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Papers authored by Schreiber SL

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Copper-mediated amidation of heterocyclic and aromatic C-H bonds.

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Wang Q and Schreiber SL

Organic letters 11(22):5178-80, 2009 Nov 19 - Who cited this? | PubMed ID: 19860425 | Fulltext

Syntheses of aminoalcohol-derived macrocycles leading to a small-molecule binder to and inhibitor of Sonic Hedgehog.

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Peng LF, Stanton BZ, Maloof N, Wang X, and Schreiber SL

Bioorganic & medicinal chemistry letters 19(22):6319-25, 2009 Nov 15 - Who cited this? | PubMed ID: 19819139 | Fulltext

Identification and characterization of novel sirtuin inhibitor scaffolds.

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Sanders BD, Jackson B, Brent M, Taylor AM, Dang W, Berger SL, Schreiber SL, Howitz K, and Marmorstein R

Bioorganic & medicinal chemistry 17(19):7031-41, 2009 Oct 1 - Who cited this? | PubMed ID: 19734050 | Fulltext

Macrocycloadditions leading to conformationally restricted small molecules.

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Looper RE, Pizzirani D, and Schreiber SL

Organic letters 11(15):3522, 2009 Aug 6 - Who cited this? | PubMed ID: 19572606 | Fulltext

SnapShot: Ca(2+)-Calcineurin-NFATSignaling.

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Crabtree GR and Schreiber SL

Cell 138(1):210-210.e1, 2009 Jul 10 - Who cited this? | PubMed ID: 19596245 | Fulltext

Amino Acid metabolic origin as an evolutionary influence on protein sequence in yeast.

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de Bivort BL, Perlstein EO, Kunes S, and Schreiber SL

Journal of molecular evolution 68(5):490-7, 2009 May - Who cited this? | PubMed ID: 19357800 | Fulltext

Identification and characterization of small molecule inhibitors of a class I histone deacetylase from Plasmodium falciparum.

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Patel V, Mazitschek R, Coleman B, Nguyen C, Urgaonkar S, Cortese J, Barker RH, Greenberg E, Tang W, Bradner JE, Schreiber SL, Duraisingh MT, Wirth DF, and Clardy J

Journal of medicinal chemistry 52(8):2185-7, 2009 Apr 23 - Who cited this? | PubMed ID: 19317450 | Fulltext

Small molecules efficiently direct endodermal differentiation of mouse and human embryonic stem cells.

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Borowiak M, Maehr R, Chen S, Chen AE, Tang W, Fox JL, Schreiber SL, and Melton DA

Cell stem cell 4(4):348-58, 2009 Apr 3 - Who cited this? | PubMed ID: 19341624 | Fulltext

Skeletally diverse small molecules using a build/couple/pair strategy.

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Uchida T, Rodriquez M, and Schreiber SL

Organic letters 11(7):1559-62, 2009 Apr 2 - Who cited this? | PubMed ID: 19275223 | Fulltext

A small molecule that directs differentiation of human ESCs into the pancreatic lineage.

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Chen S, Borowiak M, Fox JL, Maehr R, Osafune K, Davidow L, Lam K, Peng LF, Schreiber SL, Rubin LL, and Melton D

Nature chemical biology 5(4):258-65, 2009 Apr - Who cited this? | PubMed ID: 19287398 | Fulltext

Identifying the proteins to which small-molecule probes and drugs bind in cells.

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Ong SE, Schenone M, Margolin AA, Li X, Do K, Doud MK, Mani DR, Kuai L, Wang X, Wood JL, Tolliday NJ, Koehler AN, Marcaurelle LA, Golub TR, Gould RJ, Schreiber SL,

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Proceedings of the National Academy of Sciences of the United States of America 106(12):4617-22, 2009 Mar 24 - Who cited this? | PubMed ID: 19255428 | Fulltext

Synthesis and histone deacetylase inhibitory activity of largazole analogs: alteration of the zinc-binding domain and macrocyclic scaffold.

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Bowers AA, West N, Newkirk TL, Troutman-Youngman AE, Schreiber SL, Wiest O, Bradner JE, and Williams RM

Organic letters 11(6):1301-4, 2009 Mar 19 - Who cited this? | PubMed ID: 19239241 | Fulltext

A small molecule that binds Hedgehog and blocks its signaling in human cells.

