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Papers authored by Seruca R

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Estrogens, MSI and Lynch syndrome-associated tumors.

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Ferreira AM, Westers H, Albergaria A, Seruca R, and Hofstra RM

Biochimica et biophysica acta 1796(2):194-200, 2009 Dec - Who cited this? | PubMed ID: 19559756 | Fulltext

The mechanisms underlying MMR deficiency in immunodeficiency-related non-Hodgkin lymphomas are different from those in other sporadic microsatellite instable neoplasms.

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Borie C, Colas C, Dartigues P, Lazure T, Rince P, Buhard O, Folliot P, Chalastanis A, Muleris M, Hamelin R, Mercier D, Oliveira C, Seruca R, Chadburn A, Leblond V, Barete S,

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International journal of cancer. Journal international du cancer 125(10):2360-6, 2009 Nov 15 - Who cited this? | PubMed ID: 19551857 | Fulltext

Analysis of microsatellite instability in medulloblastoma.

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Viana-Pereira M, Almeida I, Sousa S, Mahler-Araújo B, Seruca R, Pimentel J, and Reis RM

Neuro-oncology 11(5):458-67, 2009 Oct - Who cited this? | PubMed ID: 19179424 | Fulltext

Mononucleotide precedes dinucleotide repeat instability during colorectal tumour development in Lynch syndrome patients.

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Ferreira AM, Westers H, Sousa S, Wu Y, Niessen RC, Olderode-Berends M, van der Sluis T, Reuvekamp PT, Seruca R, Kleibeuker JH, Hollema H, Sijmons RH, and Hofstra RM

The Journal of pathology 219(1):96-102, 2009 Sep - Who cited this? | PubMed ID: 19521971 | Fulltext

CagA associates with c-Met, E-cadherin, and p120-catenin in a multiproteic complex that suppresses Helicobacter pylori-induced cell-invasive phenotype.

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Oliveira MJ, Costa AM, Costa AC, Ferreira RM, Sampaio P, Machado JC, Seruca R, Mareel M, and Figueiredo C

The Journal of infectious diseases 200(5):745-55, 2009 Sep 1 - Who cited this? | PubMed ID: 19604117 | Fulltext

Luteolin, quercetin and ursolic acid are potent inhibitors of proliferation and inducers of apoptosis in both KRAS and BRAF mutated human colorectal cancer cells.

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Xavier CP, Lima CF, Preto A, Seruca R, Fernandes-Ferreira M, and Pereira-Wilson C

Cancer letters 281(2):162-70, 2009 Aug 28 - Who cited this? | PubMed ID: 19344998 | Fulltext

The role of N-acetylglucosaminyltransferase III and V in the post-transcriptional modifications of E-cadherin.

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Pinho SS, Reis CA, Paredes J, Magalhães AM, Ferreira AC, Figueiredo J, Xiaogang W, Carneiro F, Gärtner F, and Seruca R

Human molecular genetics 18(14):2599-608, 2009 Jul 15 - Who cited this? | PubMed ID: 19403558 | Fulltext

Quantification of epigenetic and genetic 2nd hits in CDH1 during hereditary diffuse gastric cancer syndrome progression.

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Oliveira C, Sousa S, Pinheiro H, Karam R, Bordeira-Carriço R, Senz J, Kaurah P, Carvalho J, Pereira R, Gusmão L, Wen X, Cipriano MA, Yokota J, Carneiro F, Huntsman D, and Seruca R

Gastroenterology 136(7):2137-48, 2009 Jun - Who cited this? | PubMed ID: 19269290 | Fulltext

Germline CDH1 deletions in hereditary diffuse gastric cancer families.

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Oliveira C, Senz J, Kaurah P, Pinheiro H, Sanges R, Haegert A, Corso G, Schouten J, Fitzgerald R, Vogelsang H, Keller G, Dwerryhouse S, Grimmer D, Chin SF, Yang HK, Jackson CE,

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Human molecular genetics 18(9):1545-55, 2009 May 1 - Who cited this? | PubMed ID: 19168852 | Fulltext

E-cadherin mutations and cell motility: a genotype-phenotype correlation.

