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Papers authored by Prodromou C

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Hsp90 charged-linker truncation reverses the functional consequences of weakened hydrophobic contacts in the N domain.

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Tsutsumi S, Mollapour M, Graf C, Lee CT, Scroggins BT, Xu W, Haslerova L, Hessling M, Konstantinova AA, Trepel JB, Panaretou B, Buchner J, Mayer MP, Prodromou C, and Neckers L

Nature structural & molecular biology 16(11):1141-7, 2009 Nov - Who cited this? | PubMed ID: 19838189 | Fulltext

Structural-thermodynamic relationships of interactions in the N-terminal ATP-binding domain of Hsp90.

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Nilapwar S, Williams E, Fu C, Prodromou C, Pearl LH, Williams MA, and Ladbury JE

Journal of molecular biology 392(4):923-36, 2009 Oct 2 - Who cited this? | PubMed ID: 19631219 | Fulltext

Structural basis of the radicicol resistance displayed by a fungal hsp90.

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Prodromou C, Nuttall JM, Millson SH, Roe SM, Sim TS, Tan D, Workman P, Pearl LH, and Piper PW

ACS chemical biology 4(4):289-97, 2009 Apr 17 - Who cited this? | PubMed ID: 19236053 | Fulltext

A common conformationally coupled ATPase mechanism for yeast and human cytoplasmic HSP90s.

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Vaughan CK, Piper PW, Pearl LH, and Prodromou C

The FEBS journal 276(1):199-209, 2009 Jan - Who cited this? | PubMed ID: 19032597 | Fulltext

The Hsp90 mosaic: a picture emerges.

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Mayer MP, Prodromou C, and Frydman J

Nature structural & molecular biology 16(1):2-6, 2009 Jan - Who cited this? | PubMed ID: 19125165 | Fulltext

Hsp90-dependent activation of protein kinases is regulated by chaperone-targeted dephosphorylation of Cdc37.

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Vaughan CK, Mollapour M, Smith JR, Truman A, Hu B, Good VM, Panaretou B, Neckers L, Clarke PA, Workman P, Piper PW, Prodromou C, and Pearl LH

Molecular cell 31(6):886-95, 2008 Sep 26 - Who cited this? | PubMed ID: 18922470 | Fulltext

Structural and functional coupling of Hsp90- and Sgt1-centred multi-protein complexes.

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Zhang M, Botër M, Li K, Kadota Y, Panaretou B, Prodromou C, Shirasu K, and Pearl LH

The EMBO journal, 2008 Sep 25 - Who cited this? | PubMed ID: 18818696 | Fulltext

Optimizing natural products by biosynthetic engineering: discovery of nonquinone Hsp90 inhibitors.

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Zhang MQ, Gaisser S, Nur-e-Alam M, Sheehan LS, Vousden WA, Gaitatzis N, Peck G, Coates NJ, Moss SJ, Radzom M, Foster TA, Sheridan RM, Gregory MA, Roe SM, Prodromou C, Pearl L,

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Journal of medicinal chemistry 51(18):5494-7, 2008 Sep 25 - Who cited this? | PubMed ID: 18800759 | Fulltext

Chaperone ligand-discrimination by the TPR-domain protein Tah1.

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Millson SH, Vaughan CK, Zhai C, Ali MM, Panaretou B, Piper PW, Pearl LH, and Prodromou C

The Biochemical journal 413(2):261-8, 2008 Jul 15 - Who cited this? | PubMed ID: 18412542 | Fulltext

Molecular characterization of macbecin as an Hsp90 inhibitor.

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Martin CJ, Gaisser S, Challis IR, Carletti I, Wilkinson B, Gregory M, Prodromou C, Roe SM, Pearl LH, Boyd SM, and Zhang MQ

Journal of medicinal chemistry 51(9):2853, 2008 May 8 - Who cited this? | PubMed ID: 18357975 | Fulltext

NVP-AUY922: a novel heat shock protein 90 inhibitor active against xenograft tumor growth, angiogenesis, and metastasis.

