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Papers authored by Molkentin JD

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Calcineurin deficiency decreases inflammatory lesions in transforming growth factor beta1-deficient mice.

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Bommireddy R, Bueno OF, Martin J, Ormsby I, Chen H, Gard C, Molkentin JD, Boivin GP, Babcock GF, and Doetschman T

Clinical and experimental immunology 158(3):317-24, 2009 Dec - Who cited this? | PubMed ID: 19747209 | Fulltext

Calcium influx is sufficient to induce muscular dystrophy through a TRPC-dependent mechanism.

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Millay DP, Goonasekera SA, Sargent MA, Maillet M, Aronow BJ, and Molkentin JD

Proceedings of the National Academy of Sciences of the United States of America 106(45):19023-8, 2009 Nov 10 - Who cited this? | PubMed ID: 19864620 | Fulltext

Lack of periostin leads to suppression of Notch1 signaling and calcific aortic valve disease.

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Tkatchenko TV, Moreno-Rodriguez RA, Conway SJ, Molkentin JD, Markwald RR, and Tkatchenko AV

Physiological genomics 39(3):160-8, 2009 Nov 6 - Who cited this? | PubMed ID: 19723774 | Fulltext

Genetic inhibition of calcineurin induces diastolic dysfunction in mice with chronic pressure overload.

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Gelpi RJ, Gao S, Zhai P, Yan L, Hong C, Danridge LM, Ge H, Maejima Y, Donato M, Yokota M, Molkentin JD, Vatner DE, Vatner SF, and Sadoshima J

American journal of physiology. Heart and circulatory physiology 297(5):H1814-9, 2009 Nov - Who cited this? | PubMed ID: 19717730 | Fulltext

Genetic manipulation of dysferlin expression in skeletal muscle: novel insights into muscular dystrophy.

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Millay DP, Maillet M, Roche JA, Sargent MA, McNally EM, Bloch RJ, and Molkentin JD

The American journal of pathology 175(5):1817-23, 2009 Nov - Who cited this? | PubMed ID: 19834057 | Fulltext

FoxO Transcription Factors Promote Autophagy in Cardiomyocytes.

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Sengupta A, Molkentin JD, and Yutzey KE

The Journal of biological chemistry 284(41):28319-31, 2009 Oct 9 - Who cited this? | PubMed ID: 19696026 | Fulltext

Cdc42 is an antihypertrophic molecular switch in the mouse heart.

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Maillet M, Lynch JM, Sanna B, York AJ, Zheng Y, and Molkentin JD

The Journal of clinical investigation 119(10):3079-88, 2009 Oct - Who cited this? | PubMed ID: 19741299 | Fulltext

CaMKII negatively regulates calcineurin-NFAT signaling in cardiac myocytes.

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MacDonnell SM, Weisser-Thomas J, Kubo H, Hanscome M, Liu Q, Jaleel N, Berretta R, Chen X, Brown JH, Sabri AK, Molkentin JD, and Houser SR

Circulation research 105(4):316-25, 2009 Aug 14 - Who cited this? | PubMed ID: 19608982 | Fulltext

Moderate heart dysfunction in mice with inducible cardiomyocyte-specific excision of the Serca2 gene.

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Andersson KB, Birkeland JA, Finsen AV, Louch WE, Sjaastad I, Wang Y, Chen J, Molkentin JD, Chien KR, Sejersted OM, and Christensen G

Journal of molecular and cellular cardiology 47(2):180-7, 2009 Aug - Who cited this? | PubMed ID: 19328205 | Fulltext

The mitochondrial permeability transition pore in motor neurons: Involvement in the pathobiology of ALS mice.

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Martin LJ, Gertz B, Pan Y, Price AC, Molkentin JD, and Chang Q

Experimental neurology 218(2):333-46, 2009 Aug - Who cited this? | PubMed ID: 19272377 | Fulltext

Protein kinase C{alpha}, but not PKC{beta} or PKC{gamma}, regulates contractility and heart failure susceptibility: implications for ruboxistaurin as a novel therapeutic approach.

