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Papers authored by Schultz PG

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Slit2-Robo4 signalling promotes vascular stability by blocking Arf6 activity.

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Jones CA, Nishiya N, London NR, Zhu W, Sorensen LK, Chan AC, Lim CJ, Chen H, Zhang Q, Schultz PG, Hayallah AM, Thomas KR, Famulok M, Zhang K, Ginsberg MH, and Li DY

Nature cell biology 11(11):1325-31, 2009 Nov - Who cited this? | PubMed ID: 19855388 | Fulltext

A genomic screen identifies TYRO3 as a MITF regulator in melanoma.

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Zhu S, Wurdak H, Wang Y, Galkin A, Tao H, Li J, Lyssiotis CA, Yan F, Tu BP, Miraglia L, Walker J, Sun F, Orth A, Schultz PG, and Wu X

Proceedings of the National Academy of Sciences of the United States of America 106(40):17025-30, 2009 Oct 6 - Who cited this? | PubMed ID: 19805117 | Fulltext

Site-Specific Incorporation of the Mucin-Type N-Acetylgalactosamine-alpha-O-threonine into Protein in Escherichia coli.

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Xu R, Hanson SR, Zhang Z, Yang YY, Schultz PG, and Wong CH

Journal of the American Chemical Society 131(38):13883, 2009 Sep 30 - Who cited this? | PubMed ID: 19731911 | Fulltext

Microfluidic device for single-molecule experiments with enhanced photostability.

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Lemke EA, Gambin Y, Vandelinder V, Brustad EM, Liu HW, Schultz PG, Groisman A, and Deniz AA

Journal of the American Chemical Society 131(38):13610-2, 2009 Sep 30 - Who cited this? | PubMed ID: 19772358 | Fulltext

Mutagenesis and evolution of sulfated antibodies using an expanded genetic code.

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Liu CC, Choe H, Farzan M, Smider VV, and Schultz PG

Biochemistry 48(37):8891-8, 2009 Sep 22 - Who cited this? | PubMed ID: 19715291 | Fulltext

Genetic Incorporation of a Small, Environmentally Sensitive, Fluorescent Probe into Proteins in Saccharomyces cerevisiae.

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Lee HS, Guo J, Lemke EA, Dimla RD, and Schultz PG

Journal of the American Chemical Society 131(36):12921-3, 2009 Sep 16 - Who cited this? | PubMed ID: 19702307 | Fulltext

Synthesis at the interface of chemistry and biology.

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Wu X and Schultz PG

Journal of the American Chemical Society 131(35):12497-515, 2009 Sep 9 - Who cited this? | PubMed ID: 19689159 | Fulltext

A genetically encoded direct sensor of antibody-antigen interactions.

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Mills JH, Lee HS, Liu CC, Wang J, and Schultz PG

Chembiochem : a European journal of chemical biology 10(13):2162-4, 2009 Sep 4 - Who cited this? | PubMed ID: 19672911 | Fulltext

Protein-DNA photo-crosslinking with a genetically encoded benzophenone-containing amino acid.

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Lee HS, Dimla RD, and Schultz PG

Bioorganic & medicinal chemistry letters 19(17):5222-4, 2009 Sep 1 - Who cited this? | PubMed ID: 19643606 | Fulltext

Evolution of proteins with genetically encoded "chemical warheads".

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Liu CC, Mack AV, Brustad EM, Mills JH, Groff D, Smider VV, and Schultz PG

Journal of the American Chemical Society 131(28):9616-7, 2009 Jul 22 - Who cited this? | PubMed ID: 19555063 | Fulltext

One plasmid selection system for the rapid evolution of aminoacyl-tRNA synthetases.

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Melançon CE and Schultz PG

Bioorganic & medicinal chemistry letters 19(14):3845-7, 2009 Jul 15 - Who cited this? | PubMed ID: 19398201 | Fulltext

Reprogramming of murine fibroblasts to induced pluripotent stem cells with chemical complementation of Klf4.

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Lyssiotis CA, Foreman RK, Staerk J, Garcia M, Mathur D, Markoulaki S, Hanna J, Lairson LL, Charette BD, Bouchez LC, Bollong M, Kunick C, Brinker A, Cho CY, Schultz PG, and Jaenisch R

Proceedings of the National Academy of Sciences of the United States of America 106(22):8912-7, 2009 Jun 2 - Who cited this? | PubMed ID: 19447925 | Fulltext

A small molecule primes embryonic stem cells for differentiation.