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Mateus AR, Simões-Correia J, Figueiredo J, Heindl S, Alves CC, Suriano G, Luber B, and Seruca R

Experimental cell research 315(8):1393-402, 2009 May 1 - Who cited this? | PubMed ID: 19268661 | Fulltext

Helicobacter pylori Infection Induces Genetic Instability of Nuclear and Mitochondrial DNA in Gastric Cells.

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Machado AM, Figueiredo C, Touati E, Máximo V, Sousa S, Michel V, Carneiro F, Nielsen FC, Seruca R, and Rasmussen LJ

Clinical cancer research : an official journal of the American Association for Cancer Research 15(9):2995-3002, 2009 May 1 - Who cited this? | PubMed ID: 19383819 | Fulltext

KRAS mutation testing for predicting response to anti-EGFR therapy for colorectal carcinoma: proposal for an European quality assurance program.

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van Krieken JH, Jung A, Kirchner T, Carneiro F, Seruca R, Bosman FT, Quirke P, Fléjou JF, Hansen TP, de Hertogh G, Jares P, Langner C, Hoefler G, Ligtenberg M, Tiniakos D, Tejpar S,

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Virchows Archiv : an international journal of pathology 454(2):233-5, 2009 Feb - Who cited this? | PubMed ID: 19139917 | Fulltext

Unmasking the role of KRAS and BRAF pathways in MSI colorectal tumors.

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Seruca R, Velho S, Oliveira C, Leite M, Matos P, and Jordan P

Expert review of gastroenterology & hepatology 3(1):5-9, 2009 Feb - Who cited this? | PubMed ID: 19210107 | Fulltext

KRAS Mutations and Anti-Epidermal Growth Factor Receptor Therapy in Colorectal Cancer With Lymph Node Metastases.

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Velho S, Oliveira C, and Seruca R

Journal of clinical oncology : official journal of the American Society of Clinical Oncology 27(1):158-9, 2009 Jan 1 - Who cited this? | PubMed ID: 19047277 | Fulltext

Hereditary gastric cancer.

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Oliveira C, Seruca R, and Carneiro F

Best practice & research. Clinical gastroenterology 23(2):147-57, 2009 - Who cited this? | PubMed ID: 19414142 | Fulltext

Evidence of tumor microsatellite instability in gastric cancer with familial aggregation.

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Pedrazzani C, Corso G, Velho S, Leite M, Pascale V, Bettarini F, Marrelli D, Seruca R, and Roviello F

Familial cancer 8(3):215-20, 2009 - Who cited this? | PubMed ID: 19152022 | Fulltext

TP53 germline mutations in Portugal and genetic modifiers of age at cancer onset.

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Pinto C, Veiga I, Pinheiro M, Peixoto A, Pinto A, Lopes JM, Reis RM, Oliveira C, Baptista M, Roque L, Regateiro F, Cirnes L, Hofstra RM, Seruca R, Castedo S, and Teixeira MR

Familial cancer 8(4):383-90, 2009 - Who cited this? | PubMed ID: 19468865 | Fulltext

Proliferation and survival molecules implicated in the inhibition of BRAF pathway in thyroid cancer cells harbouring different genetic mutations.

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Preto A, Gonçalves J, Rebocho AP, Figueiredo J, Meireles AM, Rocha AS, Vasconcelos HM, Seca H, Seruca R, Soares P, and Sobrinho-Simões M

BMC cancer 9:387, 2009 - Who cited this? | PubMed ID: 19878585 | Fulltext

KRAS mutation testing for predicting response to anti-EGFR therapy for colorectal carcinoma: proposal for an European quality assurance program.

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van Krieken JH, Jung A, Kirchner T, Carneiro F, Seruca R, Bosman FT, Quirke P, Fléjou JF, Plato Hansen T, de Hertogh G, Jares P, Langner C, Hoefler G, Ligtenberg M, Tiniakos D, Tejpar S,

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Virchows Archiv : an international journal of pathology 453(5):417-31, 2008 Nov - Who cited this? | PubMed ID: 18802721 | Fulltext

Molecular targets and biological modifiers in gastric cancer.

