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Papers authored by Pascoe L

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Common genetic variation in the melatonin receptor 1B gene (MTNR1B) is associated with decreased early-phase insulin response.

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Langenberg C, Pascoe L, Mari A, Tura A, Laakso M, Frayling TM, Barroso I, Loos RJ, Wareham NJ, Walker M, and RISC Consortium

Diabetologia 52(8):1537-42, 2009 Aug - Who cited this? | PubMed ID: 19455304 | Fulltext

TNFSF15 Polymorphisms Are Associated With Susceptibility to Inflammatory Bowel Disease in a New European Cohort.

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Thiébaut R, Kotti S, Jung C, Merlin F, Colombel JF, Lemann M, Almer S, Tysk C, O'Morain M, Gassull M, Binder V, Finkel Y, Pascoe L, and Hugot JP

The American journal of gastroenterology 104(2):384-91, 2009 Feb - Who cited this? | PubMed ID: 19174806 | Fulltext

Beta cell glucose sensitivity is decreased by 39% in non-diabetic individuals carrying multiple diabetes-risk alleles compared with those with no risk alleles.

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Pascoe L, Frayling TM, Weedon MN, Mari A, Tura A, Ferrannini E, Walker M, and

Diabetologia, 2008 Aug 22 - Who cited this? | PubMed ID: 18719881 | Fulltext

Common variants of the novel type 2 diabetes genes CDKAL1 and HHEX/IDE are associated with decreased pancreatic beta-cell function.

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Pascoe L, Tura A, Patel SK, Ibrahim IM, Ferrannini E, Zeggini E, Weedon MN, Mari A, Hattersley AT, McCarthy MI, Frayling TM, Walker M, RISC Consortium, and U.K. Type 2 Diabetes Genetics Consortium

Diabetes 56(12):3101-4, 2007 Dec - Who cited this? | PubMed ID: 17804762 | Fulltext

Estimating the odds ratios of Crohn disease for the main CARD15/NOD2 mutations using a conditional maximum likelihood method in pedigrees collected via affected family members.

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Pascoe L, Zouali H, Sahbatou M, and Hugot JP

European journal of human genetics : EJHG 15(8):864-71, 2007 Aug - Who cited this? | PubMed ID: 17457368 | Fulltext

Can the dextroenantiomer of the aromatase inhibitor fadrozole be useful for clinical investigation of aldosterone-synthase inhibition?.

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Ménard J and Pascoe L

Journal of hypertension 24(6):993-7, 2006 Jun - Who cited this? | PubMed ID: 16685193 | Fulltext

The relative lengths of individual telomeres are defined in the zygote and strictly maintained during life.

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Graakjaer J, Pascoe L, Der-Sarkissian H, Thomas G, Kolvraa S, Christensen K, and Londoño-Vallejo JA

Aging cell 3(3):97, 2004 Jun - Who cited this? | PubMed ID: 15153177 | Fulltext

Adult onset Still's disease: response to Enbrel.

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Asherson RA and Pascoe L

Annals of the rheumatic diseases 61(9):859-60; author reply 860, 2002 Sep - Who cited this? | PubMed ID: 12176823 | Fulltext

Structures of two intermediate filament-binding fragments of desmoplakin reveal a unique repeat motif structure.

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Choi HJ, Park-Snyder S, Pascoe LT, Green KJ, and Weis WI

Nature structural biology 9(8):612-20, 2002 Aug - Who cited this? | PubMed ID: 12101406 | Fulltext

Deletion hybrid genes, due to unequal crossing over between CYP11B1 (11beta-hydroxylase) and CYP11B2(aldosterone synthase) cause steroid 11beta-hydroxylase deficiency and congenital adrenal hyperplasia.

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Portrat S, Mulatero P, Curnow KM, Chaussain JL, Morel Y, and Pascoe L

The Journal of clinical endocrinology and metabolism 86(7):3197-201, 2001 Jul - Who cited this? | PubMed ID: 11443188 | Fulltext

Assembly of desmosomal cadherins into desmosomes is isoform dependent.

