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Papers authored by Pennington MW

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Evaluation of the cost-effectiveness of root canal treatment using conventional approaches versus replacement with an implant.

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Pennington MW, Vernazza CR, Shackley P, Armstrong NT, Whitworth JM, and Steele JG

International endodontic journal 42(10):874-83, 2009 Oct - Who cited this? | PubMed ID: 19751289 | Fulltext

Kv1.3 potassium channels as a therapeutic target in multiple sclerosis.

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Rangaraju S, Chi V, Pennington MW, and Chandy KG

Expert opinion on therapeutic targets 13(8):909-24, 2009 Aug - Who cited this? | PubMed ID: 19538097 | Fulltext

Engineering a stable and selective peptide blocker of the Kv1.3 channel in T lymphocytes.

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Pennington MW, Beeton C, Galea CA, Smith BJ, Chi V, Monaghan KP, Garcia A, Rangaraju S, Giuffrida A, Plank D, Crossley G, Nugent D, Khaytin I, Lefievre Y, Peshenko I, Dixon C,

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Molecular pharmacology 75(4):762-73, 2009 Apr - Who cited this? | PubMed ID: 19122005 | Fulltext

Efficient synthesis of protected L-phosphonophenylalanine (Ppa) derivatives suitable for solid phase synthesis.

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Chauhan SS, Varshney A, Verma B, and Pennington MW

Advances in experimental medicine and biology 611:191-2, 2009 - Who cited this? | PubMed ID: 19400155 | Fulltext

Imaging of effector memory T cells during a delayed-type hypersensitivity reaction and suppression by Kv1.3 channel block.

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Matheu MP, Beeton C, Garcia A, Chi V, Rangaraju S, Safrina O, Monaghan K, Uemura MI, Li D, Pal S, de la Maza LM, Monuki E, Flügel A, Pennington MW, Parker I, Chandy KG,

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Immunity 29(4):602-14, 2008 Oct - Who cited this? | PubMed ID: 18835197 | Fulltext

Mapping the UDP-glucuronic Acid Binding Site in UDP-glucuronosyltransferase-1A10 by Homology-Based Modeling: Confirmation with Biochemical Evidence.

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Banerjee R, Pennington MW, Garza A, and Owens IS

Biochemistry, 2008 Jun 21 - Who cited this? | PubMed ID: 18570380 | Fulltext

The D-diastereomer of ShK toxin selectively blocks voltage-gated K+ channels and inhibits T lymphocyte proliferation.

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Beeton C, Smith BJ, Sabo JK, Crossley G, Nugent D, Khaytin I, Chi V, Chandy KG, Pennington MW, and Norton RS

The Journal of biological chemistry 283(2):988, 2008 Jan 11 - Who cited this? | PubMed ID: 17984097 | Fulltext

Targeted tyrosine iodination in a multi-tyrosine vasopressin analog.

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Durr JA, Blankenship M, Chauhan SS, and Pennington MW

Journal of peptide science : an official publication of the European Peptide Society 13(11):756-61, 2007 Nov - Who cited this? | PubMed ID: 17803258 | Fulltext

Kv1.3 channels are a therapeutic target for T cell-mediated autoimmune diseases.

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Beeton C, Wulff H, Standifer NE, Azam P, Mullen KM, Pennington MW, Kolski-Andreaco A, Wei E, Grino A, Counts DR, Wang PH, LeeHealey CJ, S Andrews B, Sankaranarayanan A, Homerick D, Roeck WW,

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Proceedings of the National Academy of Sciences of the United States of America 103(46):17414-9, 2006 Nov 14 - Who cited this? | PubMed ID: 17088564 | Fulltext

Do femtonewton forces affect genetic function? A review.

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Blumberg S, Pennington MW, and Meiners JC

Journal of biological physics 32(2):73-95, 2006 Oct - Who cited this? | PubMed ID: 19669453 | Fulltext

Potassium channels Kv1.3 and Kv1.5 are expressed on blood-derived dendritic cells in the central nervous system.

