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Papers authored by Neel BG

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Neuronal protein tyrosine phosphatase 1B deficiency results in inhibition of hypothalamic AMPK and isoform-specific activation of AMPK in peripheral tissues.

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Xue B, Pulinilkunnil T, Murano I, Bence KK, He H, Minokoshi Y, Asakura K, Lee A, Haj F, Furukawa N, Catalano KJ, Delibegovic M, Balschi JA, Cinti S, Neel BG, and Kahn BB

Molecular and cellular biology 29(16):4563-73, 2009 Aug - Who cited this? | PubMed ID: 19528236 | Fulltext

Leukemogenic Ptpn11 causes fatal myeloproliferative disorder via cell-autonomous effects on multiple stages of hematopoiesis.

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Chan G, Kalaitzidis D, Usenko T, Kutok JL, Yang W, Mohi MG, and Neel BG

Blood 113(18):4414-24, 2009 Apr 30 - Who cited this? | PubMed ID: 19179468 | Fulltext

Noonan syndrome cardiac defects are caused by PTPN11 acting in endocardium to enhance endocardial-mesenchymal transformation.

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Araki T, Chan G, Newbigging S, Morikawa L, Bronson RT, and Neel BG

Proceedings of the National Academy of Sciences of the United States of America 106(12):4736-41, 2009 Mar 24 - Who cited this? | PubMed ID: 19251646 | Fulltext

Liver-Specific Deletion of Protein-Tyrosine Phosphatase 1B (PTP1B) Improves Metabolic Syndrome and Attenuates Diet-Induced Endoplasmic Reticulum Stress.

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Delibegovic M, Zimmer D, Kauffman C, Rak K, Hong EG, Cho YR, Kim JK, Kahn BB, Neel BG, and Bence KK

Diabetes 58(3):590-9, 2009 Mar - Who cited this? | PubMed ID: 19074988 | Fulltext

Noonan Syndrome/Leukemia-associated Gain-of-function Mutations in SHP-2 Phosphatase (PTPN11) Enhance Cell Migration and Angiogenesis.

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Wang S, Yu WM, Zhang W, McCrae KR, Neel BG, and Qu CK

The Journal of biological chemistry 284(2):913-20, 2009 Jan 9 - Who cited this? | PubMed ID: 19008228 | Fulltext

The Skap-hom Dimerization and PH Domains Comprise a 3'-Phosphoinositide-Gated Molecular Switch.

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Swanson KD, Tang Y, Ceccarelli DF, Poy F, Sliwa JP, Neel BG, and Eck MJ

Molecular cell 32(4):564-75, 2008 Nov 21 - Who cited this? | PubMed ID: 19026786 | Fulltext

Distinct populations of tumor-initiating cells derived from a tumor generated by rat mammary cancer stem cells.

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Zucchi I, Astigiano S, Bertalot G, Sanzone S, Cocola C, Pelucchi P, Bertoli G, Stehling M, Barbieri O, Albertini A, Schöler HR, Neel BG, Reinbold RA, and Dulbecco R

Proceedings of the National Academy of Sciences of the United States of America 105(44):16940-5, 2008 Nov 4 - Who cited this? | PubMed ID: 18957543 | Fulltext

The tyrosine phosphatase Shp2 (PTPN11) in cancer.

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Chan G, Kalaitzidis D, and Neel BG

Cancer metastasis reviews 27(2):179, 2008 Jun - Who cited this? | PubMed ID: 18286234 | Fulltext

Protein-tyrosine Phosphatase 1B Expression Is Induced by Inflammation in Vivo.

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Zabolotny JM, Kim YB, Welsh LA, Kershaw EE, Neel BG, and Kahn BB

The Journal of biological chemistry 283(21):14230-41, 2008 May 23 - Who cited this? | PubMed ID: 18281274 | Fulltext

Deletion of Ptpn11 (Shp2) in cardiomyocytes causes dilated cardiomyopathy via effects on the extracellular signal-regulated kinase/mitogen-activated protein kinase and RhoA signaling pathways.