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Liu Q, Chen X, Macdonnell SM, Kranias EG, Lorenz JN, Leitges M, Houser SR, and Molkentin JD

Circulation research 105(2):194-200, 2009 Jul 17 - Who cited this? | PubMed ID: 19556521 | Fulltext

Adenine nucleotide translocase-1 induces cardiomyocyte death through upregulation of the pro-apoptotic protein Bax.

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Baines CP and Molkentin JD

Journal of molecular and cellular cardiology 46(6):969-77, 2009 Jun - Who cited this? | PubMed ID: 19452617 | Fulltext

PDK1 coordinates survival pathways and {beta}-adrenergic response in the heart.

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Ito K, Akazawa H, Tamagawa M, Furukawa K, Ogawa W, Yasuda N, Kudo Y, Liao CH, Yamamoto R, Sato T, Molkentin JD, Kasuga M, Noda T, Nakaya H, and Komuro I

Proceedings of the National Academy of Sciences of the United States of America 106(21):8689-94, 2009 May 26 - Who cited this? | PubMed ID: 19429709 | Fulltext

Plasma membrane Ca2+-ATPase isoform 4 antagonizes cardiac hypertrophy in association with calcineurin inhibition in rodents.

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Wu X, Chang B, Blair NS, Sargent M, York AJ, Robbins J, Shull GE, and Molkentin JD

The Journal of clinical investigation 119(4):976-85, 2009 Apr - Who cited this? | PubMed ID: 19287093 | Fulltext

Cardiac Myosin Binding Protein-C Phosphorylation in a {beta}-Myosin Heavy Chain Background.

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Sadayappan S, Gulick J, Klevitsky R, Lorenz JN, Sargent M, Molkentin JD, and Robbins J

Circulation 119(9):1253-62, 2009 Mar 10 - Who cited this? | PubMed ID: 19237661 | Fulltext

Shigella induces mitochondrial dysfunction and cell death in nonmyleoid cells.

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Carneiro LA, Travassos LH, Soares F, Tattoli I, Magalhaes JG, Bozza MT, Plotkowski MC, Sansonetti PJ, Molkentin JD, Philpott DJ, and Girardin SE

Cell host & microbe 5(2):123-36, 2009 Feb 19 - Who cited this? | PubMed ID: 19218084 | Fulltext

Phosphodiesterase 5 inhibition blocks pressure overload-induced cardiac hypertrophy independent of the calcineurin pathway.

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Hsu S, Nagayama T, Koitabashi N, Zhang M, Zhou L, Bedja D, Gabrielson KL, Molkentin JD, Kass DA, and Takimoto E

Cardiovascular research 81(2):301-9, 2009 Feb 1 - Who cited this? | PubMed ID: 19029137 | Fulltext

PKCalpha regulates platelet granule secretion and thrombus formation in mice.

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Konopatskaya O, Gilio K, Harper MT, Zhao Y, Cosemans JM, Karim ZA, Whiteheart SW, Molkentin JD, Verkade P, Watson SP, Heemskerk JW, and Poole AW

The Journal of clinical investigation 119(2):399-407, 2009 Feb - Who cited this? | PubMed ID: 19147982 | Fulltext

Interaction between TAK1-TAB1-TAB2 and RCAN1-calcineurin defines a signalling nodal control point.

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Liu Q, Busby JC, and Molkentin JD

Nature cell biology 11(2):154-61, 2009 Feb - Who cited this? | PubMed ID: 19136967 | Fulltext

Estrogen attenuates left ventricular and cardiomyocyte hypertrophy by an estrogen receptor-dependent pathway that increases calcineurin degradation.

