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Papers authored by Notkins AL

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IA-2 modulates dopamine secretion in PC12 cells.

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Nishimura T, Harashima S, Yafang H, and Notkins AL

Molecular and cellular endocrinology 315(1-2):81-6, 2010 Feb 5 - Who cited this? | PubMed ID: 19799965 | Fulltext

Deletion of the secretory vesicle proteins IA-2 and IA-2beta disrupts circadian rhythms of cardiovascular and physical activity.

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Kim SM, Power A, Brown TM, Constance CM, Coon SL, Nishimura T, Hirai H, Cai T, Eisner C, Weaver DR, Piggins HD, Klein DC, Schnermann J, and Notkins AL

The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 23(9):3226-32, 2009 Sep - Who cited this? | PubMed ID: 19433624 | Fulltext

Comment on: Torii et al. (2009) Gene silencing of phogrin unveils its essential role in glucose-responsive pancreatic beta-cell growth. Diabetes 58:682-692.

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Hu Y, Nishimura T, Zhang A, and Notkins AL

Diabetes 58(5):e8, 2009 May - Who cited this? | PubMed ID: 19401431 | Fulltext

Loss of the Transcriptional Repressor PAG-3/Gfi-1 Results in Enhanced Neurosecretion that is Dependent on the Dense-Core Vesicle Membrane Protein IDA-1/IA-2.

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Cai T, Hirai H, Fukushige T, Yu P, Zhang G, Notkins AL, and Krause M

PLoS genetics 5(4):e1000447, 2009 Apr - Who cited this? | PubMed ID: 19343207 | Fulltext

Disturbances in the secretion of neurotransmitters in IA-2/IA-2beta null mice: changes in behavior, learning and lifespan.

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Nishimura T, Kobosaki A, Ito Y, and Notkins AL

Neuroscience 159(2):427-37, 2009 Mar 17 - Who cited this? | PubMed ID: 19361477 | Fulltext

Dense-core vesicle proteins IA-2 and IA-2{beta} affect renin synthesis and secretion through the {beta}-adrenergic pathway.

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Kim SM, Theilig F, Qin Y, Cai T, Mizel D, Faulhaber-Walter R, Hirai H, Bachmann S, Briggs JP, Notkins AL, and Schnermann J

American journal of physiology. Renal physiology 296(2):F382-9, 2009 Feb - Who cited this? | PubMed ID: 19019914 | Fulltext

Neutralizing the impact factor culture.

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Notkins AL

Science (New York, N.Y.) 322(5899):191, 2008 Oct 10 - Who cited this? | PubMed ID: 18845731 | Fulltext

A new luminescence assay for autoantibodies to mammalian cell-prepared insulinoma-associated protein 2.

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Burbelo PD, Hirai H, Leahy H, Lernmark A, Ivarsson SA, Iadarola MJ, and Notkins AL

Diabetes care 31(9):1824-6, 2008 Sep - Who cited this? | PubMed ID: 18535195 | Fulltext

Selective screening of secretory vesicle-associated proteins for autoantigens in type 1 diabetes: VAMP2 and NPY are new minor autoantigens.

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Hirai H, Miura J, Hu Y, Larsson H, Larsson K, Lernmark A, Ivarsson SA, Wu T, Kingman A, Tzioufas AG, and Notkins AL

Clinical immunology (Orlando, Fla.) 127(3):366-74, 2008 Jun - Who cited this? | PubMed ID: 18359275 | Fulltext

Properties and function of polyreactive antibodies and polyreactive antigen-binding B cells.

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Zhou ZH, Tzioufas AG, and Notkins AL

Journal of autoimmunity 29(4):219-28, 2007 Dec - Who cited this? | PubMed ID: 17888628 | Fulltext

RESP18, a homolog of the luminal domain IA-2, is found in dense core vesicles in pancreatic islet cells and is induced by high glucose.

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Zhang G, Hirai H, Cai T, Miura J, Yu P, Huang H, Schiller MR, Swaim WD, Leapman RD, and Notkins AL

The Journal of endocrinology 195(2):313-21, 2007 Nov - Who cited this? | PubMed ID: 17951542 | Fulltext

Overexpression of the autoantigen IA-2 puts beta cells into a pre-apoptotic state: autoantigen-induced, but non-autoimmune-mediated, tissue destruction.

