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Papers authored by Potter BV

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Highly Potent First Examples of Dual Aromatase-Steroid Sulfatase Inhibitors based on a Biphenyl Template (dagger).

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Woo LW, Jackson T, Putey A, Cozier G, Leonard P, Acharya KR, Chander SK, Purohit A, Reed MJ, and Potter BV

Journal of medicinal chemistry 53(5):2155-70, 2010 Mar 11 - Who cited this? | PubMed ID: 20148564 | Fulltext

Class III beta-tubulin expression and in vitro resistance to microtubule targeting agents.

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Stengel C, Newman SP, Leese MP, Potter BV, Reed MJ, and Purohit A

British journal of cancer 102(2):316-24, 2010 Jan 19 - Who cited this? | PubMed ID: 20029418 | Fulltext

A novel inhibitor of the PI3K/Akt pathway based on the structure of inositol 1,3,4,5,6-pentakisphosphate.

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Falasca M, Chiozzotto D, Godage HY, Mazzoletti M, Riley AM, Previdi S, Potter BV, Broggini M, and Maffucci T

British journal of cancer 102(1):104-14, 2010 Jan 5 - Who cited this? | PubMed ID: 20051961 | Fulltext

Structural basis for enzymatic evolution from a dedicated ADP-ribosyl cyclase to a multifunctional NAD hydrolase.

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Liu Q, Graeff R, Kriksunov IA, Jiang H, Zhang B, Oppenheimer N, Lin H, Potter BV, Lee HC, and Hao Q

The Journal of biological chemistry 284(40):27637-45, 2009 Oct 2 - Who cited this? | PubMed ID: 19640846 | Fulltext

Determination of the absolute configuration of aromatase and dual aromatase-sulfatase inhibitors by vibrational and electronic circular dichroism spectra analysis.

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Abbate S, Longhi G, Castiglioni E, Lebon F, Wood PM, Woo LW, and Potter BV

Chirality 21(9):802-8, 2009 Oct - Who cited this? | PubMed ID: 19161217 | Fulltext

STX140 and STX641 Cause Apoptosis via the Intrinsic Mitochondrial Pathway and Down-regulate Survivin and XIAP Expression in Ovarian and Prostate Cancer Cells.

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Foster PA, Ho YT, Newman SP, Leese MP, Potter BV, Reed MJ, and Purohit A

Anticancer research 29(10):3751-7, 2009 Oct - Who cited this? | PubMed ID: 19846905 | Fulltext

Synthetic partial agonists reveal key steps in IP3 receptor activation.

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Rossi AM, Riley AM, Tovey SC, Rahman T, Dellis O, Taylor EJ, Veresov VG, Potter BV, and Taylor CW

Nature chemical biology 5(9):631-9, 2009 Sep - Who cited this? | PubMed ID: 19668195 | Fulltext

The behaviour of inositol 1,3,4,5,6-pentakisphosphate in the presence of the major biological metal cations.

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Veiga N, Torres J, Godage HY, Riley AM, Domínguez S, Potter BV, Díaz A, and Kremer C

Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 14(7):1001-13, 2009 Sep - Who cited this? | PubMed ID: 19415348 | Fulltext

8-Bromo-cyclic inosine diphosphoribose: towards a selective cyclic ADP-ribose agonist.

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Kirchberger T, Moreau C, Wagner GK, Fliegert R, Siebrands CC, Nebel M, Schmid F, Harneit A, Odoardi F, Flügel A, Potter BV, and Guse AH

The Biochemical journal 422(1):139-49, 2009 Aug 15 - Who cited this? | PubMed ID: 19492987 | Fulltext

NAADP-mediated Ca2+ signaling via type 1 ryanodine receptor in T cells revealed by a synthetic NAADP antagonist.

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Dammermann W, Zhang B, Nebel M, Cordiglieri C, Odoardi F, Kirchberger T, Kawakami N, Dowden J, Schmid F, Dornmair K, Hohenegger M, Flügel A, Guse AH, and Potter BV

Proceedings of the National Academy of Sciences of the United States of America 106(26):10678-83, 2009 Jun 30 - Who cited this? | PubMed ID: 19541638 | Fulltext

The design of novel 17beta-hydroxysteroid dehydrogenase type 3 inhibitors.

