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Papers authored by Schimmer AD

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Coordination complex SH2 domain proteomimetics: an alternative approach to disrupting oncogenic protein-protein interactions.

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Drewry JA, Fletcher S, Yue P, Marushchak D, Zhao W, Sharmeen S, Zhang X, Schimmer AD, Gradinaru C, Turkson J, and Gunning PT

Chemical communications (Cambridge, England) 46(6):892-4, 2010 Feb 14 - Who cited this? | PubMed ID: 20107641 | Fulltext

Improved survival using an intensive, pediatric-based chemotherapy regimen in adults with T-cell acute lymphoblastic leukemia.

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Al-Khabori M, Minden MD, Yee KW, Gupta V, Schimmer AD, Schuh AC, Xu W, and Brandwein JM

Leukemia & lymphoma 51(1):61-5, 2010 Jan - Who cited this? | PubMed ID: 20017600 | Fulltext

Selective inhibition of histone deacetylases sensitizes malignant cells to death receptor ligands.

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Wood TE, Dalili S, Simpson CD, Sukhai MA, Hurren R, Anyiwe K, Mao X, Suarez Saiz F, Gronda M, Eberhard Y, MacLean N, Ketela T, Reed JC, Moffat J, Minden MD, Batey RA,

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Molecular cancer therapeutics 9(1):246-56, 2010 Jan - Who cited this? | PubMed ID: 20053768 | Fulltext

Potential use of cetrimonium bromide as an apoptosis-promoting anticancer agent for head and neck cancer.

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Ito E, Yip KW, Katz D, Fonseca SB, Hedley DW, Chow S, Xu GW, Wood TE, Bastianutto C, Schimmer AD, Kelley SO, and Liu FF

Molecular pharmacology 76(5):969-83, 2009 Nov - Who cited this? | PubMed ID: 19654225 | Fulltext

Phase I/II trial of AEG35156 X-linked inhibitor of apoptosis protein antisense oligonucleotide combined with idarubicin and cytarabine in patients with relapsed or primary refractory acute myeloid leukemia.

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Schimmer AD, Estey EH, Borthakur G, Carter BZ, Schiller GJ, Tallman MS, Altman JK, Karp JE, Kassis J, Hedley DW, Brandwein J, Xu W, Mak DH, LaCasse E, Jacob C, Morris SJ,

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Journal of clinical oncology : official journal of the American Society of Clinical Oncology 27(28):4741-6, 2009 Oct 1 - Who cited this? | PubMed ID: 19652057 | Fulltext

Chelation of intracellular iron with the antifungal agent ciclopirox olamine induces cell death in leukemia and myeloma cells.

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Eberhard Y, McDermott SP, Wang X, Gronda M, Venugopal A, Wood TE, Hurren R, Datti A, Batey RA, Wrana J, Antholine WE, Dick J, and Schimmer AD

Blood 114(14):3064-73, 2009 Oct 1 - Who cited this? | PubMed ID: 19589922 | Fulltext

Disruption of transcriptionally active Stat3 dimers with non-phosphorylated, salicylic acid-based small molecules: potent in vitro and tumor cell activities.

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Fletcher S, Singh J, Zhang X, Yue P, Page BD, Sharmeen S, Shahani VM, Zhao W, Schimmer AD, Turkson J, and Gunning PT

Chembiochem : a European journal of chemical biology 10(12):1959-64, 2009 Aug 17 - Who cited this? | PubMed ID: 19644994 | Fulltext

Health care crisis in Gaza.

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Schimmer AD, Malkin D, Zackenhaus E, Kagal A, Klip A, Rotin D, Minden MD, and Teitel J

CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne 180(12):1230, 2009 Jun 9 - Who cited this? | PubMed ID: 19506287 | Fulltext

Treatment of adults with BCR-ABL negative acute lymphoblastic leukaemia with a modified paediatric regimen.

