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Papers authored by Otsu K

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Influence of clinical and genetic factors on warfarin dose requirements among Japanese patients.

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Ohno M, Yamamoto A, Ono A, Miura G, Funamoto M, Takemoto Y, Otsu K, Kouno Y, Tanabe T, Masunaga Y, Nonen S, Fujio Y, and Azuma J

European journal of clinical pharmacology 65(11):1097-103, 2009 Nov - Who cited this? | PubMed ID: 19582440 | Fulltext

Discovery of Atg5/Atg7-independent alternative macroautophagy.

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Nishida Y, Arakawa S, Fujitani K, Yamaguchi H, Mizuta T, Kanaseki T, Komatsu M, Otsu K, Tsujimoto Y, and Shimizu S

Nature 461(7264):654-8, 2009 Oct 1 - Who cited this? | PubMed ID: 19794493 | Fulltext

Reduction of Egf signaling decides transition from crown to root in the development of mouse molars.

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Fujiwara N, Akimoto T, Otsu K, Kagiya T, Ishizeki K, and Harada H

Journal of experimental zoology. Part B. Molecular and developmental evolution 312B(5):486-94, 2009 Jul 15 - Who cited this? | PubMed ID: 19090534 | Fulltext

The I{kappa}B kinase {beta}/nuclear factor {kappa}B signaling pathway protects the heart from hemodynamic stress mediated by the regulation of manganese superoxide dismutase expression.

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Hikoso S, Yamaguchi O, Nakano Y, Takeda T, Omiya S, Mizote I, Taneike M, Oka T, Tamai T, Oyabu J, Uno Y, Matsumura Y, Nishida K, Suzuki K, Kogo M, Hori M,

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Circulation research 105(1):70-9, 2009 Jul 2 - Who cited this? | PubMed ID: 19478205 | Fulltext

Comparison of keratin expression in cultured human adenocarcinoma cell lines.

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Yamashita M, Takahashi K, Sato M, Otsu K, Hirayama T, and Katagata Y

Journal of dermatological science 55(1):59-61, 2009 Jul - Who cited this? | PubMed ID: 19376686 | Fulltext

Assessment of capsiconinoid composition, nonpungent capsaicinoid analogues, in capsicum cultivars.

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Tanaka Y, Hosokawa M, Otsu K, Watanabe T, and Yazawa S

Journal of agricultural and food chemistry 57(12):5407-12, 2009 Jun 24 - Who cited this? | PubMed ID: 19489540 | Fulltext

Cardiac steroidogenesis and glucocorticoid in the development of cardiac hypertrophy during the progression to heart failure.

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Ohtani T, Mano T, Hikoso S, Sakata Y, Nishio M, Takeda Y, Otsu K, Miwa T, Masuyama T, Hori M, and Yamamoto K

Journal of hypertension 27(5):1074-83, 2009 May - Who cited this? | PubMed ID: 19349910 | Fulltext

Concentration-dependent inhibition of angiogenesis by mesenchymal stem cells.

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Otsu K, Das S, Houser SD, Quadri SK, Bhattacharya S, and Bhattacharya J

Blood 113(18):4197-205, 2009 Apr 30 - Who cited this? | PubMed ID: 19036701 | Fulltext

Expression of osteogenic proteins during the intrasplenic transplantation of Meckel's chondrocytes: A histochemical and immunohistochemical study.

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Ishizeki K, Kagiya T, Fujiwara N, Otsu K, and Harada H

Archives of histology and cytology 72(1):1-12, 2009 Mar - Who cited this? | PubMed ID: 19789408 | Fulltext

Mouse allergens in urban elementary schools and homes of children with asthma.

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Sheehan WJ, Rangsithienchai PA, Muilenberg ML, Rogers CA, Lane JP, Ghaemghami J, Rivard DV, Otsu K, Hoffman EB, Israel E, Gold DR, and Phipatanakul W

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 102(2):125-30, 2009 Feb - Who cited this? | PubMed ID: 19230463 | Fulltext

The role of autophagy in the heart.

