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Papers authored by Ploegh HL

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Subtilase cytotoxin cleaves newly synthesized BiP and blocks antibody secretion in B lymphocytes.

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Hu CC, Dougan SK, Winter SV, Paton AW, Paton JC, and Ploegh HL

The Journal of experimental medicine 206(11):2429-40, 2009 Oct 26 - Who cited this? | PubMed ID: 19808260 | Fulltext

The Otubain YOD1 Is a Deubiquitinating Enzyme that Associates with p97 to Facilitate Protein Dislocation from the ER.

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Ernst R, Mueller B, Ploegh HL, and Schlieker C

Molecular cell 36(1):28-38, 2009 Oct 9 - Who cited this? | PubMed ID: 19818707 | Fulltext

A gammaherpesvirus ubiquitin-specific protease is involved in the establishment of murine gammaherpesvirus 68 infection.

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Gredmark-Russ S, Isaacson MK, Kattenhorn L, Cheung EJ, Watson N, and Ploegh HL

Journal of virology 83(20):10644-52, 2009 Oct - Who cited this? | PubMed ID: 19706716 | Fulltext

XBP-1-deficient plasmablasts show normal protein folding but altered glycosylation and lipid synthesis.

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McGehee AM, Dougan SK, Klemm EJ, Shui G, Park B, Kim YM, Watson N, Wenk MR, Ploegh HL, and Hu CC

Journal of immunology (Baltimore, Md. : 1950) 183(6):3690-9, 2009 Sep 15 - Who cited this? | PubMed ID: 19710472 | Fulltext

Site-specific N- and C-terminal labeling of a single polypeptide using sortases of different specificity.

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Antos JM, Chew GL, Guimaraes CP, Yoder NC, Grotenbreg GM, Popp MW, and Ploegh HL

Journal of the American Chemical Society 131(31):10800-1, 2009 Aug 12 - Who cited this? | PubMed ID: 19610623 | Fulltext

Cathepsin S Regulates Class II MHC Processing in Human CD4+ HLA-DR+ T Cells.

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Costantino CM, Ploegh HL, and Hafler DA

Journal of immunology (Baltimore, Md. : 1950) 183(2):945-52, 2009 Jul 15 - Who cited this? | PubMed ID: 19553543 | Fulltext

Ubiquitination, Ubiquitin-like Modifiers, and Deubiquitination in Viral Infection.

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Isaacson MK and Ploegh HL

Cell host & microbe 5(6):559-70, 2009 Jun 18 - Who cited this? | PubMed ID: 19527883 | Fulltext

A straight path to circular proteins.

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Antos JM, Popp MW, Ernst R, Chew GL, Spooner E, and Ploegh HL

The Journal of biological chemistry 284(23):16028-36, 2009 Jun 5 - Who cited this? | PubMed ID: 19359246 | Fulltext

XBP-1 regulates signal transduction, transcription factors and bone marrow colonization in B cells.

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Hu CC, Dougan SK, McGehee AM, Love JC, and Ploegh HL

The EMBO journal 28(11):1624-36, 2009 Jun 3 - Who cited this? | PubMed ID: 19407814 | Fulltext

Ubiquitin C-terminal electrophiles are activity-based probes for identification and mechanistic study of ubiquitin conjugating machinery.

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Love KR, Pandya RK, Spooner E, and Ploegh HL

ACS chemical biology 4(4):275-87, 2009 Apr 17 - Who cited this? | PubMed ID: 19256548 | Fulltext

Site-specific protein labeling via sortase-mediated transpeptidation.

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Popp MW, Antos JM, and Ploegh HL

Current protocols in protein science / editorial board, John E. Coligan ... [et al.] Chapter 15:Unit 15.3, 2009 Apr - Who cited this? | PubMed ID: 19365788 | Fulltext

Substrate Filtering by the Active Site Crossover Loop in UCHL3 Revealed by Sortagging and Gain-of-function Mutations.

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Popp MW, Artavanis-Tsakonas K, and Ploegh HL

The Journal of biological chemistry 284(6):3593-602, 2009 Feb 6 - Who cited this? | PubMed ID: 19047059 | Fulltext

Parasite Stage-Specific Recognition of Endogenous Toxoplasma gondii-Derived CD8(+) T Cell Epitopes.