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Eccles SA, Massey A, Raynaud FI, Sharp SY, Box G, Valenti M, Patterson L, de Haven Brandon A, Gowan S, Boxall F, Aherne W, Rowlands M, Hayes A, Martins V, Urban F, Boxall K,

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Cancer research 68(8):2850-60, 2008 Apr 15 - Who cited this? | PubMed ID: 18413753 | Fulltext

The Hsp90 molecular chaperone: an open and shut case for treatment.

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Pearl LH, Prodromou C, and Workman P

The Biochemical journal 410(3):439-53, 2008 Mar 15 - Who cited this? | PubMed ID: 18290764 | Fulltext

The ATPase-dependent chaperoning activity of Hsp90a regulates thick filament formation and integration during skeletal muscle myofibrillogenesis.

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Hawkins TA, Haramis AP, Etard C, Prodromou C, Vaughan CK, Ashworth R, Ray S, Behra M, Holder N, Talbot WS, Pearl LH, Strähle U, and Wilson SW

Development (Cambridge, England) 135(6):1147-56, 2008 Mar - Who cited this? | PubMed ID: 18256191 | Fulltext

4,5-diarylisoxazole hsp90 chaperone inhibitors: potential therapeutic agents for the treatment of cancer.

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Brough PA, Aherne W, Barril X, Borgognoni J, Boxall K, Cansfield JE, Cheung KM, Collins I, Davies NG, Drysdale MJ, Dymock B, Eccles SA, Finch H, Fink A, Hayes A, Howes R,

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Journal of medicinal chemistry 51(2):196-218, 2008 Jan 24 - Who cited this? | PubMed ID: 18020435 | Fulltext

DNA fragmentation-based combinatorial approaches to soluble protein expression Part I. Generating DNA fragment libraries.

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Prodromou C, Savva R, and Driscoll PC

Drug discovery today 12(21-22):931, 2007 Nov - Who cited this? | PubMed ID: 17993411 | Fulltext

DNA fragmentation based combinatorial approaches to soluble protein expression Part II: Library expression, screening and scale-up.

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Savva R, Prodromou C, and Driscoll PC

Drug discovery today 12(21-22):939-47, 2007 Nov - Who cited this? | PubMed ID: 17993412 | Fulltext

In the yeast heat shock response, Hsf1-directed induction of Hsp90 facilitates the activation of the Slt2 (Mpk1) mitogen-activated protein kinase required for cell integrity.

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Truman AW, Millson SH, Nuttall JM, Mollapour M, Prodromou C, and Piper PW

Eukaryotic cell 6(4):744, 2007 Apr - Who cited this? | PubMed ID: 17293484 | Fulltext

Inhibition of the heat shock protein 90 molecular chaperone in vitro and in vivo by novel, synthetic, potent resorcinylic pyrazole/isoxazole amide analogues.

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Sharp SY, Prodromou C, Boxall K, Powers MV, Holmes JL, Box G, Matthews TP, Cheung KM, Kalusa A, James K, Hayes A, Hardcastle A, Dymock B, Brough PA, Barril X, Cansfield JE,

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Molecular cancer therapeutics 6(4):1198, 2007 Apr - Who cited this? | PubMed ID: 17431102 | Fulltext

In vitro biological characterization of a novel, synthetic diaryl pyrazole resorcinol class of heat shock protein 90 inhibitors.

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Sharp SY, Boxall K, Rowlands M, Prodromou C, Roe SM, Maloney A, Powers M, Clarke PA, Box G, Sanderson S, Patterson L, Matthews TP, Cheung KM, Ball K, Hayes A, Raynaud F,

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Cancer research 67(5):2206, 2007 Mar 1 - Who cited this? | PubMed ID: 17332351 | Fulltext

Expressed in the yeast Saccharomyces cerevisiae, human ERK5 is a client of the Hsp90 chaperone that complements loss of the Slt2p (Mpk1p) cell integrity stress-activated protein kinase.

