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Papers authored by Nokihara H

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Phase I, dose escalation and pharmacokinetic study of cediranib (RECENTIN), a highly potent and selective VEGFR signaling inhibitor, in Japanese patients with advanced solid tumors.

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Yamamoto N, Tamura T, Yamamoto N, Yamada K, Yamada Y, Nokihara H, Fujiwara Y, Takahashi T, Murakami H, Boku N, Yamazaki K, Puchalski TA, and Shin E

Cancer chemotherapy and pharmacology 64(6):1165-72, 2009 Nov - Who cited this? | PubMed ID: 19308410 | Fulltext

Gender difference in treatment outcomes in patients with stage III non-small cell lung cancer receiving concurrent chemoradiotherapy.

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Sekine I, Sumi M, Ito Y, Tanai C, Nokihara H, Yamamoto N, Kunitoh H, Ohe Y, and Tamura T

Japanese journal of clinical oncology 39(11):707-12, 2009 Nov - Who cited this? | PubMed ID: 19692418 | Fulltext

Risk factors for skeletal-related events in patients with non-small cell lung cancer treated by chemotherapy.

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Sekine I, Nokihara H, Yamamoto N, Kunitoh H, Ohe Y, and Tamura T

Lung cancer (Amsterdam, Netherlands) 65(2):219-22, 2009 Aug - Who cited this? | PubMed ID: 19081161 | Fulltext

Differences in the Quality of Information on the Internet about Lung Cancer between the United States and Japan.

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Goto Y, Sekine I, Sekiguchi H, Yamada K, Nokihara H, Yamamoto N, Kunitoh H, Ohe Y, and Tamura T

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 4(7):829-33, 2009 Jul - Who cited this? | PubMed ID: 19550244 | Fulltext

Prognostic factors and clinical outcomes in patients with leptomeningeal metastasis from solid tumors.

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Waki F, Ando M, Takashima A, Yonemori K, Nokihara H, Miyake M, Tateishi U, Tsuta K, Shimada Y, Fujiwara Y, and Tamura T

Journal of neuro-oncology 93(2):205-12, 2009 Jun - Who cited this? | PubMed ID: 19043775 | Fulltext

Characteristics and outcomes of patients with advanced non-small-cell lung cancer who declined to participate in randomised clinical chemotherapy trials.

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Tanai C, Nokihara H, Yamamoto S, Kunitoh H, Yamamoto N, Sekine I, Ohe Y, and Tamura T

British journal of cancer 100(7):1037-42, 2009 Apr 7 - Who cited this? | PubMed ID: 19293799 | Fulltext

Comparative chemotherapeutic efficacy in non-small cell lung cancer patients with postoperative recurrence and stage IV disease.

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Sekine I, Nokihara H, Yamamoto N, Kunitoh H, Ohe Y, and Tamura T

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 4(4):518-21, 2009 Apr - Who cited this? | PubMed ID: 19347981 | Fulltext

Circulating endothelial cells in non-small cell lung cancer patients treated with carboplatin and paclitaxel.

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Kawaishi M, Fujiwara Y, Fukui T, Kato T, Yamada K, Ohe Y, Kunitoh H, Sekine I, Yamamoto N, Nokihara H, Watabe T, Shimoda Y, Arao T, Nishio K, Tamura T, and Koizumi F

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 4(2):208-13, 2009 Feb - Who cited this? | PubMed ID: 19179898 | Fulltext

Genetic Variations and Haplotype Structures of the Glutathione S-transferase Genes, GSTT1 and GSTM1, in a Japanese Patient Population.

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Tatewaki N, Maekawa K, Katori N, Kurose K, Kaniwa N, Yamamoto N, Kunitoh H, Ohe Y, Nokihara H, Sekine I, Tamura T, Yoshida T, Saijo N, Saito Y, and Sawada J

Drug metabolism and pharmacokinetics 24(1):118-26, 2009 - Who cited this? | PubMed ID: 19252342 | Fulltext

EGFR Mutations Predict Survival Benefit From Gefitinib in Patients With Advanced Lung Adenocarcinoma: A Historical Comparison of Patients Treated Before and After Gefitinib Approval in Japan.

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Takano T, Fukui T, Ohe Y, Tsuta K, Yamamoto S, Nokihara H, Yamamoto N, Sekine I, Kunitoh H, Furuta K, and Tamura T

Journal of clinical oncology : official journal of the American Society of Clinical Oncology 26(34):5589-95, 2008 Dec 1 - Who cited this? | PubMed ID: 18794545 | Fulltext

Prospective Study of the Accuracy of EGFR Mutational Analysis by High-Resolution Melting Analysis in Small Samples Obtained from Patients with Non-Small Cell Lung Cancer.