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Mullen KM, Rozycka M, Rus H, Hu L, Cudrici C, Zafranskaia E, Pennington MW, Johns DC, Judge SI, and Calabresi PA

Annals of neurology 60(1):118-27, 2006 Jul - Who cited this? | PubMed ID: 16729292 | Fulltext

Three-dimensional characterization of tethered microspheres by total internal reflection fluorescence microscopy.

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Blumberg S, Gajraj A, Pennington MW, and Meiners JC

Biophysical journal 89(2):1272-81, 2005 Aug - Who cited this? | PubMed ID: 15923224 | Fulltext

Targeting effector memory T cells with a selective peptide inhibitor of Kv1.3 channels for therapy of autoimmune diseases.

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Beeton C, Pennington MW, Wulff H, Singh S, Nugent D, Crossley G, Khaytin I, Calabresi PA, Chen CY, Gutman GA, and Chandy KG

Molecular pharmacology 67(4):1369-81, 2005 Apr - Who cited this? | PubMed ID: 15665253 | Fulltext

Bass hepcidin synthesis, solution structure, antimicrobial activities and synergism, and in vivo hepatic response to bacterial infections.

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Lauth X, Babon JJ, Stannard JA, Singh S, Nizet V, Carlberg JM, Ostland VE, Pennington MW, Norton RS, and Westerman ME

The Journal of biological chemistry 280(10):9272-82, 2005 Mar 11 - Who cited this? | PubMed ID: 15546886 | Fulltext

Potassium channel blockade by the sea anemone toxin ShK for the treatment of multiple sclerosis and other autoimmune diseases.

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Norton RS, Pennington MW, and Wulff H

Current medicinal chemistry 11(23):3041-52, 2004 Dec - Who cited this? | PubMed ID: 15578998 | Fulltext

Efficient asymmetric synthesis of (S)- and (R)-N-Fmoc-S-trityl-alpha-methylcysteine using camphorsultam as a chiral auxiliary.

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Singh S, Rao SJ, and Pennington MW

The Journal of organic chemistry 69(13):4551-4, 2004 Jun 25 - Who cited this? | PubMed ID: 15202920 | Fulltext

Rational design and synthesis of selective BACE-1 inhibitors.

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Brady SF, Singh S, Crouthamel MC, Holloway MK, Coburn CA, Garsky VM, Bogusky M, Pennington MW, Vacca JP, Hazuda D, and Lai MT

Bioorganic & medicinal chemistry letters 14(3):601-4, 2004 Feb 9 - Who cited this? | PubMed ID: 14741251 | Fulltext

The caspase-like sites of proteasomes, their substrate specificity, new inhibitors and substrates, and allosteric interactions with the trypsin-like sites.

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Kisselev AF, Garcia-Calvo M, Overkleeft HS, Peterson E, Pennington MW, Ploegh HL, Thornberry NA, and Goldberg AL

The Journal of biological chemistry 278(38):35869, 2003 Sep 19 - Who cited this? | PubMed ID: 12815064 | Fulltext

Mutating a critical lysine in ShK toxin alters its binding configuration in the pore-vestibule region of the voltage-gated potassium channel, Kv1.3.

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Lanigan MD, Kalman K, Lefievre Y, Pennington MW, Chandy KG, and Norton RS

Biochemistry 41(40):11963-71, 2002 Oct 8 - Who cited this? | PubMed ID: 12356296 | Fulltext

Designed peptide analogues of the potassium channel blocker ShK toxin.

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Lanigan MD, Pennington MW, Lefievre Y, Rauer H, and Norton RS

Biochemistry 40(51):15528-37, 2001 Dec 25 - Who cited this? | PubMed ID: 11747428 | Fulltext

Thirteen UDPglucuronosyltransferase genes are encoded at the human UGT1 gene complex locus.

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Gong QH, Cho JW, Huang T, Potter C, Gholami N, Basu NK, Kubota S, Carvalho S, Pennington MW, Owens IS, and Popescu NC

Pharmacogenetics 11(4):357-68, 2001 Jun - Who cited this? | PubMed ID: 11434514 | Fulltext

A helical capping motif in ShK toxin and its role in helix stabilization.

