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Papers authored by Mobashery S

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Active site ring-opening of a thiirane moiety and picomolar inhibition of gelatinases.

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Forbes C, Shi Q, Fisher JF, Lee M, Hesek D, Llarrull LI, Toth M, Gossing M, Fridman R, and Mobashery S

Chemical biology & drug design 74(6):527-34, 2009 Dec - Who cited this? | PubMed ID: 19807733 | Fulltext

Synthesis, kinetic characterization and metabolism of diastereomeric 2-(1-(4-phenoxyphenylsulfonyl)ethyl)thiiranes as potent gelatinase and MT1-MMP inhibitors.

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Gooyit M, Lee M, Hesek D, Boggess B, Oliver AG, Fridman R, Mobashery S, and Chang M

Chemical biology & drug design 74(6):535-46, 2009 Dec - Who cited this? | PubMed ID: 19824893 | Fulltext

Mechanistic Basis for the Emergence of Catalytic Competence against Carbapenem Antibiotics by the GES Family of {beta}-Lactamases.

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Frase H, Shi Q, Testero SA, Mobashery S, and Vakulenko SB

The Journal of biological chemistry 284(43):29509-13, 2009 Oct 23 - Who cited this? | PubMed ID: 19656947 | Fulltext

Matrix Metalloproteinase 2 Inhibition: Combined Quantum Mechanics and Molecular Mechanics Studies of the Inhibition Mechanism of (4-Phenoxyphenylsulfonyl)methylthiirane and Its Oxirane Analogue.

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Tao P, Fisher JF, Shi Q, Vreven T, Mobashery S, and Schlegel HB

Biochemistry 48(41):9839-47, 2009 Oct 20 - Who cited this? | PubMed ID: 19754151 | Fulltext

Crystal Structures of Penicillin-Binding Protein 6 from Escherichia coli.

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Chen Y, Zhang W, Shi Q, Hesek D, Lee M, Mobashery S, and Shoichet BK

Journal of the American Chemical Society 131(40):14345-54, 2009 Oct 14 - Who cited this? | PubMed ID: 19807181 | Fulltext

Molecular Basis and Phenotype of Methicillin Resistance in Staphylococcus aureus and Insights into New {beta}-Lactams That Meet the Challenge.

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Llarrull LI, Fisher JF, and Mobashery S

Antimicrobial agents and chemotherapy 53(10):4051-63, 2009 Oct - Who cited this? | PubMed ID: 19470504 | Fulltext

The bifunctional enzymes of antibiotic resistance.

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Zhang W, Fisher JF, and Mobashery S

Current opinion in microbiology 12(5):505-11, 2009 Oct - Who cited this? | PubMed ID: 19615931 | Fulltext

Three Decades of the Class A beta-Lactamase Acyl-Enzyme.

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Fisher JF and Mobashery S

Current protein & peptide science 10(5):401-7, 2009 Oct - Who cited this? | PubMed ID: 19538154 | Fulltext

Roles of matrix metalloproteinases in flow-induced outward vascular remodeling.

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Ota R, Kurihara C, Tsou TL, Young WL, Yeghiazarians Y, Chang M, Mobashery S, Sakamoto A, and Hashimoto T

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 29(9):1547-58, 2009 Sep - Who cited this? | PubMed ID: 19513084 | Fulltext

Total Synthesis of N-Acetylglucosamine-1,6-anhydro-N-acetylmuramylpentapeptide and Evaluation of Its Turnover by AmpD from Escherichia coli.

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Hesek D, Lee M, Zhang W, Noll BC, and Mobashery S

Journal of the American Chemical Society 131(29):10334, 2009 Jul 29 - Who cited this? | PubMed ID: 19569690 | Fulltext

Bacterial AmpD at the Crossroads of Peptidoglycan Recycling and Manifestation of Antibiotic Resistance.

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Lee M, Zhang W, Hesek D, Noll BC, Boggess B, and Mobashery S

Journal of the American Chemical Society 131(25):8742-3, 2009 Jul 1 - Who cited this? | PubMed ID: 19496566 | Fulltext

DFT studies of the ring-opening mechanism of SB-3CT, a potent inhibitor of matrix metalloproteinase 2.

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Tao P, Fisher JF, Mobashery S, and Schlegel HB

Organic letters 11(12):2559-62, 2009 Jun 18 - Who cited this? | PubMed ID: 19445474 | Fulltext

Regiospecific syntheses of 6alpha-(1R-Hydroxyoctyl)penicillanic acid and 6beta-(1R-hydroxyoctyl)penicillanic acid as mechanistic probes of class D beta-lactamases.