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Fukui T, Ohe Y, Tsuta K, Furuta K, Sakamoto H, Takano T, Nokihara H, Yamamoto N, Sekine I, Kunitoh H, Asamura H, Tsuchida T, Kaneko M, Kusumoto M, Yamamoto S, Yoshida T,

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Clinical cancer research : an official journal of the American Association for Cancer Research 14(15):4751, 2008 Aug 1 - Who cited this? | PubMed ID: 18676744 | Fulltext

Influence of Previous Chemotherapy on the Efficacy of Subsequent Docetaxel Therapy in Advanced Non-small Cell Lung Cancer Patients.

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Goto Y, Sekine I, Yamada K, Nokihara H, Yamamoto N, Kunitoh H, Ohe Y, and Tamura T

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 3(4):412-6, 2008 Apr - Who cited this? | PubMed ID: 18379361 | Fulltext

Randomised phase II trial of irinotecan plus cisplatin vs irinotecan, cisplatin plus etoposide repeated every 3 weeks in patients with extensive-disease small-cell lung cancer.

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Sekine I, Nokihara H, Takeda K, Nishiwaki Y, Nakagawa K, Isobe H, Mori K, Matsui K, Saijo N, and Tamura T

British journal of cancer 98(4):693-6, 2008 Feb 26 - Who cited this? | PubMed ID: 18253118 | Fulltext

Gender differences in treatment outcomes among patients with non-small cell lung cancer given a combination of carboplatin and paclitaxel.

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Yamamoto H, Sekine I, Yamada K, Nokihara H, Yamamoto N, Kunitoh H, Ohe Y, and Tamura T

Oncology 75(3-4):169-74, 2008 - Who cited this? | PubMed ID: 18827494 | Fulltext

Genetic Variations of VDR/NR1I1 Encoding Vitamin D Receptor in a Japanese Population.

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Ukaji M, Saito Y, Fukushima-Uesaka H, Maekawa K, Katori N, Kaniwa N, Yoshida T, Nokihara H, Sekine I, Kunitoh H, Ohe Y, Yamamoto N, Tamura T, Saijo N, and Sawada J

Drug metabolism and pharmacokinetics 22(6):462-7, 2007 Dec - Who cited this? | PubMed ID: 18159135 | Fulltext

Epidermal growth factor receptor mutation detection using high-resolution melting analysis predicts outcomes in patients with advanced non small cell lung cancer treated with gefitinib.

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Takano T, Ohe Y, Tsuta K, Fukui T, Sakamoto H, Yoshida T, Tateishi U, Nokihara H, Yamamoto N, Sekine I, Kunitoh H, Matsuno Y, Furuta K, and Tamura T

Clinical cancer research : an official journal of the American Association for Cancer Research 13(18 Pt 1):5385-90, 2007 Sep 15 - Who cited this? | PubMed ID: 17875767 | Fulltext

Bodyweight change during the first 5 days of chemotherapy as an indicator of cisplatin renal toxicity.

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Sekine I, Yamada K, Nokihara H, Yamamoto N, Kunitoh H, Ohe Y, and Tamura T

Cancer science 98(9):1408-12, 2007 Sep - Who cited this? | PubMed ID: 17596207 | Fulltext

Problems with registration-directed clinical trials for lung cancer in Japan.

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Sekine I, Nokihara H, Yamamoto N, Kunitoh H, Ohe Y, Saijo N, and Tamura T

The Tohoku journal of experimental medicine 213(1):17-23, 2007 Sep - Who cited this? | PubMed ID: 17785949 | Fulltext

Effect of platinum combined with irinotecan or paclitaxel against large cell neuroendocrine carcinoma of the lung.

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Fujiwara Y, Sekine I, Tsuta K, Ohe Y, Kunitoh H, Yamamoto N, Nokihara H, Yamada K, and Tamura T

Japanese journal of clinical oncology 37(7):482-6, 2007 Jul - Who cited this? | PubMed ID: 17652109 | Fulltext

Serum total bilirubin as a predictive factor for severe neutropenia in lung cancer patients treated with cisplatin and irinotecan.

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Fujiwara Y, Sekine I, Ohe Y, Kunitoh H, Yamamoto N, Nokihara H, Simmyo Y, Fukui T, Yamada K, and Tamura T

Japanese journal of clinical oncology 37(5):358-64, 2007 May - Who cited this? | PubMed ID: 17538190 | Fulltext

Concurrent chemoradiotherapy for limited-disease small cell lung cancer in elderly patients aged 75 years or older.