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Kontaridis MI, Yang W, Bence KK, Cullen D, Wang B, Bodyak N, Ke Q, Hinek A, Kang PM, Liao R, and Neel BG

Circulation 117(11):1423, 2008 Mar 18 - Who cited this? | PubMed ID: 18316486 | Fulltext

SOS1 mutations are rare in human malignancies: Implications for Noonan syndrome patients.

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Swanson KD, Winter JM, Reis M, Bentires-Alj M, Greulich H, Grewal R, Hruban RH, Yeo CJ, Yassin Y, Iartchouk O, Montgomery K, Whitman SP, Caligiuri MA, Loh ML, Gilliland DG, Look AT,

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Genes, chromosomes & cancer 47(3):253-9, 2008 Mar - Who cited this? | PubMed ID: 18064648 | Fulltext

Flow-cytometric phosphoprotein analysis reveals agonist and temporal differences in responses of murine hematopoietic stem/progenitor cells.

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Kalaitzidis D and Neel BG

PLoS ONE 3(11):e3776, 2008 - Who cited this? | PubMed ID: 19020663 | Fulltext

Improved glucose homeostasis in mice with muscle-specific deletion of protein-tyrosine phosphatase 1B.

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Delibegovic M, Bence KK, Mody N, Hong EG, Ko HJ, Kim JK, Kahn BB, and Neel BG

Molecular and cellular biology 27(21):7727-34, 2007 Nov - Who cited this? | PubMed ID: 17724080 | Fulltext

Protein-tyrosine phosphatase 1B deficiency reduces insulin resistance and the diabetic phenotype in mice with polygenic insulin resistance.

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Xue B, Kim YB, Lee A, Toschi E, Bonner-Weir S, Kahn CR, Neel BG, and Kahn BB

The Journal of biological chemistry 282(33):23829-40, 2007 Aug 17 - Who cited this? | PubMed ID: 17545163 | Fulltext

B cell-specific deletion of protein-tyrosine phosphatase Shp1 promotes B-1a cell development and causes systemic autoimmunity.

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Pao LI, Lam KP, Henderson JM, Kutok JL, Alimzhanov M, Nitschke L, Thomas ML, Neel BG, and Rajewsky K

Immunity 27(1):35-48, 2007 Jul - Who cited this? | PubMed ID: 17600736 | Fulltext

Control of CNS cell-fate decisions by SHP-2 and its dysregulation in Noonan syndrome.

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Gauthier AS, Furstoss O, Araki T, Chan R, Neel BG, Kaplan DR, and Miller FD

Neuron 54(2):245, 2007 Apr 19 - Who cited this? | PubMed ID: 17442246 | Fulltext

Protein-tyrosine phosphatase 1B is required for HER2/Neu-induced breast cancer.

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Bentires-Alj M and Neel BG

Cancer research 67(6):2420-4, 2007 Mar 15 - Who cited this? | PubMed ID: 17347513 | Fulltext

The role of Shp2 (PTPN11) in cancer.

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Mohi MG and Neel BG

Current opinion in genetics & development 17(1):23-30, 2007 Feb - Who cited this? | PubMed ID: 17227708 | Fulltext

ADAP is required for normal alphaIIbbeta3 activation by VWF/GP Ib-IX-V and other agonists.

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Kasirer-Friede A, Moran B, Nagrampa-Orje J, Swanson K, Ruggeri ZM, Schraven B, Neel BG, Koretzky G, and Shattil SJ

Blood 109(3):1018-25, 2007 Feb 1 - Who cited this? | PubMed ID: 17003372 | Fulltext

Combining an mTOR antagonist and receptor tyrosine kinase inhibitors for the treatment of prostate cancer.