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Storring JM, Minden MD, Kao S, Gupta V, Schuh AC, Schimmer AD, Yee KW, Kamel-Reid S, Chang H, Lipton JH, Messner HA, Xu W, and Brandwein JM

British journal of haematology 146(1):76-85, 2009 Jun - Who cited this? | PubMed ID: 19438471 | Fulltext

Identification of a potent natural triterpenoid inhibitor of proteosome chymotrypsin-like activity and NF-kappaB with antimyeloma activity in vitro and in vivo.

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Tiedemann RE, Schmidt J, Keats JJ, Shi CX, Zhu YX, Palmer SE, Mao X, Schimmer AD, and Stewart AK

Blood 113(17):4027-37, 2009 Apr 23 - Who cited this? | PubMed ID: 19096011 | Fulltext

Inhibition of the sodium potassium adenosine triphosphatase pump sensitizes cancer cells to anoikis and prevents distant tumor formation.

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Simpson CD, Mawji IA, Anyiwe K, Williams MA, Wang X, Venugopal AL, Gronda M, Hurren R, Cheng S, Serra S, Zavareh RB, Datti A, Wrana JL, Ezzat S, and Schimmer AD

Cancer research 69(7):2739-47, 2009 Apr 1 - Who cited this? | PubMed ID: 19293189 | Fulltext

A phase I study of tipifarnib combined with conventional induction and consolidation therapy for previously untreated patients with acute myeloid leukemia aged 60 years and over.

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Brandwein JM, Leber BF, Howson-Jan K, Schimmer AD, Schuh AC, Gupta V, Yee KW, Wright J, Moore M, MacAlpine K, Minden MD, and NCI CTEP Protocol 6670

Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 23(4):631-4, 2009 Apr - Who cited this? | PubMed ID: 19092853 | Fulltext

Nonionic surfactants are strong inhibitors of cytochrome P450 3A biotransformation activity in vitro and in vivo.

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Ren X, Mao X, Cao L, Xue K, Si L, Qiu J, Schimmer AD, and Li G

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 36(4-5):401-11, 2009 Mar 2 - Who cited this? | PubMed ID: 19041719 | Fulltext

SBDS-deficiency results in specific hypersensitivity to Fas stimulation and accumulation of Fas at the plasma membrane.

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Watanabe K, Ambekar C, Wang H, Ciccolini A, Schimmer AD, and Dror Y

Apoptosis : an international journal on programmed cell death 14(1):77-89, 2009 Jan - Who cited this? | PubMed ID: 19009351 | Fulltext

A phase I study of the pan bcl-2 family inhibitor obatoclax mesylate in patients with advanced hematologic malignancies.

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Schimmer AD, O'Brien S, Kantarjian H, Brandwein J, Cheson BD, Minden MD, Yee K, Ravandi F, Giles F, Schuh A, Gupta V, Andreeff M, Koller C, Chang H, Kamel-Reid S, Berger M,

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Clinical cancer research : an official journal of the American Association for Cancer Research 14(24):8295-301, 2008 Dec 15 - Who cited this? | PubMed ID: 19088047 | Fulltext

Outcomes of older patients (> or = 60 years) with acquired aplastic anaemia treated with immunosuppressive therapy.

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Kao SY, Xu W, Brandwein JM, Lipton JH, Messner HA, Minden MD, Schimmer AD, Schuh AC, Yee K, and Gupta V

British journal of haematology 143(5):738-43, 2008 Dec - Who cited this? | PubMed ID: 19062343 | Fulltext

A novel inhibitor of glucose uptake sensitizes cells to FAS-induced cell death.

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Wood TE, Dalili S, Simpson CD, Hurren R, Mao X, Saiz FS, Gronda M, Eberhard Y, Minden MD, Bilan PJ, Klip A, Batey RA, and Schimmer AD

Molecular cancer therapeutics 7(11):3546-55, 2008 Nov - Who cited this? | PubMed ID: 19001437 | Fulltext

Catalase activity and arsenic sensitivity in acute leukemia.