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Nishida K, Kyoi S, Yamaguchi O, Sadoshima J, and Otsu K

Cell death and differentiation 16(1):31-8, 2009 Jan - Who cited this? | PubMed ID: 19008922 | Fulltext

Impaired activation of caspase cascade during cell death induced by newly synthesized singlet oxygen generator, 1-buthylnaphthalene-4-propionate endoperoxide.

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Otsu K, Sato K, Sato M, Ono H, Ohba Y, and Katagata Y

Cell biology international 32(11):1380-7, 2008 Nov - Who cited this? | PubMed ID: 18782624 | Fulltext

Downregulation of ferritin heavy chain increases labile iron pool, oxidative stress and cell death in cardiomyocytes.

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Omiya S, Hikoso S, Imanishi Y, Saito A, Yamaguchi O, Takeda T, Mizote I, Oka T, Taneike M, Nakano Y, Matsumura Y, Nishida K, Sawa Y, Hori M, and Otsu K

Journal of molecular and cellular cardiology, 2008 Oct 19 - Who cited this? | PubMed ID: 18992754 | Fulltext

Reduction in hemoglobin-oxygen affinity results in the improvement of exercise capacity in mice with chronic heart failure.

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Watanabe T, Takeda T, Omiya S, Hikoso S, Yamaguchi O, Nakano Y, Higuchi Y, Nakai A, Abe Y, Aki-Jin Y, Taniike M, Mizote I, Matsumura Y, Shimizu T, Nishida K, Imai K,

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Journal of the American College of Cardiology 52(9):779, 2008 Aug 26 - Who cited this? | PubMed ID: 18718428 | Fulltext

Crosstalk between autophagy and apoptosis in heart disease.

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Nishida K, Yamaguchi O, and Otsu K

Circulation research 103(4):343, 2008 Aug 15 - Who cited this? | PubMed ID: 18703786 | Fulltext

WITHDRAWN: Autophagy in cardiomyocyte is essential for maintenance of cardiac function and response to external stress.

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Hikoso S, Nakai A, Yamaguchi O, Mizushima N, Otsu K, and Hori M

Journal of molecular and cellular cardiology, 2008 Aug 13 - Who cited this? | PubMed ID: 18706600 | Fulltext

PGE2-activated Epac promotes neointimal cushion formation of the rat ductus arteriosus by a process distinct from that of PKA.

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Yokoyama U, Minamisawa S, Quan H, Akaike T, Suzuki S, Jin M, Jiao Q, Watanabe M, Otsu K, Iwasaki S, Nishimaki S, Sato M, and Ishikawa Y

The Journal of biological chemistry, 2008 Aug 11 - Who cited this? | PubMed ID: 18697745 | Fulltext

Epac1 is upregulated during neointima formation and promotes vascular smooth muscle cell migration.

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Yokoyama U, Minamisawa S, Quan H, Akaike T, Jin M, Otsu K, Ulucan C, Wang X, Baljinnyam E, Takaoka M, Sata M, and Ishikawa Y

American journal of physiology. Heart and circulatory physiology, 2008 Aug 8 - Who cited this? | PubMed ID: 18689492 | Fulltext

The kinase p38alpha serves cell type-specific inflammatory functions in skin injury and coordinates pro- and anti-inflammatory gene expression.

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Kim C, Sano Y, Todorova K, Carlson BA, Arpa L, Celada A, Lawrence T, Otsu K, Brissette JL, Arthur JS, and Park JM

Nature immunology, 2008 Aug 1 - Who cited this? | PubMed ID: 18677317 | Fulltext

Cardiac overexpression of hormone-sensitive lipase inhibits myocardial steatosis and fibrosis in streptozotocin diabetic mice.

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Ueno M, Suzuki J, Zenimaru Y, Takahashi S, Koizumi T, Noriki S, Yamaguchi O, Otsu K, Shen WJ, Kraemer FB, and Miyamori I

American journal of physiology. Endocrinology and metabolism 294(6), 2008 Jun - Who cited this? | PubMed ID: 18413675 | Fulltext

Apoptosis Signal-Regulating Kinase 1/p38 Signaling Pathway Negatively Regulates Physiological Hypertrophy.