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Vicker N, Sharland CM, Heaton WB, Gonzalez AM, Bailey HV, Smith A, Springall JS, Day JM, Tutill HJ, Reed MJ, Purohit A, and Potter BV

Molecular and cellular endocrinology 301(1-2):259-65, 2009 Mar 25 - Who cited this? | PubMed ID: 18775469 | Fulltext

Discovery of novel inhibitors of human 11beta-hydroxysteroid dehydrogenase type 1.

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Su X, Vicker N, Trusselle M, Halem H, Culler MD, and Potter BV

Molecular and cellular endocrinology 301(1-2):169-73, 2009 Mar 25 - Who cited this? | PubMed ID: 18775471 | Fulltext

Development of hormone-dependent prostate cancer models for the evaluation of inhibitors of 17beta-hydroxysteroid dehydrogenase Type 3.

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Day JM, Tutill HJ, Foster PA, Bailey HV, Heaton WB, Sharland CM, Vicker N, Potter BV, Purohit A, and Reed MJ

Molecular and cellular endocrinology 301(1-2):251-8, 2009 Mar 25 - Who cited this? | PubMed ID: 18786604 | Fulltext

Activation of IP(3) receptors by synthetic bisphosphate ligands.

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Sureshan KM, Riley AM, Rossi AM, Tovey SC, Dedos SG, Taylor CW, and Potter BV

Chemical communications (Cambridge, England)(10):1204-6, 2009 Mar 14 - Who cited this? | PubMed ID: 19240874 | Fulltext

BCRP expression does not result in resistance to STX140 in vivo, despite the increased expression of BCRP in A2780 cells in vitro after long-term STX140 exposure.

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Day JM, Foster PA, Tutill HJ, Newman SP, Ho YT, Leese MP, Potter BV, Reed MJ, and Purohit A

British journal of cancer 100(3):476-86, 2009 Feb 10 - Who cited this? | PubMed ID: 19156141 | Fulltext

The development of steroid sulfatase inhibitors for hormone-dependent cancer therapy.

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Day JM, Purohit A, Tutill HJ, Foster PA, Woo LW, Potter BV, and Reed MJ

Annals of the New York Academy of Sciences 1155:80-7, 2009 Feb - Who cited this? | PubMed ID: 19250195 | Fulltext

2-Methoxyoestradiol-3,17-O,O-bis-sulphamate and 2-deoxy-D-glucose in combination: a potential treatment for breast and prostate cancer.

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Tagg SL, Foster PA, Leese MP, Potter BV, Reed MJ, Purohit A, and Newman SP

British journal of cancer 99(11):1842-8, 2008 Dec 2 - Who cited this? | PubMed ID: 18985042 | Fulltext

Effects of C-17 heterocyclic substituents on the anticancer activity of 2-ethylestra-1,3,5(10)-triene-3-O-sulfamates: synthesis, in vitro evaluation and computational modelling.

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Jourdan F, Bubert C, Leese MP, Smith A, Ferrandis E, Regis-Lydi S, Newman SP, Purohit A, Reed MJ, and Potter BV

Organic & biomolecular chemistry 6(22):4108-19, 2008 Nov 21 - Who cited this? | PubMed ID: 18972041 | Fulltext

The in vivo properties of STX243: a potent angiogenesis inhibitor in breast cancer.

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Parsons MF, Foster PA, Chander SK, Jhalli R, Newman SP, Leese MP, Potter BV, Purohit A, and Reed MJ

British journal of cancer 99(9):1433-41, 2008 Nov 4 - Who cited this? | PubMed ID: 18841154 | Fulltext

A New Therapeutic Strategy against Hormone-Dependent Breast Cancer: The Preclinical Development of a Dual Aromatase and Sulfatase Inhibitor.

