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Papers authored by Robl JA

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(d)-2-tert-Butoxycarbonylamino-5,5-difluoro-5-phenyl-pentanoic acid: Synthesis and incorporation into the growth hormone secretagogues.

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Li J, Chen SY, Murphy BJ, Flynn N, Seethala R, Slusarchyk D, Yan M, Sleph P, Zhang H, Humphreys WG, Ewing WR, Robl JA, Gordon D, and Tino JA

Bioorganic & medicinal chemistry letters 18(14):4072-4, 2008 Jul 15 - Who cited this? | PubMed ID: 18554903 | Fulltext

A Synthesis of N-Bridged 5,6-Bicylic Pyridines via A Mild Cyclodehydration Using the Burgess Reagent and Discovery of A Novel Carbamylsulfonylation Reaction.

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Li JJ, Li JJ, Li J, Trehan AK, Wong HS, Krishnananthan S, Kennedy LJ, Gao Q, Ng A, Robl JA, Balasubramanian B, and Chen BC

Organic letters 10(13):2897-900, 2008 Jul 3 - Who cited this? | PubMed ID: 18533675 | Fulltext

Pyridine amides as potent and selective inhibitors of 11beta-hydroxysteroid dehydrogenase type 1.

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Wang H, Ruan Z, Li JJ, Simpkins LM, Smirk RA, Wu SC, Hutchins RD, Nirschl DS, Van Kirk K, Cooper CB, Sutton JC, Ma Z, Golla R, Seethala R, Salyan ME, Nayeem A,

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Bioorganic & medicinal chemistry letters 18(11):3168-72, 2008 Jun 1 - Who cited this? | PubMed ID: 18485702 | Fulltext

(3R,5S,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(methyl(1-methyl-1h-1,2,4-triazol-5-yl)amino)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoic acid (BMS-644950): a rationally designed orally efficacious 3-hydroxy-3-methylglutaryl coenzyme-a reductase inhibitor with.

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Ahmad S, Madsen CS, Stein PD, Janovitz E, Huang C, Ngu K, Bisaha S, Kennedy LJ, Chen BC, Zhao R, Sitkoff D, Monshizadegan H, Yin X, Ryan CS, Zhang R, Giancarli M,

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Journal of medicinal chemistry 51(9):2722-33, 2008 May 8 - Who cited this? | PubMed ID: 18412317 | Fulltext

Tetrazole based amides as growth hormone secretagogues.

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Li JJ, Wang H, Li J, Qu F, Swartz SG, Hernández AS, Biller SA, Robl JA, Tino JA, Slusarchyk D, Seethala R, Sleph P, Yan M, Grover G, Flynn N, Murphy BJ,

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Bioorganic & medicinal chemistry letters 18(8):2536-9, 2008 Apr 15 - Who cited this? | PubMed ID: 18378446 | Fulltext

Discovery of Brivanib Alaninate ((S)-((R)-1-(4-(4-Fluoro-2-methyl-1H-indol-5-yloxy)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yloxy)propan-2-yl)2-aminopropanoate), A Novel Prodrug of Dual Vascular Endothelial Growth Factor Receptor-2 and Fibroblast Growth Factor Receptor-1 Kinase Inhibitor (BMS-540215).

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Cai ZW, Zhang Y, Borzilleri RM, Qian L, Barbosa S, Wei D, Zheng X, Wu L, Fan J, Shi Z, Wautlet BS, Mortillo S, Jeyaseelan R, Kukral DW, Kamath A, Marathe P,

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Journal of medicinal chemistry 51(6):1976-80, 2008 Mar 27 - Who cited this? | PubMed ID: 18288793 | Fulltext

Optimization of 1H-tetrazole-1-alkanenitriles as potent orally bioavailable growth hormone secretagogues.

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Hernández AS, Swartz SG, Slusarchyk D, Yan M, Seethala RK, Sleph P, Grover G, Dickinson K, Giupponi L, Harper TW, Humphreys WG, Longhi DA, Flynn N, Murphy BJ, Gordon DA, Biller SA,

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Bioorganic & medicinal chemistry letters 18(6):2067-72, 2008 Mar 15 - Who cited this? | PubMed ID: 18282707 | Fulltext

Design and synthesis of tetrazole-based growth hormone secretagogue: the SAR studies of the O-benzyl serine side chain.