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Taniike M, Yamaguchi O, Tsujimoto I, Hikoso S, Takeda T, Nakai A, Omiya S, Mizote I, Nakano Y, Higuchi Y, Matsumura Y, Nishida K, Ichijo H, Hori M, and Otsu K

Circulation 117(4):545-52, 2008 Jan 29 - Who cited this? | PubMed ID: 18195174 | Fulltext

Cell death in heart failure.

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Nishida K and Otsu K

Circulation journal : official journal of the Japanese Circulation Society 72 Suppl A:A17-21, 2008 - Who cited this? | PubMed ID: 18772526 | Fulltext

A function for a specific zinc metalloprotease of African trypanosomes.

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Grandgenett PM, Otsu K, Wilson HR, Wilson ME, and Donelson JE

PLoS pathogens 3(10):1432, 2007 Oct 19 - Who cited this? | PubMed ID: 17953481 | Fulltext

cAMP-mediated regulation of CYP enzymes and its application in chemotherapy.

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Ishikawa Y, Suzuki S, Otsu K, Ulucan C, Iwatsubo K, and Eguchi H

Drug metabolism letters 1(3):176-8, 2007 Aug - Who cited this? | PubMed ID: 19356040 | Fulltext

Progression of heart failure was suppressed by inhibition of apoptosis signal-regulating kinase 1 via transcoronary gene transfer.

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Hikoso S, Ikeda Y, Yamaguchi O, Takeda T, Higuchi Y, Hirotani S, Kashiwase K, Yamada M, Asahi M, Matsumura Y, Nishida K, Matsuzaki M, Hori M, and Otsu K

Journal of the American College of Cardiology 50(5):453-62, 2007 Jul 31 - Who cited this? | PubMed ID: 17662399 | Fulltext

Gab family proteins are essential for postnatal maintenance of cardiac function via neuregulin-1/ErbB signaling.

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Nakaoka Y, Nishida K, Narimatsu M, Kamiya A, Minami T, Sawa H, Okawa K, Fujio Y, Koyama T, Maeda M, Sone M, Yamasaki S, Arai Y, Koh GY, Kodama T, Hirota H,

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The Journal of clinical investigation 117(7):1771, 2007 Jul - Who cited this? | PubMed ID: 17571162 | Fulltext

The role of autophagy in cardiomyocytes in the basal state and in response to hemodynamic stress.

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Nakai A, Yamaguchi O, Takeda T, Higuchi Y, Hikoso S, Taniike M, Omiya S, Mizote I, Matsumura Y, Asahi M, Nishida K, Hori M, Mizushima N, and Otsu K

Nature medicine 13(5):619-24, 2007 May - Who cited this? | PubMed ID: 17450150 | Fulltext

Oxidative stress causes heart failure with impaired mitochondrial respiration.

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Nojiri H, Shimizu T, Funakoshi M, Yamaguchi O, Zhou H, Kawakami S, Ohta Y, Sami M, Tachibana T, Ishikawa H, Kurosawa H, Kahn RC, Otsu K, and Shirasawa T

The Journal of biological chemistry 281(44):33789-801, 2006 Nov 3 - Who cited this? | PubMed ID: 16959785 | Fulltext

Usefulness of high-resolution real-time three-dimensional echocardiography to visualize the left ventricular endocardial surface in myocardial infarction.

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Inoue K, Ito H, Iwakura K, Kawano S, Okamura A, Kurotobi T, Date M, Otsu K, Hori M, and Fujii K

The American journal of cardiology 97(11):1578-81, 2006 Jun 1 - Who cited this? | PubMed ID: 16728217 | Fulltext

Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses.

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Kato H, Takeuchi O, Sato S, Yoneyama M, Yamamoto M, Matsui K, Uematsu S, Jung A, Kawai T, Ishii KJ, Yamaguchi O, Otsu K, Tsujimura T, Koh CS, Reis e Sousa C, Matsuura Y,

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Nature 441(7089):101, 2006 May 4 - Who cited this? | PubMed ID: 16625202 | Fulltext

ATP autocrine/paracrine signaling induces calcium oscillations and NFAT activation in human mesenchymal stem cells.

