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Papers authored by Overkleeft HS

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Synthesis and evaluation of d-gluco-pyranocyclopropyl amines as potential glucosidase inhibitors.

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Risseeuw MD, van den Berg RJ, Donker-Koopman WE, van der Marel GA, Aerts JM, Overhand M, and Overkleeft HS

Bioorganic & medicinal chemistry letters 19(23):6600-3, 2009 Dec 1 - Who cited this? | PubMed ID: 19853441 | Fulltext

Syringolin A selectively labels the 20 S proteasome in murine EL4 and wild-type and bortezomib-adapted leukaemic cell lines.

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Clerc J, Florea BI, Kraus M, Groll M, Huber R, Bachmann AS, Dudler R, Driessen C, Overkleeft HS, and Kaiser M

Chembiochem : a European journal of chemical biology 10(16):2638-43, 2009 Nov 2 - Who cited this? | PubMed ID: 19746508 | Fulltext

O-GlcNAc peptide epoxyketones are recognized by mammalian proteasomes.

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Witte MD, Florea BI, Verdoes M, Adeyanju O, Van der Marel GA, and Overkleeft HS

Journal of the American Chemical Society 131(34):12064-5, 2009 Sep 2 - Who cited this? | PubMed ID: 19658393 | Fulltext

Equatorial anomeric triflates from mannuronic acid esters.

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Walvoort MT, Lodder G, Mazurek J, Overkleeft HS, Codée JD, and van der Marel GA

Journal of the American Chemical Society 131(34):12080-1, 2009 Sep 2 - Who cited this? | PubMed ID: 19663422 | Fulltext

Synthesis and biological evaluation of asymmetric gramicidin S analogues containing modified D-phenylalanine residues.

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van der Knaap M, Engels E, Busscher HJ, Otero JM, Llamas-Saiz AL, van Raaij MJ, Mars-Groenendijk RH, Noort D, van der Marel GA, Overkleeft HS, and Overhand M

Bioorganic & medicinal chemistry 17(17):6318-28, 2009 Sep 1 - Who cited this? | PubMed ID: 19674904 | Fulltext

Structural and biological evaluation of some loloatin C analogues.

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Tuin AW, Grotenbreg GM, Spalburg E, de Neeling AJ, Mars-Groenendijk RH, van der Marel GA, Noort D, Overkleeft HS, and Overhand M

Bioorganic & medicinal chemistry 17(17):6233-40, 2009 Sep 1 - Who cited this? | PubMed ID: 19679485 | Fulltext

Accumulation of ubiquitin conjugates in a polyglutamine disease model occurs without global ubiquitin/proteasome system impairment.

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Maynard CJ, Böttcher C, Ortega Z, Smith R, Florea BI, Díaz-Hernández M, Brundin P, Overkleeft HS, Li JY, Lucas JJ, and Dantuma NP

Proceedings of the National Academy of Sciences of the United States of America 106(33):13986-91, 2009 Aug 18 - Who cited this? | PubMed ID: 19666572 | Fulltext

Stereodirecting effect of the pyranosyl C-5 substituent in glycosylation reactions.

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Dinkelaar J, de Jong AR, van Meer R, Somers M, Lodder G, Overkleeft HS, Codée JD, and van der Marel GA

The Journal of organic chemistry 74(14):4982-91, 2009 Jul 17 - Who cited this? | PubMed ID: 19489535 | Fulltext

Discovery of selective luteinizing hormone receptor agonists using the bivalent ligand method.

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Bonger KM, van den Berg RJ, Knijnenburg AD, Heitman LH, van Koppen CJ, Timmers CM, Overkleeft HS, and van der Marel GA

ChemMedChem 4(7):1189-95, 2009 Jul - Who cited this? | PubMed ID: 19475639 | Fulltext

Synthesis of Hyaluronic Acid Oligomers using Chemoselective and One-Pot Strategies.

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Dinkelaar J, Gold H, Overkleeft HS, Codée JD, and van der Marel GA

The Journal of organic chemistry 74(11):4208-16, 2009 Jun 5 - Who cited this? | PubMed ID: 19402694 | Fulltext

Characterization of the ubiquitin-proteasome system in bortezomib-adapted cells.