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Stanton BZ, Peng LF, Maloof N, Nakai K, Wang X, Duffner JL, Taveras KM, Hyman JM, Lee SW, Koehler AN, Chen JK, Fox JL, Mandinova A, and Schreiber SL

Nature chemical biology 5(3):154-6, 2009 Mar - Who cited this? | PubMed ID: 19151731 | Fulltext

Organic chemistry: Molecular diversity by design.

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Schreiber SL

Nature 457(7226):153-4, 2009 Jan 8 - Who cited this? | PubMed ID: 19129834 | Fulltext

The state of the art of chemical biology.

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Altmann KH, Buchner J, Kessler H, Diederich F, Kräutler B, Lippard S, Liskamp R, Müller K, Nolan EM, Samori B, Schneider G, Schreiber SL, Schwalbe H, Toniolo C, van Boeckel CA, Waldmann H,

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Chembiochem : a European journal of chemical biology 10(1):16-29, 2009 Jan 5 - Who cited this? | PubMed ID: 19115274 | Fulltext

Using expression and genotype to predict drug response in yeast.

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Ruderfer DM, Roberts DC, Schreiber SL, Perlstein EO, and Kruglyak L

PLoS ONE 4(9):e6907, 2009 - Who cited this? | PubMed ID: 19730698 | Fulltext

Empirical bayes analysis of quantitative proteomics experiments.

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Margolin AA, Ong SE, Schenone M, Gould R, Schreiber SL, Carr SA, and Golub TR

PLoS ONE 4(10):e7454, 2009 - Who cited this? | PubMed ID: 19829701 | Fulltext

Total synthesis and biological mode of action of largazole: a potent class I histone deacetylase inhibitor.

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Bowers A, West N, Taunton J, Schreiber SL, Bradner JE, and Williams RM

Journal of the American Chemical Society 130(33):11219-22, 2008 Aug 20 - Who cited this? | PubMed ID: 18642817 | Fulltext

Diversity synthesis of complex pyridines yields a probe of a neurotrophic signaling pathway.

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Gray BL, Wang X, Brown WC, Kuai L, and Schreiber SL

Organic letters 10(13):2621-4, 2008 Jul 3 - Who cited this? | PubMed ID: 18510333 | Fulltext

Corrigendum: Large-scale chemical dissection of mitochondrial function.

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Wagner BK, Kitami T, Gilbert TJ, Peck D, Ramanathan A, Schreiber SL, Golub TR, and Mootha VK

Nature biotechnology 26(7):831, 2008 Jul - Who cited this? | PubMed ID: 18612306 | Fulltext

Perturbational profiling of nanomaterial biologic activity.

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Shaw SY, Westly EC, Pittet MJ, Subramanian A, Schreiber SL, and Weissleder R

Proceedings of the National Academy of Sciences of the United States of America 105(21):7387, 2008 May 27 - Who cited this? | PubMed ID: 18492802 | Fulltext

Small-molecule fluorophores to detect cell-state switching in the context of high-throughput screening.

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Wagner BK, Carrinski HA, Ahn YH, Kim YK, Gilbert TJ, Fomina DA, Schreiber SL, Chang YT, and Clemons PA

Journal of the American Chemical Society 130(13):4208, 2008 Apr 2 - Who cited this? | PubMed ID: 18327938 | Fulltext

The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth.

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Christofk HR, Vander Heiden MG, Harris MH, Ramanathan A, Gerszten RE, Wei R, Fleming MD, Schreiber SL, and Cantley LC

Nature 452(7184):230, 2008 Mar 13 - Who cited this? | PubMed ID: 18337823 | Fulltext

Large-scale chemical dissection of mitochondrial function.

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Wagner BK, Kitami T, Gilbert TJ, Peck D, Ramanathan A, Schreiber SL, Golub TR, and Mootha VK

Nature biotechnology 26(3):343, 2008 Mar - Who cited this? | PubMed ID: 18297058 | Fulltext

Small-molecule reagents for cellular pull-down experiments.