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Li J, Chen SY, Tao S, Wang H, Li JJ, Swartz S, Musial C, Hernandez AA, Flynn N, Murphy BJ, Beehler B, Dickinson KE, Giupponi L, Grover G, Seethala R, Sleph P,

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Bioorganic & medicinal chemistry letters 18(6):1825-9, 2008 Mar 15 - Who cited this? | PubMed ID: 18295486 | Fulltext

The Guinea pig as a preclinical model for demonstrating the efficacy and safety of statins.

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Madsen CS, Janovitz E, Zhang R, Nguyen-Tran V, Ryan CS, Yin X, Monshizadegan H, Chang M, D'Arienzo C, Scheer S, Setters R, Search D, Chen X, Zhuang S, Kunselman L, Peters A,

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The Journal of pharmacology and experimental therapeutics 324(2):576-86, 2008 Feb - Who cited this? | PubMed ID: 17986646 | Fulltext

Potent non-nitrile dipeptidic dipeptidyl peptidase IV inhibitors.

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Simpkins LM, Bolton S, Pi Z, Sutton JC, Kwon C, Zhao G, Magnin DR, Augeri DJ, Gungor T, Rotella DP, Sun Z, Liu Y, Slusarchyk WS, Marcinkeviciene J, Robertson JG, Wang A,

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Bioorganic & medicinal chemistry letters 17(23):6476-80, 2007 Dec 1 - Who cited this? | PubMed ID: 17937986 | Fulltext

Discovery of a Tetrazole-Based Growth Hormone Secretagogue: 4-(Hydroxybutyl)carbamic Acid 2-{5-[1-(2-Amino-2-methylpropionylamino)-2- benzyloxyethyl]tetrazol-1-yl}ethyl Ester (BMS-317180).

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Li J, Chen SY, Li JJ, Wang H, Hernandez AS, Tao S, Musial CM, Qu F, Swartz S, Chao ST, Flynn N, Murphy BJ, Slusarchyk DA, Seethala R, Yan M, Sleph P,

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Journal of medicinal chemistry 50(24):5890-3, 2007 Nov 29 - Who cited this? | PubMed ID: 17973363 | Fulltext

Amino(methyl) pyrrolidines as novel scaffolds for factor Xa inhibitors.

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Shi Y, Sitkoff D, Zhang J, Han W, Hu Z, Stein PD, Wang Y, Kennedy LJ, O'Connor SP, Ahmad S, Liu EC, Seiler SM, Lam PY, Robl JA, Macor JE, Atwal KS,

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Bioorganic & medicinal chemistry letters 17(21):5952-8, 2007 Nov 1 - Who cited this? | PubMed ID: 17855089 | Fulltext

Discovery, synthesis, and structure-activity studies of tetrazole based growth hormone secretagogues.

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Hernández AS, Cheng PT, Musial CM, Swartz SG, George RJ, Grover G, Slusarchyk D, Seethala RK, Smith M, Dickinson K, Giupponi L, Longhi DA, Flynn N, Murphy BJ, Gordon DA, Biller SA,

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Bioorganic & medicinal chemistry letters 17(21):5928-33, 2007 Nov 1 - Who cited this? | PubMed ID: 17869100 | Fulltext

Discovery of selective imidazole-based inhibitors of mammalian 15-lipoxygenase: highly potent against human enzyme within a cellular environment.

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Weinstein DS, Liu W, Ngu K, Langevine C, Combs DW, Zhuang S, Chen C, Madsen CS, Harper TW, and Robl JA

Bioorganic & medicinal chemistry letters 17(18):5115-20, 2007 Sep 15 - Who cited this? | PubMed ID: 17656086 | Fulltext

Acridone-based inhibitors of inosine 5'-monophosphate dehydrogenase: discovery and SAR leading to the identification of N-(2-(6-(4-ethylpiperazin-1-yl)pyridin-3-yl)propan-2-yl)-2- fluoro-9-oxo-9,10-dihydroacridine-3-carboxamide (BMS-566419).