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Truman AW, Millson SH, Nuttall JM, King V, Mollapour M, Prodromou C, Pearl LH, and Piper PW

Eukaryotic cell 5(11):1914-24, 2006 Nov - Who cited this? | PubMed ID: 16950928 | Fulltext

Inhibition of Hsp90 with synthetic macrolactones: synthesis and structural and biological evaluation of ring and conformational analogs of radicicol.

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Proisy N, Sharp SY, Boxall K, Connelly S, Roe SM, Prodromou C, Slawin AM, Pearl LH, Workman P, and Moody CJ

Chemistry & biology 13(11):1203-15, 2006 Nov - Who cited this? | PubMed ID: 17114002 | Fulltext

Combinatorial Domain Hunting: An effective approach for the identification of soluble protein domains adaptable to high-throughput applications.

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Reich S, Puckey LH, Cheetham CL, Harris R, Ali AA, Bhattacharyya U, Maclagan K, Powell KA, Prodromou C, Pearl LH, Driscoll PC, and Savva R

Protein science : a publication of the Protein Society 15(10):2356-65, 2006 Oct - Who cited this? | PubMed ID: 17008718 | Fulltext

Structure of an Hsp90-Cdc37-Cdk4 complex.

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Vaughan CK, Gohlke U, Sobott F, Good VM, Ali MM, Prodromou C, Robinson CV, Saibil HR, and Pearl LH

Molecular cell 23(5):697, 2006 Sep 1 - Who cited this? | PubMed ID: 16949366 | Fulltext

Crystal structure of an Hsp90-nucleotide-p23/Sba1 closed chaperone complex.

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Ali MM, Roe SM, Vaughan CK, Meyer P, Panaretou B, Piper PW, Prodromou C, and Pearl LH

Nature 440(7087):1013-7, 2006 Apr 20 - Who cited this? | PubMed ID: 16625188 | Fulltext

Structure and mechanism of the Hsp90 molecular chaperone machinery.

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Pearl LH and Prodromou C

Annual review of biochemistry 75:271-94, 2006 - Who cited this? | PubMed ID: 16756493 | Fulltext

Chaperoned ubiquitylation--crystal structures of the CHIP U box E3 ubiquitin ligase and a CHIP-Ubc13-Uev1a complex.

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Zhang M, Windheim M, Roe SM, Peggie M, Cohen P, Prodromou C, and Pearl LH

Molecular cell 20(4):525, 2005 Nov 23 - Who cited this? | PubMed ID: 16307917 | Fulltext

The identification, synthesis, protein crystal structure and in vitro biochemical evaluation of a new 3,4-diarylpyrazole class of Hsp90 inhibitors.

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Cheung KM, Matthews TP, James K, Rowlands MG, Boxall KJ, Sharp SY, Maloney A, Roe SM, Prodromou C, Pearl LH, Aherne GW, McDonald E, and Workman P

Bioorganic & medicinal chemistry letters 15(14):3338-43, 2005 Jul 15 - Who cited this? | PubMed ID: 15955698 | Fulltext

A two-hybrid screen of the yeast proteome for Hsp90 interactors uncovers a novel Hsp90 chaperone requirement in the activity of a stress-activated mitogen-activated protein kinase, Slt2p (Mpk1p).

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Millson SH, Truman AW, King V, Prodromou C, Pearl LH, and Piper PW

Eukaryotic cell 4(5):849-60, 2005 May - Who cited this? | PubMed ID: 15879519 | Fulltext

Qri2/Nse4, a component of the essential Smc5/6 DNA repair complex.

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Hu B, Liao C, Millson SH, Mollapour M, Prodromou C, Pearl LH, Piper PW, and Panaretou B

Molecular microbiology 55(6):1735, 2005 Mar - Who cited this? | PubMed ID: 15752197 | Fulltext

Co-chaperone regulation of conformational switching in the Hsp90 ATPase cycle.