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Rückrich T, Kraus M, Gogel J, Beck A, Ovaa H, Verdoes M, Overkleeft HS, Kalbacher H, and Driessen C

Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 23(6):1098-105, 2009 Jun - Who cited this? | PubMed ID: 19225532 | Fulltext

2-Azidoalkoxy-7-hydro-8-oxoadenine derivatives as TLR7 agonists inducing dendritic cell maturation.

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Weterings JJ, Khan S, van der Heden van Noort GJ, Melief CJ, Overkleeft HS, van der Burg SH, Ossendorp F, van der Marel GA, and Filippov DV

Bioorganic & medicinal chemistry letters 19(8):2249-51, 2009 Apr 15 - Who cited this? | PubMed ID: 19299126 | Fulltext

Chirality of TLR-2 ligand Pam(3)CysSK(4) in fully synthetic peptide conjugates critically influences the induction of specific CD8(+) T-cells.

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Khan S, Weterings JJ, Britten CM, de Jong AR, Graafland D, Melief CJ, van der Burg SH, van der Marel G, Overkleeft HS, Filippov DV, and Ossendorp F

Molecular immunology 46(6):1084-91, 2009 Mar - Who cited this? | PubMed ID: 19027958 | Fulltext

Leukocyte cathepsin S is a potent regulator of both cell and matrix turnover in advanced atherosclerosis.

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de Nooijer R, Bot I, von der Thüsen JH, Leeuwenburgh MA, Overkleeft HS, Kraaijeveld AO, Dorland R, van Santbrink PJ, van Heiningen SH, Westra MM, Kovanen PT, Jukema JW, van der Wall EE, van Berkel TJ, Shi GP, and Biessen EA

Arteriosclerosis, thrombosis, and vascular biology 29(2):188-94, 2009 Feb - Who cited this? | PubMed ID: 19095996 | Fulltext

Synthesis and biological evaluation of a chitobiose-based peptide N-glycanase inhibitor library.

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Witte MD, Horst D, Wiertz EJ, van der Marel GA, and Overkleeft HS

The Journal of organic chemistry 74(2):605-16, 2009 Jan 16 - Who cited this? | PubMed ID: 19072094 | Fulltext

The stereodirecting effect of the glycosyl C5-carboxylate ester: stereoselective synthesis of beta-mannuronic acid alginates.

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Codée JD, van den Bos LJ, de Jong AR, Dinkelaar J, Lodder G, Overkleeft HS, and van der Marel GA

The Journal of organic chemistry 74(1):38-47, 2009 Jan 2 - Who cited this? | PubMed ID: 19035740 | Fulltext

Receptor-mediated targeting of cathepsins in professional antigen presenting cells.

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Hillaert U, Verdoes M, Florea BI, Saragliadis A, Habets KL, Kuiper J, Van Calenbergh S, Ossendorp F, van der Marel GA, Driessen C, and Overkleeft HS

Angewandte Chemie (International ed. in English) 48(9):1629-32, 2009 - Who cited this? | PubMed ID: 19156780 | Fulltext

Reducing glycosphingolipid content in adipose tissue of obese mice restores insulin sensitivity, adipogenesis and reduces inflammation.

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van Eijk M, Aten J, Bijl N, Ottenhoff R, van Roomen CP, Dubbelhuis PF, Seeman I, Ghauharali-van der Vlugt K, Overkleeft HS, Arbeeny C, Groen AK, and Aerts JM

PLoS ONE 4(3):e4723, 2009 - Who cited this? | PubMed ID: 19305508 | Fulltext

Receptor-mediated targeting of cathepsins in professional antigen presenting cells.

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Hillaert U, Verdoes M, Florea BI, Saragliadis A, Habets KL, Kuiper J, Van Calenbergh S, Ossendorp F, van der Marel GA, Driessen C, and Overkleeft HS

Angewandte Chemie (International ed. in English) 48(14):2442, 2009 - Who cited this? | PubMed ID: 19294667 | Fulltext

Synthesis of modified and hybrid protein derived biopolymers.

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Weterings JJ, Khan S, Drijfhout JW, Ossendorp F, Overkleeft HS, van der Marel GA, and Filippov DV

Advances in experimental medicine and biology 611:141-2, 2009 - Who cited this? | PubMed ID: 19400130 | Fulltext

Glycosphingolipids-nature, function, and pharmacological modulation.