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Ishii K, Norvell SM, Bannon LJ, Amargo EV, Pascoe LT, and Green KJ

The Journal of investigative dermatology 117(1):26-35, 2001 Jul - Who cited this? | PubMed ID: 11442746 | Fulltext

The use of botulinum toxin-A in the treatment of patients with fibromyalgia.

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Asherson RA and Pascoe L

The Journal of rheumatology 28(7):1740, 2001 Jul - Who cited this? | PubMed ID: 11469493 | Fulltext

Angiotensin-converting enzyme and angiotensinogen gene polymorphisms are non-randomly distributed in oral contraceptive-induced hypertension.

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Mulatero P, Rabbia F, di Cella SM, Schiavone D, Plazzotta C, Pascoe L, and Veglio F

Journal of hypertension 19(4):713-9, 2001 Apr - Who cited this? | PubMed ID: 11330874 | Fulltext

The efficiency of genetic analysis of DNA from aged siblings to detect chromosomal regions implicated in longevity.

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Nemani M, Sahbatou M, Blanché H, Thomas G, and Pascoe L

Mechanisms of ageing and development 119(1-2):25-39, 2000 Oct 20 - Who cited this? | PubMed ID: 11040399 | Fulltext

Sequence similarities between a novel putative G protein-coupled receptor and Na+/Ca2+ exchangers define a cation binding domain.

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Nikkila H, McMillan DR, Nunez BS, Pascoe L, Curnow KM, and White PC

Molecular endocrinology (Baltimore, Md.) 14(9):1351-64, 2000 Sep - Who cited this? | PubMed ID: 10976914 | Fulltext

CYP11B2 gene polymorphisms in idiopathic hyperaldosteronism.

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Mulatero P, Schiavone D, Fallo F, Rabbia F, Pilon C, Chiandussi L, Pascoe L, and Veglio F

Hypertension 35(3):694-8, 2000 Mar - Who cited this? | PubMed ID: 10720580 | Fulltext

Prenatal diagnosis and treatment of 11beta-hydroxylase deficiency congenital adrenal hyperplasia resulting in normal female genitalia.

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Cerame BI, Newfield RS, Pascoe L, Curnow KM, Nimkarn S, Roe TF, New MI, and Wilson RC

The Journal of clinical endocrinology and metabolism 84(9):3129-34, 1999 Sep - Who cited this? | PubMed ID: 10487675 | Fulltext

Genetic, biochemical, and clinical studies of patients with A328V or R213C mutations in 11betaHSD2 causing apparent mineralocorticoid excess.

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Morineau G, Marc JM, Boudi A, Galons H, Gourmelen M, Corvol P, Pascoe L, and Fiet J

Hypertension 34(3):435-41, 1999 Sep - Who cited this? | PubMed ID: 10489390 | Fulltext

Recombinant CYP11B genes encode enzymes that can catalyze conversion of 11-deoxycortisol to cortisol, 18-hydroxycortisol, and 18-oxocortisol.

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Mulatero P, Curnow KM, Aupetit-Faisant B, Foekling M, Gomez-Sanchez C, Veglio F, Jeunemaitre X, Corvol P, and Pascoe L

The Journal of clinical endocrinology and metabolism 83(11):3996-4001, 1998 Nov - Who cited this? | PubMed ID: 9814482 | Fulltext

Isolated aldosterone synthase deficiency caused by simultaneous E198D and V386A mutations in the CYP11B2 gene.

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Portrat-Doyen S, Tourniaire J, Richard O, Mulatero P, Aupetit-Faisant B, Curnow KM, Pascoe L, and Morel Y

The Journal of clinical endocrinology and metabolism 83(11):4156-61, 1998 Nov - Who cited this? | PubMed ID: 9814506 | Fulltext

Structural analysis and evaluation of the 11beta-hydroxysteroid dehydrogenase type 2 (11beta-HSD2) gene in human essential hypertension.