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Testero SA, O'Daniel PI, Shi Q, Lee M, Hesek D, Ishiwata A, Noll BC, and Mobashery S

Organic letters 11(12):2515-8, 2009 Jun 18 - Who cited this? | PubMed ID: 19445490 | Fulltext

Total Synthesis of N-Acetylglucosamine-1,6-anhydro-N-acetylmuramylpentapeptide and Evaluation of Its Turnover by AmpD from Escherichia coli.

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Hesek D, Lee M, Zhang W, Noll BC, and Mobashery S

Journal of the American Chemical Society 131(14):5187-93, 2009 Apr 15 - Who cited this? | PubMed ID: 19309146 | Fulltext

Complications from dual roles of sodium hydride as a base and as a reducing agent.

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Hesek D, Lee M, Noll BC, Fisher JF, and Mobashery S

The Journal of organic chemistry 74(6):2567-70, 2009 Mar 20 - Who cited this? | PubMed ID: 19215116 | Fulltext

Source of Phosphate in the Enzymic Reaction as a Point of Distinction among Aminoglycoside 2''-Phosphotransferases.

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Toth M, Chow JW, Mobashery S, and Vakulenko SB

The Journal of biological chemistry 284(11):6690-6, 2009 Mar 13 - Who cited this? | PubMed ID: 19158087 | Fulltext

Crystal structure of CbpF, a bifunctional choline-binding protein and autolysis regulator from Streptococcus pneumoniae.

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Molina R, González A, Stelter M, Pérez-Dorado I, Kahn R, Morales M, Campuzano S, Campillo NE, Mobashery S, García JL, García P, and Hermoso JA

EMBO reports 10(3):246-51, 2009 Mar - Who cited this? | PubMed ID: 19165143 | Fulltext

A potent gelatinase inhibitor with anti-tumor-invasive activity and its metabolic disposition.

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Lee M, Celenza G, Boggess B, Blase J, Shi Q, Toth M, Bernardo MM, Wolter WR, Suckow MA, Hesek D, Noll BC, Fridman R, Mobashery S, and Chang M

Chemical biology & drug design 73(2):189-202, 2009 Feb - Who cited this? | PubMed ID: 19207421 | Fulltext

Identification and role of the homodimerization interface of the GPI-anchored MMP25 (MT6-MMP).

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Zhao H, Sohail A, Sun Q, Shi Q, Kim S, Mobashery S, and Fridman R

The Journal of biological chemistry, 2008 Oct 20 - Who cited this? | PubMed ID: 18936094 | Fulltext

Facile preparation of a highly functionalized tetrahydropyran by catalytic hydrogenation of an oxazoline.

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Hesek D, Lee M, Yamaguchi T, Noll BC, and Mobashery S

The Journal of organic chemistry 73(18):7349-52, 2008 Sep 19 - Who cited this? | PubMed ID: 18690743 | Fulltext

Lytic transglycosylase MltB of Escherichia coli and its role in recycling of peptidoglycan strands of bacterial cell wall.

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Suvorov M, Lee M, Hesek D, Boggess B, and Mobashery S

Journal of the American Chemical Society 130(36):11878-9, 2008 Sep 10 - Who cited this? | PubMed ID: 18700763 | Fulltext

Effect of ablation or inhibition of stromal matrix metalloproteinase-9 on lung metastasis in a breast cancer model is dependent on genetic background.

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Martin MD, Carter KJ, Jean-Philippe SR, Chang M, Mobashery S, Thiolloy S, Lynch CC, Matrisian LM, and Fingleton B

Cancer research 68(15):6251, 2008 Aug 1 - Who cited this? | PubMed ID: 18676849 | Fulltext

Are matrix metalloproteinases relevant therapeutic targets for prostate cancer bone metastasis?.

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Bonfil RD, Fridman R, Mobashery S, and Cher ML

Current oncology (Toronto, Ont.) 15(4):188-92, 2008 Aug - Who cited this? | PubMed ID: 18769612 | Fulltext

Co-opting the Cell Wall in Fighting Methicillin-Resistant Staphylococcus aureus: Potent Inhibition of PBP 2a by Two Anti-MRSA beta-Lactam Antibiotics.

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Villegas-Estrada A, Lee M, Hesek D, Vakulenko SB, and Mobashery S

Journal of the American Chemical Society 130(29):9212-3, 2008 Jul 23 - Who cited this? | PubMed ID: 18582062 | Fulltext

Investigation of the Mechanism of the Cell Wall dd-Carboxypeptidase Reaction of Penicillin-Binding Protein 5 of Escherichia coli by Quantum Mechanics/Molecular Mechanics Calculations.

