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Papers authored by Schoonjans K

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TGR5-mediated bile acid sensing controls glucose homeostasis.

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Thomas C, Gioiello A, Noriega L, Strehle A, Oury J, Rizzo G, Macchiarulo A, Yamamoto H, Mataki C, Pruzanski M, Pellicciari R, Auwerx J, and Schoonjans K

Cell metabolism 10(3):167-77, 2009 Sep - Who cited this? | PubMed ID: 19723493 | Fulltext

The genetic ablation of SRC-3 protects against obesity and improves insulin sensitivity by reducing the acetylation of PGC-1{alpha}.

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Coste A, Louet JF, Lagouge M, Lerin C, Antal MC, Meziane H, Schoonjans K, Puigserver P, O'Malley BW, and Auwerx J

Proceedings of the National Academy of Sciences of the United States of America 105(44):17187-92, 2008 Nov 4 - Who cited this? | PubMed ID: 18957541 | Fulltext

Cell cycle-dependent regulation of extra-adrenal glucocorticoid synthesis in murine intestinal epithelial cells.

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Atanasov AG, Leiser D, Roesselet C, Noti M, Corazza N, Schoonjans K, and Brunner T

The FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2008 Aug 18 - Who cited this? | PubMed ID: 18711026 | Fulltext

Novel Potent and Selective Bile Acid Derivatives as TGR5 Agonists: Biological Screening, Structure-Activity Relationships, and Molecular Modeling Studies.

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Sato H, Macchiarulo A, Thomas C, Gioiello A, Une M, Hofmann AF, Saladin R, Schoonjans K, Pellicciari R, and Auwerx J

Journal of medicinal chemistry 51(15):4849, 2008 Aug 14 - Who cited this? | PubMed ID: 18610994 | Fulltext

Molecular Field Analysis and 3D-Quantitative Structure-Activity Relationship Study (MFA 3D-QSAR) Unveil Novel Features of Bile Acid Recognition at TGR5.

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Macchiarulo A, Gioiello A, Thomas C, Massarotti A, Nuti R, Rosatelli E, Sabbatini P, Schoonjans K, Auwerx J, and Pellicciari R

Journal of chemical information and modeling, 2008 Aug 13 - Who cited this? | PubMed ID: 18698841 | Fulltext

Targeting bile-acid signalling for metabolic diseases.

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Thomas C, Pellicciari R, Pruzanski M, Auwerx J, and Schoonjans K

Nature reviews. Drug discovery 7(8):678, 2008 Aug - Who cited this? | PubMed ID: 18670431 | Fulltext

Liver receptor homolog 1 is essential for ovulation.

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Duggavathi R, Volle DH, Mataki C, Antal MC, Messaddeq N, Auwerx J, Murphy BD, and Schoonjans K

Genes & development 22(14):1871-6, 2008 Jul 15 - Who cited this? | PubMed ID: 18628394 | Fulltext

Cholesterol supply and SREBPs modulate transcription of the Niemann-Pick C-1 gene in steroidogenic tissues.

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Gévry N, Schoonjans K, Guay F, and Murphy BD

Journal of lipid research 49(5):1024, 2008 May - Who cited this? | PubMed ID: 18272928 | Fulltext

Structure-based design of a superagonist ligand for the vitamin D nuclear receptor.

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Hourai S, Rodrigues LC, Antony P, Reina-San-Martin B, Ciesielski F, Magnier BC, Schoonjans K, Mouriño A, Rochel N, and Moras D

Chemistry & biology 15(4):383, 2008 Apr - Who cited this? | PubMed ID: 18420145 | Fulltext

Novel Potent and Selective Bile Acid Derivatives as TGR5 Agonists: Biological Screening, Structure-Activity Relationships, and Molecular Modeling Studies.

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Sato H, Macchiarulo A, Thomas C, Gioiello A, Une M, Hofmann AF, Saladin R, Schoonjans K, Pellicciari R, and Auwerx J

Journal of medicinal chemistry 51(6):1831-41, 2008 Mar 27 - Who cited this? | PubMed ID: 18307294 | Fulltext

Bile acids and the membrane bile acid receptor TGR5--connecting nutrition and metabolism.

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Thomas C, Auwerx J, and Schoonjans K

Thyroid : official journal of the American Thyroid Association 18(2):167, 2008 Feb - Who cited this? | PubMed ID: 18279017 | Fulltext

Compromised intestinal lipid absorption in mice with a liver-specific deficiency of liver receptor homolog 1.

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Mataki C, Magnier BC, Houten SM, Annicotte JS, Argmann C, Thomas C, Overmars H, Kulik W, Metzger D, Auwerx J, and Schoonjans K

Molecular and cellular biology 27(23):8330-9, 2007 Dec - Who cited this? | PubMed ID: 17908794 | Fulltext

Nongenomic actions of bile acids. Synthesis and preliminary characterization of 23- and 6,23-alkyl-substituted bile acid derivatives as selective modulators for the G-protein coupled receptor TGR5.

