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Papers authored by Roth RA

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Trovafloxacin Enhances TNF-Induced Inflammatory Stress and Cell Death Signaling and Reduces TNF Clearance in a Murine Model of Idiosyncratic Hepatotoxicity.

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Shaw PJ, Beggs KM, Sparkenbaugh EM, Dugan CM, Ganey PE, and Roth RA

Toxicological sciences : an official journal of the Society of Toxicology 111(2):288-301, 2009 Oct - Who cited this? | PubMed ID: 19638433 | Fulltext

Sulindac metabolism and synergy with tumor necrosis factor-{alpha} in a drug-inflammation interaction model of idiosyncratic liver injury.

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Zou W, Beggs KM, Sparkenbaugh EM, Jones AD, Younis HS, Roth RA, and Ganey PE

The Journal of pharmacology and experimental therapeutics 331(1):114-21, 2009 Oct - Who cited this? | PubMed ID: 19638570 | Fulltext

Inflammatory stress and idiosyncratic hepatotoxicity: hints from animal models.

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Deng X, Luyendyk JP, Ganey PE, and Roth RA

Pharmacological reviews 61(3):262-82, 2009 Sep - Who cited this? | PubMed ID: 19805476 | Fulltext

Trovafloxacin enhances the inflammatory response to a gram-negative or a gram-positive bacterial stimulus, resulting in neutrophil-dependent liver injury in mice.

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Shaw PJ, Ganey PE, and Roth RA

The Journal of pharmacology and experimental therapeutics 330(1):72-8, 2009 Jul - Who cited this? | PubMed ID: 19351866 | Fulltext

The role of the hemostatic system in murine liver injury induced by coexposure to lipopolysaccharide and trovafloxacin, a drug with idiosyncratic liability.

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Shaw PJ, Fullerton AM, Scott MA, Ganey PE, and Roth RA

Toxicology and applied pharmacology 236(3):293-300, 2009 May 1 - Who cited this? | PubMed ID: 19367693 | Fulltext

Hepatotoxic interaction of sulindac with lipopolysaccharide: role of the hemostatic system.

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Zou W, Devi SS, Sparkenbaugh E, Younis HS, Roth RA, and Ganey PE

Toxicological sciences : an official journal of the Society of Toxicology 108(1):184-93, 2009 Mar - Who cited this? | PubMed ID: 19074762 | Fulltext

Coexposure of mice to trovafloxacin and lipopolysaccharide, a model of idiosyncratic hepatotoxicity, results in a unique gene expression profile and interferon gamma-dependent liver injury.

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Shaw PJ, Ditewig AC, Waring JF, Liguori MJ, Blomme EA, Ganey PE, and Roth RA

Toxicological sciences : an official journal of the Society of Toxicology 107(1):270-80, 2009 Jan - Who cited this? | PubMed ID: 18930950 | Fulltext

TNF{alpha} is a proximal mediator of synergistic hepatotoxicity from trovafloxacin/lipopolysaccharide coexposure.

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Shaw PJ, Ganey PE, and Roth RA

The Journal of pharmacology and experimental therapeutics, 2008 Sep 26 - Who cited this? | PubMed ID: 18820134 | Fulltext

Gene expression profiles in livers from diclofenac-treated rats reveal intestinal bacteria-dependent and -independent pathways associated with liver injury.

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Deng X, Liguori MJ, Sparkenbaugh EM, Waring JF, Blomme EA, Ganey PE, and Roth RA

The Journal of pharmacology and experimental therapeutics, 2008 Sep 18 - Who cited this? | PubMed ID: 18801949 | Fulltext

Comparing the Gleason prostate biopsy and Gleason prostatectomy grading system: the lahey clinic medical center experience and an international meta-analysis.

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Cohen MS, Hanley RS, Kurteva T, Ruthazer R, Silverman ML, Sorcini A, Hamawy K, Roth RA, Tuerk I, and Libertino JA

European urology 54(2):371-81, 2008 Aug - Who cited this? | PubMed ID: 18395322 | Fulltext

p38 mitogen-activated protein kinase-dependent tumor necrosis factor-alpha-converting enzyme is important for liver injury in hepatotoxic interaction between lipopolysaccharide and ranitidine.

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Deng X, Lu J, Lehman-McKeeman LD, Malle E, Crandall DL, Ganey PE, and Roth RA

The Journal of pharmacology and experimental therapeutics 326(1):144, 2008 Jul - Who cited this? | PubMed ID: 18390808 | Fulltext

Lipopolysaccharide and trovafloxacin coexposure in mice causes idiosyncrasy-like liver injury dependent on tumor necrosis factor-alpha.