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Masiello D, Mohi MG, McKnight NC, Smith B, Neel BG, Balk SP, and Bubley GJ

Cancer biology & therapy 6(2):195-201, 2007 Feb - Who cited this? | PubMed ID: 17218776 | Fulltext

Live-cell imaging of enzyme-substrate interaction reveals spatial regulation of PTP1B.

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Yudushkin IA, Schleifenbaum A, Kinkhabwala A, Neel BG, Schultz C, and Bastiaens PI

Science (New York, N.Y.) 315(5808):115-9, 2007 Jan 5 - Who cited this? | PubMed ID: 17204654 | Fulltext

Germline gain-of-function mutations in SOS1 cause Noonan syndrome.

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Roberts AE, Araki T, Swanson KD, Montgomery KT, Schiripo TA, Joshi VA, Li L, Yassin Y, Tamburino AM, Neel BG, and Kucherlapati RS

Nature genetics 39(1):70-4, 2007 Jan - Who cited this? | PubMed ID: 17143285 | Fulltext

Regulation of protein tyrosine phosphatase 1B by sumoylation.

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Dadke S, Cotteret S, Yip SC, Jaffer ZM, Haj F, Ivanov A, Rauscher F, Shuai K, Ng T, Neel BG, and Chernoff J

Nature cell biology 9(1):80-5, 2007 Jan - Who cited this? | PubMed ID: 17159996 | Fulltext

FcgammaRIII-dependent inhibition of interferon-gamma responses mediates suppressive effects of intravenous immune globulin.

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Park-Min KH, Serbina NV, Yang W, Ma X, Krystal G, Neel BG, Nutt SL, Hu X, and Ivashkiv LB

Immunity 26(1):67-78, 2007 Jan - Who cited this? | PubMed ID: 17239631 | Fulltext

Nonreceptor protein-tyrosine phosphatases in immune cell signaling.

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Pao LI, Badour K, Siminovitch KA, and Neel BG

Annual review of immunology 25:473-523, 2007 - Who cited this? | PubMed ID: 17291189 | Fulltext

SHP1 phosphatase-dependent T cell inhibition by CEACAM1 adhesion molecule isoforms.

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Nagaishi T, Pao L, Lin SH, Iijima H, Kaser A, Qiao SW, Chen Z, Glickman J, Najjar SM, Nakajima A, Neel BG, and Blumberg RS

Immunity 25(5):769, 2006 Nov - Who cited this? | PubMed ID: 17081782 | Fulltext

SHP-2 activates signaling of the nuclear factor of activated T cells to promote skeletal muscle growth.

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Fornaro M, Burch PM, Yang W, Zhang L, Hamilton CE, Kim JH, Neel BG, and Bennett AM

The Journal of cell biology 175(1):87-97, 2006 Oct 9 - Who cited this? | PubMed ID: 17015617 | Fulltext

The scaffolding adapter Gab2, via Shp-2, regulates kit-evoked mast cell proliferation by activating the Rac/JNK pathway.

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Yu M, Luo J, Yang W, Wang Y, Mizuki M, Kanakura Y, Besmer P, Neel BG, and Gu H

The Journal of biological chemistry 281(39):28615-26, 2006 Sep 29 - Who cited this? | PubMed ID: 16873377 | Fulltext

Neuronal PTP1B regulates body weight, adiposity and leptin action.

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Bence KK, Delibegovic M, Xue B, Gorgun CZ, Hotamisligil GS, Neel BG, and Kahn BB

Nature medicine 12(8):917-24, 2006 Aug - Who cited this? | PubMed ID: 16845389 | Fulltext

PTPN11 (Shp2) mutations in LEOPARD syndrome have dominant negative, not activating, effects.

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Kontaridis MI, Swanson KD, David FS, Barford D, and Neel BG

The Journal of biological chemistry 281(10):6785-92, 2006 Mar 10 - Who cited this? | PubMed ID: 16377799 | Fulltext

An Shp2/SFK/Ras/Erk signaling pathway controls trophoblast stem cell survival.