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Pellicciari R, Sato H, Gioiello A, Costantino G, Macchiarulo A, Sadeghpour BM, Giorgi G, Schoonjans K, and Auwerx J

Journal of medicinal chemistry 50(18):4265-8, 2007 Sep 6 - Who cited this? | PubMed ID: 17685603 | Fulltext

LRH-1-mediated glucocorticoid synthesis in enterocytes protects against inflammatory bowel disease.

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Coste A, Dubuquoy L, Barnouin R, Annicotte JS, Magnier B, Notti M, Corazza N, Antal MC, Metzger D, Desreumaux P, Brunner T, Auwerx J, and Schoonjans K

Proceedings of the National Academy of Sciences of the United States of America 104(32):13098-103, 2007 Aug 7 - Who cited this? | PubMed ID: 17670946 | Fulltext

Sirtuin functions in health and disease.

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Yamamoto H, Schoonjans K, and Auwerx J

Molecular endocrinology (Baltimore, Md.) 21(8):1745-55, 2007 Aug - Who cited this? | PubMed ID: 17456799 | Fulltext

Adipose tissue-specific inactivation of the retinoblastoma protein protects against diabesity because of increased energy expenditure.

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Dali-Youcef N, Mataki C, Coste A, Messaddeq N, Giroud S, Blanc S, Koehl C, Champy MF, Chambon P, Fajas L, Metzger D, Schoonjans K, and Auwerx J

Proceedings of the National Academy of Sciences of the United States of America 104(25):10703-8, 2007 Jun 19 - Who cited this? | PubMed ID: 17556545 | Fulltext

Peroxisome proliferator-activated receptor-alpha activation inhibits Langerhans cell function.

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Dubrac S, Stoitzner P, Pirkebner D, Elentner A, Schoonjans K, Auwerx J, Saeland S, Hengster P, Fritsch P, Romani N, and Schmuth M

Journal of immunology (Baltimore, Md. : 1950) 178(7):4362-72, 2007 Apr 1 - Who cited this? | PubMed ID: 17371993 | Fulltext

Differential regulation of glucocorticoid synthesis in murine intestinal epithelial versus adrenocortical cell lines.

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Mueller M, Atanasov A, Cima I, Corazza N, Schoonjans K, and Brunner T

Endocrinology 148(3):1445-53, 2007 Mar - Who cited this? | PubMed ID: 17170096 | Fulltext

The small heterodimer partner is a gonadal gatekeeper of sexual maturation in male mice.

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Volle DH, Duggavathi R, Magnier BC, Houten SM, Cummins CL, Lobaccaro JM, Verhoeven G, Schoonjans K, and Auwerx J

Genes & development 21(3):303, 2007 Feb 1 - Who cited this? | PubMed ID: 17289919 | Fulltext

Sirtuins: the 'magnificent seven', function, metabolism and longevity.

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Dali-Youcef N, Lagouge M, Froelich S, Koehl C, Schoonjans K, and Auwerx J

Annals of medicine 39(5):335-45, 2007 - Who cited this? | PubMed ID: 17701476 | Fulltext

The nuclear receptor LRH-1 critically regulates extra-adrenal glucocorticoid synthesis in the intestine.

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Mueller M, Cima I, Noti M, Fuhrer A, Jakob S, Dubuquoy L, Schoonjans K, and Brunner T

The Journal of experimental medicine 203(9):2057-62, 2006 Sep 4 - Who cited this? | PubMed ID: 16923850 | Fulltext

Deletion of peroxisome proliferator-activated receptor-alpha induces an alteration of cardiac functions.

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Loichot C, Jesel L, Tesse A, Tabernero A, Schoonjans K, Roul G, Carpusca I, Auwerx J, and Andriantsitohaina R

American journal of physiology. Heart and circulatory physiology 291(1):H161-6, 2006 Jul - Who cited this? | PubMed ID: 16461373 | Fulltext

Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation.

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Watanabe M, Houten SM, Mataki C, Christoffolete MA, Kim BW, Sato H, Messaddeq N, Harney JW, Ezaki O, Kodama T, Schoonjans K, Bianco AC, and Auwerx J

Nature 439(7075):484-9, 2006 Jan 26 - Who cited this? | PubMed ID: 16400329 | Fulltext

Liver receptor homolog 1 contributes to intestinal tumor formation through effects on cell cycle and inflammation.

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Schoonjans K, Dubuquoy L, Mebis J, Fayard E, Wendling O, Haby C, Geboes K, and Auwerx J

Proceedings of the National Academy of Sciences of the United States of America 102(6):2058-62, 2005 Feb 8 - Who cited this? | PubMed ID: 15684064 | Fulltext

Impaired expression of the peroxisome proliferator-activated receptor alpha during hepatitis C virus infection.