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Wang X, Imber BS, and Schreiber SL

Bioconjugate chemistry 19(3):585, 2008 Mar - Who cited this? | PubMed ID: 18193824 | Fulltext

ChemBank: a small-molecule screening and cheminformatics resource database.

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Seiler KP, George GA, Happ MP, Bodycombe NE, Carrinski HA, Norton S, Brudz S, Sullivan JP, Muhlich J, Serrano M, Ferraiolo P, Tolliday NJ, Schreiber SL, and Clemons PA

Nucleic acids research 36(Database issue), 2008 Jan - Who cited this? | PubMed ID: 17947324 | Fulltext

Towards the optimal screening collection: a synthesis strategy.

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Nielsen TE and Schreiber SL

Angewandte Chemie (International ed. in English) 47(1):48-56, 2008 - Who cited this? | PubMed ID: 18080276 | Fulltext

Identification of novel epoxide inhibitors of hepatitis C virus replication using a high-throughput screen.

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Peng LF, Kim SS, Matchacheep S, Lei X, Su S, Lin W, Runguphan W, Choe WH, Sakamoto N, Ikeda M, Kato N, Beeler AB, Porco JA, Schreiber SL, and Chung RT

Antimicrobial agents and chemotherapy 51(10):3756-9, 2007 Oct - Who cited this? | PubMed ID: 17682098 | Fulltext

Evolutionarily conserved optimization of amino acid biosynthesis.

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Perlstein EO, de Bivort BL, Kunes S, and Schreiber SL

Journal of molecular evolution 65(2):186-96, 2007 Aug - Who cited this? | PubMed ID: 17684697 | Fulltext

Rethinking relationships between natural products.

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Schreiber SL

Nature chemical biology 3(7):352, 2007 Jul - Who cited this? | PubMed ID: 17576414 | Fulltext

Ligand design by a combinatorial approach based on modeling and experiment: application to HLA-DR4.

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Evensen E, Joseph-McCarthy D, Weiss GA, Schreiber SL, and Karplus M

Journal of computer-aided molecular design 21(7):395-418, 2007 Jul - Who cited this? | PubMed ID: 17657565 | Fulltext

Quantifying fitness distributions and phenotypic relationships in recombinant yeast populations.

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Perlstein EO, Deeds EJ, Ashenberg O, Shakhnovich EI, and Schreiber SL

Proceedings of the National Academy of Sciences of the United States of America 104(25):10553, 2007 Jun 19 - Who cited this? | PubMed ID: 17566105 | Fulltext

Small molecules enhance autophagy and reduce toxicity in Huntington's disease models.

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Sarkar S, Perlstein EO, Imarisio S, Pineau S, Cordenier A, Maglathlin RL, Webster JA, Lewis TA, O'Kane CJ, Schreiber SL, and Rubinsztein DC

Nature chemical biology 3(6):331-8, 2007 Jun - Who cited this? | PubMed ID: 17486044 | Fulltext

Genetic basis of individual differences in the response to small-molecule drugs in yeast.

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Perlstein EO, Ruderfer DM, Roberts DC, Schreiber SL, and Kruglyak L

Nature genetics 39(4):496-502, 2007 Apr - Who cited this? | PubMed ID: 17334364 | Fulltext

Identification of a small-molecule inhibitor of class Ia PI3Ks with cell-based screening.

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Yang J, Shamji A, Matchacheep S, and Schreiber SL

Chemistry & biology 14(4):371-7, 2007 Apr - Who cited this? | PubMed ID: 17462572 | Fulltext

Synthesis and cellular profiling of diverse organosilicon small molecules.

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Franz AK, Dreyfuss PD, and Schreiber SL

Journal of the American Chemical Society 129(5):1020, 2007 Feb 7 - Who cited this? | PubMed ID: 17263369 | Fulltext

A cell-based, high-throughput screen for small molecule regulators of hepatitis C virus replication.

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Kim SS, Peng LF, Lin W, Choe WH, Sakamoto N, Kato N, Ikeda M, Schreiber SL, and Chung RT

Gastroenterology 132(1):311-20, 2007 Jan - Who cited this? | PubMed ID: 17241881 | Fulltext

Ring-opening and ring-closing reactions of a shikimic acid-derived substrate leading to diverse small molecules.