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Foster PA, Chander SK, Newman SP, Woo LW, Sutcliffe OB, Bubert C, Zhou D, Chen S, Potter BV, Reed MJ, and Purohit A

Clinical cancer research : an official journal of the American Association for Cancer Research 14(20):6469-77, 2008 Oct 15 - Who cited this? | PubMed ID: 18927286 | Fulltext

Synthesis of Aromatase Inhibitors and Dual Aromatase Steroid Sulfatase Inhibitors by Linking an Arylsulfamate Motif to 4-(4H-1,2,4-triazol-4-ylamino)benzonitrile: SAR, Crystal Structures, in vitro and in vivo Activities.

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Bubert C, Woo LW, Sutcliffe OB, Mahon MF, Chander SK, Purohit A, Reed MJ, and Potter BV

ChemMedChem, 2008 Sep 24 - Who cited this? | PubMed ID: 18816537 | Fulltext

2-MeOE2bisMATE and 2-EtE2bisMATE induce cell cycle arrest and apoptosis in breast cancer xenografts as shown by a novel ex vivo technique.

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Foster PA, Ho YT, Newman SP, Kasprzyk PG, Leese MP, Potter BV, Reed MJ, and Purohit A

Breast cancer research and treatment 111(2):251-60, 2008 Sep - Who cited this? | PubMed ID: 17957467 | Fulltext

The use of steroid sulfatase inhibitors as a novel therapeutic strategy against hormone-dependent endometrial cancer.

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Foster PA, Woo LW, Potter BV, Reed MJ, and Purohit A

Endocrinology 149(8):4035, 2008 Aug - Who cited this? | PubMed ID: 18450955 | Fulltext

Anticancer steroid sulfatase inhibitors: synthesis of a potent fluorinated second-generation agent, in vitro and in vivo activities, molecular modeling, and protein crystallography.

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Woo LW, Fischer DS, Sharland CM, Trusselle M, Foster PA, Chander SK, Di Fiore A, Supuran CT, De Simone G, Purohit A, Reed MJ, and Potter BV

Molecular cancer therapeutics 7(8):2435-44, 2008 Aug - Who cited this? | PubMed ID: 18723489 | Fulltext

Chiral aromatase and dual aromatase-steroid sulfatase inhibitors from the letrozole template: synthesis, absolute configuration, and in vitro activity.

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Wood PM, Woo LW, Labrosse JR, Trusselle MN, Abbate S, Longhi G, Castiglioni E, Lebon F, Purohit A, Reed MJ, and Potter BV

Journal of medicinal chemistry 51(14):4226-38, 2008 Jul 24 - Who cited this? | PubMed ID: 18590272 | Fulltext

Benzene polyphosphates as tools for cell signalling: inhibition of inositol 1,4,5-trisphosphate 5-phosphatase and interaction with the PH domain of protein kinase Balpha.

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Mills SJ, Vandeput F, Trusselle MN, Safrany ST, Erneux C, and Potter BV

Chembiochem : a European journal of chemical biology 9(11):1757-66, 2008 Jul 21 - Who cited this? | PubMed ID: 18574825 | Fulltext

17beta-hydroxysteroid dehydrogenase Type 1, and not Type 12, is a target for endocrine therapy of hormone-dependent breast cancer.

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Day JM, Foster PA, Tutill HJ, Parsons MF, Newman SP, Chander SK, Allan GM, Lawrence HR, Vicker N, Potter BV, Reed MJ, and Purohit A

International journal of cancer. Journal international du cancer 122(9):1931, 2008 May 1 - Who cited this? | PubMed ID: 18183589 | Fulltext

Novel inhibitors of 17beta-hydroxysteroid dehydrogenase type 1: Templates for design.

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Allan GM, Vicker N, Lawrence HR, Tutill HJ, Day JM, Huchet M, Ferrandis E, Reed MJ, Purohit A, and Potter BV

Bioorganic & medicinal chemistry 16(8):4438-56, 2008 Apr 15 - Who cited this? | PubMed ID: 18329273 | Fulltext

Non-steroidal aromatase inhibitors based on a biphenyl scaffold: synthesis, in vitro SAR, and molecular modelling.

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Jackson T, Woo LW, Trusselle MN, Purohit A, Reed MJ, and Potter BV

ChemMedChem 3(4):603-18, 2008 Apr - Who cited this? | PubMed ID: 18236493 | Fulltext

2'-deoxy cyclic adenosine 5'-diphosphate ribose derivatives: importance of the 2'-hydroxyl motif for the antagonistic activity of 8-substituted cADPR derivatives.

