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Papers authored by Persons DA

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Statins protect against fulminant pneumococcal infection and cytolysin toxicity in a mouse model of sickle cell disease.

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Rosch JW, Boyd AR, Hinojosa E, Pestina T, Hu Y, Persons DA, Orihuela CJ, and Tuomanen EI

The Journal of clinical investigation 120(2):627-35, 2010 Feb 1 - Who cited this? | PubMed ID: 20093777 | Fulltext

Amelioration of murine beta-thalassemia through drug selection of hematopoietic stem cells transduced with a lentiviral vector encoding both gamma-globin and the MGMT drug-resistance gene.

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Zhao H, Pestina TI, Nasimuzzaman M, Mehta P, Hargrove PW, and Persons DA

Blood 113(23):5747-56, 2009 Jun 4 - Who cited this? | PubMed ID: 19365082 | Fulltext

Sustained high-level polyclonal hematopoietic marking and transgene expression 4 years after autologous transplantation of rhesus macaques with SIV lentiviral vector-transduced CD34+ cells.

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Kim YJ, Kim YS, Larochelle A, Renaud G, Wolfsberg TG, Adler R, Donahue RE, Hematti P, Hong BK, Roayaei J, Akagi K, Riberdy JM, Nienhuis AW, Dunbar CE, and Persons DA

Blood 113(22):5434-43, 2009 May 28 - Who cited this? | PubMed ID: 19339698 | Fulltext

Genetically Modified CD34+ Hematopoietic Stem Cells Contribute to Turnover of Brain Perivascular Macrophages in Long-Term Repopulated Primates.

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Soulas C, Donahue RE, Dunbar CE, Persons DA, Alvarez X, and Williams KC

The American journal of pathology 174(5):1808-17, 2009 May - Who cited this? | PubMed ID: 19349370 | Fulltext

Optimized Lentiviral Vector Design Improves Titer and Transgene Expression of Vectors Containing the Chicken beta-Globin Locus HS4 Insulator Element.

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Hanawa H, Yamamoto M, Zhao H, Shimada T, and Persons DA

Molecular therapy : the journal of the American Society of Gene Therapy 17(4):667-74, 2009 Apr - Who cited this? | PubMed ID: 19223867 | Fulltext

Correction of murine sickle cell disease using gamma-globin lentiviral vectors to mediate high-level expression of fetal hemoglobin.

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Pestina TI, Hargrove PW, Jay D, Gray JT, Boyd KM, and Persons DA

Molecular therapy : the journal of the American Society of Gene Therapy 17(2):245-52, 2009 Feb - Who cited this? | PubMed ID: 19050697 | Fulltext

Hematopoietic stem cell gene transfer for the treatment of hemoglobin disorders.

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Persons DA

Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program:690-7, 2009 - Who cited this? | PubMed ID: 20008255 | Fulltext

Progress toward safe and effective gene therapy for beta-thalassemia and sickle cell disease.

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Lebensburger J and Persons DA

Current opinion in drug discovery & development 11(2):225-32, 2008 Mar - Who cited this? | PubMed ID: 18283610 | Fulltext

Globin Lentiviral Vector Insertions Can Perturb the Expression of Endogenous Genes in beta-thalassemic Hematopoietic Cells.

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Hargrove PW, Kepes S, Hanawa H, Obenauer JC, Pei D, Cheng C, Gray JT, Neale G, and Persons DA

Molecular therapy : the journal of the American Society of Gene Therapy 16(3):525-33, 2008 Mar - Who cited this? | PubMed ID: 18195719 | Fulltext

An experimental system for the evaluation of retroviral vector design to diminish the risk for proto-oncogene activation.

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Ryu BY, Evans-Galea MV, Gray JT, Bodine DM, Persons DA, and Nienhuis AW

Blood 111(4):1866, 2008 Feb 15 - Who cited this? | PubMed ID: 17991809 | Fulltext

A chromatin insulator blocks interactions between globin regulatory elements and cellular promoters in erythroid cells.

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Ryu BY, Persons DA, Evans-Galea MV, Gray JT, and Nienhuis AW

Blood cells, molecules & diseases 39(3):221 - Who cited this? | PubMed ID: 17601756 | Fulltext

Role of erythropoietin receptor signaling in Friend virus-induced erythroblastosis and polycythemia.