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Donaldson C, Eder S, Baker C, Aronovitz MJ, Weiss AD, Hall-Porter M, Wang F, Ackerman A, Karas RH, Molkentin JD, and Patten RD

Circulation research 104(2):265-75, 2009 Jan 30 - Who cited this? | PubMed ID: 19074476 | Fulltext

Rcan1 negatively regulates Fc{varepsilon}RI-mediated signaling and mast cell function.

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Yang YJ, Chen W, Edgar A, Li B, Molkentin JD, Berman JN, and Lin TJ

The Journal of experimental medicine 206(1):195-207, 2009 Jan 16 - Who cited this? | PubMed ID: 19124655 | Fulltext

Genetic manipulation of periostin expression in the heart does not affect myocyte content, cell cycle activity, or cardiac repair.

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Lorts A, Schwanekamp JA, Elrod JW, Sargent MA, and Molkentin JD

Circulation research 104(1):e1-7, 2009 Jan 2 - Who cited this? | PubMed ID: 19038863 | Fulltext

Endoplasmic reticulum-mitochondria crosstalk in NIX-mediated murine cell death.

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Diwan A, Matkovich SJ, Yuan Q, Zhao W, Yatani A, Brown JH, Molkentin JD, Kranias EG, and Dorn GW

The Journal of clinical investigation 119(1):203-12, 2009 Jan - Who cited this? | PubMed ID: 19065046 | Fulltext

Role of ERK1/2 signaling in congenital valve malformations in Noonan syndrome.

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Krenz M, Gulick J, Osinska HE, Colbert MC, Molkentin JD, and Robbins J

Proceedings of the National Academy of Sciences of the United States of America 105(48):18930-5, 2008 Dec 2 - Who cited this? | PubMed ID: 19017799 | Fulltext

Periostin as a heterofunctional regulator of cardiac development and disease.

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Conway SJ and Molkentin JD

Current genomics 9(8):548-55, 2008 Dec - Who cited this? | PubMed ID: 19516962 | Fulltext

Ca2+ influx through T- and L-type Ca2+ channels have different effects on myocyte contractility and induce unique cardiac phenotypes.

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Jaleel N, Nakayama H, Chen X, Kubo H, MacDonnell S, Zhang H, Berretta R, Robbins J, Cribbs L, Molkentin JD, and Houser SR

Circulation research 103(10):1109-19, 2008 Nov 7 - Who cited this? | PubMed ID: 18832749 | Fulltext

The control of Ca2+ influx and NFATc3 signaling in arterial smooth muscle during hypertension.

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Nieves-Cintrón M, Amberg GC, Navedo MF, Molkentin JD, and Santana LF

Proceedings of the National Academy of Sciences of the United States of America 105(40):15623-8, 2008 Oct 7 - Who cited this? | PubMed ID: 18832165 | Fulltext

Conditional dicer gene deletion in the postnatal myocardium provokes spontaneous cardiac remodeling.

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da Costa Martins PA, Bourajjaj M, Gladka M, Kortland M, van Oort RJ, Pinto YM, Molkentin JD, and De Windt LJ

Circulation 118(15):1567-76, 2008 Oct 7 - Who cited this? | PubMed ID: 18809798 | Fulltext

Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease.

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Du H, Guo L, Fang F, Chen D, A Sosunov A, M McKhann G, Yan Y, Wang C, Zhang H, Molkentin JD, Gunn-Moore FJ, Vonsattel JP, Arancio O, Chen JX, and Yan SD

Nature medicine, 2008 Sep 21 - Who cited this? | PubMed ID: 18806802 | Fulltext

With great power comes great responsibility: Using mouse genetics to study cardiac hypertrophy and failure.

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Molkentin JD and Robbins J

Journal of molecular and cellular cardiology, 2008 Sep 19 - Who cited this? | PubMed ID: 18845155 | Fulltext

Dusp6 (MKP3) null mice show enhanced ERK1/2 phosphorylation at baseline and increased myocyte proliferation in the heart affecting disease susceptibility.