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Yang W, Klaman LD, Chen B, Araki T, Harada H, Thomas SM, George EL, and Neel BG

Developmental cell 10(3):317, 2006 Mar - Who cited this? | PubMed ID: 16516835 | Fulltext

Stops along the RAS pathway in human genetic disease.

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Bentires-Alj M, Kontaridis MI, and Neel BG

Nature medicine 12(3):283-5, 2006 Mar - Who cited this? | PubMed ID: 16520774 | Fulltext

Scaffolding adapter Grb2-associated binder 2 requires Syk to transmit signals from FcepsilonRI.

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Yu M, Lowell CA, Neel BG, and Gu H

Journal of immunology (Baltimore, Md. : 1950) 176(4):2421-9, 2006 Feb 15 - Who cited this? | PubMed ID: 16456001 | Fulltext

Phosphorylated alpha-actinin and protein-tyrosine phosphatase 1B coregulate the disassembly of the focal adhesion kinase x Src complex and promote cell migration.

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Zhang Z, Lin SY, Neel BG, and Haimovich B

The Journal of biological chemistry 281(3):1746-54, 2006 Jan 20 - Who cited this? | PubMed ID: 16291744 | Fulltext

A role for the scaffolding adapter GAB2 in breast cancer.

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Bentires-Alj M, Gil SG, Chan R, Wang ZC, Wang Y, Imanaka N, Harris LN, Richardson A, Neel BG, and Gu H

Nature medicine 12(1):114-21, 2006 Jan - Who cited this? | PubMed ID: 16369543 | Fulltext

A nomenclature for signal regulatory protein family members.

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van den Berg TK, van Beek EM, Bühring HJ, Colonna M, Hamaguchi M, Howard CJ, Kasuga M, Liu Y, Matozaki T, Neel BG, Parkos CA, Sano S, Vignery A, Vivier E, Wright M, Zawatzky R,

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Journal of immunology (Baltimore, Md. : 1950) 175(12):7788-9, 2005 Dec 15 - Who cited this? | PubMed ID: 16339511 | Fulltext

Diverse biochemical properties of Shp2 mutants. Implications for disease phenotypes.

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Keilhack H, David FS, McGregor M, Cantley LC, and Neel BG

The Journal of biological chemistry 280(35):30984-93, 2005 Sep 2 - Who cited this? | PubMed ID: 15987685 | Fulltext

Phosphatidylinositol 3-kinase p85{alpha} subunit-dependent interaction with BCR/ABL-related fusion tyrosine kinases: molecular mechanisms and biological consequences.

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Ren SY, Bolton E, Mohi MG, Morrione A, Neel BG, and Skorski T

Molecular and cellular biology 25(18):8001-8, 2005 Sep - Who cited this? | PubMed ID: 16135792 | Fulltext

Regulation of in vitro and in vivo immune functions by the cytosolic adaptor protein SKAP-HOM.

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Togni M, Swanson KD, Reimann S, Kliche S, Pearce AC, Simeoni L, Reinhold D, Wienands J, Neel BG, Schraven B, and Gerber A

Molecular and cellular biology 25(18):8052-63, 2005 Sep - Who cited this? | PubMed ID: 16135797 | Fulltext

PTP-1B is an essential positive regulator of platelet integrin signaling.

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Arias-Salgado EG, Haj F, Dubois C, Moran B, Kasirer-Friede A, Furie BC, Furie B, Neel BG, and Shattil SJ

The Journal of cell biology 170(5):837, 2005 Aug 29 - Who cited this? | PubMed ID: 16115959 | Fulltext

Inhibition of IFN-alpha signaling by a PKC- and protein tyrosine phosphatase SHP-2-dependent pathway.