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Frickel EM, Sahoo N, Hopp J, Gubbels MJ, Craver MP, Knoll LJ, Ploegh HL, and Grotenbreg GM

The Journal of infectious diseases 198(11):1625-33, 2008 Dec 1 - Who cited this? | PubMed ID: 18922097 | Fulltext

Proteolytic cleavage in an endolysosomal compartment is required for activation of Toll-like receptor 9.

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Park B, Brinkmann MM, Spooner E, Lee CC, Kim YM, and Ploegh HL

Nature immunology 9(12):1407-14, 2008 Dec - Who cited this? | PubMed ID: 18931679 | Fulltext

A functional proteomics approach links the ubiquitin-related modifier Urm1 to a tRNA modification pathway.

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Schlieker CD, Van der Veen AG, Damon JR, Spooner E, and Ploegh HL

Proceedings of the National Academy of Sciences of the United States of America 105(47):18255-60, 2008 Nov 25 - Who cited this? | PubMed ID: 19017811 | Fulltext

Profiling antibody responses by multiparametric analysis of primary B cells.

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Story CM, Papa E, Hu CC, Ronan JL, Herlihy K, Ploegh HL, and Love JC

Proceedings of the National Academy of Sciences of the United States of America 105(46):17902-7, 2008 Nov 18 - Who cited this? | PubMed ID: 19004776 | Fulltext

Lipid Modification of Proteins through Sortase-Catalyzed Transpeptidation.

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Antos JM, Miller GM, Grotenbreg GM, and Ploegh HL

Journal of the American Chemical Society, 2008 Nov 7 - Who cited this? | PubMed ID: 18989959 | Fulltext

The CD8 T cell response against Murine gamma herpes virus (MHV-68) is directed towards a broad repertoire of epitopes from both early and late antigens.

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Gredmark-Russ S, Cheung EJ, Isaacson MK, Ploegh HL, and Grotenbreg GM

Journal of virology, 2008 Oct 15 - Who cited this? | PubMed ID: 18922872 | Fulltext

SEL1L nucleates a protein complex required for dislocation of misfolded glycoproteins.

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Mueller B, Klemm EJ, Spooner E, Claessen JH, and Ploegh HL

Proceedings of the National Academy of Sciences of the United States of America 105(34):12325-30, 2008 Aug 26 - Who cited this? | PubMed ID: 18711132 | Fulltext

Differential effects of Usp14 and Uch-L1 on the ubiquitin proteasome system and synaptic activity.

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Walters BJ, Campbell SL, Chen PC, Taylor AP, Schroeder DG, Dobrunz LE, Artavanis-Tsakonas K, Ploegh HL, Wilson JA, Cox GA, and Wilson SM

Molecular and cellular neurosciences, 2008 Aug 15 - Who cited this? | PubMed ID: 18771733 | Fulltext

The known unknowns of antigen processing and presentation.

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Vyas JM, Van der Veen AG, and Ploegh HL

Nature reviews. Immunology 8(8):607-18, 2008 Aug - Who cited this? | PubMed ID: 18641646 | Fulltext

Concurrent detection of secreted products from human lymphocytes by microengraving: Cytokines and antigen-reactive antibodies.

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Bradshaw EM, Kent SC, Tripuraneni V, Orban T, Ploegh HL, Hafler DA, and Love JC

Clinical immunology (Orlando, Fla.), 2008 Jul 31 - Who cited this? | PubMed ID: 18675591 | Fulltext

UNC93B1 delivers nucleotide-sensing toll-like receptors to endolysosomes.

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Kim YM, Brinkmann MM, Paquet ME, and Ploegh HL

Nature 452(7184):234-8, 2008 Mar 13 - Who cited this? | PubMed ID: 18305481 | Fulltext

Discovery of CD8+ T cell epitopes in Chlamydia trachomatis infection through use of caged class I MHC tetramers.

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Grotenbreg GM, Roan NR, Guillen E, Meijers R, Wang JH, Bell GW, Starnbach MN, and Ploegh HL

Proceedings of the National Academy of Sciences of the United States of America 105(10):3831, 2008 Mar 11 - Who cited this? | PubMed ID: 18245382 | Fulltext

Lysosomal cysteine and aspartic proteases are heterogeneously expressed and act redundantly to initiate human invariant chain degradation.