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Lanigan MD, Tudor JE, Pennington MW, and Norton RS

Biopolymers 58(4):422-36, 2001 Apr 5 - Who cited this? | PubMed ID: 11180055 | Fulltext

Structure-guided transformation of charybdotoxin yields an analog that selectively targets Ca(2+)-activated over voltage-gated K(+) channels.

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Rauer H, Lanigan MD, Pennington MW, Aiyar J, Ghanshani S, Cahalan MD, Norton RS, and Chandy KG

The Journal of biological chemistry 275(2):1201-8, 2000 Jan 14 - Who cited this? | PubMed ID: 10625664 | Fulltext

Role of disulfide bonds in the structure and potassium channel blocking activity of ShK toxin.

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Pennington MW, Lanigan MD, Kalman K, Mahnir VM, Rauer H, McVaugh CT, Behm D, Donaldson D, Chandy KG, Kem WR, and Norton RS

Biochemistry 38(44):14549-58, 1999 Nov 2 - Who cited this? | PubMed ID: 10545177 | Fulltext

Auto-inactivation by cleavage within the dimer interface of Kaposi's sarcoma-associated herpesvirus protease.

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Pray TR, Nomura AM, Pennington MW, and Craik CS

Journal of molecular biology 289(2):197-203, 1999 Jun 4 - Who cited this? | PubMed ID: 10366498 | Fulltext

Comparison of inhibitor binding to feline and human immunodeficiency virus proteases: structure-based drug design and the resistance problem.

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Dunn BM, Pennington MW, Frase DC, and Nash K

Biopolymers 51(1):69-77, 1999 - Who cited this? | PubMed ID: 10380354 | Fulltext

ShK-Dap22, a potent Kv1.3-specific immunosuppressive polypeptide.

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Kalman K, Pennington MW, Lanigan MD, Nguyen A, Rauer H, Mahnir V, Paschetto K, Kem WR, Grissmer S, Gutman GA, Christian EP, Cahalan MD, Norton RS, and Chandy KG

The Journal of biological chemistry 273(49):32697-707, 1998 Dec 4 - Who cited this? | PubMed ID: 9830012 | Fulltext

Ionisation behaviour and solution properties of the potassium-channel blocker ShK toxin.

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Tudor JE, Pennington MW, and Norton RS

European journal of biochemistry / FEBS 251(1-2):133-41, 1998 Jan 15 - Who cited this? | PubMed ID: 9492277 | Fulltext

The protease and the assembly protein of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8).

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Unal A, Pray TR, Lagunoff M, Pennington MW, Ganem D, and Craik CS

Journal of virology 71(9):7030-8, 1997 Sep - Who cited this? | PubMed ID: 9261433 | Fulltext

An essential binding surface for ShK toxin interaction with rat brain potassium channels.

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Pennington MW, Mahnir VM, Khaytin I, Zaydenberg I, Byrnes ME, and Kem WR

Biochemistry 35(51):16407-11, 1996 Dec 24 - Who cited this? | PubMed ID: 8987971 | Fulltext

Solution structure of ShK toxin, a novel potassium channel inhibitor from a sea anemone.

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Tudor JE, Pallaghy PK, Pennington MW, and Norton RS

Nature structural biology 3(4):317-20, 1996 Apr - Who cited this? | PubMed ID: 8599755 | Fulltext

Identification of three separate binding sites on SHK toxin, a potent inhibitor of voltage-dependent potassium channels in human T-lymphocytes and rat brain.

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Pennington MW, Mahnir VM, Krafte DS, Zaydenberg I, Byrnes ME, Khaytin I, Crowley K, and Kem WR

Biochemical and biophysical research communications 219(3):696-701, 1996 Feb 27 - Who cited this? | PubMed ID: 8645244 | Fulltext

Synthesis and structural characterisation of analogues of the potassium channel blocker charybdotoxin.

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Dyke TR, Duggan BM, Pennington MW, Byrnes ME, Kem WR, and Norton RS

Biochimica et biophysica acta 1292(1):31-8, 1996 Jan 4 - Who cited this? | PubMed ID: 8547346 | Fulltext

Chemical synthesis and characterization of ShK toxin: a potent potassium channel inhibitor from a sea anemone.

