fulltext

Nuclear ataxia-telangiectasia mutated (ATM) mediates the cellular response to DNA double strand breaks in human neuron-like cells.

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Biton S, Dar I, Mittelman L, Pereg Y, Barzilai A, and Shiloh Y

The Journal of biological chemistry 281(25):17482-91, 2006 Jun 23 - Who cited this? | PubMed ID: 16627474 | Fulltext

Parallel induction of ATM-dependent pro- and antiapoptotic signals in response to ionizing radiation in murine lymphoid tissue.

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Rashi-Elkeles S, Elkon R, Weizman N, Linhart C, Amariglio N, Sternberg G, Rechavi G, Barzilai A, Shamir R, and Shiloh Y

Oncogene 25(10):1584-92, 2006 Mar 9 - Who cited this? | PubMed ID: 16314843 | Fulltext

Deciphering transcriptional regulatory elements that encode specific cell cycle phasing by comparative genomics analysis.

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Linhart C, Elkon R, Shiloh Y, and Shamir R

Cell cycle (Georgetown, Tex.) 4(12):1788-97, 2005 Dec - Who cited this? | PubMed ID: 16294034 | Fulltext

DNA damage-induced phosphorylation of MdmX at serine 367 activates p53 by targeting MdmX for Mdm2-dependent degradation.

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Okamoto K, Kashima K, Pereg Y, Ishida M, Yamazaki S, Nota A, Teunisse A, Migliorini D, Kitabayashi I, Marine JC, Prives C, Shiloh Y, Jochemsen AG, and Taya Y

Molecular and cellular biology 25(21):9608, 2005 Nov - Who cited this? | PubMed ID: 16227609 | Fulltext

Impaired genomic stability and increased oxidative stress exacerbate different features of Ataxia-telangiectasia.

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Ziv S, Brenner O, Amariglio N, Smorodinsky NI, Galron R, Carrion DV, Zhang W, Sharma GG, Pandita RK, Agarwal M, Elkon R, Katzin N, Bar-Am I, Pandita TK, Kucherlapati R, Rechavi G,

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Human molecular genetics 14(19):2929-43, 2005 Oct 1 - Who cited this? | PubMed ID: 16150740 | Fulltext

ATM-mediated phosphorylations inhibit Mdmx/Mdm2 stabilization by HAUSP in favor of p53 activation.

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Meulmeester E, Pereg Y, Shiloh Y, and Jochemsen AG

Cell cycle (Georgetown, Tex.) 4(9):1166-70, 2005 Sep - Who cited this? | PubMed ID: 16082221 | Fulltext

ATM-dependent phosphorylation of ATF2 is required for the DNA damage response.

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Bhoumik A, Takahashi S, Breitweiser W, Shiloh Y, Jones N, and Ronai Z

Molecular cell 18(5):577-87, 2005 May 27 - Who cited this? | PubMed ID: 15916964 | Fulltext

Phosphorylation of Hdmx mediates its Hdm2- and ATM-dependent degradation in response to DNA damage.

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Pereg Y, Shkedy D, de Graaf P, Meulmeester E, Edelson-Averbukh M, Salek M, Biton S, Teunisse AF, Lehmann WD, Jochemsen AG, and Shiloh Y

Proceedings of the National Academy of Sciences of the United States of America 102(14):5056-61, 2005 Apr 5 - Who cited this? | PubMed ID: 15788536 | Fulltext

Dissection of a DNA-damage-induced transcriptional network using a combination of microarrays, RNA interference and computational promoter analysis.

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Elkon R, Rashi-Elkeles S, Lerenthal Y, Linhart C, Tenne T, Amariglio N, Rechavi G, Shamir R, and Shiloh Y

Genome biology 6(5):R43, 2005 - Who cited this? | PubMed ID: 15892871 | Fulltext

EXPANDER--an integrative program suite for microarray data analysis.

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Shamir R, Maron-Katz A, Tanay A, Linhart C, Steinfeld I, Sharan R, Shiloh Y, and Elkon R

BMC bioinformatics 6:232, 2005 - Who cited this? | PubMed ID: 16176576 | Fulltext

Maintaining integrity.

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Shiloh Y and Lehmann AR

Nature cell biology 6(10):923-8, 2004 Oct - Who cited this? | PubMed ID: 15459720 | Fulltext

In search of drug treatment for genetic defects in the DNA damage response: the example of ataxia-telangiectasia.

