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Papers authored by Mitobe Y

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Discovery of trans-N-[1-(2-fluorophenyl)-3-pyrazolyl]-3-oxospiro[6-azaisobenzofuran-1(3H),1'-cyclohexane]-4'-carboxamide, a potent and orally active neuropeptide Y Y5 receptor antagonist.

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Haga Y, Sakamoto T, Shibata T, Nonoshita K, Ishikawa M, Suga T, Takahashi H, Takahashi T, Takahashi H, Ando M, Murai T, Gomori A, Oda Z, Kitazawa H, Mitobe Y, Kanesaka M,

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Bioorganic & medicinal chemistry 17(19):6971-82, 2009 Oct 1 - Who cited this? | PubMed ID: 19720539 | Fulltext

Identification of positron emission tomography ligands for NPY Y5 receptors in the brain.

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Takahashi H, Haga Y, Shibata T, Nonoshita K, Sakamoto T, Moriya M, Ohe T, Chiba M, Mitobe Y, Kitazawa H, Iwaasa H, Ishihara A, Ishii Y, Kanatani A, and Fukami T

Bioorganic & medicinal chemistry letters 19(18):5436-9, 2009 Sep 15 - Who cited this? | PubMed ID: 19679469 | Fulltext

Discovery of pyridone-containing imidazolines as potent and selective inhibitors of neuropeptide Y Y5 receptor.

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Ando M, Sato N, Nagase T, Nagai K, Ishikawa S, Takahashi H, Ohtake N, Ito J, Hirayama M, Mitobe Y, Iwaasa H, Gomori A, Matsushita H, Tadano K, Fujino N, Tanaka S,

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Bioorganic & medicinal chemistry 17(16):6106-22, 2009 Aug 15 - Who cited this? | PubMed ID: 19616955 | Fulltext

Synthesis, structure-activity relationships, and biological profiles of a dihydrobenzoxathiin class of histamine H(3) receptor inverse agonists.

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Sasaki T, Takahashi T, Nagase T, Mizutani T, Ito S, Mitobe Y, Miyamoto Y, Kanesaka M, Yoshimoto R, Tanaka T, Takenaga N, Tokita S, and Sato N

Bioorganic & medicinal chemistry letters 19(15):4232-6, 2009 Aug 1 - Who cited this? | PubMed ID: 19520574 | Fulltext

Development of a selective and potent radioactive ligand for histamine H(3) receptors: A compound potentially useful for receptor occupancy studies.

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Mitobe Y, Ito S, Mizutani T, Nagase T, Sato N, and Tokita S

Bioorganic & medicinal chemistry letters 19(15):4075-8, 2009 Aug 1 - Who cited this? | PubMed ID: 19553110 | Fulltext

Comparison of independent and combined chronic anti-obese effects of NPY Y2 receptor agonist, PYY(3-36), and NPY Y5 receptor antagonist in diet-induced obese mice.

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Moriya R, Mashiko S, Ishihara A, Takahashi T, Murai T, Ito J, Mitobe Y, Oda Z, Iwaasa H, Takehiro F, and Kanatani A

Peptides 30(7):1318-22, 2009 Jul - Who cited this? | PubMed ID: 19394383 | Fulltext

Synthesis and evaluation of structurally constrained quinazolinone derivatives as potent and selective histamine h3 receptor inverse agonists.

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Nagase T, Mizutani T, Sekino E, Ishikawa S, Ito S, Mitobe Y, Miyamoto Y, Yoshimoto R, Tanaka T, Ishihara A, Takenaga N, Tokita S, and Sato N

Journal of medicinal chemistry 51(21):6889-901, 2008 Nov 13 - Who cited this? | PubMed ID: 18841880 | Fulltext

Design, syntheses, and structure-activity relationships of novel NPY Y5 receptor antagonists: 2-{3-Oxospiro[isobenzofuran-1(3H),4'-piperidin]-1'-yl}benzimidazole derivatives.