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Shimizu T, Sekine I, Sumi M, Ito Y, Yamada K, Nokihara H, Yamamoto N, Kunitoh H, Ohe Y, and Tamura T

Japanese journal of clinical oncology 37(3):181-5, 2007 Mar - Who cited this? | PubMed ID: 17426103 | Fulltext

Phase I study of cisplatin analogue nedaplatin, paclitaxel, and thoracic radiotherapy for unresectable stage III non-small cell lung cancer.

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Sekine I, Sumi M, Ito Y, Kato T, Fujisaka Y, Nokihara H, Yamamoto N, Kunitoh H, Ohe Y, and Tamura T

Japanese journal of clinical oncology 37(3):175-80, 2007 Mar - Who cited this? | PubMed ID: 17452427 | Fulltext

Docetaxel consolidation therapy following cisplatin, vinorelbine, and concurrent thoracic radiotherapy in patients with unresectable stage III non-small cell lung cancer.

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Sekine I, Nokihara H, Sumi M, Saijo N, Nishiwaki Y, Ishikura S, Mori K, Tsukiyama I, and Tamura T

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 1(8):810-5, 2006 Oct - Who cited this? | PubMed ID: 17409964 | Fulltext

Pharmacokinetics and pharmacodynamics of weekly epoetin beta in lung cancer patients.

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Fujisaka Y, Tamura T, Ohe Y, Kunitoh H, Sekine I, Yamamoto N, Nokihara H, Horiike A, Kodama T, and Saijo N

Japanese journal of clinical oncology 36(8):477, 2006 Aug - Who cited this? | PubMed ID: 16901911 | Fulltext

Common arm analysis: one approach to develop the basis for global standardization in clinical trials of non-small cell lung cancer.

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Sekine I, Nokihara H, Yamamoto N, Kunitoh H, Ohe Y, Saijo N, and Tamura T

Lung cancer (Amsterdam, Netherlands) 53(2):157-64, 2006 Aug - Who cited this? | PubMed ID: 16781004 | Fulltext

Retrospective analysis of steroid therapy for radiation-induced lung injury in lung cancer patients.

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Sekine I, Sumi M, Ito Y, Nokihara H, Yamamoto N, Kunitoh H, Ohe Y, Kodama T, Saijo N, and Tamura T

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 80(1):93-7, 2006 Jul - Who cited this? | PubMed ID: 16820236 | Fulltext

Knowledge of efficacy of treatments in lung cancer is not enough, their clinical effectiveness should also be known.

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Sekine I, Takada M, Nokihara H, Yamamoto S, and Tamura T

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 1(5):398-402, 2006 Jun - Who cited this? | PubMed ID: 17409889 | Fulltext

Epidermal growth factor receptor gene mutations and increased copy numbers predict gefitinib sensitivity in patients with recurrent non-small-cell lung cancer.

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Takano T, Ohe Y, Sakamoto H, Tsuta K, Matsuno Y, Tateishi U, Yamamoto S, Nokihara H, Yamamoto N, Sekine I, Kunitoh H, Shibata T, Sakiyama T, Yoshida T, and Tamura T

Journal of clinical oncology : official journal of the American Society of Clinical Oncology 23(28):6829-37, 2005 Oct 1 - Who cited this? | PubMed ID: 15998907 | Fulltext

Functional characterization of five novel CYP2C8 variants, G171S, R186X, R186G, K247R, and K383N, found in a Japanese population.

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Hichiya H, Tanaka-Kagawa T, Soyama A, Jinno H, Koyano S, Katori N, Matsushima E, Uchiyama S, Tokunaga H, Kimura H, Minami N, Katoh M, Sugai K, Goto Y, Tamura T, Yamamoto N,

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Drug metabolism and disposition: the biological fate of chemicals 33(5):630-6, 2005 May - Who cited this? | PubMed ID: 15716363 | Fulltext

Randomized pharmacokinetic and pharmacodynamic study of docetaxel: dosing based on body-surface area compared with individualized dosing based on cytochrome P450 activity estimated using a urinary metabolite of exogenous cortisol.

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Yamamoto N, Tamura T, Murakami H, Shimoyama T, Nokihara H, Ueda Y, Sekine I, Kunitoh H, Ohe Y, Kodama T, Shimizu M, Nishio K, Ishizuka N, and Saijo N

Journal of clinical oncology : official journal of the American Society of Clinical Oncology 23(6):1061-9, 2005 Feb 20 - Who cited this? | PubMed ID: 15657405 | Fulltext

Multi-institutional phase II trial of irinotecan, cisplatin, and etoposide for sensitive relapsed small-cell lung cancer.