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Shaw PJ, Hopfensperger MJ, Ganey PE, and Roth RA

Toxicological sciences : an official journal of the Society of Toxicology 100(1):259, 2007 Nov - Who cited this? | PubMed ID: 17709330 | Fulltext

The role of tumor necrosis factor alpha in lipopolysaccharide/ranitidine-induced inflammatory liver injury.

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Tukov FF, Luyendyk JP, Ganey PE, and Roth RA

Toxicological sciences : an official journal of the Society of Toxicology 100(1):267-80, 2007 Nov - Who cited this? | PubMed ID: 17698507 | Fulltext

Role of the coagulation system in acetaminophen-induced hepatotoxicity in mice.

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Ganey PE, Luyendyk JP, Newport SW, Eagle TM, Maddox JF, Mackman N, and Roth RA

Hepatology (Baltimore, Md.) 46(4):1177-86, 2007 Oct - Who cited this? | PubMed ID: 17654741 | Fulltext

Neutrophil interaction with the hemostatic system contributes to liver injury in rats cotreated with lipopolysaccharide and ranitidine.

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Deng X, Luyendyk JP, Zou W, Lu J, Malle E, Ganey PE, and Roth RA

The Journal of pharmacology and experimental therapeutics 322(2):852-61, 2007 Aug - Who cited this? | PubMed ID: 17505017 | Fulltext

PRAS40 regulates mTORC1 kinase activity by functioning as a direct inhibitor of substrate binding.

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Wang L, Harris TE, Roth RA, and Lawrence JC

The Journal of biological chemistry 282(27):20036, 2007 Jul 6 - Who cited this? | PubMed ID: 17510057 | Fulltext

2,2',4,4'-Tetrachlorobiphenyl upregulates cyclooxygenase-2 in HL-60 cells via p38 mitogen-activated protein kinase and NF-kappaB.

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Bezdecny SA, Karmaus P, Roth RA, and Ganey PE

Toxicology and applied pharmacology 221(3):285, 2007 Jun 15 - Who cited this? | PubMed ID: 17482227 | Fulltext

Hypoxia, drug therapy and toxicity.

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Lee K, Roth RA, and LaPres JJ

Pharmacology & therapeutics 113(2):229-46, 2007 Feb - Who cited this? | PubMed ID: 17046066 | Fulltext

Protein kinase B/Akt phosphorylation of PDE3A and its role in mammalian oocyte maturation.

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Han SJ, Vaccari S, Nedachi T, Andersen CB, Kovacina KS, Roth RA, and Conti M

The EMBO journal 25(24):5716-25, 2006 Dec 13 - Who cited this? | PubMed ID: 17124499 | Fulltext

Modeling inflammation-drug interactions in vitro: a rat Kupffer cell-hepatocyte coculture system.

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Tukov FF, Maddox JF, Amacher DE, Bobrowski WF, Roth RA, and Ganey PE

Toxicology in vitro : an international journal published in association with BIBRA 20(8):1488-99, 2006 Dec - Who cited this? | PubMed ID: 16782301 | Fulltext

Modest inflammation enhances diclofenac hepatotoxicity in rats: role of neutrophils and bacterial translocation.

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Deng X, Stachlewitz RF, Liguori MJ, Blomme EA, Waring JF, Luyendyk JP, Maddox JF, Ganey PE, and Roth RA

The Journal of pharmacology and experimental therapeutics 319(3):1191-9, 2006 Dec - Who cited this? | PubMed ID: 16990511 | Fulltext

PKCdelta-mediated IRS-1 Ser24 phosphorylation negatively regulates IRS-1 function.

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Greene MW, Ruhoff MS, Roth RA, Kim JA, Quon MJ, and Krause JA

Biochemical and biophysical research communications 349(3):976-86, 2006 Oct 27 - Who cited this? | PubMed ID: 16970908 | Fulltext

Anticoagulation and inhibition of nitric oxide synthase influence hepatic hypoxia after monocrotaline exposure.

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Copple BL, Roth RA, and Ganey PE

Toxicology 225(2-3):128-37, 2006 Aug 15 - Who cited this? | PubMed ID: 16828949 | Fulltext

Metformin prevents alcohol-induced liver injury in the mouse: Critical role of plasminogen activator inhibitor-1.

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Bergheim I, Guo L, Davis MA, Lambert JC, Beier JI, Duveau I, Luyendyk JP, Roth RA, and Arteel GE

Gastroenterology 130(7):2099, 2006 Jun - Who cited this? | PubMed ID: 16762632 | Fulltext

Coagulation-dependent gene expression and liver injury in rats given lipopolysaccharide with ranitidine but not with famotidine.