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Wennekes T, van den Berg RJ, Boot RG, van der Marel GA, Overkleeft HS, and Aerts JM

Angewandte Chemie (International ed. in English) 48(47):8848-69, 2009 - Who cited this? | PubMed ID: 19862781 | Fulltext

Poly(ethylene glycol)-based stable isotope labeling reagents for the quantitative analysis of low molecular weight metabolites by LC-MS.

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Abello N, Geurink PP, van der Toorn M, van Oosterhout AJ, Lugtenburg J, van der Marel GA, Kerstjens HA, Postma DS, Overkleeft HS, and Bischoff R

Analytical chemistry 80(23):9171-80, 2008 Dec 1 - Who cited this? | PubMed ID: 18954088 | Fulltext

A Versatile One-Pot Procedure to Phosphate Monoesters and Pyrophosphates Using Di(p-methoxybenzyl)-N,N-diisopropylphosphoramidite.

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van der Heden van Noort GJ, Verhagen CP, van der Horst MG, Overkleeft HS, van der Marel GA, and Filippov DV

Organic letters 10(20):4461-4, 2008 Oct 16 - Who cited this? | PubMed ID: 18800840 | Fulltext

Minitags for small molecules: detecting targets of reactive small molecules in living plant tissues using 'click-chemistry'.

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Kaschani F, Verhelst SH, van Swieten PF, Verdoes M, Wong CS, Wang Z, Kaiser M, Overkleeft HS, Bogyo M, and van der Hoorn RA

The Plant journal : for cell and molecular biology, 2008 Sep 11 - Who cited this? | PubMed ID: 18786180 | Fulltext

Stereoselective Synthesis of L-Guluronic Acid Alginates.

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Dinkelaar J, van den Bos LJ, Hogendorf WF, Lodder G, Overkleeft HS, Codée JD, and van der Marel GA

Chemistry (Weinheim an der Bergstrasse, Germany), 2008 Sep 3 - Who cited this? | PubMed ID: 18770512 | Fulltext

Azido-BODIPY Acid Reveals Quantitative Staudinger-Bertozzi Ligation in Two-Step Activity-Based Proteasome Profiling.

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Verdoes M, Florea BI, Hillaert U, Willems LI, van der Linden WA, Sae-Heng M, Filippov DV, Kisselev AF, van der Marel GA, and Overkleeft HS

Chembiochem : a European journal of chemical biology, 2008 Jul 4 - Who cited this? | PubMed ID: 18600815 | Fulltext

Synthesis and evaluation of homodimeric GnRHR antagonists having a rigid bis-propargylated benzene core.

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Bonger KM, van den Berg RJ, Knijnenburg AD, Heitman LH, Ijzerman AP, Oosterom J, Timmers CM, Overkleeft HS, and van der Marel GA

Bioorganic & medicinal chemistry 16(7):3744, 2008 Apr 1 - Who cited this? | PubMed ID: 18282756 | Fulltext

Design of azidoproline containing gluten peptides to suppress CD4(+) T-cell responses associated with Celiac disease.

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Kapoerchan VV, Wiesner M, Overhand M, van der Marel GA, Koning F, and Overkleeft HS

Bioorganic & medicinal chemistry 16(4):2053-62, 2008 Feb 15 - Who cited this? | PubMed ID: 18037302 | Fulltext

Conjugation of nucleosides and oligonucleotides by [3+2] cycloaddition.

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Jawalekar AM, Meeuwenoord N, Cremers JS, Overkleeft HS, van der Marel GA, Rutjes FP, and van Delft FL

The Journal of organic chemistry 73(1):287-90, 2008 Jan 4 - Who cited this? | PubMed ID: 18052191 | Fulltext

Bodipy-VAD-Fmk, a useful tool to study yeast peptide N-glycanase activity.

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Witte MD, Descals CV, de Lavoir SV, Florea BI, van der Marel GA, and Overkleeft HS

Organic & biomolecular chemistry 5(22):3690-7, 2007 Nov 21 - Who cited this? | PubMed ID: 17971999 | Fulltext

Acetylene functionalized BODIPY dyes and their application in the synthesis of activity based proteasome probes.