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Zhu S, Wurdak H, Wang J, Lyssiotis CA, Peters EC, Cho CY, Wu X, and Schultz PG

Cell stem cell 4(5):416-26, 2009 May 8 - Who cited this? | PubMed ID: 19427291 | Fulltext

Expanding the genetic repertoire of the methylotrophic yeast Pichia pastoris.

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Young TS, Ahmad I, Brock A, and Schultz PG

Biochemistry 48(12):2643-53, 2009 Mar 31 - Who cited this? | PubMed ID: 19265424 | Fulltext

Mechanistic studies of the immunochemical termination of self-tolerance with unnatural amino acids.

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Grünewald J, Hunt GS, Dong L, Niessen F, Wen BG, Tsao ML, Perera R, Kang M, Laffitte BA, Azarian S, Ruf W, Nasoff M, Lerner RA, Schultz PG, and Smider VV

Proceedings of the National Academy of Sciences of the United States of America 106(11):4337-42, 2009 Mar 17 - Who cited this? | PubMed ID: 19246393 | Fulltext

Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites.

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Wikoff WR, Anfora AT, Liu J, Schultz PG, Lesley SA, Peters EC, and Siuzdak G

Proceedings of the National Academy of Sciences of the United States of America 106(10):3698-703, 2009 Mar 10 - Who cited this? | PubMed ID: 19234110 | Fulltext

Photocleavage of the polypeptide backbone by 2-nitrophenylalanine.

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Peters FB, Brock A, Wang J, and Schultz PG

Chemistry & biology 16(2):148-52, 2009 Feb 27 - Who cited this? | PubMed ID: 19246005 | Fulltext

Genetic incorporation of a metal-ion chelating amino acid into proteins as a biophysical probe.

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Lee HS, Spraggon G, Schultz PG, and Wang F

Journal of the American Chemical Society 131(7):2481-3, 2009 Feb 25 - Who cited this? | PubMed ID: 19193005 | Fulltext

Identification of small-molecule inducers of pancreatic beta-cell expansion.

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Wang W, Walker JR, Wang X, Tremblay MS, Lee JW, Wu X, and Schultz PG

Proceedings of the National Academy of Sciences of the United States of America 106(5):1427-32, 2009 Feb 3 - Who cited this? | PubMed ID: 19164755 | Fulltext

A small molecule inhibitor of alpha4 integrin-dependent cell migration.

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Lee J, Hong J, Nam TG, Peters EC, Orth AP, Geierstanger BH, Goldfinger LE, Ginsberg MH, Cho CY, and Schultz PG

Bioorganic & medicinal chemistry 17(3):977-80, 2009 Feb 1 - Who cited this? | PubMed ID: 18329275 | Fulltext

The role of PTEN/Akt/PI3K signaling in the maintenance and viability of prostate cancer stem-like cell populations.

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Dubrovska A, Kim S, Salamone RJ, Walker JR, Maira SM, García-Echeverría C, Schultz PG, and Reddy VA

Proceedings of the National Academy of Sciences of the United States of America 106(1):268-73, 2009 Jan 6 - Who cited this? | PubMed ID: 19116269 | Fulltext

Efforts toward the direct experimental characterization of enzyme microenvironments: tyrosine100 in dihydrofolate reductase.

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Groff D, Thielges MC, Cellitti S, Schultz PG, and Romesberg FE

Angewandte Chemie (International ed. in English) 48(19):3478-81, 2009 - Who cited this? | PubMed ID: 19347910 | Fulltext

Incorporation of the unnatural amino acid p-benzoyl-L-phenylalanine (Bpa) into a G protein-coupled receptor in its native context.

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Umanah G, Huang LY, Schultz PG, Naider F, and Becker JM

Advances in experimental medicine and biology 611:333-5, 2009 - Who cited this? | PubMed ID: 19400216 | Fulltext

A facile system for encoding unnatural amino acids in Mammalian cells.

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Chen PR, Groff D, Guo J, Ou W, Cellitti S, Geierstanger BH, and Schultz PG

Angewandte Chemie (International ed. in English) 48(22):4052-5, 2009 - Who cited this? | PubMed ID: 19378306 | Fulltext

Evolution of amber suppressor tRNAs for efficient bacterial production of proteins containing nonnatural amino acids.

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Guo J, Melançon CE, Lee HS, Groff D, and Schultz PG

Angewandte Chemie (International ed. in English) 48(48):9148-51, 2009 - Who cited this? | PubMed ID: 19856359 | Fulltext

A general and efficient method for the site-specific dual-labeling of proteins for single molecule fluorescence resonance energy transfer.