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Harashima SI, Harashima C, Nishimura T, Hu Y, and Notkins AL

Clinical and experimental immunology 150(1):49, 2007 Oct - Who cited this? | PubMed ID: 17725654 | Fulltext

Human chorionic gonadotropin is an immune modulator and can prevent autoimmune diabetes in NOD mice.

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Khil LY, Jun HS, Kwon H, Yoo JK, Kim S, Notkins AL, and Yoon JW

Diabetologia 50(10):2147-55, 2007 Oct - Who cited this? | PubMed ID: 17676307 | Fulltext

Human chorionic gonadotropin prevents Sjögren's syndrome-like exocrinopathy in mice.

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Li N, Shigihara T, Tzioufas AG, Notkins AL, Yoon JW, and Jun HS

Arthritis and rheumatism 56(7):2211-5, 2007 Jul - Who cited this? | PubMed ID: 17599739 | Fulltext

The broad antibacterial activity of the natural antibody repertoire is due to polyreactive antibodies.

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Zhou ZH, Zhang Y, Hu YF, Wahl LM, Cisar JO, and Notkins AL

Cell host & microbe 1(1):51-61, 2007 Mar 15 - Who cited this? | PubMed ID: 18005681 | Fulltext

New predictors of disease. Molecules called predictive autoantibodies appear in the blood years before people show symptoms of various disorders. Tests that detected these molecules could warn of the need to take preventive action.

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Notkins AL

Scientific American 296(3):72-9, 2007 Mar - Who cited this? | PubMed ID: 17348162 | Fulltext

Disruption of the transmembrane dense core vesicle proteins IA-2 and IA-2beta causes female infertility.

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Kubosaki A, Nakamura S, Clark A, Morris JF, and Notkins AL

Endocrinology 147(2):811-5, 2006 Feb - Who cited this? | PubMed ID: 16269463 | Fulltext

Dense core vesicle proteins IA-2 and IA-2beta: metabolic alterations in double knockout mice.

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Kubosaki A, Nakamura S, and Notkins AL

Diabetes 54 Suppl 2:S46-51, 2005 Dec - Who cited this? | PubMed ID: 16306340 | Fulltext

The IA-2 interactome.

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Hu YF, Zhang HL, Cai T, Harashima S, and Notkins AL

Diabetologia 48(12):2576-81, 2005 Dec - Who cited this? | PubMed ID: 16273344 | Fulltext

The dense core transmembrane vesicle protein IA-2 is a regulator of vesicle number and insulin secretion.

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Harashima S, Clark A, Christie MR, and Notkins AL

Proceedings of the National Academy of Sciences of the United States of America 102(24):8704-9, 2005 Jun 14 - Who cited this? | PubMed ID: 15939893 | Fulltext

A nonneutralizing anti-HIV-1 antibody turns into a neutralizing antibody when expressed on the surface of HIV-1-susceptible cells: a new way to fight HIV.

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Lee SJ, Garza L, Yao J, Notkins AL, and Zhou P

Journal of immunology (Baltimore, Md. : 1950) 173(7):4618-26, 2004 Oct 1 - Who cited this? | PubMed ID: 15383596 | Fulltext

Polyreactive antigen-binding B (PAB-) cells are widely distributed and the PAB population consists of both B-1+ and B-1- phenotypes.

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Zhou ZH and Notkins AL

Clinical and experimental immunology 137(1):88-100, 2004 Jul - Who cited this? | PubMed ID: 15196248 | Fulltext

Targeted disruption of the IA-2beta gene causes glucose intolerance and impairs insulin secretion but does not prevent the development of diabetes in NOD mice.

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Kubosaki A, Gross S, Miura J, Saeki K, Zhu M, Nakamura S, Hendriks W, and Notkins AL

Diabetes 53(7):1684-91, 2004 Jul - Who cited this? | PubMed ID: 15220191 | Fulltext

Type 1 diabetes as a model for autoantibodies as predictors of autoimmune diseases.