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Coe E and Schimmer AD

Leukemia & lymphoma 49(10):1976-81, 2008 Oct - Who cited this? | PubMed ID: 18949620 | Fulltext

The toxicology of Clioquinol.

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Mao X and Schimmer AD

Toxicology letters, 2008 Sep 4 - Who cited this? | PubMed ID: 18812216 | Fulltext

Pharmaceutical excipients inhibit cytochrome P450 activity in cell free systems and after systemic administration.

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Ren X, Mao X, Si L, Cao L, Xiong H, Qiu J, Schimmer AD, and Li G

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V 70(1):279, 2008 Sep - Who cited this? | PubMed ID: 18499414 | Fulltext

Dexamethasone increases ubiquitin transcription through an SP-1 dependent mechanism in multiple myeloma cells.

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Mao X, Zhu X, Hurren R, Ezzat S, and Schimmer AD

Leukemia research 32(9):1480-2, 2008 Sep - Who cited this? | PubMed ID: 18177934 | Fulltext

Clioquinol inhibits the proteasome and displays preclinical activity in leukemia and myeloma.

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Mao X, Li X, Sprangers R, Wang X, Venugopal A, Wood T, Zhang Y, Kuntz DA, Coe E, Trudel S, Rose D, Batey RA, Kay LE, and Schimmer AD

Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 2008 Aug 28 - Who cited this? | PubMed ID: 18754030 | Fulltext

Inhibition of the sodium/potassium ATPase impairs N-glycan expression and function.

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Zavareh RB, Lau KS, Hurren R, Datti A, Ashline DJ, Gronda M, Cheung P, Simpson CD, Liu W, Wasylishen AR, Boutros PC, Shi H, Vengopal A, Jurisica I, Penn LZ, Reinhold VN,

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Cancer research 68(16):6688, 2008 Aug 15 - Who cited this? | PubMed ID: 18701493 | Fulltext

Cyproheptadine displays preclinical activity in myeloma and leukemia.

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Mao X, Liang SB, Hurren R, Gronda M, Chow S, Xu GW, Wang X, Zavareh RB, Jamal N, Messner H, Hedley DW, Datti A, Wrana JL, Zhu Y, Shi CX, Lee K,

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Blood 112(3):760, 2008 Aug 1 - Who cited this? | PubMed ID: 18502826 | Fulltext

TROSY-based NMR evidence for a novel class of 20S proteasome inhibitors.

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Sprangers R, Li X, Mao X, Rubinstein JL, Schimmer AD, and Kay LE

Biochemistry 47(26):6727, 2008 Jul 1 - Who cited this? | PubMed ID: 18540636 | Fulltext

Anoikis resistance and tumor metastasis.

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Simpson CD, Anyiwe K, and Schimmer AD

Cancer letters, 2008 Jun 23 - Who cited this? | PubMed ID: 18579285 | Fulltext

DNA Methyl-Transferase 3B Promotes Epigenetic Silencing through Histone 3 Chromatin Modifications in Pituitary Cells.

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Zhu X, Mao X, Hurren R, Schimmer AD, Ezzat S, and Asa SL

The Journal of clinical endocrinology and metabolism, 2008 Jun 10 - Who cited this? | PubMed ID: 18544619 | Fulltext

A novel diquinolonium displays preclinical anti-cancer activity and induces caspase-independent cell death.

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Hurren R, Zavareh RB, Dalili S, Wood T, Rose D, Chang H, Jamal N, Messner H, Batey RA, and Schimmer AD

Apoptosis : an international journal on programmed cell death 13(6):748-55, 2008 Jun - Who cited this? | PubMed ID: 18415680 | Fulltext

Bcl-B expression in human epithelial and nonepithelial malignancies.

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Krajewska M, Kitada S, Winter JN, Variakojis D, Lichtenstein A, Zhai D, Cuddy M, Huang X, Luciano F, Baker CH, Kim H, Shin E, Kennedy S, Olson AH, Badzio A, Jassem J,

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Clinical cancer research : an official journal of the American Association for Cancer Research 14(10):3011-21, 2008 May 15 - Who cited this? | PubMed ID: 18483366 | Fulltext

Identification of kinetin riboside as a repressor of CCND1 and CCND2 with preclinical antimyeloma activity.