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Luyendyk JP, Lehman-McKeeman LD, Nelson DM, Bhaskaran VM, Reilly TP, Car BD, Cantor GH, Deng X, Maddox JF, Ganey PE, and Roth RA

The Journal of pharmacology and experimental therapeutics 317(2):635-43, 2006 May - Who cited this? | PubMed ID: 16401727 | Fulltext

Unique gene expression and hepatocellular injury in the lipopolysaccharide-ranitidine drug idiosyncrasy rat model: comparison with famotidine.

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Luyendyk JP, Lehman-McKeeman LD, Nelson DM, Bhaskaran VM, Reilly TP, Car BD, Cantor GH, Maddox JF, Ganey PE, and Roth RA

Toxicological sciences : an official journal of the Society of Toxicology 90(2):569, 2006 Apr - Who cited this? | PubMed ID: 16415329 | Fulltext

Metabonomic evaluation of idiosyncrasy-like liver injury in rats cotreated with ranitidine and lipopolysaccharide.

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Maddox JF, Luyendyk JP, Cosma GN, Breau AP, Bible RH, Harrigan GG, Goodacre R, Ganey PE, Cantor GH, Cockerell GL, and Roth RA

Toxicology and applied pharmacology 212(1):35-44, 2006 Apr 1 - Who cited this? | PubMed ID: 16051291 | Fulltext

Mechanism of Akt1 inhibition of breast cancer cell invasion reveals a protumorigenic role for TSC2.

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Liu H, Radisky DC, Nelson CM, Zhang H, Fata JE, Roth RA, and Bissell MJ

Proceedings of the National Academy of Sciences of the United States of America 103(11):4134-9, 2006 Mar 14 - Who cited this? | PubMed ID: 16537497 | Fulltext

Metformin prevents endotoxin-induced liver injury after partial hepatectomy.

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Bergheim I, Luyendyk JP, Steele C, Russell GK, Guo L, Roth RA, and Arteel GE

The Journal of pharmacology and experimental therapeutics 316(3):1053, 2006 Mar - Who cited this? | PubMed ID: 16322356 | Fulltext

Microarray analysis of lipopolysaccharide potentiation of trovafloxacin-induced liver injury in rats suggests a role for proinflammatory chemokines and neutrophils.

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Waring JF, Liguori MJ, Luyendyk JP, Maddox JF, Ganey PE, Stachlewitz RF, North C, Blomme EA, and Roth RA

The Journal of pharmacology and experimental therapeutics 316(3):1080, 2006 Mar - Who cited this? | PubMed ID: 16299187 | Fulltext

Coagulation-mediated hypoxia and neutrophil-dependent hepatic injury in rats given lipopolysaccharide and ranitidine.

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Luyendyk JP, Shaw PJ, Green CD, Maddox JF, Ganey PE, and Roth RA

The Journal of pharmacology and experimental therapeutics 314(3):1023-31, 2005 Sep - Who cited this? | PubMed ID: 15933155 | Fulltext

Successes and frustrations in developing animal models of idiosyncratic drug reactions.

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Roth RA and Ganey PE

Chemico-biological interactions 152(2-3):165; author reply 167-8, 2005 Apr 15 - Who cited this? | PubMed ID: 15840389 | Fulltext

Effects of 2,2',4,4'-tetrachlorobiphenyl on granulocytic HL-60 cell function and expression of cyclooxygenase-2.

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Bezdecny SA, Roth RA, and Ganey PE

Toxicological sciences : an official journal of the Society of Toxicology 84(2):328-34, 2005 Apr - Who cited this? | PubMed ID: 15673847 | Fulltext

On the mechanism for neomycin reversal of wortmannin inhibition of insulin stimulation of glucose uptake.

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Shimaya A, Kovacina KS, and Roth RA

The Journal of biological chemistry 279(53):55277, 2004 Dec 31 - Who cited this? | PubMed ID: 15504741 | Fulltext

Role of hepatic fibrin in idiosyncrasy-like liver injury from lipopolysaccharide-ranitidine coexposure in rats.

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Luyendyk JP, Maddox JF, Green CD, Ganey PE, and Roth RA

Hepatology (Baltimore, Md.) 40(6):1342-51, 2004 Dec - Who cited this? | PubMed ID: 15565632 | Fulltext

Inhibition of mTOR activity restores tamoxifen response in breast cancer cells with aberrant Akt Activity.

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deGraffenried LA, Friedrichs WE, Russell DH, Donzis EJ, Middleton AK, Silva JM, Roth RA, and Hidalgo M

Clinical cancer research : an official journal of the American Association for Cancer Research 10(23):8059-67, 2004 Dec 1 - Who cited this? | PubMed ID: 15585641 | Fulltext

Adverse hepatic drug reactions: inflammatory episodes as consequence and contributor.