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Brand E, Kato N, Chatelain N, Krozowski ZS, Jeunemaitre X, Corvol P, Plouin PF, Cambien F, Pascoe L, and Soubrier F

Journal of hypertension 16(11):1627-33, 1998 Nov - Who cited this? | PubMed ID: 9856363 | Fulltext

Structural analysis and evaluation of the aldosterone synthase gene in hypertension.

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Brand E, Chatelain N, Mulatero P, Féry I, Curnow K, Jeunemaitre X, Corvol P, Pascoe L, and Soubrier F

Hypertension 32(2):198-204, 1998 Aug - Who cited this? | PubMed ID: 9719043 | Fulltext

[A case of apparent mineralocorticoid excess caused by type 2 11 beta- hydroxysteroid dehydrogenase deficiency].

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Morineau G, Pascoe L, Marc JM, Caillette A, Krozowski Z, Corvol P, and Fiet J

Archives des maladies du coeur et des vaisseaux 90(8):1111-5, 1997 Aug - Who cited this? | PubMed ID: 9404418 | Fulltext

The amino acid substitutions Ser288Gly and Val320Ala convert the cortisol producing enzyme, CYP11B1, into an aldosterone producing enzyme.

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Curnow KM, Mulatero P, Emeric-Blanchouin N, Aupetit-Faisant B, Corvol P, and Pascoe L

Nature structural biology 4(1):32-5, 1997 Jan - Who cited this? | PubMed ID: 8989319 | Fulltext

Glucocorticoid-suppressible hyperaldosteronism and adrenal tumors occurring in a single French pedigree.

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Pascoe L, Jeunemaitre X, Lebrethon MC, Curnow KM, Gomez-Sanchez CE, Gasc JM, Saez JM, and Corvol P

The Journal of clinical investigation 96(5):2236-46, 1995 Nov - Who cited this? | PubMed ID: 7593610 | Fulltext

[Hyperaldosteronism sensitive to dexamethasone with adrenal adenoma. Clinical, biological and genetic study].

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Jeunemaitre X, Charru A, Pascoe L, Guyene TT, Aupetit-Faisant B, Shackleton CH, Schambelan M, Plouin PF, and Corvol P

Presse medicale (Paris, France : 1983) 24(27):1243-8, 1995 Sep 23 - Who cited this? | PubMed ID: 7501605 | Fulltext

Alternatively spliced human type 1 angiotensin II receptor mRNAs are translated at different efficiencies and encode two receptor isoforms.

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Curnow KM, Pascoe L, Davies E, White PC, Corvol P, and Clauser E

Molecular endocrinology (Baltimore, Md.) 9(9):1250-62, 1995 Sep - Who cited this? | PubMed ID: 7491117 | Fulltext

Reduced genetic load revealed by slow inbreeding in Drosophila melanogaster.

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Latter BD, Mulley JC, Reid D, and Pascoe L

Genetics 139(1):287-97, 1995 Jan - Who cited this? | PubMed ID: 7705630 | Fulltext

Genetic recombination as a cause of inherited disorders of aldosterone and cortisol biosynthesis and a contributor to genetic variation in blood pressure.

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Pascoe L and Curnow KM

Steroids 60(1):22-7, 1995 Jan - Who cited this? | PubMed ID: 7792811 | Fulltext

The biochemical phenotypes of two inborn errors in the biosynthesis of aldosterone.

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Pascoe L

Journal of endocrinological investigation 18(7):571-5, 1995 - Who cited this? | PubMed ID: 9221276 | Fulltext

Disorders of steroid 11 beta-hydroxylase isozymes.

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White PC, Curnow KM, and Pascoe L

Endocrine reviews 15(4):421-38, 1994 Aug - Who cited this? | PubMed ID: 7988480 | Fulltext

Enamel hypoplasia and dental caries in Australian aboriginal children: prevalence and correlation between the two diseases.