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Shi Q, Meroueh SO, Fisher JF, and Mobashery S

Journal of the American Chemical Society, 2008 Jun 25 - Who cited this? | PubMed ID: 18576637 | Fulltext

Conformational analyses of thiirane-based gelatinase inhibitors.

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Lee M, Hesek D, Shi Q, Noll BC, Fisher JF, Chang M, and Mobashery S

Bioorganic & medicinal chemistry letters 18(10):3064-7, 2008 May 15 - Who cited this? | PubMed ID: 18083555 | Fulltext

Restoration of susceptibility of methicillin-resistant Staphylococcus aureus to beta-lactam antibiotics by acidic pH: role of penicillin-binding protein PBP 2a.

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Lemaire S, Fuda C, Van Bambeke F, Tulkens PM, and Mobashery S

The Journal of biological chemistry 283(19):12769, 2008 May 9 - Who cited this? | PubMed ID: 18337244 | Fulltext

Why clinically used tazobactam and sulbactam are poor inhibitors of OXA-10 beta-lactamase: Raman crystallographic evidence.

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Totir MA, Cha J, Ishiwata A, Wang B, Sheri A, Anderson VE, Buynak J, Mobashery S, and Carey PR

Biochemistry 47(13):4094-101, 2008 Apr 1 - Who cited this? | PubMed ID: 18324783 | Fulltext

Aminoglycoside 2''-Phosphotransferase Type IIIa from Enterococcus.

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Badarau A, Shi Q, Chow JW, Zajicek J, Mobashery S, and Vakulenko S

The Journal of biological chemistry 283(12):7638-47, 2008 Mar 21 - Who cited this? | PubMed ID: 18199745 | Fulltext

Metabolism of (4-phenoxyphenylsulfonyl) methylthiirane, a selective gelatinase inhibitor.

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Celenza G, Villegas-Estrada A, Lee M, Boggess B, Forbes C, Wolter WR, Suckow MA, Mobashery S, and Chang M

Chemical biology & drug design 71(3):187-96, 2008 Mar - Who cited this? | PubMed ID: 18221479 | Fulltext

Testosterone-induced matrix metalloproteinase activation is a checkpoint for neuronal addition to the adult songbird brain.

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Kim DH, Lilliehook C, Roides B, Chen Z, Chang M, Mobashery S, and Goldman SA

The Journal of neuroscience : the official journal of the Society for Neuroscience 28(1):208-16, 2008 Jan 2 - Who cited this? | PubMed ID: 18171938 | Fulltext

Molecular structures and dynamics of the stepwise activation mechanism of a matrix metalloproteinase zymogen: challenging the cysteine switch dogma.

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Rosenblum G, Meroueh S, Toth M, Fisher JF, Fridman R, Mobashery S, and Sagi I

Journal of the American Chemical Society 129(44):13566, 2007 Nov 7 - Who cited this? | PubMed ID: 17929919 | Fulltext

Metabolism of a highly selective gelatinase inhibitor generates active metabolite.

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Lee M, Villegas-Estrada A, Celenza G, Boggess B, Toth M, Kreitinger G, Forbes C, Fridman R, Mobashery S, and Chang M

Chemical biology & drug design 70(5):371-82, 2007 Nov - Who cited this? | PubMed ID: 17927722 | Fulltext

Prospects of therapies targeting resistant bacteria-New challenges 20 years post emergence of vancomycin-resistant enterococcus.

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Brickner SJ and Mobashery S

Current opinion in microbiology 10(5):425-7, 2007 Oct - Who cited this? | PubMed ID: 17951102 | Fulltext

Catalytic mechanism of penicillin-binding protein 5 of Escherichia coli.

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Zhang W, Shi Q, Meroueh SO, Vakulenko SB, and Mobashery S

Biochemistry 46(35):10113-21, 2007 Sep 4 - Who cited this? | PubMed ID: 17685588 | Fulltext

Elucidation of the molecular recognition of bacterial cell wall by modular pneumococcal phage endolysin CPL-1.

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Pérez-Dorado I, Campillo NE, Monterroso B, Hesek D, Lee M, Páez JA, García P, Martínez-Ripoll M, García JL, Mobashery S, Menéndez M, and Hermoso JA

The Journal of biological chemistry 282(34):24990-9, 2007 Aug 24 - Who cited this? | PubMed ID: 17581815 | Fulltext

Cytoplasmic-membrane anchoring of a class A beta-lactamase and its capacity in manifesting antibiotic resistance.