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Ogino Y, Ohtake N, Nagae Y, Matsuda K, Moriya M, Suga T, Ishikawa M, Kanesaka M, Mitobe Y, Ito J, Kanno T, Ishihara A, Iwaasa H, Ohe T, Kanatani A, and Fukami T

Bioorganic & medicinal chemistry letters 18(18):5010-4, 2008 Sep 15 - Who cited this? | PubMed ID: 18723347 | Fulltext

Syntheses and structure-activity relationships of novel, potent, and selective trans-2-[3-oxospiro[isobenzofuran-1(3H),1'-cyclohexan]-4'-yl]benzimidazole NPY Y5 receptor antagonists.

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Ogino Y, Ohtake N, Nagae Y, Matsuda K, Ishikawa M, Moriya M, Kanesaka M, Mitobe Y, Ito J, Kanno T, Ishihara A, Iwaasa H, Ohe T, Kanatani A, and Fukami T

Bioorganic & medicinal chemistry letters 18(18):4997-5001, 2008 Sep 15 - Who cited this? | PubMed ID: 18752943 | Fulltext

Synthesis, structure-activity relationships, and biological profiles of a quinazolinone class of histamine h3 receptor inverse agonists.

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Nagase T, Mizutani T, Ishikawa S, Sekino E, Sasaki T, Fujimura T, Ito S, Mitobe Y, Miyamoto Y, Yoshimoto R, Tanaka T, Ishihara A, Takenaga N, Tokita S, Fukami T, and Sato N

Journal of medicinal chemistry 51(15):4780-9, 2008 Aug 14 - Who cited this? | PubMed ID: 18598020 | Fulltext

Effects of a novel y5 antagonist in obese mice: combination with food restriction or sibutramine.

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Mashiko S, Ishihara A, Iwaasa H, Moriya R, Kitazawa H, Mitobe Y, Ito J, Gomori A, Matsushita H, Takahashi T, Macneil DJ, Van der Ploeg LH, Fukami T, and Kanatani A

Obesity (Silver Spring, Md.) 16(7):1510-5, 2008 Jul - Who cited this? | PubMed ID: 18421274 | Fulltext

A neuropeptide Y Y5 antagonist selectively ameliorates body weight gain and associated parameters in diet-induced obese mice.

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Ishihara A, Kanatani A, Mashiko S, Tanaka T, Hidaka M, Gomori A, Iwaasa H, Murai N, Egashira S, Murai T, Mitobe Y, Matsushita H, Okamoto O, Sato N, Jitsuoka M, Fukuroda T,

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Proceedings of the National Academy of Sciences of the United States of America 103(18):7154-8, 2006 May 2 - Who cited this? | PubMed ID: 16636293 | Fulltext

Detailed pharmacological characterization of GT-2331 for the rat histamine H3 receptor.

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Ito S, Yoshimoto R, Miyamoto Y, Mitobe Y, Nakamura T, Ishihara A, MacNeil DJ, Kanatani A, and Tokita S

European journal of pharmacology 529(1-3):40-6, 2006 Jan 4 - Who cited this? | PubMed ID: 16316645 | Fulltext

Effect of PPARgamma ligands on the viability of gastric epithelial cells.

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Kojima K, Shimada T, Mitobe Y, Yoshiura K, Hiraishi H, and Terano A

Alimentary pharmacology & therapeutics 16 Suppl 2:67-73, 2002 Apr - Who cited this? | PubMed ID: 11966526 | Fulltext

The effects of aspirin on antioxidant defences of cultured rat gastric mucosal cells.

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Mitobe Y, Hiraishi H, Sasai T, Shimada T, and Terano A

Alimentary pharmacology & therapeutics 14 Suppl 1:10-7, 2000 Apr - Who cited this? | PubMed ID: 10807398 | Fulltext

[Further studies on the action of adrenocortical hormones upon cultured chick embryo fibroblasts].

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Mitobe Y

Shigaku. Odontology; journal of Nippon Dental College 58(6):749-64, 1971 Feb - Who cited this? | PubMed ID: 5282859 | Fulltext

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