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Goto K, Sekine I, Nishiwaki Y, Kakinuma R, Kubota K, Matsumoto T, Ohmatsu H, Niho S, Kodama T, Shinkai T, Tamura T, Ohe Y, Kunitoh H, Yamamoto N, Nokihara H, Yoshida K,

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British journal of cancer 91(4):659-65, 2004 Aug 16 - Who cited this? | PubMed ID: 15280919 | Fulltext

Phase I study of cisplatin, vinorelbine, and concurrent thoracic radiotherapy for unresectable stage III non-small cell lung cancer.

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Sekine I, Noda K, Oshita F, Yamada K, Tanaka M, Yamashita K, Nokihara H, Yamamoto N, Kunitoh H, Ohe Y, Tamura T, Kodama T, Sumi M, and Saijo N

Cancer science 95(8):691-5, 2004 Aug - Who cited this? | PubMed ID: 15298734 | Fulltext

Comparison of pharmacokinetics and pharmacodynamics of docetaxel and Cisplatin in elderly and non-elderly patients: why is toxicity increased in elderly patients?.

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Minami H, Ohe Y, Niho S, Goto K, Ohmatsu H, Kubota K, Kakinuma R, Nishiwaki Y, Nokihara H, Sekine I, Saijo N, Hanada K, and Ogata H

Journal of clinical oncology : official journal of the American Society of Clinical Oncology 22(14):2901-8, 2004 Jul 15 - Who cited this? | PubMed ID: 15254059 | Fulltext

Risk factors for interstitial lung disease and predictive factors for tumor response in patients with advanced non-small cell lung cancer treated with gefitinib.

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Takano T, Ohe Y, Kusumoto M, Tateishi U, Yamamoto S, Nokihara H, Yamamoto N, Sekine I, Kunitoh H, Tamura T, Kodama T, and Saijo N

Lung cancer (Amsterdam, Netherlands) 45(1):93-104, 2004 Jul - Who cited this? | PubMed ID: 15196739 | Fulltext

Phase I study of cisplatin analogue nedaplatin (254-S) and paclitaxel in patients with unresectable squamous cell carcinoma.

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Sekine I, Nokihara H, Horiike A, Yamamoto N, Kunitoh H, Ohe Y, Tamura T, Kodama T, and Saijo N

British journal of cancer 90(6):1125-8, 2004 Mar 22 - Who cited this? | PubMed ID: 15026789 | Fulltext

A phase II study of cisplatin and docetaxel administered as three consecutive weekly infusions for advanced non-small-cell lung cancer in elderly patients.

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Ohe Y, Niho S, Kakinuma R, Kubota K, Ohmatsu H, Goto K, Nokihara H, Kunitoh H, Saijo N, Aono H, Watanabe K, Tango M, Yokoyama A, and Nishiwaki Y

Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 15(1):45-50, 2004 Jan - Who cited this? | PubMed ID: 14679118 | Fulltext

Study of paclitaxel and dose escalation of cisplatin in patients with advanced non-small cell lung cancer.

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Watanabe H, Yamamoto N, Tamura T, Shimoyama T, Hotta K, Inoue A, Sawada M, Akiyama Y, Kusaba H, Nokihara H, Sekine I, Kunitoh H, Ohe Y, Kodama T, and Saijo N

Japanese journal of clinical oncology 33(12):626-30, 2003 Dec - Who cited this? | PubMed ID: 14769840 | Fulltext

Multifunctional interleukin-1beta promotes metastasis of human lung cancer cells in SCID mice via enhanced expression of adhesion-, invasion- and angiogenesis-related molecules.

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Yano S, Nokihara H, Yamamoto A, Goto H, Ogawa H, Kanematsu T, Miki T, Uehara H, Saijo Y, Nukiwa T, and Sone S

Cancer science 94(3):244-52, 2003 Mar - Who cited this? | PubMed ID: 12824917 | Fulltext

[Recent progress in the treatment of ED small cell lung cancer].

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Nokihara H and Ohe Y

Nippon rinsho. Japanese journal of clinical medicine 60 Suppl 5:480-4, 2002 May - Who cited this? | PubMed ID: 12101718 | Fulltext

Antiangiogenic effect by SU5416 is partly attributable to inhibition of Flt-1 receptor signaling.

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Itokawa T, Nokihara H, Nishioka Y, Sone S, Iwamoto Y, Yamada Y, Cherrington J, McMahon G, Shibuya M, Kuwano M, and Ono M

Molecular cancer therapeutics 1(5):295-302, 2002 Mar - Who cited this? | PubMed ID: 12489845 | Fulltext

Phase I/II study of 3-week cycle cisplatin-gemcitabine in advanced non-small cell lung cancer.