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Zhang J, Randall MS, Loyd MR, Li W, Schweers RL, Persons DA, Rehg JE, Noguchi CT, Ihle JN, and Ney PA

Blood 107(1):73-8, 2006 Jan 1 - Who cited this? | PubMed ID: 16174761 | Fulltext

Mobilization and mechanism of transcription of integrated self-inactivating lentiviral vectors.

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Hanawa H, Persons DA, and Nienhuis AW

Journal of virology 79(13):8410, 2005 Jul - Who cited this? | PubMed ID: 15956585 | Fulltext

Transgenic mice with pancellular enhanced green fluorescent protein expression in primitive hematopoietic cells and all blood cell progeny.

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Dominici M, Tadjali M, Kepes S, Allay ER, Boyd K, Ney PA, Horwitz E, and Persons DA

Genesis (New York, N.Y. : 2000) 42(1):17-22, 2005 May - Who cited this? | PubMed ID: 15828004 | Fulltext

Distinct genomic integration of MLV and SIV vectors in primate hematopoietic stem and progenitor cells.

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Hematti P, Hong BK, Ferguson C, Adler R, Hanawa H, Sellers S, Holt IE, Eckfeldt CE, Sharma Y, Schmidt M, von Kalle C, Persons DA, Billings EM, Verfaillie CM, Nienhuis AW, Wolfsberg TG,

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PLoS biology 2(12):e423, 2004 Dec - Who cited this? | PubMed ID: 15550989 | Fulltext

Extended beta-globin locus control region elements promote consistent therapeutic expression of a gamma-globin lentiviral vector in murine beta-thalassemia.

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Hanawa H, Hargrove PW, Kepes S, Srivastava DK, Nienhuis AW, and Persons DA

Blood 104(8):2281-90, 2004 Oct 15 - Who cited this? | PubMed ID: 15198957 | Fulltext

Gene therapy for the hemoglobin disorders.

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Persons DA and Tisdale JF

Seminars in hematology 41(4):279-86, 2004 Oct - Who cited this? | PubMed ID: 15508113 | Fulltext

Hematopoietic cells and osteoblasts are derived from a common marrow progenitor after bone marrow transplantation.

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Dominici M, Pritchard C, Garlits JE, Hofmann TJ, Persons DA, and Horwitz EM

Proceedings of the National Academy of Sciences of the United States of America 101(32):11761-6, 2004 Aug 10 - Who cited this? | PubMed ID: 15282377 | Fulltext

Efficient gene transfer into rhesus repopulating hematopoietic stem cells using a simian immunodeficiency virus-based lentiviral vector system.

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Hanawa H, Hematti P, Keyvanfar K, Metzger ME, Krouse A, Donahue RE, Kepes S, Gray J, Dunbar CE, Persons DA, and Nienhuis AW

Blood 103(11):4062, 2004 Jun 1 - Who cited this? | PubMed ID: 14976042 | Fulltext

Transient in vivo selection of transduced peripheral blood cells using antifolate drug selection in rhesus macaques that received transplants with hematopoietic stem cells expressing dihydrofolate reductase vectors.

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Persons DA, Allay JA, Bonifacino A, Lu T, Agricola B, Metzger ME, Donahue RE, Dunbar CE, and Sorrentino BP

Blood 103(3):796-803, 2004 Feb 1 - Who cited this? | PubMed ID: 12920024 | Fulltext

Update on gene therapy for hemoglobin disorders.

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Persons DA

Current opinion in molecular therapeutics 5(5):508-16, 2003 Oct - Who cited this? | PubMed ID: 14601520 | Fulltext

Reduction in hematopoietic stem cell numbers with in vivo drug selection can be partially abrogated by HOXB4 gene expression.

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Sawai N, Persons DA, Zhou S, Lu T, and Sorrentino BP

Molecular therapy : the journal of the American Society of Gene Therapy 8(3):376-84, 2003 Sep - Who cited this? | PubMed ID: 12946310 | Fulltext

Successful treatment of murine beta-thalassemia using in vivo selection of genetically modified, drug-resistant hematopoietic stem cells.

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Persons DA, Allay ER, Sawai N, Hargrove PW, Brent TP, Hanawa H, Nienhuis AW, and Sorrentino BP

Blood 102(2):506-13, 2003 Jul 15 - Who cited this? | PubMed ID: 12663444 | Fulltext

Gene therapy for the hemoglobin disorders.