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Tiedemann RE, Mao X, Shi CX, Zhu YX, Palmer SE, Sebag M, Marler R, Chesi M, Fonseca R, Bergsagel PL, Schimmer AD, and Stewart AK

The Journal of clinical investigation 118(5):1750, 2008 May - Who cited this? | PubMed ID: 18431519 | Fulltext

A high-content chemical screen identifies ellipticine as a modulator of p53 nuclear localization.

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Xu GW, Mawji IA, Macrae CJ, Koch CA, Datti A, Wrana JL, Dennis JW, and Schimmer AD

Apoptosis : an international journal on programmed cell death 13(3):413, 2008 Mar - Who cited this? | PubMed ID: 18181020 | Fulltext

Apoptosis in leukemia: From molecular pathways to targeted therapies.

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Schimmer AD

Best practice & research. Clinical haematology 21(1):5-11, 2008 Mar - Who cited this? | PubMed ID: 18342807 | Fulltext

Superstition but not distrust in the medical system predicts the use of complementary and alternative medicine in a group of patients with acute leukemia.

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Lourenco MT, Walsh A, Boon H, Al-Khabouri M, Brandwein J, Gupta V, Schuh A, Yee K, Rodin G, and Schimmer AD

Leukemia & lymphoma 49(2):339-41, 2008 Feb - Who cited this? | PubMed ID: 18231922 | Fulltext

Increased efficiency for performing colony formation assays in 96-well plates: novel applications to combination therapies and high-throughput screening.

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Katz D, Ito E, Lau KS, Mocanu JD, Bastianutto C, Schimmer AD, and Liu FF

BioTechniques 44(2):ix-xiv, 2008 Feb - Who cited this? | PubMed ID: 18422490 | Fulltext

Predictors of response to reinduction chemotherapy for patients with acute myeloid leukemia who do not achieve complete remission with frontline induction chemotherapy.

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Brandwein JM, Gupta V, Schuh AC, Schimmer AD, Yee K, Xu W, Messner HA, Lipton JH, and Minden MD

American journal of hematology 83(1):54-8, 2008 Jan - Who cited this? | PubMed ID: 17696207 | Fulltext

JOE DOUPE LECTURE: Chemical biology - understanding biology and advancing therapy.

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Schimmer AD

Clinical and investigative medicine. Medecine clinique et experimentale 31(5):E282, 2008 - Who cited this? | PubMed ID: 18980718 | Fulltext

A chemical biology screen identifies glucocorticoids that regulate c-maf expression by increasing its proteasomal degradation through up-regulation of ubiquitin.

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Mao X, Stewart AK, Hurren R, Datti A, Zhu X, Zhu Y, Shi C, Lee K, Tiedemann R, Eberhard Y, Trudel S, Liang S, Corey SJ, Gillis LC, Barber DL, Wrana JL,

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Blood 110(12):4047-54, 2007 Dec 1 - Who cited this? | PubMed ID: 17875808 | Fulltext

A chemical screen identifies anisomycin as an anoikis sensitizer that functions by decreasing FLIP protein synthesis.

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Mawji IA, Simpson CD, Gronda M, Williams MA, Hurren R, Henderson CJ, Datti A, Wrana JL, and Schimmer AD

Cancer research 67(17):8307-15, 2007 Sep 1 - Who cited this? | PubMed ID: 17804746 | Fulltext

Acute promyelocytic leukemia in patients aged 70 years and over -- a single center experience of unselected patients.

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Disperati P, Minden MD, Gupta V, Schimmer AD, Schuh AC, Yee KW, Kamel-Reid S, Chang H, Xu W, and Brandwein JM

Leukemia & lymphoma 48(8):1654-8, 2007 Aug - Who cited this? | PubMed ID: 17701604 | Fulltext

Novel therapies targeting the apoptosis pathway for the treatment of acute myeloid leukemia.