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Carneiro F, Oliveira C, Leite M, and Seruca R

Seminars in diagnostic pathology 25(4):274-87, 2008 Nov - Who cited this? | PubMed ID: 19013893 | Fulltext

BRAF, KRAS and PIK3CA mutations in colorectal serrated polyps and cancer: primary or secondary genetic events in colorectal carcinogenesis?.

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Velho S, Moutinho C, Cirnes L, Albuquerque C, Hamelin R, Schmitt F, Carneiro F, Oliveira C, and Seruca R

BMC cancer 8(1):255, 2008 Sep 9 - Who cited this? | PubMed ID: 18782444 | Fulltext

Endoplasmic Reticulum Quality Control: a new mechanism of E-cadherin regulation and its implication in cancer.

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Simões-Correia J, Figueiredo J, Oliveira C, van Hengel J, Seruca R, van Roy F, and Suriano G

Human molecular genetics, 2008 Sep 4 - Who cited this? | PubMed ID: 18772194 | Fulltext

Tumor necrosis factor alpha extended haplotypes and risk of gastric carcinoma.

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Canedo P, Durães C, Pereira F, Regalo G, Lunet N, Barros H, Carneiro F, Seruca R, Rocha J, and Machado JC

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 17(9):2416-20, 2008 Sep - Who cited this? | PubMed ID: 18768512 | Fulltext

B-Raf(V600E) Cooperates With Alternative Spliced Rac1b to Sustain Colorectal Cancer Cell Survival.

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Matos P, Oliveira C, Velho S, Gonçalves V, da Costa LT, Moyer MP, Seruca R, and Jordan P

Gastroenterology 135(3):899-906, 2008 Sep - Who cited this? | PubMed ID: 18602919 | Fulltext

The NMD mRNA surveillance pathway downregulates aberrant E-cadherin transcripts in gastric cancer cells and in CDH1 mutation carriers.

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Karam R, Carvalho J, Bruno I, Graziadio C, Senz J, Huntsman D, Carneiro F, Seruca R, Wilkinson MF, and Oliveira C

Oncogene 27(30):4255, 2008 Jul 10 - Who cited this? | PubMed ID: 18427545 | Fulltext

The interferon gamma receptor 1 (IFNGR1) -56C/T gene polymorphism is associated with increased risk of early gastric carcinoma.

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Canedo P, Corso G, Pereira F, Lunet N, Suriano G, Figueiredo C, Pedrazzani C, Moreira H, Barros H, Carneiro F, Seruca R, Roviello F, and Machado JC

Gut, 2008 Jul 1 - Who cited this? | PubMed ID: 18593809 | Fulltext

BRAF provides proliferation and survival signals in MSI colorectal carcinoma cells displaying BRAF(V600E) but not KRAS mutations.

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Preto A, Figueiredo J, Velho S, Ribeiro AS, Soares P, Oliveira C, and Seruca R

The Journal of pathology 214(3):320, 2008 Feb - Who cited this? | PubMed ID: 18098337 | Fulltext

The interleukin-8-251*T/*A polymorphism is not associated with risk for gastric carcinoma development in a Portuguese population.

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Canedo P, Castanheira-Vale AJ, Lunet N, Pereira F, Figueiredo C, Gioia-Patricola L, Canzian F, Moreira H, Suriano G, Barros H, Carneiro F, Seruca R, and Machado JC

European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) 17(1):28-32, 2008 Feb - Who cited this? | PubMed ID: 18090907 | Fulltext

Somatic mutations in mismatch repair genes in sporadic gastric carcinomas are not a cause but a consequence of the mutator phenotype.

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Pinto M, Wu Y, Mensink RG, Cirnes L, Seruca R, and Hofstra RM

Cancer genetics and cytogenetics 180(2):110-4, 2008 Jan 15 - Who cited this? | PubMed ID: 18206535 | Fulltext

Molecular pathology of familial gastric cancer, with an emphasis on hereditary diffuse gastric cancer.

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Carneiro F, Oliveira C, Suriano G, and Seruca R

Journal of clinical pathology 61(1):25-30, 2008 Jan - Who cited this? | PubMed ID: 17513507 | Fulltext

Epidermal growth factor receptor structural alterations in gastric cancer.