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Kawano S, Otsu K, Kuruma A, Shoji S, Yanagida E, Muto Y, Yoshikawa F, Hirayama Y, Mikoshiba K, and Furuichi T

Cell calcium 39(4):313-24, 2006 Apr - Who cited this? | PubMed ID: 16445977 | Fulltext

Impact of atherosclerosis-related gene polymorphisms on mortality and recurrent events after myocardial infarction.

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Mizuno H, Sato H, Sakata Y, Ohnishi Y, Hishida E, Kinjo K, Nakatani D, Shimizu M, Kondo H, Tanaka T, Ozaki K, Hirayama A, Ito H, Otsu K, Hori M, and Osaka Acute Coronary Insufficiency Study (OACIS) Group

Atherosclerosis 185(2):400-5, 2006 Apr - Who cited this? | PubMed ID: 16054631 | Fulltext

Caveolin-3 inhibits growth signal in cardiac myoblasts in a Ca2+-dependent manner.

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Fujita T, Otsu K, Oshikawa J, Hori H, Kitamura H, Ito T, Umemura S, Minamisawa S, and Ishikawa Y

Journal of cellular and molecular medicine 10(1):216-24, 2006 - Who cited this? | PubMed ID: 16563233 | Fulltext

The role of apoptosis signal-regulating kinase 1 in cardiomyocyte apoptosis.

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Nishida K and Otsu K

Antioxidants & redox signaling 8(9-10):1729-36, 2006 - Who cited this? | PubMed ID: 16987025 | Fulltext

Presenilin 2 regulates the systolic function of heart by modulating Ca2+ signaling.

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Takeda T, Asahi M, Yamaguchi O, Hikoso S, Nakayama H, Kusakari Y, Kawai M, Hongo K, Higuchi Y, Kashiwase K, Watanabe T, Taniike M, Nakai A, Nishida K, Kurihara S, Donoviel DB,

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The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 19(14):2069, 2005 Dec - Who cited this? | PubMed ID: 16204356 | Fulltext

Caveolin; different roles for insulin signal?.

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Ishikawa Y, Otsu K, and Oshikawa J

Cellular signalling 17(10):1175-82, 2005 Oct - Who cited this? | PubMed ID: 15913956 | Fulltext

[Calcium channel blocker and cardiac hypertrophy].

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Takeda T, Otsu K, and Hori M

Clinical calcium 15(10):1645-9, 2005 Oct - Who cited this? | PubMed ID: 16199909 | Fulltext

Signaling pathways and genes that inhibit pathogen-induced macrophage apoptosis--CREB and NF-kappaB as key regulators.

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Park JM, Greten FR, Wong A, Westrick RJ, Arthur JS, Otsu K, Hoffmann A, Montminy M, and Karin M

Immunity 23(3):319, 2005 Sep - Who cited this? | PubMed ID: 16169504 | Fulltext

Apoptosis signal-regulating kinase 1 is involved not only in apoptosis but also in non-apoptotic cardiomyocyte death.

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Watanabe T, Otsu K, Takeda T, Yamaguchi O, Hikoso S, Kashiwase K, Higuchi Y, Taniike M, Nakai A, Matsumura Y, Nishida K, Ichijo H, and Hori M

Biochemical and biophysical research communications 333(2):562-7, 2005 Jul 29 - Who cited this? | PubMed ID: 15953587 | Fulltext

An abortive apoptotic pathway induced by singlet oxygen is due to the suppression of caspase activation.

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Otsu K, Sato K, Ikeda Y, Imai H, Nakagawa Y, Ohba Y, and Fujii J

The Biochemical journal 389(Pt 1):197-206, 2005 Jul 1 - Who cited this? | PubMed ID: 15796713 | Fulltext

Specific inactivation of cysteine protease-type cathepsin by singlet oxygen generated from naphthalene endoperoxides.

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Nagaoka Y, Otsu K, Okada F, Sato K, Ohba Y, Kotani N, and Fujii J

Biochemical and biophysical research communications 331(1):215-23, 2005 May 27 - Who cited this? | PubMed ID: 15845381 | Fulltext

The antioxidant edaravone attenuates pressure overload-induced left ventricular hypertrophy.