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Verdoes M, Hillaert U, Florea BI, Sae-Heng M, Risseeuw MD, Filippov DV, van der Marel GA, and Overkleeft HS

Bioorganic & medicinal chemistry letters 17(22):6169-71, 2007 Nov 15 - Who cited this? | PubMed ID: 17888658 | Fulltext

Synthesis of alkylated sugar amino acids: conformationally restricted L-Xaa-L-Ser/Thr mimics.

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Risseeuw MD, Mazurek J, van Langenvelde A, van der Marel GA, Overkleeft HS, and Overhand M

Organic & biomolecular chemistry 5(14):2311-4, 2007 Jul 21 - Who cited this? | PubMed ID: 17609763 | Fulltext

Synthesis of hyaluronic acid oligomers using Ph2SO/Tf2O-mediated glycosylations.

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Dinkelaar J, Codée JD, van den Bos LJ, Overkleeft HS, and van der Marel GA

The Journal of organic chemistry 72(15):5737-42, 2007 Jul 20 - Who cited this? | PubMed ID: 17585821 | Fulltext

Distinct uptake mechanisms but similar intracellular processing of two different toll-like receptor ligand-peptide conjugates in dendritic cells.

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Khan S, Bijker MS, Weterings JJ, Tanke HJ, Adema GJ, van Hall T, Drijfhout JW, Melief CJ, Overkleeft HS, van der Marel GA, Filippov DV, van der Burg SH, and Ossendorp F

The Journal of biological chemistry 282(29):21145-59, 2007 Jul 20 - Who cited this? | PubMed ID: 17462991 | Fulltext

Synthesis and evaluation of homo-bivalent GnRHR ligands.

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Bonger KM, van den Berg RJ, Heitman LH, Ijzerman AP, Oosterom J, Timmers CM, Overkleeft HS, and van der Marel GA

Bioorganic & medicinal chemistry 15(14):4841, 2007 Jul 15 - Who cited this? | PubMed ID: 17517510 | Fulltext

A cell-permeable inhibitor and activity-based probe for the caspase-like activity of the proteasome.

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van Swieten PF, Samuel E, Hernández RO, van den Nieuwendijk AM, Leeuwenburgh MA, van der Marel GA, Kessler BM, Overkleeft HS, and Kisselev AF

Bioorganic & medicinal chemistry letters 17(12):3402, 2007 Jun 15 - Who cited this? | PubMed ID: 17442566 | Fulltext

N-azidoacetylmannosamine-mediated chemical tagging of gangliosides.

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Bussink AP, van Swieten PF, Ghauharali K, Scheij S, van Eijk M, Wennekes T, van der Marel GA, Boot RG, Aerts JM, and Overkleeft HS

Journal of lipid research 48(6):1417-21, 2007 Jun - Who cited this? | PubMed ID: 17392268 | Fulltext

Mixing of peptides and electrophilic traps gives rise to potent, broad-spectrum proteasome inhibitors.

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Verdoes M, Florea BI, van der Linden WA, Renou D, van den Nieuwendijk AM, van der Marel GA, and Overkleeft HS

Organic & biomolecular chemistry 5(9):1416-26, 2007 May 7 - Who cited this? | PubMed ID: 17464411 | Fulltext

Pharmacological inhibition of glucosylceramide synthase enhances insulin sensitivity.

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Aerts JM, Ottenhoff R, Powlson AS, Grefhorst A, van Eijk M, Dubbelhuis PF, Aten J, Kuipers F, Serlie MJ, Wennekes T, Sethi JK, O'Rahilly S, and Overkleeft HS

Diabetes 56(5):1341-9, 2007 May - Who cited this? | PubMed ID: 17287460 | Fulltext

Endocytosis targets exogenous material selectively to cathepsin S in live human dendritic cells, while cell-penetrating peptides mediate nonselective transport to cysteine cathepsins.

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Reich M, van Swieten PF, Sommandas V, Kraus M, Fischer R, Weber E, Kalbacher H, Overkleeft HS, and Driessen C

Journal of leukocyte biology 81(4):990, 2007 Apr - Who cited this? | PubMed ID: 17261546 | Fulltext

The use of cyclic bifunctional protecting groups in oligosaccharide synthesis--an overview.

