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Papers authored by Metzler WJ

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Multiple and single binding modes of fragment-like kinase inhibitors revealed by molecular modeling, residue type-selective protonation, and nuclear overhauser effects.

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Constantine KL, Mueller L, Metzler WJ, McDonnell PA, Todderud G, Goldfarb V, Fan Y, Newitt JA, Kiefer SE, Gao M, Tortolani D, Vaccaro W, and Tokarski J

Journal of medicinal chemistry 51(19):6225-9, 2008 Oct 9 - Who cited this? | PubMed ID: 18771253 | Fulltext

Involvement of DPP-IV catalytic residues in enzyme-saxagliptin complex formation.

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Metzler WJ, Yanchunas J, Weigelt C, Kish K, Klei HE, Xie D, Zhang Y, Corbett M, Tamura JK, He B, Hamann LG, Kirby MS, and Marcinkeviciene J

Protein science : a publication of the Protein Society 17(2):240-50, 2008 Feb - Who cited this? | PubMed ID: 18227430 | Fulltext

NMR structure of a potent small molecule inhibitor bound to human keratinocyte fatty acid-binding protein.

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McDonnell PA, Constantine KL, Goldfarb V, Johnson SR, Sulsky R, Magnin DR, Robl JA, Caulfield TJ, Parker RA, Taylor DS, Adam LP, Metzler WJ, Mueller L, and Farmer BT

Journal of medicinal chemistry 49(16):5013-7, 2006 Aug 10 - Who cited this? | PubMed ID: 16884313 | Fulltext

Protein-ligand NOE matching: a high-throughput method for binding pose evaluation that does not require protein NMR resonance assignments.

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Constantine KL, Davis ME, Metzler WJ, Mueller L, and Claus BL

Journal of the American Chemical Society 128(22):7252-63, 2006 Jun 7 - Who cited this? | PubMed ID: 16734479 | Fulltext

Mechanism of Gly-Pro-pNA cleavage catalyzed by dipeptidyl peptidase-IV and its inhibition by saxagliptin (BMS-477118).

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Kim YB, Kopcho LM, Kirby MS, Hamann LG, Weigelt CA, Metzler WJ, and Marcinkeviciene J

Archives of biochemistry and biophysics 445(1):9-18, 2006 Jan 1 - Who cited this? | PubMed ID: 16364232 | Fulltext

Structure-based design of potent and selective inhibitors of collagenase-3 (MMP-13).

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Kim SH, Pudzianowski AT, Leavitt KJ, Barbosa J, McDonnell PA, Metzler WJ, Rankin BM, Liu R, Vaccaro W, and Pitts W

Bioorganic & medicinal chemistry letters 15(4):1101-6, 2005 Feb 15 - Who cited this? | PubMed ID: 15686921 | Fulltext

Kinetic studies on beta-site amyloid precursor protein-cleaving enzyme (BACE). Confirmation of an iso mechanism.

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Toulokhonova L, Metzler WJ, Witmer MR, Copeland RA, and Marcinkeviciene J

The Journal of biological chemistry 278(7):4582-9, 2003 Feb 14 - Who cited this? | PubMed ID: 12458195 | Fulltext

Hydrophobicity profiles for protein sequence analysis.

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Krystek SR, Metzler WJ, and Novotny J

Current protocols in protein science / editorial board, John E. Coligan ... [et al.] 0:0, 2001 May - Who cited this? | PubMed ID: 18429150 | Fulltext

Protein secondary structure prediction.

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Krystek SR, Metzler WJ, and Novotny J

Current protocols in protein science / editorial board, John E. Coligan ... [et al.] Chapter 2:Unit2.3, 2001 May - Who cited this? | PubMed ID: 18429151 | Fulltext

Analysis of the three-dimensional antigenic structure of giant ragweed allergen, Amb t 5.

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Rafnar T, Brummet ME, Bassolino-Klimas D, Metzler WJ, and Marsh DG

Molecular immunology 35(8):459-67, 1998 Jun - Who cited this? | PubMed ID: 9798650 | Fulltext

Solution structure of human CTLA-4 and delineation of a CD80/CD86 binding site conserved in CD28.

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Metzler WJ, Bajorath J, Fenderson W, Shaw SY, Constantine KL, Naemura J, Leytze G, Peach RJ, Lavoie TB, Mueller L, and Linsley PS

Nature structural biology 4(7):527-31, 1997 Jul - Who cited this? | PubMed ID: 9228944 | Fulltext

Characterization of NADP+ binding to perdeuterated MurB: backbone atom NMR assignments and chemical-shift changes.

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Constantine KL, Mueller L, Goldfarb V, Wittekind M, Metzler WJ, Yanchunas J, Robertson JG, Malley MF, Friedrichs MS, and Farmer BT

Journal of molecular biology 267(5):1223-46, 1997 Apr 18 - Who cited this? | PubMed ID: 9150408 | Fulltext

Molecular modeling of CD28 and three-dimensional analysis of residue conservation in the CD28/CD152 family.

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Bajorath J, Metzler WJ, and Linsley PS

Journal of molecular graphics & modelling 15(2):135-9, 108-11, 1997 Apr - Who cited this? | PubMed ID: 9385561 | Fulltext

The three-dimensional solution structure of the SH2 domain from p55blk kinase.

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Metzler WJ, Leiting B, Pryor K, Mueller L, and Farmer BT

Biochemistry 35(20):6201-11, 1996 May 21 - Who cited this? | PubMed ID: 8639560 | Fulltext

Simulated annealing with restrained molecular dynamics using a flexible restraint potential: theory and evaluation with simulated NMR constraints.