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Tsujimoto I, Hikoso S, Yamaguchi O, Kashiwase K, Nakai A, Takeda T, Watanabe T, Taniike M, Matsumura Y, Nishida K, Hori M, Kogo M, and Otsu K

Hypertension 45(5):921-6, 2005 May - Who cited this? | PubMed ID: 15824197 | Fulltext

Cyclophilin D-dependent mitochondrial permeability transition regulates some necrotic but not apoptotic cell death.

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Nakagawa T, Shimizu S, Watanabe T, Yamaguchi O, Otsu K, Yamagata H, Inohara H, Kubo T, and Tsujimoto Y

Nature 434(7033):652-8, 2005 Mar 31 - Who cited this? | PubMed ID: 15800626 | Fulltext

CaMKII activates ASK1 and NF-kappaB to induce cardiomyocyte hypertrophy.

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Kashiwase K, Higuchi Y, Hirotani S, Yamaguchi O, Hikoso S, Takeda T, Watanabe T, Taniike M, Nakai A, Tsujimoto I, Matsumura Y, Ueno H, Nishida K, Hori M, and Otsu K

Biochemical and biophysical research communications 327(1):136-42, 2005 Feb 4 - Who cited this? | PubMed ID: 15629441 | Fulltext

Na+/K+ ATPase and its functional coupling with Na+/Ca2+ exchanger in mouse embryonic stem cells during differentiation into cardiomyocytes.

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Otsu K, Kuruma A, Yanagida E, Shoji S, Inoue T, Hirayama Y, Uematsu H, Hara Y, and Kawano S

Cell calcium 37(2):137-51, 2005 Feb - Who cited this? | PubMed ID: 15589994 | Fulltext

Impact of smoking status on long-term mortality in patients with acute myocardial infarction.

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Kinjo K, Sato H, Sakata Y, Nakatani D, Mizuno H, Shimizu M, Sasaki T, Kijima Y, Nishino M, Uematsu M, Tanouchi J, Nanto S, Otsu K, Hori M, and Osaka Acute Coronary Insufficiency Study (OACIS) Group

Circulation journal : official journal of the Japanese Circulation Society 69(1):7-12, 2005 Jan - Who cited this? | PubMed ID: 15635194 | Fulltext

HSP70 binds to the fast-twitch skeletal muscle sarco(endo)plasmic reticulum Ca2+ -ATPase (SERCA1a) and prevents thermal inactivation.

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Tupling AR, Gramolini AO, Duhamel TA, Kondo H, Asahi M, Tsuchiya SC, Borrelli MJ, Lepock JR, Otsu K, Hori M, MacLennan DH, and Green HJ

The Journal of biological chemistry 279(50):52382-9, 2004 Dec 10 - Who cited this? | PubMed ID: 15371420 | Fulltext

p38alpha mitogen-activated protein kinase plays a critical role in cardiomyocyte survival but not in cardiac hypertrophic growth in response to pressure overload.

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Nishida K, Yamaguchi O, Hirotani S, Hikoso S, Higuchi Y, Watanabe T, Takeda T, Osuka S, Morita T, Kondoh G, Uno Y, Kashiwase K, Taniike M, Nakai A, Matsumura Y, Miyazaki J,

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Molecular and cellular biology 24(24):10611-20, 2004 Dec - Who cited this? | PubMed ID: 15572667 | Fulltext

[Signal transduction in heart failure].

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Watanabe T and Otsu K

Nippon rinsho. Japanese journal of clinical medicine 62(12):2337-42, 2004 Dec - Who cited this? | PubMed ID: 15597806 | Fulltext

Pressure overload induces cardiac dysfunction and dilation in signal transducer and activator of transcription 6-deficient mice.

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Hikoso S, Yamaguchi O, Higuchi Y, Hirotani S, Takeda T, Kashiwase K, Watanabe T, Taniike M, Tsujimoto I, Asahi M, Matsumura Y, Nishida K, Nakajima H, Akira S, Hori M, and Otsu K

Circulation 110(17):2631-7, 2004 Oct 26 - Who cited this? | PubMed ID: 15492321 | Fulltext

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