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Dharancy S, Malapel M, Perlemuter G, Roskams T, Cheng Y, Dubuquoy L, Podevin P, Conti F, Canva V, Philippe D, Gambiez L, Mathurin P, Paris JC, Schoonjans K, Calmus Y, Pol S,

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Gastroenterology 128(2):334-42, 2005 Feb - Who cited this? | PubMed ID: 15685545 | Fulltext

Synergy between LRH-1 and beta-catenin induces G1 cyclin-mediated cell proliferation.

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Botrugno OA, Fayard E, Annicotte JS, Haby C, Brennan T, Wendling O, Tanaka T, Kodama T, Thomas W, Auwerx J, and Schoonjans K

Molecular cell 15(4):499-509, 2004 Aug 27 - Who cited this? | PubMed ID: 15327767 | Fulltext

LRH-1: an orphan nuclear receptor involved in development, metabolism and steroidogenesis.

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Fayard E, Auwerx J, and Schoonjans K

Trends in cell biology 14(5):250, 2004 May - Who cited this? | PubMed ID: 15130581 | Fulltext

Adipose tissue expression of the lipid droplet-associating proteins S3-12 and perilipin is controlled by peroxisome proliferator-activated receptor-gamma.

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Dalen KT, Schoonjans K, Ulven SM, Weedon-Fekjaer MS, Bentzen TG, Koutnikova H, Auwerx J, and Nebb HI

Diabetes 53(5):1243-52, 2004 May - Who cited this? | PubMed ID: 15111493 | Fulltext

Peroxisome proliferator-activated receptor (PPAR)-beta/delta stimulates differentiation and lipid accumulation in keratinocytes.

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Schmuth M, Haqq CM, Cairns WJ, Holder JC, Dorsam S, Chang S, Lau P, Fowler AJ, Chuang G, Moser AH, Brown BE, Mao-Qiang M, Uchida Y, Schoonjans K, Auwerx J, Chambon P,

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The Journal of investigative dermatology 122(4):971, 2004 Apr - Who cited this? | PubMed ID: 15102088 | Fulltext

Expression of the liver X receptor alpha and beta in embryonic and adult mice.

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Annicotte JS, Schoonjans K, and Auwerx J

The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology 277(2):312-6, 2004 Apr - Who cited this? | PubMed ID: 15052659 | Fulltext

Pancreatic-duodenal homeobox 1 regulates expression of liver receptor homolog 1 during pancreas development.

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Annicotte JS, Fayard E, Swift GH, Selander L, Edlund H, Tanaka T, Kodama T, Schoonjans K, and Auwerx J

Molecular and cellular biology 23(19):6713-24, 2003 Oct - Who cited this? | PubMed ID: 12972592 | Fulltext

Liver receptor homolog 1 controls the expression of carboxyl ester lipase.

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Fayard E, Schoonjans K, Annicotte JS, and Auwerx J

The Journal of biological chemistry 278(37):35725-31, 2003 Sep 12 - Who cited this? | PubMed ID: 12853459 | Fulltext

Liver receptor homolog 1 controls the expression of the scavenger receptor class B type I.

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Schoonjans K, Annicotte JS, Huby T, Botrugno OA, Fayard E, Ueda Y, Chapman J, and Auwerx J

EMBO reports 3(12):1181-7, 2002 Dec - Who cited this? | PubMed ID: 12446566 | Fulltext

Role of peroxisome proliferator-activated receptor alpha in epidermal development in utero.

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Schmuth M, Schoonjans K, Yu QC, Fluhr JW, Crumrine D, Hachem JP, Lau P, Auwerx J, Elias PM, and Feingold KR

The Journal of investigative dermatology 119(6):1298-303, 2002 Dec - Who cited this? | PubMed ID: 12485431 | Fulltext

[Thiazolidinediones in type 2 diabetes. Role of peroxisome proliferator-activated receptor gamma (PPARgamma)].

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Dubois M, Vantyghem MC, Schoonjans K, and Pattou F

Annales d'endocrinologie 63(6 Pt 1):511-23, 2002 Dec - Who cited this? | PubMed ID: 12527853 | Fulltext

Progesterone receptor knockout mice have an improved glucose homeostasis secondary to beta -cell proliferation.

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Picard F, Wanatabe M, Schoonjans K, Lydon J, O'Malley BW, and Auwerx J

Proceedings of the National Academy of Sciences of the United States of America 99(24):15644-8, 2002 Nov 26 - Who cited this? | PubMed ID: 12438645 | Fulltext

The role of PPAR-gamma/RXR-alpha heterodimers in the regulation of human trophoblast invasion.