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Maillet M, Purcell NH, Sargent MA, York A, Bueno OF, and Molkentin JD

The Journal of biological chemistry, 2008 Aug 27 - Who cited this? | PubMed ID: 18753132 | Fulltext

Nuclear Dbf2-related protein kinases (NDRs) in isolated cardiac myocytes and the myocardium: Activation by cellular stresses and by phosphoprotein serine-/threonine-phosphatase inhibitors.

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Fuller SJ, Pikkarainen S, Tham el L, Cullingford TE, Molkentin JD, Cornils H, Hergovich A, Hemmings BA, Clerk A, and Sugden PH

Cellular signalling 20(8):1564, 2008 Aug - Who cited this? | PubMed ID: 18555663 | Fulltext

Periostin facilitates eosinophil tissue infiltration in allergic lung and esophageal responses.

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Blanchard C, Mingler MK, McBride M, Putnam PE, Collins MH, Chang G, Stringer K, Abonia JP, Molkentin JD, and Rothenberg ME

Mucosal immunology 1(4):289-96, 2008 Jul - Who cited this? | PubMed ID: 19079190 | Fulltext

A redox-dependent pathway for regulating class II HDACs and cardiac hypertrophy.

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Ago T, Liu T, Zhai P, Chen W, Li H, Molkentin JD, Vatner SF, and Sadoshima J

Cell 133(6):978, 2008 Jun 13 - Who cited this? | PubMed ID: 18555775 | Fulltext

Periostin is required for maturation and extracellular matrix stabilization of noncardiomyocyte lineages of the heart.

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Snider P, Hinton RB, Moreno-Rodriguez RA, Wang J, Rogers R, Lindsley A, Li F, Ingram DA, Menick D, Field L, Firulli AB, Molkentin JD, Markwald R, and Conway SJ

Circulation research 102(7):752, 2008 Apr 11 - Who cited this? | PubMed ID: 18296617 | Fulltext

Genetic and pharmacologic inhibition of mitochondrial-dependent necrosis attenuates muscular dystrophy.

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Millay DP, Sargent MA, Osinska H, Baines CP, Barton ER, Vuagniaux G, Sweeney HL, Robbins J, and Molkentin JD

Nature medicine 14(4):442, 2008 Apr - Who cited this? | PubMed ID: 18345011 | Fulltext

Negative regulation of cyclin-dependent kinase 5 targets by protein kinase C.

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Sahin B, Hawasli AH, Greene RW, Molkentin JD, and Bibb JA

European journal of pharmacology 581(3):270, 2008 Mar 10 - Who cited this? | PubMed ID: 18190909 | Fulltext

Calcineurin-induced energy wasting in a transgenic mouse model of heart failure.

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Pinz I, Ostroy SE, Hoyer K, Osinska H, Robbins J, Molkentin JD, and Ingwall JS

American journal of physiology. Heart and circulatory physiology 294(3), 2008 Mar - Who cited this? | PubMed ID: 18192216 | Fulltext

Critical role for the mitochondrial permeability transition pore and cyclophilin D in platelet activation and thrombosis.

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Jobe SM, Wilson KM, Leo L, Raimondi A, Molkentin JD, Lentz SR, and Di Paola J

Blood 111(3):1257-65, 2008 Feb 1 - Who cited this? | PubMed ID: 17989312 | Fulltext

Analysis of the transcriptional activity of endogenous NFAT5 in primary cells using transgenic NFAT-luciferase reporter mice.

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Morancho B, Minguillón J, Molkentin JD, López-Rodríguez C, and Aramburu J

BMC molecular biology 9:13, 2008 - Who cited this? | PubMed ID: 18221508 | Fulltext

Requirement of calcineurin a for the survival of naive T cells.