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Persons DA and Nienhuis AW

Current hematology reports 2(4):348-55, 2003 Jul - Who cited this? | PubMed ID: 12901333 | Fulltext

Development of gene therapy for hemoglobin disorders.

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Nienhuis AW, Hanawa H, Sawai N, Sorrentino BP, and Persons DA

Annals of the New York Academy of Sciences 996:101-11, 2003 May - Who cited this? | PubMed ID: 12799288 | Fulltext

The degree of phenotypic correction of murine beta -thalassemia intermedia following lentiviral-mediated transfer of a human gamma-globin gene is influenced by chromosomal position effects and vector copy number.

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Persons DA, Hargrove PW, Allay ER, Hanawa H, and Nienhuis AW

Blood 101(6):2175-83, 2003 Mar 15 - Who cited this? | PubMed ID: 12411297 | Fulltext

High-level erythroid lineage-directed gene expression using globin gene regulatory elements after lentiviral vector-mediated gene transfer into primitive human and murine hematopoietic cells.

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Hanawa H, Persons DA, and Nienhuis AW

Human gene therapy 13(17):2007-16, 2002 Nov 20 - Who cited this? | PubMed ID: 12489996 | Fulltext

In vivo selection to improve gene therapy of hematopoietic disorders.

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Persons DA and Nienhuis AW

Current opinion in molecular therapeutics 4(5):491-8, 2002 Oct - Who cited this? | PubMed ID: 12435051 | Fulltext

Comparison of various envelope proteins for their ability to pseudotype lentiviral vectors and transduce primitive hematopoietic cells from human blood.

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Hanawa H, Kelly PF, Nathwani AC, Persons DA, Vandergriff JA, Hargrove P, Vanin EF, and Nienhuis AW

Molecular therapy : the journal of the American Society of Gene Therapy 5(3):242-51, 2002 Mar - Who cited this? | PubMed ID: 11863413 | Fulltext

Targeting gene-modified hematopoietic cells to the central nervous system: use of green fluorescent protein uncovers microglial engraftment.

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Priller J, Flügel A, Wehner T, Boentert M, Haas CA, Prinz M, Fernández-Klett F, Prass K, Bechmann I, de Boer BA, Frotscher M, Kreutzberg GW, Persons DA, and Dirnagl U

Nature medicine 7(12):1356-61, 2001 Dec - Who cited this? | PubMed ID: 11726978 | Fulltext

Neogenesis of cerebellar Purkinje neurons from gene-marked bone marrow cells in vivo.

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Priller J, Persons DA, Klett FF, Kempermann G, Kreutzberg GW, and Dirnagl U

The Journal of cell biology 155(5):733-8, 2001 Nov 26 - Who cited this? | PubMed ID: 11724815 | Fulltext

Functional requirements for phenotypic correction of murine beta-thalassemia: implications for human gene therapy.

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Persons DA, Allay ER, Sabatino DE, Kelly P, Bodine DM, and Nienhuis AW

Blood 97(10):3275-82, 2001 May 15 - Who cited this? | PubMed ID: 11342459 | Fulltext

Gene therapy for the hemoglobin disorders: past, present, and future.

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Persons DA and Nienhuis AW

Proceedings of the National Academy of Sciences of the United States of America 97(10):5022-4, 2000 May 9 - Who cited this? | PubMed ID: 10805762 | Fulltext

High levels of lymphoid expression of enhanced green fluorescent protein in nonhuman primates transplanted with cytokine-mobilized peripheral blood CD34(+) cells.

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Donahue RE, Wersto RP, Allay JA, Agricola BA, Metzger ME, Nienhuis AW, Persons DA, and Sorrentino BP

Blood 95(2):445-52, 2000 Jan 15 - Who cited this? | PubMed ID: 10627448 | Fulltext

Fv2 encodes a truncated form of the Stk receptor tyrosine kinase.

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Persons DA, Paulson RF, Loyd MR, Herley MT, Bodner SM, Bernstein A, Correll PH, and Ney PA

Nature genetics 23(2):159-65, 1999 Oct - Who cited this? | PubMed ID: 10508511 | Fulltext

Adenovirus-mediated expresssion of the murine ecotropic receptor facilitates transduction of human hematopoietic cells with an ecotropic retroviral vector.