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Watterson SH, Chen P, Zhao Y, Gu HH, Dhar TG, Xiao Z, Ballentine SK, Shen Z, Fleener CA, Rouleau KA, Obermeier M, Yang Z, McIntyre KW, Shuster DJ, Witmer M, Dambach D,

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Journal of medicinal chemistry 50(15):3730-42, 2007 Jul 26 - Who cited this? | PubMed ID: 17585753 | Fulltext

Treatment of diabetes and atherosclerosis by inhibiting fatty-acid-binding protein aP2.

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Furuhashi M, Tuncman G, Görgün CZ, Makowski L, Atsumi G, Vaillancourt E, Kono K, Babaev VR, Fazio S, Linton MF, Sulsky R, Robl JA, Parker RA, and Hotamisligil GS

Nature 447(7147):959-65, 2007 Jun 21 - Who cited this? | PubMed ID: 17554340 | Fulltext

Potent and selective biphenyl azole inhibitors of adipocyte fatty acid binding protein (aFABP).

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Sulsky R, Magnin DR, Huang Y, Simpkins L, Taunk P, Patel M, Zhu Y, Stouch TR, Bassolino-Klimas D, Parker R, Harrity T, Stoffel R, Taylor DS, Lavoie TB, Kish K, Jacobson BL,

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Bioorganic & medicinal chemistry letters 17(12):3511-5, 2007 Jun 15 - Who cited this? | PubMed ID: 17502136 | Fulltext

2-hydroxy-N-arylbenzenesulfonamides as ATP-citrate lyase inhibitors.

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Li JJ, Wang H, Tino JA, Robl JA, Herpin TF, Lawrence RM, Biller S, Jamil H, Ponticiello R, Chen L, Chu CH, Flynn N, Cheng D, Zhao R, Chen B, Schnur D,

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Bioorganic & medicinal chemistry letters 17(11):3208-11, 2007 Jun 1 - Who cited this? | PubMed ID: 17383874 | Fulltext

Discovery of (R)-9-ethyl-1,3,4,10b-tetrahydro-7-trifluoromethylpyrazino[2,1-a]isoindol- 6(2H)-one, a selective, orally active agonist of the 5-HT(2C) receptor.

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Wacker DA, Varnes JG, Malmstrom SE, Cao X, Hung CP, Ung T, Wu G, Zhang G, Zuvich E, Thomas MA, Keim WJ, Cullen MJ, Rohrbach KW, Qu Q, Narayanan R, Rossi K,

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Journal of medicinal chemistry 50(6):1365-79, 2007 Mar 22 - Who cited this? | PubMed ID: 17315987 | Fulltext

Discovery of potent, orally-active, and muscle-selective androgen receptor modulators based on an N-aryl-hydroxybicyclohydantoin scaffold.

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Sun C, Robl JA, Wang TC, Huang Y, Kuhns JE, Lupisella JA, Beehler BC, Golla R, Sleph PG, Seethala R, Fura A, Krystek SR, An Y, Malley MF, Sack JS, Salvati ME,

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Journal of medicinal chemistry 49(26):7596-9, 2006 Dec 28 - Who cited this? | PubMed ID: 17181141 | Fulltext

Discovery and development of 5-[(5S,9R)-9-(4-cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]non-7-yl-methyl]-3-thiophenecarboxylic acid (BMS-587101)--a small molecule antagonist of leukocyte function associated antigen-1.

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Potin D, Launay M, Monatlik F, Malabre P, Fabreguettes M, Fouquet A, Maillet M, Nicolai E, Dorgeret L, Chevallier F, Besse D, Dufort M, Caussade F, Ahmad SZ, Stetsko DK, Skala S,

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Journal of medicinal chemistry 49(24):6946-9, 2006 Nov 30 - Who cited this? | PubMed ID: 17125246 | Fulltext

NMR structure of a potent small molecule inhibitor bound to human keratinocyte fatty acid-binding protein.

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McDonnell PA, Constantine KL, Goldfarb V, Johnson SR, Sulsky R, Magnin DR, Robl JA, Caulfield TJ, Parker RA, Taylor DS, Adam LP, Metzler WJ, Mueller L, and Farmer BT

Journal of medicinal chemistry 49(16):5013-7, 2006 Aug 10 - Who cited this? | PubMed ID: 16884313 | Fulltext

Diprolyl nitriles as potent dipeptidyl peptidase IV inhibitors.