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Notkins AL

Autoimmunity reviews 3 Suppl 1:S7-9, 2004 Jun - Who cited this? | PubMed ID: 15309765 | Fulltext

Polyreactivity of antibody molecules.

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Notkins AL

Trends in immunology 25(4):174-9, 2004 Apr - Who cited this? | PubMed ID: 15039043 | Fulltext

Insulinoma-Associated Protein IA-2, a Vesicle Transmembrane Protein, Genetically Interacts with UNC-31/CAPS and Affects Neurosecretion in Caenorhabditis elegans.

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Cai T, Fukushige T, Notkins AL, and Krause M

The Journal of neuroscience : the official journal of the Society for Neuroscience 24(12):3115-24, 2004 Mar 24 - Who cited this? | PubMed ID: 15044551 | Fulltext

IA-2 is not required for the development of diabetes in NOD mice.

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Kubosaki A, Miura J, and Notkins AL

Diabetologia 47(1):149-50, 2004 Jan - Who cited this? | PubMed ID: 14614561 | Fulltext

Autoantibodies in Type 1 and Type 2 diabetes in the Old Order Amish of Lancaster County, Pennsylvania.

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Miura J, Pollin TI, Hu Y, Harashima SI, Notkins AL, and Shuldiner AR

Diabetologia 46(7):1024-5, 2003 Jul - Who cited this? | PubMed ID: 12819905 | Fulltext

Inhibition of HIV-1 replication by the combined action of anti-gp41 single chain antibody and IL-16.

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Devadas K, Zhou P, Tewari D, and Notkins AL

Antiviral research 59(1):67-70, 2003 Jun - Who cited this? | PubMed ID: 12834863 | Fulltext

Multiple autoantibodies as predictors of Type 1 diabetes in a general population.

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Maclaren NK, Lan MS, Schatz D, Malone J, Notkins AL, and Krischer J

Diabetologia 46(6):873-4, 2003 Jun - Who cited this? | PubMed ID: 12802500 | Fulltext

Inhibition of HIV-1 replication in primary human T cells transduced with an intracellular anti-HIV-1 p17 antibody gene.

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Tewari D, Notkins AL, and Zhou P

The journal of gene medicine 5(3):182-9, 2003 Mar - Who cited this? | PubMed ID: 12666184 | Fulltext

Immunologic and genetic factors in type 1 diabetes.

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Notkins AL

The Journal of biological chemistry 277(46):43545-8, 2002 Nov 15 - Who cited this? | PubMed ID: 12270944 | Fulltext

Elevated levels of tumor necrosis factor alpha (TNF-alpha) in human immunodeficiency virus type 1-transgenic mice: prevention of death by antibody to TNF-alpha.

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De SK, Devadas K, and Notkins AL

Journal of virology 76(22):11710-4, 2002 Nov - Who cited this? | PubMed ID: 12388730 | Fulltext

The zinc-finger transcription factor INSM1 is expressed during embryo development and interacts with the Cbl-associated protein.

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Xie J, Cai T, Zhang H, Lan MS, and Notkins AL

Genomics 80(1):54-61, 2002 Jul - Who cited this? | PubMed ID: 12079283 | Fulltext

Targeted disruption of the protein tyrosine phosphatase-like molecule IA-2 results in alterations in glucose tolerance tests and insulin secretion.

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Saeki K, Zhu M, Kubosaki A, Xie J, Lan MS, and Notkins AL

Diabetes 51(6):1842-50, 2002 Jun - Who cited this? | PubMed ID: 12031972 | Fulltext

Neuroendocrine differentiation factor, IA-1, is a transcriptional repressor and contains a specific DNA-binding domain: identification of consensus IA-1 binding sequence.

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Breslin MB, Zhu M, Notkins AL, and Lan MS

Nucleic acids research 30(4):1038-45, 2002 Feb 15 - Who cited this? | PubMed ID: 11842116 | Fulltext

Autoimmune type 1 diabetes: resolved and unresolved issues.