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Du Z, Shen Y, Yang W, Mecklenbrauker I, Neel BG, and Ivashkiv LB

Proceedings of the National Academy of Sciences of the United States of America 102(29):10267-72, 2005 Jul 19 - Who cited this? | PubMed ID: 16000408 | Fulltext

Modulation of epithelial neoplasia and lymphoid hyperplasia in PTEN+/- mice by the p85 regulatory subunits of phosphoinositide 3-kinase.

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Luo J, Sobkiw CL, Logsdon NM, Watt JM, Signoretti S, O'Connell F, Shin E, Shim Y, Pao L, Neel BG, Depinho RA, Loda M, and Cantley LC

Proceedings of the National Academy of Sciences of the United States of America 102(29):10238-43, 2005 Jul 19 - Who cited this? | PubMed ID: 16006513 | Fulltext

Resveratrol inhibits angiotensin II- and epidermal growth factor-mediated Akt activation: role of Gab1 and Shp2.

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Haider UG, Roos TU, Kontaridis MI, Neel BG, Sorescu D, Griendling KK, Vollmar AM, and Dirsch VM

Molecular pharmacology 68(1):41-8, 2005 Jul - Who cited this? | PubMed ID: 15849355 | Fulltext

The tumor suppressor RASSF1A and MAP-1 link death receptor signaling to Bax conformational change and cell death.

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Baksh S, Tommasi S, Fenton S, Yu VC, Martins LM, Pfeifer GP, Latif F, Downward J, and Neel BG

Molecular cell 18(6):637, 2005 Jun 10 - Who cited this? | PubMed ID: 15949439 | Fulltext

Liver-specific protein-tyrosine phosphatase 1B (PTP1B) re-expression alters glucose homeostasis of PTP1B-/-mice.

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Haj FG, Zabolotny JM, Kim YB, Kahn BB, and Neel BG

The Journal of biological chemistry 280(15):15038-46, 2005 Apr 15 - Who cited this? | PubMed ID: 15699041 | Fulltext

Prognostic, therapeutic, and mechanistic implications of a mouse model of leukemia evoked by Shp2 (PTPN11) mutations.

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Mohi MG, Williams IR, Dearolf CR, Chan G, Kutok JL, Cohen S, Morgan K, Boulton C, Shigematsu H, Keilhack H, Akashi K, Gilliland DG, and Neel BG

Cancer cell 7(2):179-91, 2005 Feb - Who cited this? | PubMed ID: 15710330 | Fulltext

Tyrosine phosphatase SHP-2 is a mediator of activity-dependent neuronal excitotoxicity.

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Rusanescu G, Yang W, Bai A, Neel BG, and Feig LA

The EMBO journal 24(2):305-14, 2005 Jan 26 - Who cited this? | PubMed ID: 15650750 | Fulltext

Coordinated regulation of insulin signaling by the protein tyrosine phosphatases PTP1B and TCPTP.

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Galic S, Hauser C, Kahn BB, Haj FG, Neel BG, Tonks NK, and Tiganis T

Molecular and cellular biology 25(2):819-29, 2005 Jan - Who cited this? | PubMed ID: 15632081 | Fulltext

Activating mutations of the noonan syndrome-associated SHP2/PTPN11 gene in human solid tumors and adult acute myelogenous leukemia.

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Bentires-Alj M, Paez JG, David FS, Keilhack H, Halmos B, Naoki K, Maris JM, Richardson A, Bardelli A, Sugarbaker DJ, Richards WG, Du J, Girard L, Minna JD, Loh ML, Fisher DE,

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Cancer research 64(24):8816-20, 2004 Dec 15 - Who cited this? | PubMed ID: 15604238 | Fulltext

CD22 is a functional ligand for SH2 domain-containing protein-tyrosine phosphatase-1 in primary T cells.

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Sathish JG, Walters J, Luo JC, Johnson KG, Leroy FG, Brennan P, Kim KP, Gygi SP, Neel BG, and Matthews RJ

The Journal of biological chemistry 279(46):47783, 2004 Nov 12 - Who cited this? | PubMed ID: 15364920 | Fulltext

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