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Pascoe L and Seow WK

Pediatric dentistry 16(3):193-9, 1994 - Who cited this? | PubMed ID: 8058543 | Fulltext

Mutations in the CYP11B1 gene causing congenital adrenal hyperplasia and hypertension cluster in exons 6, 7, and 8.

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Curnow KM, Slutsker L, Vitek J, Cole T, Speiser PW, New MI, White PC, and Pascoe L

Proceedings of the National Academy of Sciences of the United States of America 90(10):4552-6, 1993 May 15 - Who cited this? | PubMed ID: 8506298 | Fulltext

Glucocorticoid-suppressible hyperaldosteronism results from hybrid genes created by unequal crossovers between CYP11B1 and CYP11B2.

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Pascoe L, Curnow KM, Slutsker L, Connell JM, Speiser PW, New MI, and White PC

Proceedings of the National Academy of Sciences of the United States of America 89(17):8327-31, 1992 Sep 1 - Who cited this? | PubMed ID: 1518866 | Fulltext

Disorders of steroid 11beta-hydroxylase isozymes.

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White PC and Pascoe L

Trends in endocrinology and metabolism: TEM 3(6):229-34, 1992 Aug - Who cited this? | PubMed ID: 18407105 | Fulltext

Genetic analysis of the human type-1 angiotensin II receptor.

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Curnow KM, Pascoe L, and White PC

Molecular endocrinology (Baltimore, Md.) 6(7):1113-8, 1992 Jul - Who cited this? | PubMed ID: 1508224 | Fulltext

Mutations in the human CYP11B2 (aldosterone synthase) gene causing corticosterone methyloxidase II deficiency.

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Pascoe L, Curnow KM, Slutsker L, Rösler A, and White PC

Proceedings of the National Academy of Sciences of the United States of America 89(11):4996-5000, 1992 Jun 1 - Who cited this? | PubMed ID: 1594605 | Fulltext

The product of the CYP11B2 gene is required for aldosterone biosynthesis in the human adrenal cortex.

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Curnow KM, Tusie-Luna MT, Pascoe L, Natarajan R, Gu JL, Nadler JL, and White PC

Molecular endocrinology (Baltimore, Md.) 5(10):1513-22, 1991 Oct - Who cited this? | PubMed ID: 1775135 | Fulltext

The genetics of Crohn disease: complex segregation analysis of a family study with 265 patients with Crohn disease and 5,387 relatives.

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Küster W, Pascoe L, Purrmann J, Funk S, and Majewski F

American journal of medical genetics 32(1):105-8, 1989 Jan - Who cited this? | PubMed ID: 2705471 | Fulltext

Combined segregation and linkage analysis for IDDM and HLA-DR under several ascertainment assumptions.

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Pascoe L, Sherman S, Wu D, Becker M, and Falk C

Genetic epidemiology 6(1):131-6, 1989 - Who cited this? | PubMed ID: 2499499 | Fulltext

Occurrence of desmoids in patients with familial adenomatous polyposis of the colon.

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Klemmer S, Pascoe L, and DeCosse J

American journal of medical genetics 28(2):385, 1987 Oct - Who cited this? | PubMed ID: 2827474 | Fulltext

The inheritance of cutaneous malignant melanoma (CMM) and dysplastic nevus syndrome (DNS).

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Pascoe L

American journal of human genetics 40(5):464-7, 1987 May - Who cited this? | PubMed ID: 3578283 | Fulltext

The use of map functions in multipoint mapping.

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Pascoe L and Morton NE

American journal of human genetics 40(2):174-83, 1987 Feb - Who cited this? | PubMed ID: 3565379 | Fulltext

Formation and distribution of vitamin C in the radical and cotyledon of the broad bean (Vicia faba).

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SHAW AC and PASCOE LC

Nature 164(4171):624, 1949 Oct 8 - Who cited this? | PubMed ID: 18142473 | Fulltext

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