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Zhang B, Wagner GK, Weber K, Garnham C, Morgan AJ, Galione A, Guse AH, and Potter BV

Journal of medicinal chemistry 51(6):1623, 2008 Mar 27 - Who cited this? | PubMed ID: 18303825 | Fulltext

Structure-activity relationships of C-17 cyano-substituted estratrienes as anticancer agents.

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Leese MP, Jourdan FL, Gaukroger K, Mahon MF, Newman SP, Foster PA, Stengel C, Regis-Lydi S, Ferrandis E, Fiore AD, De Simone G, Supuran CT, Purohit A, Reed MJ, and Potter BV

Journal of medicinal chemistry 51(5):1295-308, 2008 Mar 13 - Who cited this? | PubMed ID: 18260615 | Fulltext

Chemoenzymatic synthesis of 7-deaza cyclic adenosine 5'-diphosphate ribose analogues, membrane-permeant modulators of intracellular calcium release.

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Zhang B, Bailey VC, and Potter BV

The Journal of organic chemistry 73(5):1693, 2008 Mar 7 - Who cited this? | PubMed ID: 18229937 | Fulltext

2-Position base-modified analogues of adenophostin A as high-affinity agonists of the D-myo-inositol trisphosphate receptor: in vitro evaluation and molecular modeling.

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Sureshan KM, Trusselle M, Tovey SC, Taylor CW, and Potter BV

The Journal of organic chemistry 73(5):1682, 2008 Mar 7 - Who cited this? | PubMed ID: 18247493 | Fulltext

Direct evidence for ArO-S bond cleavage upon inactivation of Pseudomonas aeruginosa arylsulfatase by aryl sulfamates.

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Bojarová P, Denehy E, Walker I, Loft K, De Souza DP, Woo LW, Potter BV, McConville MJ, and Williams SJ

Chembiochem : a European journal of chemical biology 9(4):613-23, 2008 Mar 3 - Who cited this? | PubMed ID: 18288656 | Fulltext

Inhibition of steroid sulphatase activity in endometriotic implants by 667 COUMATE: a potential new therapy.

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Purohit A, Fusi L, Brosens J, Woo LW, Potter BV, and Reed MJ

Human reproduction (Oxford, England) 23(2):290-7, 2008 Feb - Who cited this? | PubMed ID: 18056119 | Fulltext

STX140 Is Efficacious In vitro and In vivo in Taxane-Resistant Breast Carcinoma Cells.

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Newman SP, Foster PA, Stengel C, Day JM, Ho YT, Judde JG, Lassalle M, Prevost G, Leese MP, Potter BV, Reed MJ, and Purohit A

Clinical cancer research : an official journal of the American Association for Cancer Research 14(2):597-606, 2008 Jan 15 - Who cited this? | PubMed ID: 18223236 | Fulltext

2 inhibitors of 11beta-hydroxysteroid dehydrogenase type 1.

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Su X, Vicker N, and Potter BV

Progress in medicinal chemistry 46:29-130, 2008 - Who cited this? | PubMed ID: 18381124 | Fulltext

A new micronized formulation of 2-methoxyestradiol-bis-sulfamate (STX140) is therapeutically potent against breast cancer.

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Foster PA, Newman SP, Leese MP, Bernetiere S, Diolez C, Camara J, Hacher B, Baronnet MM, Ali T, Potter BV, Reed MJ, and Purohit A

Anticancer research 28(2A):577-81, 2008 - Who cited this? | PubMed ID: 18506995 | Fulltext

A comparison of two orally bioavailable anti-cancer agents, IRC-110160 and STX140.

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Foster PA, Stengel C, Ali T, Leese MP, Potter BV, Reed MJ, Purohit A, and Newman SP

Anticancer research 28(3A):1483-91, 2008 - Who cited this? | PubMed ID: 18630502 | Fulltext

Inhibition of steroid sulphatase activity via the percutaneous route: a new option for breast cancer therapy.