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Zhao G, Taunk PC, Magnin DR, Simpkins LM, Robl JA, Wang A, Robertson JG, Marcinkeviciene J, Sitkoff DF, Parker RA, Kirby MS, and Hamann LG

Bioorganic & medicinal chemistry letters 15(18):3992-5, 2005 Sep 15 - Who cited this? | PubMed ID: 16046120 | Fulltext

Discovery and preclinical profile of Saxagliptin (BMS-477118): a highly potent, long-acting, orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes.

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Augeri DJ, Robl JA, Betebenner DA, Magnin DR, Khanna A, Robertson JG, Wang A, Simpkins LM, Taunk P, Huang Q, Han SP, Abboa-Offei B, Cap M, Xin L, Tao L, Tozzo E,

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Journal of medicinal chemistry 48(15):5025-37, 2005 Jul 28 - Who cited this? | PubMed ID: 16033281 | Fulltext

Tetrahydroisoquinoline 1-carboxamides as growth hormone secretagogues.

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Li JJ, Wang H, Qu F, Musial C, Tino JA, Robl JA, Slusarchyk D, Golla R, Seethala R, Dickinson K, Giupponi L, Grover G, Sleph P, Flynn N, Murphy BJ, Gordon D,

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Bioorganic & medicinal chemistry letters 15(7):1799-802, 2005 Apr 1 - Who cited this? | PubMed ID: 15780609 | Fulltext

5-Carboxamido-1,3,2-dioxaphosphorinanes, potent inhibitors of MTP.

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Sulsky R, Robl JA, Biller SA, Harrity TW, Wetterau J, Connolly F, Jolibois K, and Kunselman L

Bioorganic & medicinal chemistry letters 14(20):5067-70, 2004 Oct 18 - Who cited this? | PubMed ID: 15380200 | Fulltext

Synthesis of novel potent dipeptidyl peptidase IV inhibitors with enhanced chemical stability: interplay between the N-terminal amino acid alkyl side chain and the cyclopropyl group of alpha-aminoacyl-l-cis-4,5-methanoprolinenitrile-based inhibitors.

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Magnin DR, Robl JA, Sulsky RB, Augeri DJ, Huang Y, Simpkins LM, Taunk PC, Betebenner DA, Robertson JG, Abboa-Offei BE, Wang A, Cap M, Xin L, Tao L, Sitkoff DF, Malley MF,

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Journal of medicinal chemistry 47(10):2587-98, 2004 May 6 - Who cited this? | PubMed ID: 15115400 | Fulltext

Microsomal triglyceride transfer protein inhibitors: discovery and synthesis of alkyl phosphonates as potent MTP inhibitors and cholesterol lowering agents.

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Magnin DR, Biller SA, Wetterau J, Robl JA, Dickson JK, Taunk P, Harrity TW, Lawrence RM, Sun CQ, Wang T, Logan J, Fryszman O, Connolly F, Jolibois K, and Kunselman L

Bioorganic & medicinal chemistry letters 13(7):1337-40, 2003 Apr 7 - Who cited this? | PubMed ID: 12657277 | Fulltext

A novel series of highly potent benzimidazole-based microsomal triglyceride transfer protein inhibitors.

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Robl JA, Sulsky R, Sun CQ, Simpkins LM, Wang T, Dickson JK, Chen Y, Magnin DR, Taunk P, Slusarchyk WA, Biller SA, Lan SJ, Connolly F, Kunselman LK, Sabrah T, Jamil H,

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Journal of medicinal chemistry 44(6):851-6, 2001 Mar 15 - Who cited this? | PubMed ID: 11300866 | Fulltext

N-formyl hydroxylamine containing dipeptides: generation of a new class of vasopeptidase inhibitors.

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Robl JA, Simpkins LM, and Asaad MM

Bioorganic & medicinal chemistry letters 10(3):257-60, 2000 Feb 7 - Who cited this? | PubMed ID: 10698448 | Fulltext

Vasopeptidase inhibitors: incorporation of geminal and spirocyclic substituted azepinones in mercaptoacyl dipeptides.