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Schimmer AD

Current treatment options in oncology 8(4):277-86, 2007 Aug - Who cited this? | PubMed ID: 18004514 | Fulltext

Critical role for Fas-associated death domain-like interleukin-1-converting enzyme-like inhibitory protein in anoikis resistance and distant tumor formation.

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Mawji IA, Simpson CD, Hurren R, Gronda M, Williams MA, Filmus J, Jonkman J, Da Costa RS, Wilson BC, Thomas MP, Reed JC, Glinsky GV, and Schimmer AD

Journal of the National Cancer Institute 99(10):811, 2007 May 16 - Who cited this? | PubMed ID: 17505076 | Fulltext

A phase II study of temozolomide therapy for poor-risk patients aged >or=60 years with acute myeloid leukemia: low levels of MGMT predict for response.

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Brandwein JM, Yang L, Schimmer AD, Schuh AC, Gupta V, Wells RA, Alibhai SM, Xu W, and Minden MD

Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 21(4):821-4, 2007 Apr - Who cited this? | PubMed ID: 17252015 | Fulltext

Myelodysplastic syndromes: the complexity of stem-cell diseases.

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Corey SJ, Minden MD, Barber DL, Kantarjian H, Wang JC, and Schimmer AD

Nature reviews. Cancer 7(2):118-29, 2007 Feb - Who cited this? | PubMed ID: 17251918 | Fulltext

Livin/melanoma inhibitor of apoptosis protein as a potential therapeutic target for the treatment of malignancy.

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Chang H and Schimmer AD

Molecular cancer therapeutics 6(1):24-30, 2007 Jan - Who cited this? | PubMed ID: 17237263 | Fulltext

Characteristics and outcomes of acute myelogenous leukemia patients with very late relapse (>5 years).

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Medeiros BC, Minden MD, Schuh AC, Schimmer AD, Yee K, Lipton JH, Messner HA, Gupta V, Chun K, Xu W, Das P, Kamel-Reid S, and Brandwein JM

Leukemia & lymphoma 48(1):65-71, 2007 Jan - Who cited this? | PubMed ID: 17325849 | Fulltext

Induction of apoptosis in lymphoid and myeloid leukemia.

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Schimmer AD

Current oncology reports 8(6):430-6, 2006 Nov - Who cited this? | PubMed ID: 17040621 | Fulltext

Disruption of the endoplasmic reticulum and increases in cytoplasmic calcium are early events in cell death induced by the natural triterpenoid Asiatic acid.

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Gurfinkel DM, Chow S, Hurren R, Gronda M, Henderson C, Berube C, Hedley DW, and Schimmer AD

Apoptosis : an international journal on programmed cell death 11(9):1463-71, 2006 Sep - Who cited this? | PubMed ID: 16820960 | Fulltext

Global profiles of gene expression induced by adrenocorticotropin in Y1 mouse adrenal cells.

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Schimmer BP, Cordova M, Cheng H, Tsao A, Goryachev AB, Schimmer AD, and Morris Q

Endocrinology 147(5):2357, 2006 May - Who cited this? | PubMed ID: 16484322 | Fulltext

Identification of small molecules that sensitize resistant tumor cells to tumor necrosis factor-family death receptors.

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Schimmer AD, Thomas MP, Hurren R, Gronda M, Pellecchia M, Pond GR, Konopleva M, Gurfinkel D, Mawji IA, Brown E, and Reed JC

Cancer research 66(4):2367-75, 2006 Feb 15 - Who cited this? | PubMed ID: 16489043 | Fulltext

Targeting XIAP for the treatment of malignancy.

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Schimmer AD, Dalili S, Batey RA, and Riedl SJ

Cell death and differentiation 13(2):179, 2006 Feb - Who cited this? | PubMed ID: 16322751 | Fulltext

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