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Brustad EM, Lemke EA, Schultz PG, and Deniz AA

Journal of the American Chemical Society 130(52):17664-5, 2008 Dec 31 - Who cited this? | PubMed ID: 19108697 | Fulltext

A chemical biology approach reveals period shortening of the mammalian circadian clock by specific inhibition of GSK-3{beta}.

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Hirota T, Lewis WG, Liu AC, Lee JW, Schultz PG, and Kay SA

Proceedings of the National Academy of Sciences of the United States of America 105(52):20746-51, 2008 Dec 30 - Who cited this? | PubMed ID: 19104043 | Fulltext

Protein evolution with an expanded genetic code.

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Liu CC, Mack AV, Tsao ML, Mills JH, Lee HS, Choe H, Farzan M, Schultz PG, and Smider VV

Proceedings of the National Academy of Sciences of the United States of America 105(46):17688-93, 2008 Nov 18 - Who cited this? | PubMed ID: 19004806 | Fulltext

A promiscuous aminoacyl-tRNA synthetase that incorporates cysteine, methionine, and alanine homologs into proteins.

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Brustad E, Bushey ML, Brock A, Chittuluru J, and Schultz PG

Bioorganic & medicinal chemistry letters 18(22):6004-6, 2008 Nov 15 - Who cited this? | PubMed ID: 18845434 | Fulltext

Biosynthesis of a Site-Specific DNA Cleaving Protein.

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Lee HS and Schultz PG

Journal of the American Chemical Society, 2008 Sep 13 - Who cited this? | PubMed ID: 18788806 | Fulltext

Immunochemical termination of self-tolerance.

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Grünewald J, Tsao ML, Perera R, Dong L, Niessen F, Wen BG, Kubitz DM, Smider VV, Ruf W, Nasoff M, Lerner RA, and Schultz PG

Proceedings of the National Academy of Sciences of the United States of America, 2008 Aug 6 - Who cited this? | PubMed ID: 18685087 | Fulltext

In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen.

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Plouffe D, Brinker A, McNamara C, Henson K, Kato N, Kuhen K, Nagle A, Adrián F, Matzen JT, Anderson P, Nam TG, Gray NS, Chatterjee A, Janes J, Yan SF, Trager R,

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Proceedings of the National Academy of Sciences of the United States of America, 2008 Jun 25 - Who cited this? | PubMed ID: 18579783 | Fulltext

In vivo Incorporation of Unnatural Amino Acids to Probe Structure, Dynamics, and Ligand Binding in a Large Protein by Nuclear Magnetic Resonance Spectroscopy.

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Cellitti SE, Jones DH, Lagpacan L, Hao X, Zhang Q, Hu H, Brittain SM, Brinker A, Caldwell J, Bursulaya B, Spraggon G, Brock A, Ryu Y, Uno T, Schultz PG, and Geierstanger BH

Journal of the American Chemical Society, 2008 Jun 25 - Who cited this? | PubMed ID: 18576636 | Fulltext

Gene expression signatures and small-molecule compounds link a protein kinase to Plasmodium falciparum motility.

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Kato N, Sakata T, Breton G, Le Roch KG, Nagle A, Andersen C, Bursulaya B, Henson K, Johnson J, Kumar KA, Marr F, Mason D, McNamara C, Plouffe D, Ramachandran V, Spooner M,

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Nature chemical biology 4(6):347, 2008 Jun - Who cited this? | PubMed ID: 18454143 | Fulltext

Deeply inverted electron-hole recombination in a luminescent antibody-stilbene complex.

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Debler EW, Kaufmann GF, Meijler MM, Heine A, Mee JM, Pljevaljcic G, Di Bilio AJ, Schultz PG, Millar DP, Janda KD, Wilson IA, Gray HB, and Lerner RA

Science (New York, N.Y.) 319(5867):1232-5, 2008 Feb 29 - Who cited this? | PubMed ID: 18309081 | Fulltext

Selecting folded proteins from a library of secondary structural elements.

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Graziano JJ, Liu W, Perera R, Geierstanger BH, Lesley SA, and Schultz PG

Journal of the American Chemical Society 130(1):176-85, 2008 Jan 9 - Who cited this? | PubMed ID: 18067292 | Fulltext

Identification of human kinases involved in hepatitis C virus replication by small interference RNA library screening.