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Shiloh Y, Andegeko Y, and Tsarfaty I

Seminars in cancer biology 14(4):295-305, 2004 Aug - Who cited this? | PubMed ID: 15219622 | Fulltext

PIVOT: protein interacions visualizatiOn tool.

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Orlev N, Shamir R, and Shiloh Y

Bioinformatics (Oxford, England) 20(3):424, 2004 Feb 12 - Who cited this? | PubMed ID: 14960471 | Fulltext

In silico identification of transcriptional regulators associated with c-Myc.

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Elkon R, Zeller KI, Linhart C, Dang CV, Shamir R, and Shiloh Y

Nucleic acids research 32(17):4955, 2004 - Who cited this? | PubMed ID: 15388797 | Fulltext

Requirement of the MRN complex for ATM activation by DNA damage.

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Uziel T, Lerenthal Y, Moyal L, Andegeko Y, Mittelman L, and Shiloh Y

The EMBO journal 22(20):5612-21, 2003 Oct 15 - Who cited this? | PubMed ID: 14532133 | Fulltext

Genome-wide in silico identification of transcriptional regulators controlling the cell cycle in human cells.

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Elkon R, Linhart C, Sharan R, Shamir R, and Shiloh Y

Genome research 13(5):773, 2003 May - Who cited this? | PubMed ID: 12727897 | Fulltext

ATM and related protein kinases: safeguarding genome integrity.

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Shiloh Y

Nature reviews. Cancer 3(3):155-68, 2003 Mar - Who cited this? | PubMed ID: 12612651 | Fulltext

Contribution of the Atm protein to maintaining cellular homeostasis evidenced by continuous activation of the AP-1 pathway in Atm-deficient brains.

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Weizman N, Shiloh Y, and Barzilai A

The Journal of biological chemistry 278(9):6741-7, 2003 Feb 28 - Who cited this? | PubMed ID: 12496286 | Fulltext

ATM: ready, set, go.

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Shiloh Y

Cell cycle (Georgetown, Tex.) 2(2):116-7, 2003 - Who cited this? | PubMed ID: 12695660 | Fulltext

Ionizing radiation induces ataxia telangiectasia mutated kinase (ATM)-mediated phosphorylation of LKB1/STK11 at Thr-366.

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Sapkota GP, Deak M, Kieloch A, Morrice N, Goodarzi AA, Smythe C, Shiloh Y, Lees-Miller SP, and Alessi DR

The Biochemical journal 368(Pt 2):507-16, 2002 Dec 1 - Who cited this? | PubMed ID: 12234250 | Fulltext

Ubiquitination capabilities in response to neocarzinostatin and H(2)O(2) stress in cell lines from patients with ataxia-telangiectasia.

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Taylor A, Shang F, Nowell T, Galanty Y, and Shiloh Y

Oncogene 21(28):4363-73, 2002 Jun 27 - Who cited this? | PubMed ID: 12080467 | Fulltext

ATM-dependent activation of the gene encoding MAP kinase phosphatase 5 by radiomimetic DNA damage.

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Bar-Shira A, Rashi-Elkeles S, Zlochover L, Moyal L, Smorodinsky NI, Seger R, and Shiloh Y

Oncogene 21(5):849-55, 2002 Jan 24 - Who cited this? | PubMed ID: 11850813 | Fulltext

ATM deficiency and oxidative stress: a new dimension of defective response to DNA damage.

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Barzilai A, Rotman G, and Shiloh Y

DNA repair 1(1):3-25, 2002 Jan 22 - Who cited this? | PubMed ID: 12509294 | Fulltext

Accumulation of DNA damage and reduced levels of nicotine adenine dinucleotide in the brains of Atm-deficient mice.

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Stern N, Hochman A, Zemach N, Weizman N, Hammel I, Shiloh Y, Rotman G, and Barzilai A

The Journal of biological chemistry 277(1):602-8, 2002 Jan 4 - Who cited this? | PubMed ID: 11679583 | Fulltext

ATM: from phenotype to functional genomics--and back.

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Shiloh Y

Ernst Schering Research Foundation workshop(36):51-70, 2002 - Who cited this? | PubMed ID: 11859564 | Fulltext

ATM (ataxia telangiectasia mutated): expanding roles in the DNA damage response and cellular homeostasis.

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Shiloh Y

Biochemical Society transactions 29(Pt 6):661-6, 2001 Nov - Who cited this? | PubMed ID: 11709050 | Fulltext

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