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Kusaba H, Tamura T, Shimoyama T, Hotta K, Inoue A, Nokihara H, Ueda Y, Akiyama Y, Yamamoto N, Sekine I, Kunitoh H, Ohe Y, Kodama T, and Saijo N

Japanese journal of clinical oncology 32(2):43-7, 2002 Feb - Who cited this? | PubMed ID: 11948227 | Fulltext

Three novel single nucleotide polymorphisms in UGT1A10.

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Saeki M, Ozawa S, Saito Y, Jinno H, Hamaguchi T, Nokihara H, Shimada Y, Kunitoh H, Yamamoto N, Ohe Y, Yamada Y, Shirao K, Muto M, Mera K, Goto K, Ohmatsu H,

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Drug metabolism and pharmacokinetics 17(5):488-90, 2002 - Who cited this? | PubMed ID: 15618702 | Fulltext

A phase I/II study of cisplatin and vinorelbine chemotherapy in patients with advanced non-small cell lung cancer.

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Hotta K, Sekine I, Tamura T, Sawada M, Watanabe H, Kusaba H, Akiyama Y, Inoue A, Shimoyama T, Nokihara H, Ueda Y, Yamamoto N, Kunitoh H, Ohe Y, Kodama T, and Saijo N

Japanese journal of clinical oncology 31(12):596-600, 2001 Dec - Who cited this? | PubMed ID: 11902490 | Fulltext

Transduction of KAI1/CD82 cDNA promotes hematogenous spread of human lung-cancer cells in natural killer cell-depleted SCID mice.

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Shinohara T, Nishimura N, Hanibuchi M, Nokihara H, Miki T, Hamada H, and Sone S

International journal of cancer. Journal international du cancer 94(1):16-23, 2001 Oct 1 - Who cited this? | PubMed ID: 11668473 | Fulltext

A new quinoline derivative MS-209 reverses multidrug resistance and inhibits multiorgan metastases by P-glycoprotein-expressing human small cell lung cancer cells.

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Nokihara H, Yano S, Nishioka Y, Hanibuchi M, Higasida T, Tsuruo T, and Sone S

Japanese journal of cancer research : Gann 92(7):785-92, 2001 Jul - Who cited this? | PubMed ID: 11473730 | Fulltext

Nuclear factor-kappaB-dependent expression of metastasis suppressor KAI1/CD82 gene in lung cancer cell lines expressing mutant p53.

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Shinohara T, Miki T, Nishimura N, Nokihara H, Hamada H, Mukaida N, and Sone S

Cancer research 61(2):673-8, 2001 Jan 15 - Who cited this? | PubMed ID: 11212267 | Fulltext

Natural killer cell-dependent suppression of systemic spread of human lung adenocarcinoma cells by monocyte chemoattractant protein-1 gene transfection in severe combined immunodeficient mice.

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Nokihara H, Yanagawa H, Nishioka Y, Yano S, Mukaida N, Matsushima K, and Sone S

Cancer research 60(24):7002-7, 2000 Dec 15 - Who cited this? | PubMed ID: 11156403 | Fulltext

Intrapleural therapy with MDP-Lys (L18), a synthetic derivative of muramyl dipeptide, against malignant pleurisy associated with lung cancer.

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Yanagawa H, Haku T, Takeuchi E, Suzuki Y, Nokihara H, and Sone S

Lung cancer (Amsterdam, Netherlands) 27(2):67-73, 2000 Feb - Who cited this? | PubMed ID: 10688489 | Fulltext

Combined therapy with anti-P-glycoprotein antibody and macrophage colony-stimulating factor gene transduction for multiorgan metastases of multidrug-resistant human small cell lung cancer in NK cell-depleted SCID mice.

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Yano S, Hanibuchi M, Nishioka Y, Nokihara H, Nishimura N, Tsuruo T, and Sone S

International journal of cancer. Journal international du cancer 82(1):105-11, 1999 Jul 2 - Who cited this? | PubMed ID: 10360828 | Fulltext

Cytolysis of human dendritic cells by autologous lymphokine-activated killer cells: participation of both T cells and NK cells in the killing.

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Parajuli P, Nishioka Y, Nishimura N, Singh SM, Hanibuchi M, Nokihara H, Yanagawa H, and Sone S

Journal of leukocyte biology 65(6):764-70, 1999 Jun - Who cited this? | PubMed ID: 10380897 | Fulltext

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