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Costantino CM, Hang HC, Kent SC, Hafler DA, and Ploegh HL

Journal of immunology (Baltimore, Md. : 1950) 180(5):2876-85, 2008 Mar 1 - Who cited this? | PubMed ID: 18292509 | Fulltext

N-linked glycosylation does not impair proteasomal degradation but affects class I major histocompatibility complex presentation.

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Kario E, Tirosh B, Ploegh HL, and Navon A

The Journal of biological chemistry 283(1):244-54, 2008 Jan 4 - Who cited this? | PubMed ID: 17951257 | Fulltext

Erratum.

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Gounaris E, Tung CH, Restaino C, Maehr R, Kohler R, Joyce JA, Ploegh HL, Barrett TA, Weissleder R, and Khazaie K

PLoS ONE 3(10), 2008 - Who cited this? | PubMed ID: 18958296 | Fulltext

Bridging B cell and T cell recognition of antigen.

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Ploegh HL

Journal of immunology (Baltimore, Md. : 1950) 179(11):7193, 2007 Dec 1 - Who cited this? | PubMed ID: 18025158 | Fulltext

Sortagging: a versatile method for protein labeling.

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Popp MW, Antos JM, Grotenbreg GM, Spooner E, and Ploegh HL

Nature chemical biology 3(11):707-8, 2007 Nov - Who cited this? | PubMed ID: 17891153 | Fulltext

Mechanisms, biology and inhibitors of deubiquitinating enzymes.

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Love KR, Catic A, Schlieker C, and Ploegh HL

Nature chemical biology 3(11):697-705, 2007 Nov - Who cited this? | PubMed ID: 17948018 | Fulltext

A functional ubiquitin-specific protease embedded in the large tegument protein (ORF64) of murine gammaherpesvirus 68 is active during the course of infection.

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Gredmark S, Schlieker C, Quesada V, Spooner E, and Ploegh HL

Journal of virology 81(19):10300-9, 2007 Oct - Who cited this? | PubMed ID: 17634221 | Fulltext

The peptide cargo of class I molecules: not just passive passengers.

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Ploegh HL

Journal of immunology (Baltimore, Md. : 1950) 179(7):4299-300, 2007 Oct 1 - Who cited this? | PubMed ID: 17878322 | Fulltext

Differential priming of CD8 and CD4 T-cells in animal models of autoimmune hepatitis and cholangitis.

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Derkow K, Loddenkemper C, Mintern J, Kruse N, Klugewitz K, Berg T, Wiedenmann B, Ploegh HL, and Schott E

Hepatology (Baltimore, Md.) 46(4):1155-65, 2007 Oct - Who cited this? | PubMed ID: 17657820 | Fulltext

A lipid-based model for the creation of an escape hatch from the endoplasmic reticulum.

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Ploegh HL

Nature 448(7152):435-8, 2007 Jul 26 - Who cited this? | PubMed ID: 17653186 | Fulltext

Sequence and structure evolved separately in a ribosomal ubiquitin variant.

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Catic A, Sun ZY, Ratner DM, Misaghi S, Spooner E, Samuelson J, Wagner G, and Ploegh HL

The EMBO journal 26(14):3474-83, 2007 Jul 25 - Who cited this? | PubMed ID: 17599068 | Fulltext

Empty class II major histocompatibility complex created by peptide photolysis establishes the role of DM in peptide association.

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Grotenbreg GM, Nicholson MJ, Fowler KD, Wilbuer K, Octavio L, Yang M, Chakraborty AK, Ploegh HL, and Wucherpfennig KW

The Journal of biological chemistry 282(29):21425-36, 2007 Jul 20 - Who cited this? | PubMed ID: 17525157 | Fulltext

TLRs bent into shape.

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Kim YM, Brinkmann MM, and Ploegh HL

Nature immunology 8(7):675-7, 2007 Jul - Who cited this? | PubMed ID: 17579642 | Fulltext

The mouse polyubiquitin gene UbC is essential for fetal liver development, cell-cycle progression and stress tolerance.

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Ryu KY, Maehr R, Gilchrist CA, Long MA, Bouley DM, Mueller B, Ploegh HL, and Kopito RR

The EMBO journal 26(11):2693, 2007 Jun 6 - Who cited this? | PubMed ID: 17491588 | Fulltext

Tubulation of class II MHC compartments is microtubule dependent and involves multiple endolysosomal membrane proteins in primary dendritic cells.