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Siligardi G, Hu B, Panaretou B, Piper PW, Pearl LH, and Prodromou C

The Journal of biological chemistry 279(50):51989-98, 2004 Dec 10 - Who cited this? | PubMed ID: 15466438 | Fulltext

High-throughput screening assay for inhibitors of heat-shock protein 90 ATPase activity.

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Rowlands MG, Newbatt YM, Prodromou C, Pearl LH, Workman P, and Aherne W

Analytical biochemistry 327(2):176-83, 2004 Apr 15 - Who cited this? | PubMed ID: 15051534 | Fulltext

Structural basis for recruitment of the ATPase activator Aha1 to the Hsp90 chaperone machinery.

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Meyer P, Prodromou C, Liao C, Hu B, Roe SM, Vaughan CK, Vlasic I, Panaretou B, Piper PW, and Pearl LH

The EMBO journal 23(6):1402-10, 2004 Mar 24 - Who cited this? | PubMed ID: 15039704 | Fulltext

Structural basis for recruitment of the ATPase activator Aha1 to the Hsp90 chaperone machinery.

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Meyer P, Prodromou C, Liao C, Hu B, Mark Roe S, Vaughan CK, Vlasic I, Panaretou B, Piper PW, and Pearl LH

The EMBO journal 23(3):511-9, 2004 Feb 11 - Who cited this? | PubMed ID: 14739935 | Fulltext

The Mechanism of Hsp90 regulation by the protein kinase-specific cochaperone p50(cdc37).

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Roe SM, Ali MM, Meyer P, Vaughan CK, Panaretou B, Piper PW, Prodromou C, and Pearl LH

Cell 116(1):87-98, 2004 Jan 9 - Who cited this? | PubMed ID: 14718169 | Fulltext

Investigating the protein-protein interactions of the yeast Hsp90 chaperone system by two-hybrid analysis: potential uses and limitations of this approach.

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Millson SH, Truman AW, Wolfram F, King V, Panaretou B, Prodromou C, Pearl LH, and Piper PW

Cell stress & chaperones 9(4):359-68, 2004 - Who cited this? | PubMed ID: 15633294 | Fulltext

Sensitivity to Hsp90-targeting drugs can arise with mutation to the Hsp90 chaperone, cochaperones and plasma membrane ATP binding cassette transporters of yeast.

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Piper PW, Millson SH, Mollapour M, Panaretou B, Siligardi G, Pearl LH, and Prodromou C

European journal of biochemistry / FEBS 270(23):4689-95, 2003 Dec - Who cited this? | PubMed ID: 14622256 | Fulltext

Structure and functional relationships of Hsp90.

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Prodromou C and Pearl LH

Current cancer drug targets 3(5):301-23, 2003 Oct - Who cited this? | PubMed ID: 14529383 | Fulltext

Structural and functional analysis of the middle segment of hsp90: implications for ATP hydrolysis and client protein and cochaperone interactions.

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Meyer P, Prodromou C, Hu B, Vaughan C, Roe SM, Panaretou B, Piper PW, and Pearl LH

Molecular cell 11(3):647-58, 2003 Mar - Who cited this? | PubMed ID: 12667448 | Fulltext

Yeast is selectively hypersensitised to heat shock protein 90 (Hsp90)-targetting drugs with heterologous expression of the human Hsp90beta, a property that can be exploited in screens for new Hsp90 chaperone inhibitors.

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Piper PW, Panaretou B, Millson SH, Trumana A, Mollapour M, Pearl LH, and Prodromou C

Gene 302(1-2):165-70, 2003 Jan 2 - Who cited this? | PubMed ID: 12527207 | Fulltext

Assays for HSP90 and inhibitors.