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Supekova L, Supek F, Lee J, Chen S, Gray N, Pezacki JP, Schlapbach A, and Schultz PG

The Journal of biological chemistry 283(1):29-36, 2008 Jan 4 - Who cited this? | PubMed ID: 17951261 | Fulltext

Addition of an alpha-hydroxy acid to the genetic code of bacteria.

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Guo J, Wang J, Anderson JC, and Schultz PG

Angewandte Chemie (International ed. in English) 47(4):722-5, 2008 - Who cited this? | PubMed ID: 18069708 | Fulltext

Site-specific incorporation of methyl- and acetyl-lysine analogues into recombinant proteins.

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Guo J, Wang J, Lee JS, and Schultz PG

Angewandte Chemie (International ed. in English) 47(34):6399-401, 2008 - Who cited this? | PubMed ID: 18624319 | Fulltext

A genetically encoded boronate-containing amino acid.

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Brustad E, Bushey ML, Lee JW, Groff D, Liu W, and Schultz PG

Angewandte Chemie (International ed. in English) 47(43):8220-3, 2008 - Who cited this? | PubMed ID: 18816552 | Fulltext

A genetically encoded diazirine photocrosslinker in Escherichia coli.

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Tippmann EM, Liu W, Summerer D, Mack AV, and Schultz PG

Chembiochem : a European journal of chemical biology 8(18):2210-4, 2007 Dec 17 - Who cited this? | PubMed ID: 18000916 | Fulltext

Site-specific insertion of 3-aminotyrosine into subunit alpha2 of E. coli ribonucleotide reductase: direct evidence for involvement of Y730 and Y731 in radical propagation.

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Seyedsayamdost MR, Xie J, Chan CT, Schultz PG, and Stubbe J

Journal of the American Chemical Society 129(48):15060-71, 2007 Dec 5 - Who cited this? | PubMed ID: 17990884 | Fulltext

Control of protein phosphorylation with a genetically encoded photocaged amino acid.

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Lemke EA, Summerer D, Geierstanger BH, Brittain SM, and Schultz PG

Nature chemical biology 3(12):769-72, 2007 Dec - Who cited this? | PubMed ID: 17965709 | Fulltext

A small-molecule antagonist of the hedgehog signaling pathway.

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Lee J, Wu X, Pasca di Magliano M, Peters EC, Wang Y, Hong J, Hebrok M, Ding S, Cho CY, and Schultz PG

Chembiochem : a European journal of chemical biology 8(16):1916-9, 2007 Nov 5 - Who cited this? | PubMed ID: 17886323 | Fulltext

Inhibition of histone deacetylase activity induces developmental plasticity in oligodendrocyte precursor cells.

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Lyssiotis CA, Walker J, Wu C, Kondo T, Schultz PG, and Wu X

Proceedings of the National Academy of Sciences of the United States of America 104(38):14982-7, 2007 Sep 18 - Who cited this? | PubMed ID: 17855562 | Fulltext

A metalloantibody that irreversibly binds a protein antigen.

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Trisler K, Looger LL, Sharma V, Baker M, Benson DE, Trauger S, Schultz PG, and Smider VV

The Journal of biological chemistry 282(36):26344-53, 2007 Sep 7 - Who cited this? | PubMed ID: 17617633 | Fulltext

Crystal structure of a biosynthetic sulfo-hirudin complexed to thrombin.

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Liu CC, Brustad E, Liu W, and Schultz PG

Journal of the American Chemical Society 129(35):10648, 2007 Sep 5 - Who cited this? | PubMed ID: 17685615 | Fulltext

Efforts toward expansion of the genetic alphabet: structure and replication of unnatural base pairs.

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Matsuda S, Fillo JD, Henry AA, Rai P, Wilkens SJ, Dwyer TJ, Geierstanger BH, Wemmer DE, Schultz PG, Spraggon G, and Romesberg FE

Journal of the American Chemical Society 129(34):10466-73, 2007 Aug 29 - Who cited this? | PubMed ID: 17685517 | Fulltext

An improved system for the generation and analysis of mutant proteins containing unnatural amino acids in Saccharomyces cerevisiae.

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Chen S, Schultz PG, and Brock A

Journal of molecular biology 371(1):112-22, 2007 Aug 3 - Who cited this? | PubMed ID: 17560600 | Fulltext

A genetically encoded metabolically stable analogue of phosphotyrosine in Escherichia coli.

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Xie J, Supekova L, and Schultz PG

ACS chemical biology 2(7):474, 2007 Jul 20 - Who cited this? | PubMed ID: 17622177 | Fulltext

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