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Vyas JM, Kim YM, Artavanis-Tsakonas K, Love JC, Van der Veen AG, and Ploegh HL

Journal of immunology (Baltimore, Md. : 1950) 178(11):7199-210, 2007 Jun 1 - Who cited this? | PubMed ID: 17513769 | Fulltext

The interaction between the ER membrane protein UNC93B and TLR3, 7, and 9 is crucial for TLR signaling.

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Brinkmann MM, Spooner E, Hoebe K, Beutler B, Ploegh HL, and Kim YM

The Journal of cell biology 177(2):265, 2007 Apr 23 - Who cited this? | PubMed ID: 17452530 | Fulltext

Chemical probes for the rapid detection of Fatty-acylated proteins in Mammalian cells.

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Hang HC, Geutjes EJ, Grotenbreg G, Pollington AM, Bijlmakers MJ, and Ploegh HL

Journal of the American Chemical Society 129(10):2744-5, 2007 Mar 14 - Who cited this? | PubMed ID: 17305342 | Fulltext

Structure of a herpesvirus-encoded cysteine protease reveals a unique class of deubiquitinating enzymes.

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Schlieker C, Weihofen WA, Frijns E, Kattenhorn LM, Gaudet R, and Ploegh HL

Molecular cell 25(5):677-87, 2007 Mar 9 - Who cited this? | PubMed ID: 17349955 | Fulltext

AID-/-mus-/- mice are agammaglobulinemic and fail to maintain B220-CD138+ plasma cells.

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Kumazaki K, Tirosh B, Maehr R, Boes M, Honjo T, and Ploegh HL

Journal of immunology (Baltimore, Md. : 1950) 178(4):2192-203, 2007 Feb 15 - Who cited this? | PubMed ID: 17277124 | Fulltext

ElaD, a Deubiquitinating protease expressed by E. coli.

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Catic A, Misaghi S, Korbel GA, and Ploegh HL

PLoS ONE 2(4), 2007 - Who cited this? | PubMed ID: 17440617 | Fulltext

Screen for ISG15-crossreactive deubiquitinases.

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Catic A, Fiebiger E, Korbel GA, Blom D, Galardy PJ, and Ploegh HL

PLoS ONE 2(7), 2007 - Who cited this? | PubMed ID: 17653289 | Fulltext

Mechanism-based probe for the analysis of cathepsin cysteine proteases in living cells.

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Hang HC, Loureiro J, Spooner E, van der Velden AW, Kim YM, Pollington AM, Maehr R, Starnbach MN, and Ploegh HL

ACS chemical biology 1(11):713-23, 2006 Dec 20 - Who cited this? | PubMed ID: 17184136 | Fulltext

Viral interference with B7-1 costimulation: a new role for murine cytomegalovirus fc receptor-1.

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Mintern JD, Klemm EJ, Wagner M, Paquet ME, Napier MD, Kim YM, Koszinowski UH, and Ploegh HL

Journal of immunology (Baltimore, Md. : 1950) 177(12):8422-31, 2006 Dec 15 - Who cited this? | PubMed ID: 17142739 | Fulltext

Development of intravital intermittent confocal imaging system for studying Langerhans cell turnover.

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Vishwanath M, Nishibu A, Saeland S, Ward BR, Mizumoto N, Ploegh HL, Boes M, and Takashima A

The Journal of investigative dermatology 126(11):2452-7, 2006 Nov - Who cited this? | PubMed ID: 16794586 | Fulltext

Recruitment of CD63 to Cryptococcus neoformans phagosomes requires acidification.

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Artavanis-Tsakonas K, Love JC, Ploegh HL, and Vyas JM

Proceedings of the National Academy of Sciences of the United States of America 103(43):15945-50, 2006 Oct 24 - Who cited this? | PubMed ID: 17043215 | Fulltext

SEL1L, the homologue of yeast Hrd3p, is involved in protein dislocation from the mammalian ER.

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Mueller B, Lilley BN, and Ploegh HL

The Journal of cell biology 175(2):261, 2006 Oct 23 - Who cited this? | PubMed ID: 17043138 | Fulltext

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