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Robl JA, Sulsky R, Sieber-McMaster E, Ryono DE, Cimarusti MP, Simpkins LM, Karanewsky DS, Chao S, Asaad MM, Seymour AA, Fox M, Smith PL, and Trippodo NC

Journal of medicinal chemistry 42(2):305-11, 1999 Jan 28 - Who cited this? | PubMed ID: 9925736 | Fulltext

An MTP inhibitor that normalizes atherogenic lipoprotein levels in WHHL rabbits.

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Wetterau JR, Gregg RE, Harrity TW, Arbeeny C, Cap M, Connolly F, Chu CH, George RJ, Gordon DA, Jamil H, Jolibois KG, Kunselman LK, Lan SJ, Maccagnan TJ, Ricci B, Yan M,

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Science (New York, N.Y.) 282(5389):751-4, 1998 Oct 23 - Who cited this? | PubMed ID: 9784135 | Fulltext

Effects of omapatrilat in low, normal, and high renin experimental hypertension.

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Trippodo NC, Robl JA, Asaad MM, Fox M, Panchal BC, and Schaeffer TR

American journal of hypertension : journal of the American Society of Hypertension 11(3 Pt 1):363-72, 1998 Mar - Who cited this? | PubMed ID: 9544878 | Fulltext

Dual metalloprotease inhibitors: mercaptoacetyl-based fused heterocyclic dipeptide mimetics as inhibitors of angiotensin-converting enzyme and neutral endopeptidase.

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Robl JA, Sun CQ, Stevenson J, Ryono DE, Simpkins LM, Cimarusti MP, Dejneka T, Slusarchyk WA, Chao S, Stratton L, Misra RN, Bednarz MS, Asaad MM, Cheung HS, Abboa-Offei BE, Smith PL,

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Journal of medicinal chemistry 40(11):1570-7, 1997 May 23 - Who cited this? | PubMed ID: 9171867 | Fulltext

Dual metalloprotease inhibitors. 6. Incorporation of bicyclic and substituted monocyclic azepinones as dipeptide surrogates in angiotensin-converting enzyme/neutral endopeptidase inhibitors.

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Robl JA, Cimarusti MP, Simpkins LM, Brown B, Ryono DE, Bird JE, Asaad MM, Schaeffer TR, and Trippodo NC

Journal of medicinal chemistry 39(2):494-502, 1996 Jan 19 - Who cited this? | PubMed ID: 8558518 | Fulltext

Cardiovascular effects of the novel dual inhibitor of neutral endopeptidase and angiotensin-converting enzyme BMS-182657 in experimental hypertension and heart failure.

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Trippodo NC, Robl JA, Asaad MM, Bird JE, Panchal BC, Schaeffer TR, Fox M, Giancarli MR, and Cheung HS

The Journal of pharmacology and experimental therapeutics 275(2):745-52, 1995 Nov - Who cited this? | PubMed ID: 7473162 | Fulltext

Phosphorus-containing inhibitors of HMG-CoA reductase. 2. Synthesis and biological activities of a series of substituted pyridines containing a hydroxyphosphinyl moiety.

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Robl JA, Duncan LA, Pluscec J, Karanewsky DS, Gordon EM, Ciosek CP, Rich LC, Dehmel VC, Slusarchyk DA, and Harrity TW

Journal of medicinal chemistry 34(9):2804-15, 1991 Sep - Who cited this? | PubMed ID: 1895299 | Fulltext

Phosphorus-containing inhibitors of HMG-CoA reductase. 1. 4-[(2-arylethyl)hydroxyphosphinyl]-3-hydroxy-butanoic acids: a new class of cell-selective inhibitors of cholesterol biosynthesis.

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Karanewsky DS, Badia MC, Ciosek CP, Robl JA, Sofia MJ, Simpkins LM, DeLange B, Harrity TW, Biller SA, and Gordon EM

Journal of medicinal chemistry 33(11):2952-6, 1990 Nov - Who cited this? | PubMed ID: 2231594 | Fulltext

Instrumentation and separation results of medium pressure liquid chromatography.

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Hwu JR, Robl JA, and Khoudary KP

Journal of chromatographic science 25(11):501-5, 1987 Nov - Who cited this? | PubMed ID: 3437030 | Fulltext

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