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Moutinho C, Mateus AR, Milanezi F, Carneiro F, Seruca R, and Suriano G

BMC cancer 8:10, 2008 - Who cited this? | PubMed ID: 18199332 | Fulltext

Characterization of the P373L E-cadherin germline missense mutation and implication for clinical management.

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Corso G, Roviello F, Paredes J, Pedrazzani C, Novais M, Correia J, Marrelli D, Cirnes L, Seruca R, Oliveira C, and Suriano G

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology 33(9):1061-7, 2007 Nov - Who cited this? | PubMed ID: 17434710 | Fulltext

Specific clinical and biological features characterize inflammatory bowel disease associated colorectal cancers showing microsatellite instability.

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Svrcek M, El-Bchiri J, Chalastanis A, Capel E, Dumont S, Buhard O, Oliveira C, Seruca R, Bossard C, Mosnier JF, Berger F, Leteurtre E, Lavergne-Slove A, Chenard MP, Hamelin R, Cosnes J,

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Journal of clinical oncology : official journal of the American Society of Clinical Oncology 25(27):4231-8, 2007 Sep 20 - Who cited this? | PubMed ID: 17878476 | Fulltext

In vitro demonstration of intra-locus compensation using the ornithine transcarbamylase protein as model.

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Suriano G, Azevedo L, Novais M, Boscolo B, Seruca R, Amorim A, and Ghibaudi EM

Human molecular genetics 16(18):2209, 2007 Sep 15 - Who cited this? | PubMed ID: 17613537 | Fulltext

EGFR regulates RhoA-GTP dependent cell motility in E-cadherin mutant cells.

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Mateus AR, Seruca R, Machado JC, Keller G, Oliveira MJ, Suriano G, and Luber B

Human molecular genetics 16(13):1639-47, 2007 Jul 1 - Who cited this? | PubMed ID: 17510211 | Fulltext

A subset of colorectal carcinomas express c-KIT protein independently of BRAF and/or KRAS activation.

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Preto A, Moutinho C, Velho S, Oliveira C, Rebocho AP, Figueiredo J, Soares P, Lopes JM, and Seruca R

Virchows Archiv : an international journal of pathology 450(6):619-26, 2007 Jun - Who cited this? | PubMed ID: 17487504 | Fulltext

Hereditary diffuse gastric cancer and E-cadherin: description of the first germline mutation in an Italian family.

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Roviello F, Corso G, Pedrazzani C, Marrelli D, De Falco G, Berardi A, Garosi L, Suriano G, Vindigni C, De Stefano A, Leoncini L, Seruca R, and Pinto E

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology 33(4):448-51, 2007 May - Who cited this? | PubMed ID: 17126523 | Fulltext

Identification of seven novel germline mutations in the human E-cadherin (CDH1) gene.

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More H, Humar B, Weber W, Ward R, Christian A, Lintott C, Graziano F, Ruzzo AM, Acosta E, Boman B, Harlan M, Ferreira P, Seruca R, Suriano G, and Guilford P

Human mutation 28(2):203, 2007 Feb - Who cited this? | PubMed ID: 17221870 | Fulltext

Sequence diversity at the proximal 14q32.1 SERPIN subcluster: evidence for natural selection favoring the pseudogenization of SERPINA2.

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Seixas S, Suriano G, Carvalho F, Seruca R, Rocha J, and Di Rienzo A

Molecular biology and evolution 24(2):587-98, 2007 Feb - Who cited this? | PubMed ID: 17135331 | Fulltext

High EPHB2 mutation rate in gastric but not endometrial tumors with microsatellite instability.

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Davalos V, Dopeso H, Velho S, Ferreira AM, Cirnes L, Díaz-Chico N, Bilbao C, Ramírez R, Rodríguez G, Falcón O, León L, Niessen RC, Keller G, Dallenbach-Hellweg G, Espín E, Armengol M,

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Oncogene 26(2):308-11, 2007 Jan 11 - Who cited this? | PubMed ID: 16819508 | Fulltext

KRAS and BRAF oncogenic mutations in MSS colorectal carcinoma progression.