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Miao H, Tallarico JA, Hayakawa H, Münger K, Duffner JL, Koehler AN, Schreiber SL, and Lewis TA

Journal of combinatorial chemistry 9(2):245-53, 2007 - Who cited this? | PubMed ID: 17348730 | Fulltext

Multilevel regulation of growth rate in yeast revealed using systems biology.

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Ramanathan A and Schreiber SL

Journal of biology 6(2):3, 2007 - Who cited this? | PubMed ID: 17472733 | Fulltext

Small molecule enhancers of rapamycin-induced TOR inhibition promote autophagy, reduce toxicity in Huntington's disease models and enhance killing of mycobacteria by macrophages.

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Floto RA, Sarkar S, Perlstein EO, Kampmann B, Schreiber SL, and Rubinsztein DC

Autophagy 3(6):620-2, 2007 - Who cited this? | PubMed ID: 17786022 | Fulltext

Fluorous-based small-molecule microarrays for the discovery of histone deacetylase inhibitors.

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Vegas AJ, Bradner JE, Tang W, McPherson OM, Greenberg EF, Koehler AN, and Schreiber SL

Angewandte Chemie (International ed. in English) 46(42):7960-4, 2007 - Who cited this? | PubMed ID: 17868168 | Fulltext

Complex alpha-Pyrones Synthesized by a Gold-Catalyzed Coupling Reaction.

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Luo T and Schreiber SL

Angewandte Chemie (International ed. in English) 46(43):8250-3, 2007 - Who cited this? | PubMed ID: 17893896 | Fulltext

Skeletal diversity in small-molecule synthesis using ligand-controlled catalysis.

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Gray BL and Schreiber SL

Journal of combinatorial chemistry 9(6):1028-35, 2007 - Who cited this? | PubMed ID: 17960894 | Fulltext

An oligomer-based approach to skeletal diversity in small-molecule synthesis.

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Spiegel DA, Schroeder FC, Duvall JR, and Schreiber SL

Journal of the American Chemical Society 128(46):14766-7, 2006 Nov 22 - Who cited this? | PubMed ID: 17105261 | Fulltext

Small molecules, big players: the National Cancer Institute's Initiative for Chemical Genetics.

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Tolliday N, Clemons PA, Ferraiolo P, Koehler AN, Lewis TA, Li X, Schreiber SL, Gerhard DS, and Eliasof S

Cancer research 66(18):8935, 2006 Sep 15 - Who cited this? | PubMed ID: 16982730 | Fulltext

Query Chem: a Google-powered web search combining text and chemical structures.

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Klekota J, Roth FP, and Schreiber SL

Bioinformatics (Oxford, England) 22(13):1670, 2006 Jul 1 - Who cited this? | PubMed ID: 16672261 | Fulltext

Short synthesis of skeletally and stereochemically diverse small molecules by coupling petasis condensation reactions to cyclization reactions.

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Kumagai N, Muncipinto G, and Schreiber SL

Angewandte Chemie (International ed. in English) 45(22):3635-8, 2006 May 26 - Who cited this? | PubMed ID: 16646101 | Fulltext

Macrocycloadditions leading to conformationally restricted small molecules.

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Looper RE, Pizzirani D, and Schreiber SL

Organic letters 8(10):2063-6, 2006 May 11 - Who cited this? | PubMed ID: 16671782 | Fulltext

A robust small-molecule microarray platform for screening cell lysates.

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Bradner JE, McPherson OM, Mazitschek R, Barnes-Seeman D, Shen JP, Dhaliwal J, Stevenson KE, Duffner JL, Park SB, Neuberg DS, Nghiem P, Schreiber SL, and Koehler AN

Chemistry & biology 13(5):493-504, 2006 May - Who cited this? | PubMed ID: 16720270 | Fulltext

A bivalent chromatin structure marks key developmental genes in embryonic stem cells.

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Bernstein BE, Mikkelsen TS, Xie X, Kamal M, Huebert DJ, Cuff J, Fry B, Meissner A, Wernig M, Plath K, Jaenisch R, Wagschal A, Feil R, Schreiber SL, and Lander ES

Cell 125(2):315, 2006 Apr 21 - Who cited this? | PubMed ID: 16630819 | Fulltext

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