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Ganey PE, Luyendyk JP, Maddox JF, and Roth RA

Chemico-biological interactions 150(1):35-51, 2004 Nov 1 - Who cited this? | PubMed ID: 15522260 | Fulltext

Gene expression analysis points to hemostasis in livers of rats cotreated with lipopolysaccharide and ranitidine.

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Luyendyk JP, Mattes WB, Burgoon LD, Zacharewski TR, Maddox JF, Cosma GN, Ganey PE, and Roth RA

Toxicological sciences : an official journal of the Society of Toxicology 80(1):203, 2004 Jul - Who cited this? | PubMed ID: 15084757 | Fulltext

Workshop overview: Hepatotoxicity assessment for botanical dietary supplements.

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Willett KL, Roth RA, and Walker L

Toxicological sciences : an official journal of the Society of Toxicology 79(1):4-9, 2004 May - Who cited this? | PubMed ID: 14976355 | Fulltext

Modulation of human insulin receptor substrate-1 tyrosine phosphorylation by protein kinase Cdelta.

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Greene MW, Morrice N, Garofalo RS, and Roth RA

The Biochemical journal 378(Pt 1):105-16, 2004 Feb 15 - Who cited this? | PubMed ID: 14583092 | Fulltext

Application of high-throughput Fourier-transform infrared spectroscopy in toxicology studies: contribution to a study on the development of an animal model for idiosyncratic toxicity.

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Harrigan GG, LaPlante RH, Cosma GN, Cockerell G, Goodacre R, Maddox JF, Luyendyk JP, Ganey PE, and Roth RA

Toxicology letters 146(3):197-205, 2004 Feb 2 - Who cited this? | PubMed ID: 14687757 | Fulltext

15-deoxy prostaglandin J2 enhances allyl alcohol-induced toxicity in rat hepatocytes.

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Maddox JF, Domzalski AC, Roth RA, and Ganey PE

Toxicological sciences : an official journal of the Society of Toxicology 77(2):290-8, 2004 Feb - Who cited this? | PubMed ID: 14657518 | Fulltext

Modes of cell death in rat liver after monocrotaline exposure.

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Copple BL, Rondelli CM, Maddox JF, Hoglen NC, Ganey PE, and Roth RA

Toxicological sciences : an official journal of the Society of Toxicology 77(1):172-82, 2004 Jan - Who cited this? | PubMed ID: 14600277 | Fulltext

Akt promotes increased mammalian cell size by stimulating protein synthesis and inhibiting protein degradation.

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Faridi J, Fawcett J, Wang L, and Roth RA

American journal of physiology. Endocrinology and metabolism 285(5):E964-72, 2003 Nov - Who cited this? | PubMed ID: 12876075 | Fulltext

Basement membrane and matrix metalloproteinases in monocrotaline-induced liver injury.

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Hanumegowda UM, Copple BL, Shibuya M, Malle E, Ganey PE, and Roth RA

Toxicological sciences : an official journal of the Society of Toxicology 76(1):237-46, 2003 Nov - Who cited this? | PubMed ID: 12970574 | Fulltext

Ranitidine treatment during a modest inflammatory response precipitates idiosyncrasy-like liver injury in rats.

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Luyendyk JP, Maddox JF, Cosma GN, Ganey PE, Cockerell GL, and Roth RA

The Journal of pharmacology and experimental therapeutics 307(1):9-16, 2003 Oct - Who cited this? | PubMed ID: 12893837 | Fulltext

Inflammation and drug idiosyncrasy--is there a connection?.

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Roth RA, Luyendyk JP, Maddox JF, and Ganey PE

The Journal of pharmacology and experimental therapeutics 307(1):1-8, 2003 Oct - Who cited this? | PubMed ID: 12954806 | Fulltext

Inorganic polyphosphate stimulates mammalian TOR, a kinase involved in the proliferation of mammary cancer cells.

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Wang L, Fraley CD, Faridi J, Kornberg A, and Roth RA

Proceedings of the National Academy of Sciences of the United States of America 100(20):11249-54, 2003 Sep 30 - Who cited this? | PubMed ID: 12970465 | Fulltext

Liver inflammation during monocrotaline hepatotoxicity.

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Copple BL, Ganey PE, and Roth RA

Toxicology 190(3):155-69, 2003 Aug 28 - Who cited this? | PubMed ID: 12927372 | Fulltext

The coagulation system contributes to synergistic liver injury from exposure to monocrotaline and bacterial lipopolysaccharide.

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Yee SB, Harkema JR, Ganey PE, and Roth RA

Toxicological sciences : an official journal of the Society of Toxicology 74(2):457-69, 2003 Aug - Who cited this? | PubMed ID: 12773766 | Fulltext

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