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Manicassamy S, Gupta S, Huang Z, Molkentin JD, Shang W, and Sun Z

Journal of immunology (Baltimore, Md. : 1950) 180(1):106-12, 2008 Jan 1 - Who cited this? | PubMed ID: 18097009 | Fulltext

Cholecystokinin Activates Pancreatic Calcineurin-NFAT Signaling In Vitro and In Vivo.

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Gurda GT, Guo L, Lee SH, Molkentin JD, and Williams JA

Molecular biology of the cell 19(1):198-206, 2008 Jan - Who cited this? | PubMed ID: 17978097 | Fulltext

Does Contractile Ca2+ Control Calcineurin-NFAT Signaling and Pathological Hypertrophy in Cardiac Myocytes?.

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Houser SR and Molkentin JD

Science signaling 1(25):pe31, 2008 - Who cited this? | PubMed ID: 18577756 | Fulltext

Inducible and myocyte-specific inhibition of PKC{alpha} enhances cardiac contractility and protects against infarction-induced heart failure.

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Hambleton M, York A, Sargent MA, Kaiser RA, Lorenz JN, Robbins J, and Molkentin JD

American journal of physiology. Heart and circulatory physiology 293(6):H3768-71, 2007 Dec - Who cited this? | PubMed ID: 17921332 | Fulltext

Cardiomyocyte GATA4 functions as a stress-responsive regulator of angiogenesis in the murine heart.

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Heineke J, Auger-Messier M, Xu J, Oka T, Sargent MA, York A, Klevitsky R, Vaikunth S, Duncan SA, Aronow BJ, Robbins J, Cromblehol TM, and Molkentin JD

The Journal of clinical investigation 117(11):3198-210, 2007 Nov - Who cited this? | PubMed ID: 17975667 | Fulltext

Renaming the DSCR1/Adapt78 gene family as RCAN: regulators of calcineurin.

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Davies KJ, Ermak G, Rothermel BA, Pritchard M, Heitman J, Ahnn J, Henrique-Silva F, Crawford D, Canaider S, Strippoli P, Carinci P, Min KT, Fox DS, Cunningham KW, Bassel-Duby R, Olson EN,

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The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 21(12):3023-8, 2007 Oct - Who cited this? | PubMed ID: 17595344 | Fulltext

Ca2+- and mitochondrial-dependent cardiomyocyte necrosis as a primary mediator of heart failure.

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Nakayama H, Chen X, Baines CP, Klevitsky R, Zhang X, Zhang H, Jaleel N, Chua BH, Hewett TE, Robbins J, Houser SR, and Molkentin JD

The Journal of clinical investigation 117(9):2431-44, 2007 Sep - Who cited this? | PubMed ID: 17694179 | Fulltext

Genetic inhibition of cardiac ERK1/2 promotes stress-induced apoptosis and heart failure but has no effect on hypertrophy in vivo.

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Purcell NH, Wilkins BJ, York A, Saba-El-Leil MK, Meloche S, Robbins J, and Molkentin JD

Proceedings of the National Academy of Sciences of the United States of America 104(35):14074, 2007 Aug 28 - Who cited this? | PubMed ID: 17709754 | Fulltext

Genetic manipulation of periostin expression reveals a role in cardiac hypertrophy and ventricular remodeling.

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Oka T, Xu J, Kaiser RA, Melendez J, Hambleton M, Sargent MA, Lorts A, Brunskill EW, Dorn GW, Conway SJ, Aronow BJ, Robbins J, and Molkentin JD

Circulation research 101(3):313-21, 2007 Aug 3 - Who cited this? | PubMed ID: 17569887 | Fulltext

Mediating ERK 1/2 signaling rescues congenital heart defects in a mouse model of Noonan syndrome.

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Nakamura T, Colbert M, Krenz M, Molkentin JD, Hahn HS, Dorn GW, and Robbins J

The Journal of clinical investigation 117(8):2123, 2007 Aug - Who cited this? | PubMed ID: 17641779 | Fulltext

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