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Pennington MW, Byrnes ME, Zaydenberg I, Khaytin I, de Chastonay J, Krafte DS, Hill R, Mahnir VM, Volberg WA, and Gorczyca W

International journal of peptide and protein research 46(5):354-8, 1995 Nov - Who cited this? | PubMed ID: 8567178 | Fulltext

A continuous fluorescence-based assay of human cytomegalovirus protease using a peptide substrate.

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Holskin BP, Bukhtiyarova M, Dunn BM, Baur P, de Chastonay J, and Pennington MW

Analytical biochemistry 227(1):148-55, 1995 May 1 - Who cited this? | PubMed ID: 7668375 | Fulltext

Evaluation of TiCl4-mediated reduction of methionine sulfoxide in peptides with oxidizable or reducible residues.

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Pennington MW and Byrnes ME

Peptide research 8(1):39-43, 1995 - Who cited this? | PubMed ID: 7756753 | Fulltext

Synthesis of the cardiac inotropic polypeptide anthopleurin-A.

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Pennington MW, Zadenberg I, Byrnes ME, Norton RS, and Kem WR

International journal of peptide and protein research 43(5):463-70, 1994 May - Who cited this? | PubMed ID: 8070970 | Fulltext

Synthesis of a fluorogenic interleukin-1 beta converting enzyme substrate based on resonance energy transfer.

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Pennington MW and Thornberry NA

Peptide research 7(2):72-6, 1994 - Who cited this? | PubMed ID: 8012123 | Fulltext

Procedures to improve difficult couplings.

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Pennington MW and Byrnes ME

Methods in molecular biology (Clifton, N.J.) 35:1-16, 1994 - Who cited this? | PubMed ID: 7894597 | Fulltext

Site-specific chemical modification procedures.

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Pennington MW

Methods in molecular biology (Clifton, N.J.) 35:171-85, 1994 - Who cited this? | PubMed ID: 7894599 | Fulltext

Solid-phase synthesis of phosphorylated Tyr-peptides by "phosphite triester" phosphorylation.

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Pennington MW

Methods in molecular biology (Clifton, N.J.) 35:195-200, 1994 - Who cited this? | PubMed ID: 7894601 | Fulltext

Solid-phase synthesis of peptides containing the CH2NH reduced bond surrogate.

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Pennington MW

Methods in molecular biology (Clifton, N.J.) 35:241-7, 1994 - Who cited this? | PubMed ID: 7894603 | Fulltext

HF cleavage and deprotection procedures for peptides synthesized using a Boc/Bzl strategy.

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Pennington MW

Methods in molecular biology (Clifton, N.J.) 35:41-62, 1994 - Who cited this? | PubMed ID: 7894608 | Fulltext

Three-dimensional structure in solution of the calcium channel blocker omega-conotoxin.

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Pallaghy PK, Duggan BM, Pennington MW, and Norton RS

Journal of molecular biology 234(2):405-20, 1993 Nov 20 - Who cited this? | PubMed ID: 8230223 | Fulltext

Synthesis and characterization of a disulfide bond isomer of omega-conotoxin GVIA.

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Pennington MW, Festin SM, Maccecchini ML, and Kem WR

Toxicon : official journal of the International Society on Toxinology 30(7):755-64, 1992 Jul - Who cited this? | PubMed ID: 1509493 | Fulltext

Chemical synthesis of a neurotoxic polypeptide from the sea anemone Stichodactyla helianthus.

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Pennington MW, Kem WR, Norton RS, and Dunn BM

International journal of peptide and protein research 36(4):335-43, 1990 Oct - Who cited this? | PubMed ID: 1981881 | Fulltext

Synthesis and biological activity of six monosubstituted analogs of a sea anemone polypeptide neurotoxin.

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Pennington MW, Kem WR, and Dunn BM

Peptide research 3(5):228-32, 1990 - Who cited this? | PubMed ID: 2134066 | Fulltext

Isolation, characterization, and amino acid sequence of a polypeptide neurotoxin occurring in the sea anemone Stichodactyla helianthus.

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Kem WR, Parten B, Pennington MW, Price DA, and Dunn BM

Biochemistry 28(8):3483-9, 1989 Apr 18 - Who cited this? | PubMed ID: 2568126 | Fulltext

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