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Notkins AL and Lernmark A

The Journal of clinical investigation 108(9):1247-52, 2001 Nov - Who cited this? | PubMed ID: 11696564 | Fulltext

Autoantibodies as predictors of disease.

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Leslie D, Lipsky P, and Notkins AL

The Journal of clinical investigation 108(10):1417-22, 2001 Nov - Who cited this? | PubMed ID: 11714731 | Fulltext

Analysis of the coding and promoter regions of the autoantigen IA-2 in subjects with and without autoantibodies to IA-2.

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Cai T, Xie J, She JX, and Notkins AL

Diabetes 50(10):2406-9, 2001 Oct - Who cited this? | PubMed ID: 11574427 | Fulltext

HLA-DQ8 transgenic and NOD mice recognize different epitopes within the cytoplasmic region of the tyrosine phosphatase-like molecule, IA-2.

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Kudva YC, Deng YJ, Govindarajan R, Abraham RS, Marietta EV, Notkins AL, and David CS

Human immunology 62(10):1099-105, 2001 Oct - Who cited this? | PubMed ID: 11600216 | Fulltext

Characterization of murine polyreactive antigen-binding B cells: presentation of antigens to T cells.

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Wang Z, Chen ZJ, Wheeler J, Shen S, and Notkins AL

European journal of immunology 31(4):1106-14, 2001 Apr - Who cited this? | PubMed ID: 11298335 | Fulltext

The IA-2 gene family: homologs in Caenorhabditis elegans, Drosophila and zebrafish.

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Cai T, Krause MW, Odenwald WF, Toyama R, and Notkins AL

Diabetologia 44(1):81-8, 2001 Jan - Who cited this? | PubMed ID: 11206415 | Fulltext

Genomic structure of mouse IA-2: comparison with its human homologue.

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Saeki K, Xie J, and Notkins AL

Diabetologia 43(11):1429-34, 2000 Nov - Who cited this? | PubMed ID: 11126414 | Fulltext

The development of monoclonal human rabies virus-neutralizing antibodies as a substitute for pooled human immune globulin in the prophylactic treatment of rabies virus exposure.

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Champion JM, Kean RB, Rupprecht CE, Notkins AL, Koprowski H, Dietzschold B, and Hooper DC

Journal of immunological methods 235(1-2):81-90, 2000 Feb 21 - Who cited this? | PubMed ID: 10675760 | Fulltext

Antibodies to IA-2 and GAD65 in type 1 and type 2 diabetes: isotype restriction and polyclonality.

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Hawa MI, Fava D, Medici F, Deng YJ, Notkins AL, De Mattia G, and Leslie RD

Diabetes care 23(2):228-33, 2000 Feb - Who cited this? | PubMed ID: 10868836 | Fulltext

Molecular determinants of polyreactive antibody binding: HCDR3 and cyclic peptides.

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Deng YJ and Notkins AL

Clinical and experimental immunology 119(1):69-76, 2000 Jan - Who cited this? | PubMed ID: 10606966 | Fulltext

Polyreactive antibodies and polyreactive antigen-binding B (PAB) Cells.

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Notkins AL

Current topics in microbiology and immunology 252:241-9, 2000 - Who cited this? | PubMed ID: 11125481 | Fulltext

Processing, secretion, and anti-HIV-1 activity of IL-16 with or without a signal peptide in CD4+ T cells.

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Zhou P, Devadas K, Tewari D, Jegorow A, and Notkins AL

Journal of immunology (Baltimore, Md. : 1950) 163(2):906-12, 1999 Jul 15 - Who cited this? | PubMed ID: 10395686 | Fulltext

Autoantigens IA-2 and GAD in Type I (insulin-dependent) diabetes.

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Leslie RD, Atkinson MA, and Notkins AL

Diabetologia 42(1):3-14, 1999 Jan - Who cited this? | PubMed ID: 10027571 | Fulltext

Genomic structure and promoter sequence of the insulin-dependent diabetes mellitus autoantigen, IA-2 (PTPRN).

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Xie J, Zhang B, Lan MS, and Notkins AL

Genomics 54(2):338-43, 1998 Dec 1 - Who cited this? | PubMed ID: 9828138 | Fulltext

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