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Suvorov M, Vakulenko SB, and Mobashery S

Antimicrobial agents and chemotherapy 51(8):2937-42, 2007 Aug - Who cited this? | PubMed ID: 17502412 | Fulltext

Shared functional attributes between the mecA gene product of Staphylococcus sciuri and penicillin-binding protein 2a of methicillin-resistant Staphylococcus aureus.

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Fuda C, Suvorov M, Shi Q, Hesek D, Lee M, and Mobashery S

Biochemistry 46(27):8050-7, 2007 Jul 10 - Who cited this? | PubMed ID: 17567045 | Fulltext

Design and synthesis of a structurally constrained aminoglycoside.

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Kling D, Hesek D, Shi Q, and Mobashery S

The Journal of organic chemistry 72(14):5450-3, 2007 Jul 6 - Who cited this? | PubMed ID: 17579461 | Fulltext

Characterization of the beta-lactam antibiotic sensor domain of the MecR1 signal sensor/transducer protein from methicillin-resistant Staphylococcus aureus.

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Cha J, Vakulenko SB, and Mobashery S

Biochemistry 46(26):7822-31, 2007 Jul 3 - Who cited this? | PubMed ID: 17550272 | Fulltext

Prostate cancer-associated membrane type 1-matrix metalloproteinase: a pivotal role in bone response and intraosseous tumor growth.

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Bonfil RD, Dong Z, Trindade Filho JC, Sabbota A, Osenkowski P, Nabha S, Yamamoto H, Chinni SR, Zhao H, Mobashery S, Vessella RL, Fridman R, and Cher ML

The American journal of pathology 170(6):2100-11, 2007 Jun - Who cited this? | PubMed ID: 17525276 | Fulltext

Structural insights into the bactericidal mechanism of human peptidoglycan recognition proteins.

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Cho S, Wang Q, Swaminathan CP, Hesek D, Lee M, Boons GJ, Mobashery S, and Mariuzza RA

Proceedings of the National Academy of Sciences of the United States of America 104(21):8761, 2007 May 22 - Who cited this? | PubMed ID: 17502600 | Fulltext

Kinetic mechanism of enterococcal aminoglycoside phosphotransferase 2"-Ib.

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Toth M, Zajicek J, Kim C, Chow JW, Smith C, Mobashery S, and Vakulenko S

Biochemistry 46(18):5570-8, 2007 May 8 - Who cited this? | PubMed ID: 17425289 | Fulltext

Conformational transition in the aminoacyl t-RNA site of the bacterial ribosome both in the presence and absence of an aminoglycoside antibiotic.

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Meroueh SO and Mobashery S

Chemical biology & drug design 69(5):291, 2007 May - Who cited this? | PubMed ID: 17539821 | Fulltext

Mechanistic characterization of the bifunctional aminoglycoside-modifying enzyme AAC(3)-Ib/AAC(6')-Ib' from Pseudomonas aeruginosa.

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Kim C, Villegas-Estrada A, Hesek D, and Mobashery S

Biochemistry 46(17):5270-82, 2007 May 1 - Who cited this? | PubMed ID: 17417880 | Fulltext

Lysine N(zeta)-decarboxylation in the BlaR1 protein from Staphylococcus aureus at the root of its function as an antibiotic sensor.

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Cha J and Mobashery S

Journal of the American Chemical Society 129(13):3834-5, 2007 Apr 4 - Who cited this? | PubMed ID: 17343387 | Fulltext

Effect of synthetic matrix metalloproteinase inhibitors on lipopolysaccharide-induced blood-brain barrier opening in rodents: Differences in response based on strains and solvents.

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Rosenberg GA, Estrada EY, and Mobashery S

Brain research 1133(1):186, 2007 Feb 16 - Who cited this? | PubMed ID: 17184743 | Fulltext

MT1-MMP shedding involves an ADAM and is independent of its localization in lipid rafts.

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Toth M, Sohail A, Mobashery S, and Fridman R

Biochemical and biophysical research communications 350(2):377-84, 2006 Nov 17 - Who cited this? | PubMed ID: 17007816 | Fulltext

Synthesis of an inhibitor-tethered resin for detection of active matrix metalloproteinases involved in disease.

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Hesek D, Toth M, Krchnak V, Fridman R, and Mobashery S

The Journal of organic chemistry 71(16):5848-54, 2006 Aug 4 - Who cited this? | PubMed ID: 16872162 | Fulltext

Characterization of the bifunctional aminoglycoside-modifying enzyme ANT(3'')-Ii/AAC(6')-IId from Serratia marcescens.

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Kim C, Hesek D, Zajícek J, Vakulenko SB, and Mobashery S

Biochemistry 45(27):8368-77, 2006 Jul 11 - Who cited this? | PubMed ID: 16819836 | Fulltext

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