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Purohit A, Chander SK, Woo LW, Parsons MF, Jhalli R, Potter BV, and Reed MJ

Anticancer research 28(3A):1517-23, 2008 - Who cited this? | PubMed ID: 18630506 | Fulltext

Inhibition of Steroid Sulfatase Activity in Endometriotic Implants by STX64 (667Coumate): A Potential New Therapy.

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Fusi L, Purohit A, Brosens J, Woo LW, Potter BV, and Reed MJ

TheScientificWorldJournal 8:1325-7, 2008 - Who cited this? | PubMed ID: 19112542 | Fulltext

The therapeutic potential of a series of orally bioavailable anti-angiogenic microtubule disruptors as therapy for hormone-independent prostate and breast cancers.

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Newman SP, Foster PA, Ho YT, Day JM, Raobaikady B, Kasprzyk PG, Leese MP, Potter BV, Reed MJ, and Purohit A

British journal of cancer 97(12):1673-82, 2007 Dec 17 - Who cited this? | PubMed ID: 18026194 | Fulltext

Dual aromatase-sulfatase inhibitors based on the anastrozole template: synthesis, in vitro SAR, molecular modelling and in vivo activity.

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Jackson T, Woo LW, Trusselle MN, Chander SK, Purohit A, Reed MJ, and Potter BV

Organic & biomolecular chemistry 5(20):3369-81, 2007 Oct 21 - Who cited this? | PubMed ID: 17972413 | Fulltext

Efficacy of three potent steroid sulfatase inhibitors: pre-clinical investigations for their use in the treatment of hormone-dependent breast cancer.

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Foster PA, Chander SK, Parsons MF, Newman SP, Woo LW, Potter BV, Reed MJ, and Purohit A

Breast cancer research and treatment, 2007 Oct 4 - Who cited this? | PubMed ID: 17914670 | Fulltext

Dual aromatase-sulfatase inhibitors based on the anastrozole template: synthesis, in vitro SAR, molecular modelling and in vivo activity.

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Jackson T, Woo LW, Trusselle MN, Chander SK, Purohit A, Reed MJ, and Potter BV

Organic & biomolecular chemistry 5(18):2940-52, 2007 Sep 21 - Who cited this? | PubMed ID: 17728860 | Fulltext

3,17-disubstituted 2-alkylestra-1,3,5(10)-trien-3-ol derivatives: synthesis, in vitro and in vivo anticancer activity.

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Bubert C, Leese MP, Mahon MF, Ferrandis E, Regis-Lydi S, Kasprzyk PG, Newman SP, Ho YT, Purohit A, Reed MJ, and Potter BV

Journal of medicinal chemistry 50(18):4431-43, 2007 Sep 6 - Who cited this? | PubMed ID: 17696419 | Fulltext

Catalysis-associated conformational changes revealed by human CD38 complexed with a non-hydrolyzable substrate analog.

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Liu Q, Kriksunov IA, Moreau C, Graeff R, Potter BV, Lee HC, and Hao Q

The Journal of biological chemistry 282(34):24825-32, 2007 Aug 24 - Who cited this? | PubMed ID: 17591784 | Fulltext

Dual aromatase-steroid sulfatase inhibitors.

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Woo LW, Bubert C, Sutcliffe OB, Smith A, Chander SK, Mahon MF, Purohit A, Reed MJ, and Potter BV

Journal of medicinal chemistry 50(15):3540-60, 2007 Jul 26 - Who cited this? | PubMed ID: 17580845 | Fulltext

In vivo inhibition of angiogenesis by sulphamoylated derivatives of 2-methoxyoestradiol.

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Chander SK, Foster PA, Leese MP, Newman SP, Potter BV, Purohit A, and Reed MJ

British journal of cancer 96(9):1368, 2007 May 7 - Who cited this? | PubMed ID: 17426705 | Fulltext

Biphenyl 2,3',4,5',6-pentakisphosphate, a novel inositol polyphosphate surrogate, modulates Ca2+ responses in rat hepatocytes.

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Vandeput F, Combettes L, Mills SJ, Backers K, Wohlkönig A, Parys JB, De Smedt H, Missiaen L, Dupont G, Potter BV, and Erneux C

The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 21(7):1481-91, 2007 May - Who cited this? | PubMed ID: 17264160 | Fulltext

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