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Oliveira C, Velho S, Moutinho C, Ferreira A, Preto A, Domingo E, Capelinha AF, Duval A, Hamelin R, Machado JC, Schwartz S, Carneiro F, and Seruca R

Oncogene 26(1):158-63, 2007 Jan 4 - Who cited this? | PubMed ID: 16953233 | Fulltext

Tumour selection advantage of non-dominant negative P53 mutations in homozygotic MDM2-SNP309 colorectal cancer cells.

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Alazzouzi H, Suriano G, Guerra A, Plaja A, Espín E, Armengol M, Alhopuro P, Velho S, Shinomura Y, González-Aguilera JJ, Yamamoto H, Aaltonen LA, Moreno V, Capellà G, Peinado MA, Seruca R,

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Journal of medical genetics 44(1):75-80, 2007 Jan - Who cited this? | PubMed ID: 16825434 | Fulltext

High incidence of familial gastric cancer in tuscany, a region in Italy.

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Roviello F, Corso G, Pedrazzani C, Marrelli D, De Falco G, Suriano G, Vindigni C, Berardi A, Garosi L, De Stefano A, Leoncini L, Seruca R, and Pinto E

Oncology 72(3-4):243-7, 2007 - Who cited this? | PubMed ID: 18185018 | Fulltext

C/EBPbeta is over-expressed in gastric carcinogenesis and is associated with COX-2 expression.

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Regalo G, Canedo P, Suriano G, Resende C, Campos ML, Oliveira MJ, Figueiredo C, Rodrigues-Pereira P, Blin N, Seruca R, Carneiro F, and Machado JC

The Journal of pathology 210(4):398-404, 2006 Dec - Who cited this? | PubMed ID: 16981245 | Fulltext

A model to infer the pathogenic significance of CDH1 germline missense variants.

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Suriano G, Seixas S, Rocha J, and Seruca R

Journal of molecular medicine (Berlin, Germany) 84(12):1023-31, 2006 Dec - Who cited this? | PubMed ID: 16924464 | Fulltext

Helicobacter pylori induces gastric epithelial cell invasion in a c-Met and type IV secretion system-dependent manner.

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Oliveira MJ, Costa AC, Costa AM, Henriques L, Suriano G, Atherton JC, Machado JC, Carneiro F, Seruca R, Mareel M, Leroy A, and Figueiredo C

The Journal of biological chemistry 281(46):34888-96, 2006 Nov 17 - Who cited this? | PubMed ID: 16990273 | Fulltext

H-RAS 81 polymorphism is significantly associated with aneuploidy in follicular tumors of the thyroid.

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Castro P, Soares P, Gusmão L, Seruca R, and Sobrinho-Simões M

Oncogene 25(33):4620-7, 2006 Aug 3 - Who cited this? | PubMed ID: 16532025 | Fulltext

Genetics of hereditary diffuse gastric cancer: progress and future challenges.

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Suriano G, Ferreira P, Mateus AR, Correia J, Henriques L, and Seruca R

Future oncology (London, England) 2(3):363-70, 2006 Jun - Who cited this? | PubMed ID: 16787116 | Fulltext

E-cadherin missense mutations, associated with hereditary diffuse gastric cancer (HDGC) syndrome, display distinct invasive behaviors and genetic interactions with the Wnt and Notch pathways in Drosophila epithelia.

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Pereira PS, Teixeira A, Pinho S, Ferreira P, Fernandes J, Oliveira C, Seruca R, Suriano G, and Casares F

Human molecular genetics 15(10):1704, 2006 May 15 - Who cited this? | PubMed ID: 16600987 | Fulltext

Cleft lip/palate and CDH1/E-cadherin mutations in families with hereditary diffuse gastric cancer.

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Frebourg T, Oliveira C, Hochain P, Karam R, Manouvrier S, Graziadio C, Vekemans M, Hartmann A, Baert-Desurmont S, Alexandre C, Lejeune Dumoulin S, Marroni C, Martin C, Castedo S, Lovett M, Winston J,

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Journal of medical genetics 43(2):138-42, 2006 Feb - Who cited this? | PubMed ID: 15831593 | Fulltext

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