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Fournier T, Pavan L, Tarrade A, Schoonjans K, Auwerx J, Rochette-Egly C, and Evain-Brion D

Annals of the New York Academy of Sciences 973:26-30, 2002 Nov - Who cited this? | PubMed ID: 12485829 | Fulltext

The small heterodimer partner interacts with the liver X receptor alpha and represses its transcriptional activity.

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Brendel C, Schoonjans K, Botrugno OA, Treuter E, and Auwerx J

Molecular endocrinology (Baltimore, Md.) 16(9):2065-76, 2002 Sep - Who cited this? | PubMed ID: 12198243 | Fulltext

A sharper image of SHP.

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Schoonjans K and Auwerx J

Nature medicine 8(8):789-91, 2002 Aug - Who cited this? | PubMed ID: 12152032 | Fulltext

Activation of the peroxisome proliferator-activated receptor alpha protects against myocardial ischaemic injury and improves endothelial vasodilatation.

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Tabernero A, Schoonjans K, Jesel L, Carpusca I, Auwerx J, and Andriantsitohaina R

BMC pharmacology 2:10, 2002 Apr 9 - Who cited this? | PubMed ID: 11940253 | Fulltext

Topical peroxisome proliferator activated receptor-alpha activators reduce inflammation in irritant and allergic contact dermatitis models.

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Sheu MY, Fowler AJ, Kao J, Schmuth M, Schoonjans K, Auwerx J, Fluhr JW, Man MQ, Elias PM, and Feingold KR

The Journal of investigative dermatology 118(1):94-101, 2002 Jan - Who cited this? | PubMed ID: 11851881 | Fulltext

An E-box in pGL3 reporter vectors precludes their use for the study of sterol regulatory element-binding proteins.

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Annicotte JS, Schoonjans K, Haby C, and Auwerx J

BioTechniques 31(5):993-4, 996, 2001 Nov - Who cited this? | PubMed ID: 11730028 | Fulltext

PPAR gamma/RXR alpha heterodimers are involved in human CG beta synthesis and human trophoblast differentiation.

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Tarrade A, Schoonjans K, Guibourdenche J, Bidart JM, Vidaud M, Auwerx J, Rochette-Egly C, and Evain-Brion D

Endocrinology 142(10):4504-14, 2001 Oct - Who cited this? | PubMed ID: 11564716 | Fulltext

PPARgamma/RXRalpha heterodimers control human trophoblast invasion.

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Tarrade A, Schoonjans K, Pavan L, Auwerx J, Rochette-Egly C, Evain-Brion D, and Fournier T

The Journal of clinical endocrinology and metabolism 86(10):5017-24, 2001 Oct - Who cited this? | PubMed ID: 11600579 | Fulltext

Attenuation of colon inflammation through activators of the retinoid X receptor (RXR)/peroxisome proliferator-activated receptor gamma (PPARgamma) heterodimer. A basis for new therapeutic strategies.

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Desreumaux P, Dubuquoy L, Nutten S, Peuchmaur M, Englaro W, Schoonjans K, Derijard B, Desvergne B, Wahli W, Chambon P, Leibowitz MD, Colombel JF, and Auwerx J

The Journal of experimental medicine 193(7):827-38, 2001 Apr 2 - Who cited this? | PubMed ID: 11283155 | Fulltext

Xol INXS: role of the liver X and the farnesol X receptors.

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Fayard E, Schoonjans K, and Auwerx J

Current opinion in lipidology 12(2):113-20, 2001 Apr - Who cited this? | PubMed ID: 11264982 | Fulltext

Sterols and gene expression: control of affluence.

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Schoonjans K, Brendel C, Mangelsdorf D, and Auwerx J

Biochimica et biophysica acta 1529(1-3):114-25, 2000 Dec 15 - Who cited this? | PubMed ID: 11111081 | Fulltext

Induction of LPL gene expression by sterols is mediated by a sterol regulatory element and is independent of the presence of multiple E boxes.

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Schoonjans K, Gelman L, Haby C, Briggs M, and Auwerx J

Journal of molecular biology 304(3):323-34, 2000 Dec 1 - Who cited this? | PubMed ID: 11090277 | Fulltext

Molecular basis for feedback regulation of bile acid synthesis by nuclear receptors.

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Lu TT, Makishima M, Repa JJ, Schoonjans K, Kerr TA, Auwerx J, and Mangelsdorf DJ

Molecular cell 6(3):507-15, 2000 Sep - Who cited this? | PubMed ID: 11030331 | Fulltext

Expression of peroxisome proliferator-activated receptor gamma (PPARgamma) in normal human pancreatic islet cells.

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Dubois M, Pattou F, Kerr-Conte J, Gmyr V, Vandewalle B, Desreumaux P, Auwerx J, Schoonjans K, and Lefebvre J

Diabetologia 43(9):1165-9, 2000 Sep - Who cited this? | PubMed ID: 11043863 | Fulltext

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