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Nathwani AC, Persons DA, Stevenson SC, Frare P, McClelland A, Nienhuis AW, and Vanin EF

Gene therapy 6(8):1456-68, 1999 Aug - Who cited this? | PubMed ID: 10467370 | Fulltext

High-efficiency transduction and long-term gene expression with a murine stem cell retroviral vector encoding the green fluorescent protein in human marrow stromal cells.

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Marx JC, Allay JA, Persons DA, Nooner SA, Hargrove PW, Kelly PF, Vanin EF, and Horwitz EM

Human gene therapy 10(7):1163-73, 1999 May 1 - Who cited this? | PubMed ID: 10340548 | Fulltext

Enforced expression of the GATA-2 transcription factor blocks normal hematopoiesis.

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Persons DA, Allay JA, Allay ER, Ashmun RA, Orlic D, Jane SM, Cunningham JM, and Nienhuis AW

Blood 93(2):488-99, 1999 Jan 15 - Who cited this? | PubMed ID: 9885210 | Fulltext

In vivo selection of retrovirally transduced hematopoietic stem cells.

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Allay JA, Persons DA, Galipeau J, Riberdy JM, Ashmun RA, Blakley RL, and Sorrentino BP

Nature medicine 4(10):1136-43, 1998 Oct - Who cited this? | PubMed ID: 9771746 | Fulltext

Use of the green fluorescent protein as a marker to identify and track genetically modified hematopoietic cells.

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Persons DA, Allay JA, Riberdy JM, Wersto RP, Donahue RE, Sorrentino BP, and Nienhuis AW

Nature medicine 4(10):1201-5, 1998 Oct - Who cited this? | PubMed ID: 9771757 | Fulltext

Tumor lysis syndrome and acute renal failure after treatment of non-small-cell lung carcinoma with combination irinotecan and cisplatin.

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Persons DA, Garst J, Vollmer R, and Crawford J

American journal of clinical oncology 21(4):426-9, 1998 Aug - Who cited this? | PubMed ID: 9708649 | Fulltext

An improved method for generating retroviral producer clones for vectors lacking a selectable marker gene.

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Persons DA, Mehaffey MG, Kaleko M, Nienhuis AW, and Vanin EF

Blood cells, molecules & diseases 24(2):167-82, 1998 Jun - Who cited this? | PubMed ID: 9642098 | Fulltext

Retroviral-mediated transfer of the green fluorescent protein gene into murine hematopoietic cells facilitates scoring and selection of transduced progenitors in vitro and identification of genetically modified cells in vivo.

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Persons DA, Allay JA, Allay ER, Smeyne RJ, Ashmun RA, Sorrentino BP, and Nienhuis AW

Blood 90(5):1777-86, 1997 Sep 1 - Who cited this? | PubMed ID: 9292510 | Fulltext

Fluconazole and Candida krusei fungemia.

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Persons DA, Laughlin M, Tanner D, Perfect J, Gockerman JP, and Hathorn JW

The New England journal of medicine 325(18):1315, 1991 Oct 31 - Who cited this? | PubMed ID: 1922232 | Fulltext

Retroviral transduction of protein kinase C-gamma into cytotoxic T lymphocyte clones leads to immortalization with retention of specific function.

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Finn OJ, Persons DA, Bendt KM, Pirami L, and Ricciardi P

Journal of immunology (Baltimore, Md. : 1950) 146(4):1099-103, 1991 Feb 15 - Who cited this? | PubMed ID: 1991961 | Fulltext

Protein kinase C gamma expression mimics phorbol ester-induced transcriptional activation of a murine VL30 enhancer element.

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Persons DA, Owen RD, Ostrowski MC, and Finn OJ

Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 2(1):7-14, 1991 Jan - Who cited this? | PubMed ID: 2007096 | Fulltext

Increased expression of glycolysis-associated genes in oncogene-transformed and growth-accelerated states.

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Persons DA, Schek N, Hall BL, and Finn OJ

Molecular carcinogenesis 2(2):88-94, 1989 - Who cited this? | PubMed ID: 2765128 | Fulltext

Altered growth regulation and enhanced tumorigenicity of NIH 3T3 fibroblasts transfected with protein kinase C-I cDNA.

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Persons DA, Wilkison WO, Bell RM, and Finn OJ

Cell 52(3):447-58, 1988 Feb 12 - Who cited this? | PubMed ID: 3162207 | Fulltext

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