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Litjens RE, van den Bos LJ, Codée JD, Overkleeft HS, and van der Marel GA

Carbohydrate research 342(3-4):419-29, 2007 Feb 26 - Who cited this? | PubMed ID: 17007825 | Fulltext

Development of adamantan-1-yl-methoxy-functionalized 1-deoxynojirimycin derivatives as selective inhibitors of glucosylceramide metabolism in man.

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Wennekes T, van den Berg RJ, Donker W, van der Marel GA, Strijland A, Aerts JM, and Overkleeft HS

The Journal of organic chemistry 72(4):1088-97, 2007 Feb 16 - Who cited this? | PubMed ID: 17243712 | Fulltext

Solid-phase synthesis and purification of a set of uniformly 13C, 15N labelled de novo designed membrane fusogenic peptides.

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Agrawal PR, Hofmann MW, Meeuwenoord NJ, Filippov DV, Stalz H, Hulsbergen F, Langosch D, Overkleeft HS, and De Groot H

Journal of peptide science : an official publication of the European Peptide Society 13(2):75, 2007 Feb - Who cited this? | PubMed ID: 17121421 | Fulltext

Identification of the non-lysosomal glucosylceramidase as beta-glucosidase 2.

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Boot RG, Verhoek M, Donker-Koopman W, Strijland A, van Marle J, Overkleeft HS, Wennekes T, and Aerts JM

The Journal of biological chemistry 282(2):1305-12, 2007 Jan 12 - Who cited this? | PubMed ID: 17105727 | Fulltext

A fluorescent broad-spectrum proteasome inhibitor for labeling proteasomes in vitro and in vivo.

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Verdoes M, Florea BI, Menendez-Benito V, Maynard CJ, Witte MD, van der Linden WA, van den Nieuwendijk AM, Hofmann T, Berkers CR, van Leeuwen FW, Groothuis TA, Leeuwenburgh MA, Ovaa H, Neefjes JJ, Filippov DV, van der Marel GA,

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Chemistry & biology 13(11):1217-26, 2006 Nov - Who cited this? | PubMed ID: 17114003 | Fulltext

Stereocontrolled synthesis of beta-D-mannuronic acid esters: synthesis of an alginate trisaccharide.

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van den Bos LJ, Dinkelaar J, Overkleeft HS, and van der Marel GA

Journal of the American Chemical Society 128(40):13066-7, 2006 Oct 11 - Who cited this? | PubMed ID: 17017782 | Fulltext

NIS/TFA: a general method for hydrolyzing thioglycosides.

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Dinkelaar J, Witte MD, van den Bos LJ, Overkleeft HS, and van der Marel GA

Carbohydrate research 341(10):1723-9, 2006 Jul 24 - Who cited this? | PubMed ID: 16584717 | Fulltext

Facile synthesis and application of uniformly 13C, 15N-labeled phosphotyrosine for ligand binding studies.

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Tuin AW, Siegal G, van der Marel GA, Overkleeft HS, and Filippov DV

Bioorganic & medicinal chemistry letters 16(14):3806-8, 2006 Jul 15 - Who cited this? | PubMed ID: 16650988 | Fulltext

Synthesis of 2-alkoxy-8-hydroxyadenylpeptides: towards synthetic epitope-based vaccines.

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Weterings JJ, Khan S, van der Heden GJ, Drijfhout JW, Melief CJ, Overkleeft HS, van der Burg SH, Ossendorp F, van der Marel GA, and Filippov DV

Bioorganic & medicinal chemistry letters 16(12):3258-61, 2006 Jun 15 - Who cited this? | PubMed ID: 16581248 | Fulltext

Beta-turn modified gramicidin S analogues containing arylated sugar amino acids display antimicrobial and hemolytic activity comparable to the natural product.

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Grotenbreg GM, Buizert AE, Llamas-Saiz AL, Spalburg E, van Hooft PA, de Neeling AJ, Noort D, van Raaij MJ, van der Marel GA, Overkleeft HS, and Overhand M

Journal of the American Chemical Society 128(23):7559-65, 2006 Jun 14 - Who cited this? | PubMed ID: 16756311 | Fulltext

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