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Bassolino-Klimas D, Tejero R, Krystek SR, Metzler WJ, Montelione GT, and Bruccoleri RE

Protein science : a publication of the Protein Society 5(4):593-603, 1996 Apr - Who cited this? | PubMed ID: 8845749 | Fulltext

The ligand binding domain of the human retinoic acid receptor gamma is predominantly alpha-helical with a Trp residue in the ligand binding site.

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Lupisella JA, Driscoll JE, Metzler WJ, and Reczek PR

The Journal of biological chemistry 270(42):24884-90, 1995 Oct 20 - Who cited this? | PubMed ID: 7559612 | Fulltext

Refined solution structure of human profilin I.

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Metzler WJ, Farmer BT, Constantine KL, Friedrichs MS, Lavoie T, and Mueller L

Protein science : a publication of the Protein Society 4(3):450-9, 1995 Mar - Who cited this? | PubMed ID: 7795529 | Fulltext

Immunologic and molecular characterization of Amb p V allergens from Ambrosia psilostachya (western Ragweed) pollen.

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Ghosh B, Rafnar T, Perry MP, Bassolino-Klimas D, Metzler WJ, Klapper DG, and Marsh DG

Journal of immunology (Baltimore, Md. : 1950) 152(6):2882-9, 1994 Mar 15 - Who cited this? | PubMed ID: 7511632 | Fulltext

Identification of the poly-L-proline-binding site on human profilin.

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Metzler WJ, Bell AJ, Ernst E, Lavoie TB, and Mueller L

The Journal of biological chemistry 269(6):4620-5, 1994 Feb 11 - Who cited this? | PubMed ID: 8308034 | Fulltext

Solution structure of an isolated antibody VL domain.

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Constantine KL, Friedrichs MS, Metzler WJ, Wittekind M, Hensley P, and Mueller L

Journal of molecular biology 236(1):310-27, 1994 Feb 11 - Who cited this? | PubMed ID: 8107112 | Fulltext

Relaxation study of the backbone dynamics of human profilin by two-dimensional 1H-15N NMR.

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Constantine KL, Friedrichs MS, Bell AJ, Lavoie TB, Mueller L, and Metzler WJ

FEBS letters 336(3):457-61, 1993 Dec 28 - Who cited this? | PubMed ID: 8282110 | Fulltext

Characterization of the three-dimensional solution structure of human profilin: 1H, 13C, and 15N NMR assignments and global folding pattern.

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Metzler WJ, Constantine KL, Friedrichs MS, Bell AJ, Ernst EG, Lavoie TB, and Mueller L

Biochemistry 32(50):13818-29, 1993 Dec 21 - Who cited this? | PubMed ID: 8268157 | Fulltext

Solution structure of the calcium channel antagonist omega-conotoxin GVIA.

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Skalicky JJ, Metzler WJ, Ciesla DJ, Galdes A, and Pardi A

Protein science : a publication of the Protein Society 2(10):1591-603, 1993 Oct - Who cited this? | PubMed ID: 8251934 | Fulltext

Expression and analysis of recombinant Amb a V and Amb t V allergens. Comparison with native proteins by immunological assays and NMR spectroscopy.

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Rafnar T, Ghosh B, Metzler WJ, Huang SK, Perry MP, Mueller L, and Marsh DG

The Journal of biological chemistry 267(29):21119-23, 1992 Oct 15 - Who cited this? | PubMed ID: 1400422 | Fulltext

Proton resonance assignments and three-dimensional solution structure of the ragweed allergen Amb a V by nuclear magnetic resonance spectroscopy.

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Metzler WJ, Valentine K, Roebber M, Marsh DG, and Mueller L

Biochemistry 31(37):8697-705, 1992 Sep 22 - Who cited this? | PubMed ID: 1390654 | Fulltext

Determination of the three-dimensional solution structure of ragweed allergen Amb t V by nuclear magnetic resonance spectroscopy.

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Metzler WJ, Valentine K, Roebber M, Friedrichs MS, Marsh DG, and Mueller L

Biochemistry 31(22):5117-27, 1992 Jun 9 - Who cited this? | PubMed ID: 1606135 | Fulltext

Determining local conformational variations in DNA. Nuclear magnetic resonance structures of the DNA duplexes d(CGCCTAATCG) and d(CGTCACGCGC) generated using back-calculation of the nuclear Overhauser effect spectra, a distance geometry algorithm and constrained molecular dynamics.

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Metzler WJ, Wang C, Kitchen DB, Levy RM, and Pardi A

Journal of molecular biology 214(3):711-36, 1990 Aug 5 - Who cited this? | PubMed ID: 2167379 | Fulltext

Limited sampling of conformational space by the distance geometry algorithm: implications for structures generated from NMR data.

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Metzler WJ, Hare DR, and Pardi A

Biochemistry 28(17):7045-52, 1989 Aug 22 - Who cited this? | PubMed ID: 2819047 | Fulltext

Lambda cro repressor complex with OR3 operator DNA. 19F nuclear magnetic resonance observations.

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Metzler WJ and Lu P

Journal of molecular biology 205(1):149-64, 1989 Jan 5 - Who cited this? | PubMed ID: 2522553 | Fulltext

Lambda phage cro repressor interaction with its operator DNA: 2'-deoxy-5-fluorouracil OR3 analogues.

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Metzler WJ, Arndt K, Tecza E, Wasilewski J, and Lu P

Biochemistry 24(6):1418-24, 1985 Mar 12 - Who cited this? | PubMed ID: 3157402 | Fulltext

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