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Aherne W, Maloney A, Prodromou C, Rowlands MG, Hardcastle A, Boxall K, Clarke P, Walton MI, Pearl L, and Workman P

Methods in molecular medicine 85:149-61, 2003 - Who cited this? | PubMed ID: 12710206 | Fulltext

Activation of the ATPase activity of hsp90 by the stress-regulated cochaperone aha1.

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Panaretou B, Siligardi G, Meyer P, Maloney A, Sullivan JK, Singh S, Millson SH, Clarke PA, Naaby-Hansen S, Stein R, Cramer R, Mollapour M, Workman P, Piper PW, Pearl LH, and Prodromou C

Molecular cell 10(6):1307-18, 2002 Dec - Who cited this? | PubMed ID: 12504007 | Fulltext

Backbone resonance assignments of the 25kD N-terminal ATPase domain from the Hsp90 chaperone.

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Salek RM, Williams MA, Prodromou C, Pearl LH, and Ladbury JE

Journal of biomolecular NMR 23(4):327-8, 2002 Aug - Who cited this? | PubMed ID: 12398355 | Fulltext

Regulation of Hsp90 ATPase activity by the co-chaperone Cdc37p/p50cdc37.

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Siligardi G, Panaretou B, Meyer P, Singh S, Woolfson DN, Piper PW, Pearl LH, and Prodromou C

The Journal of biological chemistry 277(23):20151-9, 2002 Jun 7 - Who cited this? | PubMed ID: 11916974 | Fulltext

Structure, function, and mechanism of the Hsp90 molecular chaperone.

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Pearl LH and Prodromou C

Advances in protein chemistry 59:157-86, 2001 - Who cited this? | PubMed ID: 11868271 | Fulltext

The ATPase cycle of Hsp90 drives a molecular 'clamp' via transient dimerization of the N-terminal domains.

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Prodromou C, Panaretou B, Chohan S, Siligardi G, O'Brien R, Ladbury JE, Roe SM, Piper PW, and Pearl LH

The EMBO journal 19(16):4383-92, 2000 Aug 15 - Who cited this? | PubMed ID: 10944121 | Fulltext

Structure and in vivo function of Hsp90.

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Pearl LH and Prodromou C

Current opinion in structural biology 10(1):46-51, 2000 Feb - Who cited this? | PubMed ID: 10679459 | Fulltext

The Hsp90 of Candida albicans can confer Hsp90 functions in Saccharomyces cerevisiae: a potential model for the processes that generate immunogenic fragments of this molecular chaperone in C. albicans infections.

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Panaretou B, Sinclair K, Prodromou C, Johal J, Pearl L, and Piper PW

Microbiology (Reading, England) 145 ( Pt 12):3455-63, 1999 Dec - Who cited this? | PubMed ID: 10627043 | Fulltext

Regulation of Hsp90 ATPase activity by tetratricopeptide repeat (TPR)-domain co-chaperones.

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Prodromou C, Siligardi G, O'Brien R, Woolfson DN, Regan L, Panaretou B, Ladbury JE, Piper PW, and Pearl LH

The EMBO journal 18(3):754-62, 1999 Feb 1 - Who cited this? | PubMed ID: 9927435 | Fulltext

Structural basis for inhibition of the Hsp90 molecular chaperone by the antitumor antibiotics radicicol and geldanamycin.

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Roe SM, Prodromou C, O'Brien R, Ladbury JE, Piper PW, and Pearl LH

Journal of medicinal chemistry 42(2):260-6, 1999 Jan 28 - Who cited this? | PubMed ID: 9925731 | Fulltext

ATP binding and hydrolysis are essential to the function of the Hsp90 molecular chaperone in vivo.

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Panaretou B, Prodromou C, Roe SM, O'Brien R, Ladbury JE, Piper PW, and Pearl LH

The EMBO journal 17(16):4829-36, 1998 Aug 17 - Who cited this? | PubMed ID: 9707442 | Fulltext

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